{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T02:37:03Z","timestamp":1760236623621,"version":"build-2065373602"},"reference-count":65,"publisher":"MDPI AG","issue":"24","license":[{"start":{"date-parts":[[2021,12,9]],"date-time":"2021-12-09T00:00:00Z","timestamp":1639008000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Norwegian Research Centre","award":["311392"],"award-info":[{"award-number":["311392"]}]},{"name":"Coegin Pharma","award":["90211100"],"award-info":[{"award-number":["90211100"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>Cytosolic phospholipase A2\u03b1 (cPLA2\u03b1) is the rate-limiting enzyme in releasing arachidonic acid and biosynthesis of its derivative eicosanoids. Thus, the catalytic activity of cPLA2\u03b1 plays an important role in cellular metabolism in healthy as well as cancer cells. There is mounting evidence suggesting that cPLA2\u03b1 is an interesting target for cancer treatment; however, it is unclear which cancers are most relevant for further investigation. Here we report the relative expression of cPLA2\u03b1 in a variety of cancers and cancer cell lines using publicly available datasets. The profiling of a panel of cancer cell lines representing different tissue origins suggests that hematological malignancies are particularly sensitive to the growth inhibitory effect of cPLA2\u03b1 inhibition. Several hematological cancers and cancer cell lines overexpressed cPLA2\u03b1, including multiple myeloma. Multiple myeloma is an incurable hematological cancer of plasma cells in the bone marrow with an emerging requirement of therapeutic approaches. We show here that two cPLA2\u03b1 inhibitors AVX420 and AVX002, significantly and dose-dependently reduced the viability of multiple myeloma cells and induced apoptosis in vitro. Our findings implicate cPLA2\u03b1 activity in the survival of multiple myeloma cells and support further studies into cPLA2\u03b1 as a potential target for treating hematological cancers, including multiple myeloma.<\/jats:p>","DOI":"10.3390\/molecules26247447","type":"journal-article","created":{"date-parts":[[2021,12,9]],"date-time":"2021-12-09T21:46:58Z","timestamp":1639086418000},"page":"7447","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Inhibition of Cytosolic Phospholipase A2\u03b1 Induces Apoptosis in Multiple Myeloma Cells"],"prefix":"10.3390","volume":"26","author":[{"given":"Nur","family":"Mahammad","sequence":"first","affiliation":[{"name":"Department of Biology, Norwegian University of Science and Technology (NTNU), 7491 Trondheim, Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Felicity J.","family":"Ashcroft","sequence":"additional","affiliation":[{"name":"Department of Biology, Norwegian University of Science and Technology (NTNU), 7491 Trondheim, Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Astrid J.","family":"Feuerherm","sequence":"additional","affiliation":[{"name":"Department of Biology, Norwegian University of Science and Technology (NTNU), 7491 Trondheim, Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5554-0771","authenticated-orcid":false,"given":"Samah","family":"Elsaadi","sequence":"additional","affiliation":[{"name":"Center for Myeloma Research, Department of Clinical and Molecular Medicine, Faculty of Medicine and Health Science, Norwegian University of Science and Technology (NTNU), 7491 Trondheim, Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Esten N.","family":"Vandsemb","sequence":"additional","affiliation":[{"name":"Center for Myeloma Research, Department of Clinical and Molecular Medicine, Faculty of Medicine and Health Science, Norwegian University of Science and Technology (NTNU), 7491 Trondheim, Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5179-2835","authenticated-orcid":false,"given":"Magne","family":"B\u00f8rset","sequence":"additional","affiliation":[{"name":"Center for Myeloma Research, Department of Clinical and Molecular Medicine, Faculty of Medicine and Health Science, Norwegian University of Science and Technology (NTNU), 7491 Trondheim, Norway"},{"name":"Department of Immunology and Transfusion Medicine, St. Olav\u2019s University Hospital, 7491 Trondheim, Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Berit","family":"Johansen","sequence":"additional","affiliation":[{"name":"Department of Biology, Norwegian University of Science and Technology (NTNU), 7491 Trondheim, Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2021,12,9]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"i3","DOI":"10.1093\/annonc\/mdl443","article-title":"Epidemiology of hematological malignancies","volume":"18","author":"Bordoni","year":"2007","journal-title":"Ann. 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