{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T02:36:35Z","timestamp":1760236595318,"version":"build-2065373602"},"reference-count":56,"publisher":"MDPI AG","issue":"23","license":[{"start":{"date-parts":[[2021,12,6]],"date-time":"2021-12-06T00:00:00Z","timestamp":1638748800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>The possibility to form new C\u2013B bonds with aziridines using diboron derivatives continues to be a particularly challenging field in view of the direct preparation of functionalized \u03b2-aminoboronates, which are important compounds in drug discovery, being a bioisostere of \u03b2-aminoacids. We now report experimental and computational data that allows the individuation of the structural requisites and of reaction conditions necessary to open alkyl aziridines using bis(pinacolate)diboron (B2pin2) in a regioselective nucleophilic addition reaction under copper catalysis.<\/jats:p>","DOI":"10.3390\/molecules26237399","type":"journal-article","created":{"date-parts":[[2021,12,7]],"date-time":"2021-12-07T02:48:13Z","timestamp":1638845293000},"page":"7399","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Copper-Catalyzed Ring-Opening Reactions of Alkyl Aziridines with B2pin2: Experimental and Computational Studies"],"prefix":"10.3390","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3178-7566","authenticated-orcid":false,"given":"Lucilla","family":"Favero","sequence":"first","affiliation":[{"name":"Department of Pharmacy, University of Pisa, Via Bonanno 33, 56126 Pisa, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrea","family":"Menichetti","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, University of Pisa, Via Bonanno 33, 56126 Pisa, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cosimo","family":"Boldrini","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, University of Pisa, Via Bonanno 33, 56126 Pisa, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lucrezia Margherita","family":"Comparini","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, University of Pisa, Via Bonanno 33, 56126 Pisa, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6126-9984","authenticated-orcid":false,"given":"Valeria","family":"Di Bussolo","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, University of Pisa, Via Bonanno 33, 56126 Pisa, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3585-6573","authenticated-orcid":false,"given":"Sebastiano","family":"Di Pietro","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, University of Pisa, Via Bonanno 33, 56126 Pisa, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6063-2198","authenticated-orcid":false,"given":"Mauro","family":"Pineschi","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, University of Pisa, Via Bonanno 33, 56126 Pisa, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2021,12,6]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"3702","DOI":"10.1002\/slct.201800170","article-title":"Aziridine Ring Opening: An Overview of Sustainable Methods","volume":"3","author":"Sabir","year":"2018","journal-title":"ChemistrySelect"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"5461","DOI":"10.1016\/j.tet.2017.07.062","article-title":"Recent advances in the transformations of cycloalkane-fused oxiranes and aziridines","volume":"73","author":"Nonn","year":"2017","journal-title":"Tetrahedron"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"4979","DOI":"10.1002\/ejoc.200600384","article-title":"Asymmetric Ring-Opening of Epoxides and Aziridines with Carbon Nucleophiles","volume":"2006","author":"Pineschi","year":"2006","journal-title":"Eur. 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