{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,27]],"date-time":"2026-06-27T20:51:16Z","timestamp":1782593476465,"version":"3.54.5"},"reference-count":231,"publisher":"MDPI AG","issue":"24","license":[{"start":{"date-parts":[[2021,12,9]],"date-time":"2021-12-09T00:00:00Z","timestamp":1639008000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>COVID-19 is the name of the disease caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection that occurred in 2019. The virus\u2013host-specific interactions, molecular targets on host cell deaths, and the involved signaling are crucial issues, which become potential targets for treatment. Spike protein, angiotensin-converting enzyme 2 (ACE2), cathepsin L-cysteine peptidase, transmembrane protease serine 2 (TMPRSS2), nonstructural protein 1 (Nsp1), open reading frame 7a (ORF7a), viral main protease (3C-like protease (3CLpro) or Mpro), RNA dependent RNA polymerase (RdRp) (Nsp12), non-structural protein 13 (Nsp13) helicase, and papain-like proteinase (PLpro) are molecules associated with SARS-CoV infection and propagation. SARS-CoV-2 can induce host cell death via five kinds of regulated cell death, i.e., apoptosis, necroptosis, pyroptosis, autophagy, and PANoptosis. The mechanisms of these cell deaths are well established and can be disrupted by synthetic small molecules or natural products. There are a variety of compounds proven to play roles in the cell death inhibition, such as pan-caspase inhibitor (z-VAD-fmk) for apoptosis, necrostatin-1 for necroptosis, MCC950, a potent and specific inhibitor of the NLRP3 inflammasome in pyroptosis, and chloroquine\/hydroxychloroquine, which can mitigate the corresponding cell death pathways. However, NF-\u03baB signaling is another critical anti-apoptotic or survival route mediated by SARS-CoV-2. Such signaling promotes viral survival, proliferation, and inflammation by inducing the expression of apoptosis inhibitors such as Bcl-2 and XIAP, as well as cytokines, e.g., TNF. As a result, tiny natural compounds functioning as proteasome inhibitors such as celastrol and curcumin can be used to modify NF-\u03baB signaling, providing a responsible method for treating SARS-CoV-2-infected patients. The natural constituents that aid in inhibiting viral infection, progression, and amplification of coronaviruses are also emphasized, which are in the groups of alkaloids, flavonoids, terpenoids, diarylheptanoids, and anthraquinones. Natural constituents derived from medicinal herbs have anti-inflammatory and antiviral properties, as well as inhibitory effects, on the viral life cycle, including viral entry, replication, assembly, and release of COVID-19 virions. The phytochemicals contain a high potential for COVID-19 treatment. As a result, SARS-CoV-2-infected cell death processes and signaling might be of high efficacy for therapeutic targeting effects and yielding encouraging outcomes.<\/jats:p>","DOI":"10.3390\/molecules26247459","type":"journal-article","created":{"date-parts":[[2021,12,9]],"date-time":"2021-12-09T21:46:58Z","timestamp":1639086418000},"page":"7459","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":55,"title":["Coronavirus Infection-Associated Cell Death Signaling and Potential Therapeutic Targets"],"prefix":"10.3390","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5157-7614","authenticated-orcid":false,"given":"Rittibet","family":"Yapasert","sequence":"first","affiliation":[{"name":"Department of Biochemistry, Faculty of Medicine, Chiang Mai University, Chiang Mai 50200, Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9965-5319","authenticated-orcid":false,"given":"Patompong","family":"Khaw-on","sequence":"additional","affiliation":[{"name":"Faculty of Nursing, Chiang Mai University, Chiang Mai 50200, Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ratana","family":"Banjerdpongchai","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, Faculty of Medicine, Chiang Mai University, Chiang Mai 50200, Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2021,12,9]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1038\/s41586-020-2012-7","article-title":"A pneumonia outbreak associated with a new coronavirus of probable bat origin","volume":"579","author":"Zhou","year":"2020","journal-title":"Nature"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1056\/NEJMoa2001017","article-title":"A novel coronavirus from patients with pneumonia in China, 2019","volume":"382","author":"Zhu","year":"2020","journal-title":"N. Engl. J. Med."},{"key":"ref_3","unstructured":"Roser, M., Ritchie, H., Ortiz-Ospina, E., and Hasell, J. (2021, September 11). Coronavirus Pandemic (COVID-19). Available online: Ourworldindata.org."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"731","DOI":"10.1016\/j.immuni.2020.04.003","article-title":"COVID-19: A new virus, but a familiar receptor and cytokine release syndrome","volume":"52","author":"Hirano","year":"2020","journal-title":"Immunity"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"1033","DOI":"10.1016\/S0140-6736(20)30628-0","article-title":"COVID-19: Consider cytokine storm syndromes and immunosuppression","volume":"395","author":"Mehta","year":"2020","journal-title":"Lancet"},{"key":"ref_6","first-page":"1","article-title":"Immune responses in COVID-19 and potential vaccines: Lessons learned from SARS and MERS epidemic","volume":"38","author":"Prompetchara","year":"2020","journal-title":"Asian Pac. J. Allergy Immunol."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1016\/j.cell.2020.02.058","article-title":"Structure, function, and antigenicity of the SARS-CoV-2 spike glycoprotein","volume":"181","author":"Walls","year":"2020","journal-title":"Cell"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"490","DOI":"10.1016\/j.tim.2016.03.003","article-title":"Epidemiology, genetic recombination, and pathogenesis of coronaviruses","volume":"24","author":"Su","year":"2016","journal-title":"Trends Microbiol."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1016\/j.cell.2020.02.052","article-title":"SARS-CoV-2 cell entry depends on ACE2 and TMPRSS2 and is blocked by a clinically proven protease inhibitor","volume":"181","author":"Hoffmann","year":"2020","journal-title":"Cell"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"586","DOI":"10.1007\/s00134-020-05985-9","article-title":"Angiotensin-converting enzyme 2 (ACE2) as a SARS-CoV-2 receptor: Molecular mechanisms and potential therapeutic target","volume":"46","author":"Zhang","year":"2020","journal-title":"Intensive Care Med."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1038\/s41392-020-00334-0","article-title":"SARS-CoV-2 triggers inflammatory responses and cell death through caspase-8 activation","volume":"5","author":"Li","year":"2020","journal-title":"Signal Transduct. Target. Ther."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1016\/j.bj.2020.05.023","article-title":"Comprehensive review of coronavirus disease 2019 (COVID-19)","volume":"43","author":"Chauhan","year":"2020","journal-title":"Biomed. J."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"516","DOI":"10.1186\/s13054-020-03240-7","article-title":"Incidence of ARDS and outcomes in hospitalized patients with COVID-19: A global literature survey","volume":"24","author":"Tzotzos","year":"2020","journal-title":"Crit. Care"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"173890","DOI":"10.1016\/j.ejphar.2021.173890","article-title":"A review of potential suggested drugs for coronavirus disease (COVID-19) treatment","volume":"895","author":"Tarighi","year":"2021","journal-title":"Eur. J. Pharmacol."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"n949","DOI":"10.1136\/bmj.n949","article-title":"Prophylaxis against covid-19: Living systematic review and network meta-analysis","volume":"373","author":"Bartoszko","year":"2021","journal-title":"BMJ"},{"key":"ref_16","doi-asserted-by":"crossref","unstructured":"Marshall, A.C. (2020). Traditional Chinese medicine and clinical pharmacology. Drug Discov. Eval. Methods Clin. Pharmacol., 455\u2013482.","DOI":"10.1007\/978-3-319-68864-0_60"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"16711","DOI":"10.1039\/D1RA00644D","article-title":"A review on potential of natural products in the management of COVID-19","volume":"11","author":"Chakravarti","year":"2021","journal-title":"RSC Adv."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"100180","DOI":"10.1016\/j.cpb.2020.100180","article-title":"Challenges and future directions of potential natural products leads against 2019-nCoV outbreak","volume":"24","author":"Ospanov","year":"2020","journal-title":"Curr. Plant Biol."},{"key":"ref_19","doi-asserted-by":"crossref","unstructured":"Musarra-Pizzo, M., Pennisi, R., Ben-Amor, I., Mandalari, G., and Sciortino, M.T. (2021). Antiviral Activity Exerted by Natural Products against Human Viruses. Viruses, 13.","DOI":"10.3390\/v13050828"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"2000607","DOI":"10.1183\/13993003.00607-2020","article-title":"Pathogenesis of COVID-19 from a cell biology perspective","volume":"55","author":"Mason","year":"2020","journal-title":"Eur. Respir. Soc."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"4541","DOI":"10.1038\/s41467-020-18319-6","article-title":"Molecular interaction and inhibition of SARS-CoV-2 binding to the ACE2 receptor","volume":"11","author":"Yang","year":"2020","journal-title":"Nat. Commun."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"914","DOI":"10.1093\/bib\/bbaa214","article-title":"Unveiling COVID-19-associated organ-specific cell types and cell-specific pathway cascade","volume":"22","author":"Dey","year":"2021","journal-title":"Brief. Bioinform."},{"key":"ref_23","doi-asserted-by":"crossref","unstructured":"Yadav, R., Chaudhary, J.K., Jain, N., Chaudhary, P.K., Khanra, S., Dhamija, P., Sharma, A., Kumar, A., and Handu, S. (2021). Role of Structural and Non-Structural Proteins and Therapeutic Targets of SARS-CoV-2 for COVID-19. Cells, 10.","DOI":"10.3390\/cells10040821"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"418","DOI":"10.1002\/jmv.25681","article-title":"Emerging coronaviruses: Genome structure, replication, and pathogenesis","volume":"92","author":"Chen","year":"2020","journal-title":"J. Med. Virol."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1186\/s12929-020-00703-5","article-title":"Insights to SARS-CoV-2 life cycle, pathophysiology, and rationalized treatments that target COVID-19 clinical complications","volume":"28","author":"Trougakos","year":"2021","journal-title":"J. Biomed. Sci."},{"key":"ref_26","doi-asserted-by":"crossref","unstructured":"Fehr, A.R., and Perlman, S. (2015). Coronaviruses: An overview of their replication and pathogenesis. Coronaviruses, 1\u201323.","DOI":"10.1007\/978-1-4939-2438-7_1"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"ftaa006","DOI":"10.1093\/femspd\/ftaa006","article-title":"Coronaviruses: A paradigm of new emerging zoonotic diseases","volume":"77","author":"Salata","year":"2019","journal-title":"Pathog. Dis."},{"key":"ref_28","first-page":"2006","article-title":"COVID-19 (Novel Coronavirus 2019)-recent trends","volume":"24","author":"Kannan","year":"2020","journal-title":"Eur. Rev. Med. Pharmacol. Sci."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1080\/22221751.2020.1719902","article-title":"Genomic characterization of the 2019 novel human-pathogenic coronavirus isolated from a patient with atypical pneumonia after visiting Wuhan","volume":"9","author":"Chan","year":"2020","journal-title":"Emerg. Microbes Infect."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"1620","DOI":"10.1038\/s41467-020-15562-9","article-title":"Characterization of spike glycoprotein of SARS-CoV-2 on virus entry and its immune cross-reactivity with SARS-CoV","volume":"11","author":"Ou","year":"2020","journal-title":"Nat. Commun."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"102433","DOI":"10.1016\/j.jaut.2020.102433","article-title":"The epidemiology and pathogenesis of coronavirus disease (COVID-19) outbreak","volume":"109","author":"Rothan","year":"2020","journal-title":"J. Autoimmun."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"129","DOI":"10.12688\/f1000research.22457.2","article-title":"Prediction of the SARS-CoV-2 (2019-nCoV) 3C-like protease (3CL pro) structure: Virtual screening reveals velpatasvir, ledipasvir, and other drug repurposing candidates","volume":"9","author":"Chen","year":"2020","journal-title":"F1000Research"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1002\/jmv.25761","article-title":"The potential chemical structure of anti-SARS-CoV-2 RNA-dependent RNA polymerase","volume":"92","author":"Lung","year":"2020","journal-title":"J. Med. Virol."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1006\/viro.2000.0757","article-title":"Coronavirus spike proteins in viral entry and pathogenesis","volume":"279","author":"Gallagher","year":"2001","journal-title":"Virology"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"1444","DOI":"10.1126\/science.abb2762","article-title":"Structural basis for the recognition of SARS-CoV-2 by full-length human ACE2","volume":"367","author":"Yan","year":"2020","journal-title":"Science"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"11876","DOI":"10.1073\/pnas.0505577102","article-title":"Inhibitors of cathepsin L prevent severe acute respiratory syndrome coronavirus entry","volume":"102","author":"Simmons","year":"2005","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"873","DOI":"10.1128\/JVI.02062-10","article-title":"A transmembrane serine protease is linked to the severe acute respiratory syndrome coronavirus receptor and activates virus entry","volume":"85","author":"Shulla","year":"2011","journal-title":"J. Virol."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"12885","DOI":"10.1073\/pnas.0603144103","article-title":"Severe acute respiratory syndrome coronavirus nsp1 protein suppresses host gene expression by promoting host mRNA degradation","volume":"103","author":"Kamitani","year":"2006","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"11820","DOI":"10.1128\/JVI.02274-15","article-title":"Severe acute respiratory syndrome coronavirus ORF7a inhibits bone marrow stromal antigen 2 virion tethering through a novel mechanism of glycosylation interference","volume":"89","author":"Taylor","year":"2015","journal-title":"J. Virol."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"766","DOI":"10.1016\/j.apsb.2020.02.008","article-title":"Analysis of therapeutic targets for SARS-CoV-2 and discovery of potential drugs by computational methods","volume":"10","author":"Wu","year":"2020","journal-title":"Acta Pharm. Sin. B"},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"13600","DOI":"10.1128\/JVI.78.24.13600-13612.2004","article-title":"Identification of severe acute respiratory syndrome coronavirus replicase products and characterization of papain-like protease activity","volume":"78","author":"Harcourt","year":"2004","journal-title":"J. Virol."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"1763","DOI":"10.1126\/science.1085658","article-title":"Coronavirus main proteinase (3CLpro) structure: Basis for design of anti-SARS drugs","volume":"300","author":"Anand","year":"2003","journal-title":"Science"},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"3037","DOI":"10.1002\/cbic.200800491","article-title":"Differential inhibitory activities and stabilisation of DNA aptamers against the SARS coronavirus helicase","volume":"9","author":"Shum","year":"2008","journal-title":"Chembiochem"},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1038\/s41392-021-00679-0","article-title":"The signal pathways and treatment of cytokine storm in COVID-19","volume":"6","author":"Yang","year":"2021","journal-title":"Signal Transduct. Target. Ther."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"109772","DOI":"10.1016\/j.cellsig.2020.109772","article-title":"Cell death signalling in virus infection","volume":"76","author":"Imre","year":"2020","journal-title":"Cell. Signal."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"829","DOI":"10.1038\/s41590-021-00937-x","article-title":"TLR2 senses the SARS-CoV-2 envelope protein to produce inflammatory cytokines","volume":"22","author":"Zheng","year":"2021","journal-title":"Nat. Immunol."},{"key":"ref_47","doi-asserted-by":"crossref","unstructured":"Liu, Y., Garron, T.M., Chang, Q., Su, Z., Zhou, C., Qiu, Y., Gong, E.C., Zheng, J., Yin, Y.W., and Ksiazek, T. (2021). Cell-type apoptosis in lung during SARS-CoV-2 infection. Pathogens, 10.","DOI":"10.3390\/pathogens10050509"},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"881","DOI":"10.1038\/s41423-020-0485-9","article-title":"The ORF3a protein of SARS-CoV-2 induces apoptosis in cells","volume":"17","author":"Ren","year":"2020","journal-title":"Cell. Mol. Immunol."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"820","DOI":"10.1016\/j.ijbiomac.2020.12.142","article-title":"SARS-Cov-2 ORF3a: Mutability and function","volume":"170","author":"Bianchi","year":"2021","journal-title":"Int. J. Biol. Macromol."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"e00266-20","DOI":"10.1128\/mSystems.00266-20","article-title":"SARS-CoV-2 and ORF3a: Nonsynonymous mutations, functional domains, and viral pathogenesis","volume":"5","author":"Issa","year":"2020","journal-title":"Msystems"},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"12540","DOI":"10.1073\/pnas.0605402103","article-title":"Severe acute respiratory syndrome-associated coronavirus 3a protein forms an ion channel and modulates virus release","volume":"103","author":"Lu","year":"2006","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"2000","DOI":"10.1099\/vir.0.000201","article-title":"Viroporins: Structure, function and potential as antiviral targets","volume":"96","author":"Scott","year":"2015","journal-title":"J. Gen. Virol."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"108863","DOI":"10.1016\/j.celrep.2021.108863","article-title":"Metabolic programs define dysfunctional immune responses in severe COVID-19 patients","volume":"34","author":"Thompson","year":"2021","journal-title":"Cell Rep."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"e02325-17","DOI":"10.1128\/mBio.02325-17","article-title":"Role of severe acute respiratory syndrome coronavirus viroporins E, 3a, and 8a in replication and pathogenesis","volume":"9","author":"Honrubia","year":"2018","journal-title":"MBio"},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"1762","DOI":"10.1093\/infdis\/jiaa150","article-title":"Characteristics of peripheral lymphocyte subset alteration in COVID-19 pneumonia","volume":"221","author":"Wang","year":"2020","journal-title":"J. Infect. Dis."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"e1259","DOI":"10.1038\/cddis.2014.160","article-title":"Systems biology of death receptor networks: Live and let die","volume":"5","author":"Lavrik","year":"2014","journal-title":"Cell Death Dis."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1111\/bjh.17034","article-title":"Increased CD95 (Fas) and PD-1 expression in peripheral blood T lymphocytes in COVID-19 patients","volume":"191","author":"Bellesi","year":"2020","journal-title":"Br. J. Haematol."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"761","DOI":"10.1080\/22221751.2020.1747363","article-title":"Transcriptomic characteristics of bronchoalveolar lavage fluid and peripheral blood mononuclear cells in COVID-19 patients","volume":"9","author":"Xiong","year":"2020","journal-title":"Emerg. Microbes Infect."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1016\/j.molcel.2011.06.011","article-title":"cIAPs block Ripoptosome formation, a RIP1\/caspase-8 containing intracellular cell death complex differentially regulated by cFLIP isoforms","volume":"43","author":"Feoktistova","year":"2011","journal-title":"Mol. Cell"},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"1106","DOI":"10.1038\/s41423-020-00630-3","article-title":"Necroptosis, pyroptosis and apoptosis: An intricate game of cell death","volume":"18","author":"Bertheloot","year":"2021","journal-title":"Cell. Mol. Immunol."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"50","DOI":"10.3389\/fmicb.2019.00050","article-title":"Severe acute respiratory syndrome coronavirus viroporin 3a activates the NLRP3 inflammasome","volume":"10","author":"Chen","year":"2019","journal-title":"Front. Microbiol."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"11282","DOI":"10.1073\/pnas.1117765109","article-title":"Critical role for calcium mobilization in activation of the NLRP3 inflammasome","volume":"109","author":"Murakami","year":"2012","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"913","DOI":"10.1128\/JVI.02576-13","article-title":"Inhibition of NF-\u03baB-mediated inflammation in severe acute respiratory syndrome coronavirus-infected mice increases survival","volume":"88","author":"DeDiego","year":"2014","journal-title":"J. Virol."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"6807","DOI":"10.1016\/j.febslet.2006.11.046","article-title":"Augmentation of chemokine production by severe acute respiratory syndrome coronavirus 3a\/X1 and 7a\/X4 proteins through NF-\u03baB activation","volume":"580","author":"Kanzawa","year":"2006","journal-title":"FEBS Lett."},{"key":"ref_65","doi-asserted-by":"crossref","unstructured":"Kelley, N., Jeltema, D., Duan, Y., and He, Y. (2019). The NLRP3 inflammasome: An overview of mechanisms of activation and regulation. Int. J. Mol. Sci., 20.","DOI":"10.3390\/ijms20133328"},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"8865","DOI":"10.1096\/fj.201802418R","article-title":"Severe acute respiratory syndrome Coronavirus ORF3a protein activates the NLRP3 inflammasome by promoting TRAF3-dependent ubiquitination of ASC","volume":"33","author":"Siu","year":"2019","journal-title":"FASEB J."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"307","DOI":"10.4049\/jimmunol.2000513","article-title":"Inflammasomes and pyroptosis as therapeutic targets for COVID-19","volume":"205","author":"Yap","year":"2020","journal-title":"J. Immunol."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"422","DOI":"10.1186\/s13054-020-03120-0","article-title":"Role of angiotensin-converting enzyme 2 (ACE2) in COVID-19","volume":"24","author":"Ni","year":"2020","journal-title":"Crit. Care"},{"key":"ref_69","first-page":"111","article-title":"Angiotensin receptors: Structure, function, signaling and clinical applications","volume":"1","author":"Singh","year":"2016","journal-title":"J. Cell Signal."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"E43","DOI":"10.1152\/ajpendo.00219.2020","article-title":"SARS-CoV-2 perturbs the renin-angiotensin system and energy metabolism","volume":"319","author":"Mori","year":"2020","journal-title":"Am. J. Physiol. Endocrinol. Metab."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"1518","DOI":"10.3389\/fimmu.2020.01518","article-title":"Targeting the NLRP3 inflammasome in severe COVID-19","volume":"11","author":"Freeman","year":"2020","journal-title":"Front. Immunol."},{"key":"ref_72","doi-asserted-by":"crossref","unstructured":"Chun, Y., and Kim, J. (2018). Autophagy: An essential degradation program for cellular homeostasis and life. Cells, 7.","DOI":"10.3390\/cells7120278"},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"119","DOI":"10.15698\/mic2020.05.715","article-title":"Digesting the crisis: Autophagy and coronaviruses","volume":"7","author":"Bauer","year":"2020","journal-title":"Microb. Cell"},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1038\/s41420-019-0181-7","article-title":"SARS-Coronavirus Open Reading Frame-8b triggers intracellular stress pathways and activates NLRP3 inflammasomes","volume":"5","author":"Shi","year":"2019","journal-title":"Cell Death Discov."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"5770","DOI":"10.1038\/s41467-019-13659-4","article-title":"SKP2 attenuates autophagy through Beclin1-ubiquitination and its inhibition reduces MERS-Coronavirus infection","volume":"10","author":"Gassen","year":"2019","journal-title":"Nat. Commun."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"166260","DOI":"10.1016\/j.bbadis.2021.166260","article-title":"SARS-CoV-2 spike promotes inflammation and apoptosis through autophagy by ROS-suppressed PI3K\/AKT\/mTOR signaling","volume":"1867","author":"Li","year":"2021","journal-title":"Biochim. Biophys. Acta BBA Mol. Basis Dis."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/j.cell.2020.11.025","article-title":"Synergism of TNF-\u03b1 and IFN-\u03b3 triggers inflammatory cell death, tissue damage, and mortality in SARS-CoV-2 infection and cytokine shock syndromes","volume":"184","author":"Karki","year":"2021","journal-title":"Cell"},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"1285","DOI":"10.1038\/cr.2015.139","article-title":"Gasdermin D is an executor of pyroptosis and required for interleukin-1\u03b2 secretion","volume":"25","author":"He","year":"2015","journal-title":"Cell Res."},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"666","DOI":"10.1038\/nature15541","article-title":"Caspase-11 cleaves gasdermin D for non-canonical inflammasome signalling","volume":"526","author":"Kayagaki","year":"2015","journal-title":"Nature"},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"1064","DOI":"10.1126\/science.aau2818","article-title":"Pathogen blockade of TAK1 triggers caspase-8\u2013dependent cleavage of gasdermin D and cell death","volume":"362","author":"Orning","year":"2018","journal-title":"Science"},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"E10888","DOI":"10.1073\/pnas.1809548115","article-title":"Caspase-8 induces cleavage of gasdermin D to elicit pyroptosis during Yersinia infection","volume":"115","author":"Sarhan","year":"2018","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"660","DOI":"10.1038\/nature15514","article-title":"Cleavage of GSDMD by inflammatory caspases determines pyroptotic cell death","volume":"526","author":"Shi","year":"2015","journal-title":"Nature"},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1038\/nature22393","article-title":"Chemotherapy drugs induce pyroptosis through caspase-3 cleavage of a gasdermin","volume":"547","author":"Wang","year":"2017","journal-title":"Nature"},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"aaz7548","DOI":"10.1126\/science.aaz7548","article-title":"Granzyme A from cytotoxic lymphocytes cleaves GSDMB to trigger pyroptosis in target cells","volume":"368","author":"Zhou","year":"2020","journal-title":"Science"},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1080\/01926230701320337","article-title":"Apoptosis: A review of programmed cell death","volume":"35","author":"Elmore","year":"2007","journal-title":"Toxicol. Pathol."},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"847","DOI":"10.1126\/science.1115035","article-title":"Caspases 3 and 7: Key mediators of mitochondrial events of apoptosis","volume":"311","author":"Lakhani","year":"2006","journal-title":"Science"},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1186\/s12974-018-1235-0","article-title":"Necroptosis: A regulated inflammatory mode of cell death","volume":"15","author":"Dhuriya","year":"2018","journal-title":"J. Neuroinflamm."},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"490275","DOI":"10.1155\/2014\/490275","article-title":"Necroptosis: Molecular signalling and translational implications","volume":"2014","author":"Giampietri","year":"2014","journal-title":"Int. J. Cell Biol."},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1016\/j.immuni.2013.06.018","article-title":"The pseudokinase MLKL mediates necroptosis via a molecular switch mechanism","volume":"39","author":"Murphy","year":"2013","journal-title":"Immunity"},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"11163","DOI":"10.18632\/aging.103528","article-title":"PANoptosis components, regulation, and implications","volume":"12","author":"Malireddi","year":"2020","journal-title":"Aging"},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"568","DOI":"10.4049\/immunohorizons.2100059","article-title":"Inflammatory cell death, PANoptosis, mediated by cytokines in diverse cancer lineages inhibits tumor growth","volume":"5","author":"Malireddi","year":"2021","journal-title":"Immunohorizons"},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"237","DOI":"10.3389\/fcimb.2020.00237","article-title":"Identification of the PANoptosome: A molecular platform triggering pyroptosis, apoptosis, and necroptosis (PANoptosis)","volume":"10","author":"Christgen","year":"2020","journal-title":"Front. Cell. Infect. Microbiol."},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1146\/annurev-immunol-073119-095439","article-title":"Caspases in cell death, inflammation, and pyroptosis","volume":"38","author":"Kesavardhana","year":"2020","journal-title":"Annu. Rev. Immunol."},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"e20191644","DOI":"10.1084\/jem.20191644","article-title":"Innate immune priming in the absence of TAK1 drives RIPK1 kinase activity\u2013independent pyroptosis, apoptosis, necroptosis, and inflammatory disease","volume":"217","author":"Malireddi","year":"2020","journal-title":"J. Exp. Med."},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"406","DOI":"10.3389\/fcimb.2019.00406","article-title":"ZBP1 and TAK1: Master regulators of NLRP3 inflammasome\/pyroptosis, apoptosis, and necroptosis (PAN-optosis)","volume":"9","author":"Malireddi","year":"2019","journal-title":"Front. Cell. Infect. Microbiol."},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"238","DOI":"10.3389\/fcimb.2020.00238","article-title":"The PANoptosome: A deadly protein complex driving pyroptosis, apoptosis, and necroptosis (PANoptosis)","volume":"10","author":"Samir","year":"2020","journal-title":"Front. Cell. Infect. Microbiol."},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1111\/imr.12909","article-title":"The regulation of the ZBP1-NLRP3 inflammasome and its implications in pyroptosis, apoptosis, and necroptosis (PANoptosis)","volume":"297","author":"Zheng","year":"2020","journal-title":"Immunol. Rev."},{"key":"ref_98","first-page":"341","article-title":"Newly Identified Function of Caspase-6 in ZBP1-mediated Innate Immune Responses, NLRP3 Inflammasome Activation, PANoptosis, and Host Defense","volume":"2","author":"Zheng","year":"2020","journal-title":"J. Cell. Immunol."},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"e101638","DOI":"10.15252\/embj.2019101638","article-title":"Extrinsic and intrinsic apoptosis activate pannexin-1 to drive NLRP 3 inflammasome assembly","volume":"38","author":"Chen","year":"2019","journal-title":"EMBO J."},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1016\/j.chembiol.2017.03.009","article-title":"Pyroptosis and apoptosis pathways engage in bidirectional crosstalk in monocytes and macrophages","volume":"24","author":"Taabazuing","year":"2017","journal-title":"Cell Chem. Biol."},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"1623","DOI":"10.1038\/s41591-020-1038-6","article-title":"A dynamic COVID-19 immune signature includes associations with poor prognosis","volume":"26","author":"Laing","year":"2020","journal-title":"Nat. Med."},{"key":"ref_102","first-page":"3521","article-title":"In vivo and in vitro apoptosis of human thymocytes are associated with nitrotyrosine formation","volume":"97","author":"Moulian","year":"2001","journal-title":"Blood J. Am. Soc. Hematol."},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"730","DOI":"10.1002\/cbic.202000047","article-title":"Learning from the past: Possible urgent prevention and treatment options for severe acute respiratory infections caused by 2019-nCoV","volume":"21","author":"Morse","year":"2020","journal-title":"Chembiochem"},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1038\/s41392-020-0190-2","article-title":"Overview of lethal human coronaviruses","volume":"5","author":"Chen","year":"2020","journal-title":"Signal Transduct. Target. Ther."},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1016\/j.virusres.2007.01.022","article-title":"Pathogenetic mechanisms of severe acute respiratory syndrome","volume":"133","author":"Guo","year":"2008","journal-title":"Virus Res."},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"1012","DOI":"10.1093\/nsr\/nwaa036","article-title":"On the origin and continuing evolution of SARS-CoV-2","volume":"7","author":"Tang","year":"2020","journal-title":"Natl. Sci. Rev."},{"key":"ref_107","doi-asserted-by":"crossref","unstructured":"Nassar, A., Ibrahim, I.M., Amin, F.G., Magdy, M., Elgharib, A.M., Azzam, E.B., Nasser, F., Yousry, K., Shamkh, I.M., and Mahdy, S.M. (2021). A Review of Human Coronaviruses\u2019 Receptors: The Host-Cell Targets for the Crown Bearing Viruses. Molecules, 26.","DOI":"10.3390\/molecules26216455"},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1038\/s41467-019-13940-6","article-title":"Comparative therapeutic efficacy of remdesivir and combination lopinavir, ritonavir, and interferon beta against MERS-CoV","volume":"11","author":"Sheahan","year":"2020","journal-title":"Nat. Commun."},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"732","DOI":"10.1093\/cid\/ciaa237","article-title":"In vitro antiviral activity and projection of optimized dosing design of hydroxychloroquine for the treatment of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)","volume":"71","author":"Yao","year":"2020","journal-title":"Clin. Infect. Dis."},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"1293","DOI":"10.1128\/JVI.02202-13","article-title":"TMPRSS2 and ADAM17 cleave ACE2 differentially and only proteolysis by TMPRSS2 augments entry driven by the severe acute respiratory syndrome coronavirus spike protein","volume":"88","author":"Heurich","year":"2014","journal-title":"J. Virol."},{"key":"ref_111","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1007\/s11427-020-1643-8","article-title":"Clinical and biochemical indexes from 2019-nCoV infected patients linked to viral loads and lung injury","volume":"63","author":"Liu","year":"2020","journal-title":"Sci. China Life Sci."},{"key":"ref_112","doi-asserted-by":"crossref","first-page":"762","DOI":"10.1093\/cid\/ciaa248","article-title":"Dysregulation of immune response in patients with coronavirus 2019 (COVID-19) in Wuhan, China","volume":"71","author":"Qin","year":"2020","journal-title":"Clin. Infect. Dis."},{"key":"ref_113","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1016\/S0140-6736(20)30183-5","article-title":"Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China","volume":"395","author":"Huang","year":"2020","journal-title":"Lancet"},{"key":"ref_114","doi-asserted-by":"crossref","first-page":"558","DOI":"10.1080\/22221751.2020.1736644","article-title":"A tug-of-war between severe acute respiratory syndrome coronavirus 2 and host antiviral defence: Lessons from other pathogenic viruses","volume":"9","author":"Fung","year":"2020","journal-title":"Emerg. Microbes Infect."},{"key":"ref_115","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1016\/j.micinf.2005.06.007","article-title":"Role of vascular cell adhesion molecules and leukocyte apoptosis in the lymphopenia and thrombocytopenia of patients with severe acute respiratory syndrome (SARS)","volume":"8","author":"Chen","year":"2006","journal-title":"Microbes Infect."},{"key":"ref_116","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1158\/2326-6066.CIR-21-0008","article-title":"At the crossroads: COVID-19 and immune-checkpoint blockade for cancer","volume":"9","author":"Garassino","year":"2021","journal-title":"Cancer Immunol. Res."},{"key":"ref_117","doi-asserted-by":"crossref","first-page":"6346","DOI":"10.1128\/JVI.00090-07","article-title":"Induction of apoptosis by the severe acute respiratory syndrome coronavirus 7a protein is dependent on its interaction with the Bcl-XL protein","volume":"81","author":"Tan","year":"2007","journal-title":"J. Virol."},{"key":"ref_118","doi-asserted-by":"crossref","first-page":"904","DOI":"10.1093\/infdis\/jiv380","article-title":"Middle East respiratory syndrome coronavirus efficiently infects human primary T lymphocytes and activates the extrinsic and intrinsic apoptosis pathways","volume":"213","author":"Chu","year":"2016","journal-title":"J. Infect. Dis."},{"key":"ref_119","doi-asserted-by":"crossref","first-page":"5202","DOI":"10.1093\/nar\/gku118","article-title":"Ribonuclease L and metal-ion\u2013independent endoribonuclease cleavage sites in host and viral RNAs","volume":"42","author":"Cooper","year":"2014","journal-title":"Nucleic Acids Res."},{"key":"ref_120","doi-asserted-by":"crossref","first-page":"12720","DOI":"10.1128\/JVI.01471-07","article-title":"Viral encounters with 2\u2032, 5\u2032-oligoadenylate synthetase and RNase L during the interferon antiviral response","volume":"81","author":"Silverman","year":"2007","journal-title":"J. Virol."},{"key":"ref_121","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1016\/j.molcel.2013.12.025","article-title":"Dimeric structure of pseudokinase RNase L bound to 2-5A reveals a basis for interferon-induced antiviral activity","volume":"53","author":"Huang","year":"2014","journal-title":"Mol. Cell"},{"key":"ref_122","doi-asserted-by":"crossref","first-page":"3181","DOI":"10.3390\/v6083181","article-title":"Human immunodeficiency virus-1 (HIV-1)-mediated apoptosis: New therapeutic targets","volume":"6","author":"Mbita","year":"2014","journal-title":"Viruses"},{"key":"ref_123","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1080\/10731190601188422","article-title":"SARS-CoV nucleocapsid protein induced apoptosis of COS-1 mediated by the mitochondrial pathway","volume":"35","author":"Zhang","year":"2007","journal-title":"Artif. Cells Blood Substit. Biotechnol."},{"key":"ref_124","doi-asserted-by":"crossref","first-page":"627","DOI":"10.3389\/fcimb.2021.706252","article-title":"SARS-CoV-2 Membrane Glycoprotein M Triggers Apoptosis with the Assistance of Nucleocapsid Protein N in Cells","volume":"11","author":"Ren","year":"2021","journal-title":"Front. Cell. Infect. Microbiol."},{"key":"ref_125","doi-asserted-by":"crossref","first-page":"728896","DOI":"10.3389\/fimmu.2021.728896","article-title":"SARS-CoV-2 Coronavirus Spike Protein-Induced Apoptosis, Inflammatory, and Oxidative Stress Responses in THP-1-Like-Macrophages: Potential Role of Angiotensin-Converting Enzyme Inhibitor (Perindopril)","volume":"12","author":"Barhoumi","year":"2021","journal-title":"Front. Immunol."},{"key":"ref_126","first-page":"61","article-title":"SARS-CoV-2 spike protein induces monocyte apoptosis and interleukin-8 production","volume":"29","author":"Chandrasekar","year":"2021","journal-title":"Top. Antivir. Med."},{"key":"ref_127","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1038\/s41420-020-00331-w","article-title":"The role of death domain proteins in host response upon SARS-CoV-2 infection: Modulation of programmed cell death and translational applications","volume":"6","author":"Ivanisenko","year":"2020","journal-title":"Cell Death Discov."},{"key":"ref_128","doi-asserted-by":"crossref","first-page":"2117","DOI":"10.1038\/s41418-020-0489-0","article-title":"Dissecting DISC regulation via pharmacological targeting of caspase-8\/c-FLIP L heterodimer","volume":"27","author":"Hillert","year":"2020","journal-title":"Cell Death Differ."},{"key":"ref_129","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1016\/j.tcb.2020.02.006","article-title":"Controlling cell death through post-translational modifications of DED proteins","volume":"30","author":"Seyrek","year":"2020","journal-title":"Trends Cell Biol."},{"key":"ref_130","doi-asserted-by":"crossref","first-page":"580","DOI":"10.1016\/j.chom.2017.04.005","article-title":"CRISPR\/Cas9 screens reveal Epstein-Barr virus-transformed B cell host dependency factors","volume":"21","author":"Ma","year":"2017","journal-title":"Cell Host Microbe"},{"key":"ref_131","doi-asserted-by":"crossref","first-page":"1639","DOI":"10.3390\/cancers3021639","article-title":"Targeting the anti-apoptotic protein c-FLIP for cancer therapy","volume":"3","author":"Safa","year":"2011","journal-title":"Cancers"},{"key":"ref_132","doi-asserted-by":"crossref","first-page":"5193","DOI":"10.1038\/s41467-018-07654-4","article-title":"Induction of immunosuppressive functions and NF-\u03baB by FLIP in monocytes","volume":"9","author":"Fiore","year":"2018","journal-title":"Nat. Commun."},{"key":"ref_133","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1038\/386517a0","article-title":"Viral FLICE-inhibitory proteins (FLIPs) prevent apoptosis induced by death receptors","volume":"386","author":"Thome","year":"1997","journal-title":"Nature"},{"key":"ref_134","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1038\/40657","article-title":"Inhibition of death receptor signals by cellular FLIP","volume":"388","author":"Irmler","year":"1997","journal-title":"Nature"},{"key":"ref_135","doi-asserted-by":"crossref","first-page":"1786","DOI":"10.1038\/s41467-020-15576-3","article-title":"Modulation of virus-induced NF-\u03baB signaling by NEMO coiled coil mimics","volume":"11","author":"Sadek","year":"2020","journal-title":"Nat. Commun."},{"key":"ref_136","doi-asserted-by":"crossref","first-page":"1295","DOI":"10.1084\/jem.20051556","article-title":"The c-FLIP\u2013NH2 terminus (p22-FLIP) induces NF-\u03baB activation","volume":"203","author":"Golks","year":"2006","journal-title":"J. Exp. Med."},{"key":"ref_137","doi-asserted-by":"crossref","first-page":"6539","DOI":"10.1128\/JVI.00276-14","article-title":"Viral and cellular FLICE-inhibitory proteins: A comparison of their roles in regulating intrinsic immune responses","volume":"88","author":"Shisler","year":"2014","journal-title":"J. Virol."},{"key":"ref_138","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1242\/jcs.058602","article-title":"Modulation of Wnt signaling by the nuclear localization of cellular FLIP-L","volume":"123","author":"Katayama","year":"2010","journal-title":"J. Cell Sci."},{"key":"ref_139","doi-asserted-by":"crossref","first-page":"3704","DOI":"10.1093\/emboj\/cdf356","article-title":"c-FLIPL is a dual function regulator for caspase-8 activation and CD95-mediated apoptosis","volume":"21","author":"Chang","year":"2002","journal-title":"EMBO J."},{"key":"ref_140","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1083\/jcb.201002060","article-title":"Model-based dissection of CD95 signaling dynamics reveals both a pro-and antiapoptotic role of c-FLIPL","volume":"190","author":"Fricker","year":"2010","journal-title":"J. Cell Biol."},{"key":"ref_141","first-page":"6083","article-title":"Fatal cytokine release syndrome by an aberrant FLIP\/STAT3 axis","volume":"27","author":"Musiu","year":"2021","journal-title":"Cell Death Differ."},{"key":"ref_142","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1038\/s41586-020-2757-z","article-title":"Modulating TRADD to restore cellular homeostasis and inhibit apoptosis","volume":"587","author":"Xu","year":"2020","journal-title":"Nature"},{"key":"ref_143","doi-asserted-by":"crossref","first-page":"24986","DOI":"10.1074\/jbc.M116.744284","article-title":"Novel compounds targeting the mitochondrial protein VDAC1 inhibit apoptosis and protect against mitochondrial dysfunction","volume":"291","author":"Shalev","year":"2016","journal-title":"J. Biol. Chem."},{"key":"ref_144","doi-asserted-by":"crossref","first-page":"1906","DOI":"10.1242\/jcs.040188","article-title":"The VDAC1 N-terminus is essential both for apoptosis and the protective effect of anti-apoptotic proteins","volume":"122","author":"Arbel","year":"2009","journal-title":"J. Cell Sci."},{"key":"ref_145","doi-asserted-by":"crossref","first-page":"12321","DOI":"10.1074\/jbc.275.16.12321","article-title":"Electrophysiological study of a novel large pore formed by Bax and the voltage-dependent anion channel that is permeable to cytochrome c","volume":"275","author":"Shimizu","year":"2000","journal-title":"J. Biol. Chem."},{"key":"ref_146","doi-asserted-by":"crossref","first-page":"1036","DOI":"10.1016\/j.cell.2020.04.026","article-title":"Imbalanced host response to SARS-CoV-2 drives development of COVID-19","volume":"181","author":"Liu","year":"2020","journal-title":"Cell"},{"key":"ref_147","doi-asserted-by":"crossref","first-page":"2881","DOI":"10.3389\/fmicb.2020.593857","article-title":"Comparative transcriptome analysis reveals the intensive early stage responses of host cells to SARS-CoV-2 infection","volume":"11","author":"Sun","year":"2020","journal-title":"Front. Microbiol."},{"key":"ref_148","doi-asserted-by":"crossref","first-page":"1272","DOI":"10.1016\/j.bcp.2009.12.021","article-title":"Identification of known drugs that act as inhibitors of NF-\u03baB signaling and their mechanism of action","volume":"79","author":"Miller","year":"2010","journal-title":"Biochem. Pharmacol."},{"key":"ref_149","doi-asserted-by":"crossref","first-page":"173709","DOI":"10.1016\/j.ejphar.2020.173709","article-title":"Identification of proteasome inhibitors using analysis of gene expression profiles","volume":"889","author":"Mofers","year":"2020","journal-title":"Eur. J. Pharmacol."},{"key":"ref_150","doi-asserted-by":"crossref","unstructured":"Ramadass, V., Vaiyapuri, T., and Tergaonkar, V. (2020). Small molecule NF-\u03baB pathway inhibitors in clinic. Int. J. Mol. Sci., 21.","DOI":"10.3390\/ijms21145164"},{"key":"ref_151","unstructured":"Acerta Pharma, B. (2021, October 01). A Phase 2, Open Label, Randomized Study of the Efficacy and Safety of Acalabrutinib with Best Supportive Care versus Best Supportive Care in Subjects Hospitalized with COVID-19. Available online: https:\/\/pesquisa.bvsalud.org\/global-literature-on-novel-coronavirus-2019-ncov\/resource\/pt\/ictrp-PER-018-20."},{"key":"ref_152","doi-asserted-by":"crossref","first-page":"eabd0110","DOI":"10.1126\/sciimmunol.abd0110","article-title":"Inhibition of Bruton tyrosine kinase in patients with severe COVID-19","volume":"5","author":"Roschewski","year":"2020","journal-title":"Sci. Immunol."},{"key":"ref_153","unstructured":"Agree, I. (2021, October 02). Karyopharm to Evaluate Low Dose Selinexor as a Potential Treatment for Hospitalized Patients with COVID-19. Available online: https:\/\/stockhouse.com\/news\/press-releases\/2020\/04\/07\/karyopharm-to-evaluate-low-dose-selinexor-as-a-potential-treatment-for."},{"key":"ref_154","doi-asserted-by":"crossref","first-page":"105297","DOI":"10.1016\/j.phrs.2020.105297","article-title":"Necrostatin-1 and necroptosis inhibition: Pathophysiology and therapeutic implications","volume":"163","author":"Cao","year":"2020","journal-title":"Pharmacol. Res."},{"key":"ref_155","doi-asserted-by":"crossref","first-page":"1126","DOI":"10.1038\/ni.3015","article-title":"RNA viruses promote activation of the NLRP3 inflammasome through a RIP1-RIP3-DRP1 signaling pathway","volume":"15","author":"Wang","year":"2014","journal-title":"Nat. Immunol."},{"key":"ref_156","doi-asserted-by":"crossref","first-page":"626","DOI":"10.1007\/s10495-017-1358-2","article-title":"RIPK1\/RIPK3\/MLKL-mediated necroptosis contributes to compression-induced rat nucleus pulposus cells death","volume":"22","author":"Chen","year":"2017","journal-title":"Apoptosis"},{"key":"ref_157","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1038\/s41420-021-00428-w","article-title":"SARS-CoV-2 engages inflammasome and pyroptosis in human primary monocytes","volume":"7","author":"Ferreira","year":"2021","journal-title":"Cell Death Discov."},{"key":"ref_158","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/j.brainresbull.2020.03.011","article-title":"Hypothermia protects neurons against ischemia\/reperfusion-induced pyroptosis via m6A-mediated activation of PTEN and the PI3K\/Akt\/GSK-3\u03b2 signaling pathway","volume":"159","author":"Diao","year":"2020","journal-title":"Brain Res. Bull."},{"key":"ref_159","doi-asserted-by":"crossref","first-page":"113686","DOI":"10.1016\/j.jep.2020.113686","article-title":"Tiliacora racemosa leaves induce oxidative stress mediated DNA damage leading to G2\/M phase arrest and apoptosis in cervical cancer cells SiHa","volume":"269","author":"Pal","year":"2021","journal-title":"J. Ethnopharmacol."},{"key":"ref_160","doi-asserted-by":"crossref","unstructured":"Kashyap, D., Garg, V.K., Tuli, H.S., Yerer, M.B., Sak, K., Sharma, A.K., Kumar, M., Aggarwal, V., and Sandhu, S.S. (2019). Fisetin and quercetin: Promising flavonoids with chemopreventive potential. Biomolecules, 9.","DOI":"10.3390\/biom9050174"},{"key":"ref_161","doi-asserted-by":"crossref","first-page":"2260","DOI":"10.1080\/15548627.2020.1779467","article-title":"Autophagy as an emerging target for COVID-19: Lessons from an old friend, chloroquine","volume":"16","author":"Bonam","year":"2020","journal-title":"Autophagy"},{"key":"ref_162","doi-asserted-by":"crossref","first-page":"72","DOI":"10.5582\/bst.2020.01047","article-title":"Breakthrough: Chloroquine phosphate has shown apparent efficacy in treatment of COVID-19 associated pneumonia in clinical studies","volume":"14","author":"Gao","year":"2020","journal-title":"Biosci. Trends"},{"key":"ref_163","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1038\/s41421-020-0156-0","article-title":"Hydroxychloroquine, a less toxic derivative of chloroquine, is effective in inhibiting SARS-CoV-2 infection in vitro","volume":"6","author":"Liu","year":"2020","journal-title":"Cell Discov."},{"key":"ref_164","doi-asserted-by":"crossref","first-page":"1179","DOI":"10.1016\/S0140-6736(20)30817-5","article-title":"Regulators split on antimalarials for COVID-19","volume":"395","author":"Jaffe","year":"2020","journal-title":"Lancet"},{"key":"ref_165","doi-asserted-by":"crossref","first-page":"m1432","DOI":"10.1136\/bmj.m1432","article-title":"Chloroquine and hydroxychloroquine in covid-19","volume":"369","author":"Ferner","year":"2020","journal-title":"Br. Med. J. Publ. Group"},{"key":"ref_166","doi-asserted-by":"crossref","first-page":"1435","DOI":"10.1080\/15548627.2018.1474314","article-title":"Chloroquine inhibits autophagic flux by decreasing autophagosome-lysosome fusion","volume":"14","author":"Mauthe","year":"2018","journal-title":"Autophagy"},{"key":"ref_167","doi-asserted-by":"crossref","first-page":"e00293","DOI":"10.1002\/prp2.293","article-title":"Targeting endosomal acidification by chloroquine analogs as a promising strategy for the treatment of emerging viral diseases","volume":"5","year":"2017","journal-title":"Pharmacol. Res. Perspect."},{"key":"ref_168","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1128\/AAC.03999-14","article-title":"Inhibition of endoplasmic reticulum-resident glucosidases impairs severe acute respiratory syndrome coronavirus and human coronavirus NL63 spike protein-mediated entry by altering the glycan processing of angiotensin I-converting enzyme 2","volume":"59","author":"Zhao","year":"2015","journal-title":"Antimicrob. Agents Chemother."},{"key":"ref_169","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1002\/iid3.400","article-title":"Efficacy of canakinumab in mild or severe COVID-19 pneumonia","volume":"9","author":"Katia","year":"2021","journal-title":"Immun. Inflamm. Dis."},{"key":"ref_170","doi-asserted-by":"crossref","first-page":"310","DOI":"10.3389\/fmolb.2021.671263","article-title":"Current Strategies of Antiviral Drug Discovery for COVID-19","volume":"8","author":"Mei","year":"2021","journal-title":"Front. Mol. Biosci."},{"key":"ref_171","doi-asserted-by":"crossref","first-page":"3168","DOI":"10.1093\/cid\/ciaa812","article-title":"Compassionate use of tocilizumab for treatment of SARS-CoV-2 pneumonia","volume":"71","author":"Jordan","year":"2020","journal-title":"Clin. Infect. Dis."},{"key":"ref_172","doi-asserted-by":"crossref","first-page":"2479","DOI":"10.1007\/s40121-021-00525-4","article-title":"Efficacy of bamlanivimab\/etesevimab and casirivimab\/imdevimab in preventing progression to severe covid-19 and role of variants of concern","volume":"10","author":"Falcone","year":"2021","journal-title":"Infect. Dis. Ther."},{"key":"ref_173","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1002\/art.41526","article-title":"The longitudinal immune response to coronavirus disease 2019: Chasing the cytokine storm","volume":"73","author":"Chau","year":"2021","journal-title":"Arthritis Rheumatol."},{"key":"ref_174","doi-asserted-by":"crossref","first-page":"588508","DOI":"10.3389\/fphar.2020.588508","article-title":"Current prevention of COVID-19: Natural products and herbal medicine","volume":"11","author":"Huang","year":"2020","journal-title":"Front. Pharmacol."},{"key":"ref_175","doi-asserted-by":"crossref","first-page":"864","DOI":"10.1002\/ptr.6873","article-title":"Natural products for COVID-19 prevention and treatment regarding to previous coronavirus infections and novel studies","volume":"35","author":"Boozari","year":"2021","journal-title":"Phytother. Res."},{"key":"ref_176","doi-asserted-by":"crossref","first-page":"1207","DOI":"10.3389\/fphar.2019.01207","article-title":"The signaling pathways, and therapeutic targets of antiviral agents: Focusing on the antiviral approaches and clinical perspectives of anthocyanins in the management of viral diseases","volume":"10","author":"Fakhri","year":"2019","journal-title":"Front. Pharmacol."},{"key":"ref_177","doi-asserted-by":"crossref","first-page":"11157","DOI":"10.1073\/pnas.1708727114","article-title":"Tectonic conformational changes of a coronavirus spike glycoprotein promote membrane fusion","volume":"114","author":"Walls","year":"2017","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_178","doi-asserted-by":"crossref","first-page":"612","DOI":"10.1111\/j.1440-1681.2006.04415.x","article-title":"Antiviral effects of saikosaponins on human coronavirus 229E in vitro","volume":"33","author":"Cheng","year":"2006","journal-title":"Clin. Exp. Pharmacol. Physiol."},{"key":"ref_179","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1016\/j.antiviral.2006.04.014","article-title":"Emodin blocks the SARS coronavirus spike protein and angiotensin-converting enzyme 2 interaction","volume":"74","author":"Ho","year":"2007","journal-title":"Antivir. Res."},{"key":"ref_180","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1016\/j.antiviral.2011.02.008","article-title":"Emodin inhibits current through SARS-associated coronavirus 3a protein","volume":"90","author":"Schwarz","year":"2011","journal-title":"Antivir. Res."},{"key":"ref_181","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1016\/j.antiviral.2005.02.007","article-title":"Identification of natural compounds with antiviral activities against SARS-associated coronavirus","volume":"67","author":"Li","year":"2005","journal-title":"Antivir. Res."},{"key":"ref_182","doi-asserted-by":"crossref","first-page":"10012","DOI":"10.1073\/pnas.0403596101","article-title":"Small molecules targeting severe acute respiratory syndrome human coronavirus","volume":"101","author":"Wu","year":"2004","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_183","doi-asserted-by":"crossref","first-page":"956","DOI":"10.1038\/s12276-021-00624-9","article-title":"Platycodin D, a natural component of Platycodon grandiflorum, prevents both lysosome-and TMPRSS2-driven SARS-CoV-2 infection by hindering membrane fusion","volume":"53","author":"Kim","year":"2021","journal-title":"Exp. Mol. Med."},{"key":"ref_184","doi-asserted-by":"crossref","unstructured":"Rahman, N., Basharat, Z., Yousuf, M., Castaldo, G., Rastrelli, L., and Khan, H. (2020). Virtual screening of natural products against type II transmembrane serine protease (TMPRSS2), the priming agent of coronavirus 2 (SARS-CoV-2). Molecules, 25.","DOI":"10.3390\/molecules25102271"},{"key":"ref_185","first-page":"6660","article-title":"Identification of potential anti-TMPRSS2 natural products through homology modelling, virtual screening and molecular dynamics simulation studies","volume":"37","author":"Chikhale","year":"2020","journal-title":"J. Biomol. Struct. Dyn."},{"key":"ref_186","doi-asserted-by":"crossref","first-page":"e181","DOI":"10.1038\/emm.2015.76","article-title":"Middle East respiratory syndrome coronavirus: Transmission, virology and therapeutic targeting to aid in outbreak control","volume":"47","author":"Durai","year":"2015","journal-title":"Exp. Mol. Med."},{"key":"ref_187","doi-asserted-by":"crossref","unstructured":"Ratia, K., Kilianski, A., Baez-Santos, Y.M., Baker, S.C., and Mesecar, A. (2014). Structural basis for the ubiquitin-linkage specificity and deISGylating activity of SARS-CoV papain-like protease. PLoS Pathog., 10.","DOI":"10.1371\/journal.ppat.1004113"},{"key":"ref_188","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1016\/j.antiviral.2005.07.002","article-title":"Anti-SARS coronavirus 3C-like protease effects of Isatis indigotica root and plant-derived phenolic compounds","volume":"68","author":"Lin","year":"2005","journal-title":"Antivir. Res."},{"key":"ref_189","doi-asserted-by":"crossref","first-page":"1873","DOI":"10.1016\/j.bmcl.2010.01.152","article-title":"SARS-CoV 3CLpro inhibitory effects of quinone-methide triterpenes from Tripterygium regelii","volume":"20","author":"Ryu","year":"2010","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"ref_190","doi-asserted-by":"crossref","first-page":"8295","DOI":"10.1016\/j.bmc.2006.09.014","article-title":"Binding interaction of quercetin-3-\u03b2-galactoside and its synthetic derivatives with SARS-CoV 3CLpro: Structure\u2013activity relationship studies reveal salient pharmacophore features","volume":"14","author":"Chen","year":"2006","journal-title":"Bioorg. Med. Chem."},{"key":"ref_191","first-page":"3092","article-title":"Andrographolide as a potential inhibitor of SARS-CoV-2 main protease: An in silico approach","volume":"39","author":"Enmozhi","year":"2021","journal-title":"J. Biomol. Struct. Dyn."},{"key":"ref_192","doi-asserted-by":"crossref","first-page":"5928","DOI":"10.1016\/j.bmc.2012.07.038","article-title":"Tanshinones as selective and slow-binding inhibitors for SARS-CoV cysteine proteases","volume":"20","author":"Park","year":"2012","journal-title":"Bioorg. Med. Chem."},{"key":"ref_193","doi-asserted-by":"crossref","first-page":"b12-00623","DOI":"10.1248\/bpb.b12-00623","article-title":"Diarylheptanoids from Alnus japonica inhibit papain-like protease of severe acute respiratory syndrome coronavirus","volume":"35","author":"Park","year":"2012","journal-title":"Biol. Pharm. Bull."},{"key":"ref_194","unstructured":"Ganeshpurkar, A., Gutti, G., and Singh, S. (2018). Viral Polymerases: Structures, Functions and Roles as Antiviral Drug Targets, Elsevier."},{"key":"ref_195","doi-asserted-by":"crossref","first-page":"22398","DOI":"10.1039\/D1RA03937G","article-title":"In silico study of natural compounds from sesame against COVID-19 by targeting M pro, PL pro and RdRp","volume":"11","author":"Allam","year":"2021","journal-title":"RSC Adv."},{"key":"ref_196","doi-asserted-by":"crossref","first-page":"3051","DOI":"10.1016\/j.bmc.2013.03.027","article-title":"Geranylated flavonoids displaying SARS-CoV papain-like protease inhibition from the fruits of Paulownia tomentosa","volume":"21","author":"Cho","year":"2013","journal-title":"Bioorg. Med. Chem."},{"key":"ref_197","doi-asserted-by":"crossref","first-page":"4049","DOI":"10.1016\/j.bmcl.2012.04.081","article-title":"Identification of myricetin and scutellarein as novel chemical inhibitors of the SARS coronavirus helicase, nsP13","volume":"22","author":"Yu","year":"2012","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"ref_198","doi-asserted-by":"crossref","first-page":"153440","DOI":"10.1016\/j.phymed.2020.153440","article-title":"Lycorine, a non-nucleoside RNA dependent RNA polymerase inhibitor, as potential treatment for emerging coronavirus infections","volume":"86","author":"Jin","year":"2021","journal-title":"Phytomedicine"},{"key":"ref_199","doi-asserted-by":"crossref","unstructured":"Mazumder, A., Dwivedi, A., and Du Plessis, J. (2016). Sinigrin and its therapeutic benefits. Molecules, 21.","DOI":"10.3390\/molecules21040416"},{"key":"ref_200","doi-asserted-by":"crossref","first-page":"e02577-20","DOI":"10.1128\/AAC.02577-20","article-title":"Kinetic characterization and inhibitor screening for the proteases leading to identification of drugs against SARS-CoV-2","volume":"65","author":"Kuo","year":"2021","journal-title":"Antimicrob. Agents Chemother."},{"key":"ref_201","doi-asserted-by":"crossref","first-page":"1051","DOI":"10.1097\/CM9.0000000000000797","article-title":"Repurposing of clinically approved drugs for treatment of coronavirus disease 2019 in a 2019-novel coronavirus-related coronavirus model","volume":"133","author":"Fan","year":"2020","journal-title":"Chin. Med. J."},{"key":"ref_202","doi-asserted-by":"crossref","first-page":"102367","DOI":"10.1016\/j.isci.2021.102367","article-title":"Potential anti-COVID-19 agents, cepharanthine and nelfinavir, and their usage for combination treatment","volume":"24","author":"Ohashi","year":"2021","journal-title":"Iscience"},{"key":"ref_203","doi-asserted-by":"crossref","unstructured":"Dejani, N.N., Elshabrawy, H.A., Bezerra Filho, C.D.S.M., and de Sousa, D.P. (2021). Anticoronavirus and Immunomodulatory Phenolic Compounds: Opportunities and Pharmacotherapeutic Perspectives. Biomolecules, 11.","DOI":"10.3390\/biom11081254"},{"key":"ref_204","doi-asserted-by":"crossref","first-page":"530","DOI":"10.3906\/biy-2104-5","article-title":"Targeting CoV-2 Spike RBD and ACE-2 Interaction with Flavonoids of Anatolian Propolis by in silico and in vitro Studies in terms of possible COVID-19 therapeutics","volume":"45","author":"Guler","year":"2021","journal-title":"Turk J. Biol."},{"key":"ref_205","doi-asserted-by":"crossref","first-page":"7940","DOI":"10.1016\/j.bmc.2010.09.035","article-title":"Biflavonoids from Torreya nucifera displaying SARS-CoV 3CLpro inhibition","volume":"18","author":"Ryu","year":"2010","journal-title":"Bioorg. Med. Chem."},{"key":"ref_206","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1080\/14756366.2019.1690480","article-title":"Inhibition of SARS-CoV 3CL protease by flavonoids","volume":"35","author":"Jo","year":"2020","journal-title":"J. Enzym. Inhib. Med. Chem."},{"key":"ref_207","doi-asserted-by":"crossref","first-page":"590509","DOI":"10.3389\/fphar.2021.590509","article-title":"Anti\u2013SARS-CoV-2 Natural Products as Potentially Therapeutic Agents","volume":"12","author":"Kim","year":"2021","journal-title":"Front. Pharmacol."},{"key":"ref_208","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1080\/14756366.2021.1873977","article-title":"Scutellaria baicalensis extract and baicalein inhibit replication of SARS-CoV-2 and its 3C-like protease in vitro","volume":"36","author":"Liu","year":"2021","journal-title":"J. Enzym. Inhib. Med. Chem."},{"key":"ref_209","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1093\/ecam\/neh081","article-title":"Inhibition of SARS-CoV 3C-like protease activity by theaflavin-3, 3\u2019-digallate (TF3)","volume":"2","author":"Chen","year":"2005","journal-title":"Evid.-Based Complement. Altern. Med."},{"key":"ref_210","first-page":"4538","article-title":"Tannic acid suppresses SARS-CoV-2 as a dual inhibitor of the viral main protease and the cellular TMPRSS2 protease","volume":"10","author":"Wang","year":"2020","journal-title":"Am. J. Cancer Res."},{"key":"ref_211","doi-asserted-by":"crossref","first-page":"5630838","DOI":"10.1155\/2020\/5630838","article-title":"Tea polyphenols EGCG and theaflavin inhibit the activity of SARS-CoV-2 3CL-protease in vitro","volume":"2020","author":"Jang","year":"2020","journal-title":"Evid.-Based Complement. Altern. Med."},{"key":"ref_212","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/j.cofs.2020.08.004","article-title":"Potential use of polyphenols in the battle against COVID-19","volume":"32","author":"Paraiso","year":"2020","journal-title":"Curr. Opin. Food Sci."},{"key":"ref_213","doi-asserted-by":"crossref","first-page":"504","DOI":"10.1080\/14756366.2016.1265519","article-title":"Evaluation of polyphenols from Broussonetia papyrifera as coronavirus protease inhibitors","volume":"32","author":"Park","year":"2017","journal-title":"J. Enzym. Inhib. Med. Chem."},{"key":"ref_214","doi-asserted-by":"crossref","first-page":"23","DOI":"10.3109\/14756366.2014.1003215","article-title":"Chalcones isolated from Angelica keiskei inhibit cysteine proteases of SARS-CoV","volume":"31","author":"Park","year":"2016","journal-title":"J. Enzym. Inhib. Med. Chem."},{"key":"ref_215","doi-asserted-by":"crossref","unstructured":"Van de Sand, L., Bormann, M., Alt, M., Schipper, L., Heilingloh, C.S., Steinmann, E., Todt, D., Dittmer, U., Elsner, C., and Witzke, O. (2021). Glycyrrhizin Effectively Inhibits SARS-CoV-2 Replication by Inhibiting the Viral Main Protease. Viruses, 13.","DOI":"10.3390\/v13040609"},{"key":"ref_216","doi-asserted-by":"crossref","first-page":"4087","DOI":"10.1021\/jm070295s","article-title":"Specific plant terpenoids and lignoids possess potent antiviral activities against severe acute respiratory syndrome coronavirus","volume":"50","author":"Wen","year":"2007","journal-title":"J. Med. Chem."},{"key":"ref_217","doi-asserted-by":"crossref","unstructured":"Alhadrami, H.A., Sayed, A.M., Sharif, A.M., Azhar, E.I., and Rateb, M.E. (2021). Olive-Derived Triterpenes Suppress SARS COV-2 Main Protease: A Promising Scaffold for Future Therapeutics. Molecules, 26.","DOI":"10.3390\/molecules26092654"},{"key":"ref_218","doi-asserted-by":"crossref","first-page":"1261","DOI":"10.1021\/acs.jnatprod.0c01324","article-title":"Anti-SARS-CoV-2 activity of Andrographis paniculata extract and its major component Andrographolide in human lung epithelial cells and cytotoxicity evaluation in major organ cell representatives","volume":"84","author":"Suksatu","year":"2021","journal-title":"J. Nat. Prod."},{"key":"ref_219","doi-asserted-by":"crossref","first-page":"19963","DOI":"10.1038\/s41598-020-77003-3","article-title":"High-content screening of Thai medicinal plants reveals Boesenbergia rotunda extract and its component Panduratin A as anti-SARS-CoV-2 agents","volume":"10","author":"Kanjanasirirat","year":"2020","journal-title":"Sci. Rep."},{"key":"ref_220","doi-asserted-by":"crossref","first-page":"2517","DOI":"10.1016\/j.bmc.2004.03.035","article-title":"Old drugs as lead compounds for a new disease? Binding analysis of SARS coronavirus main proteinase with HIV, psychotic and parasite drugs","volume":"12","author":"Zhang","year":"2004","journal-title":"Bioorg. Med. Chem."},{"key":"ref_221","doi-asserted-by":"crossref","first-page":"829","DOI":"10.1126\/science.abb9332","article-title":"Rapid repurposing of drugs for COVID-19","volume":"368","author":"Guy","year":"2020","journal-title":"Science"},{"key":"ref_222","first-page":"338","article-title":"Anthraquinones: A Promising Multi-target Therapeutic Scaffold To Treat Covid-19","volume":"12","author":"Aanniz","year":"2021","journal-title":"Int. J. Appl. Biol. Pharm. Technol."},{"key":"ref_223","doi-asserted-by":"crossref","unstructured":"Stewart, C.A., Gay, C.M., Ramkumar, K., Cargill, K.R., Cardnell, R.J., Nilsson, M.B., Heeke, S., Park, E.M., Kundu, S.T., and Diao, L. (2021). Lung cancer models reveal SARS-CoV-2-induced EMT contributes to COVID-19 pathophysiology. bioRxiv.","DOI":"10.1101\/2020.05.28.122291"},{"key":"ref_224","doi-asserted-by":"crossref","first-page":"102644","DOI":"10.1016\/j.jaut.2021.102644","article-title":"An autoantigen profile of human A549 lung cells reveals viral and host etiologic molecular attributes of autoimmunity in COVID-19","volume":"120","author":"Wang","year":"2021","journal-title":"J. Autoimmun."},{"key":"ref_225","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1021\/acs.jnatprod.9b00515","article-title":"Clerodane diterpenoids isolated from the leaves of Casearia graveolens","volume":"83","author":"Liu","year":"2020","journal-title":"J. Nat. Prod."},{"key":"ref_226","doi-asserted-by":"crossref","first-page":"13437","DOI":"10.2147\/OTT.S278268","article-title":"ERK activation-mediated autophagy induction resists licochalcone A-induced anticancer activities in lung cancer cells in vitro","volume":"13","author":"Luo","year":"2020","journal-title":"OncoTargets Ther."},{"key":"ref_227","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1038\/s41392-020-0149-3","article-title":"Erianin, a novel dibenzyl compound in Dendrobium extract, inhibits lung cancer cell growth and migration via calcium\/calmodulin-dependent ferroptosis","volume":"5","author":"Chen","year":"2020","journal-title":"Signal Transduct. Target. Ther."},{"key":"ref_228","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1055\/a-1295-8606","article-title":"Erianthridin induces non-small cell lung cancer cell apoptosis through the suppression of extracellular signal-regulated kinase activity","volume":"87","author":"Boonjing","year":"2021","journal-title":"Planta Med."},{"key":"ref_229","doi-asserted-by":"crossref","first-page":"233","DOI":"10.2147\/DDDT.S278975","article-title":"Gracillin isolated from Reineckia carnea induces apoptosis of A549 Cells via the mitochondrial pathway","volume":"15","author":"Yang","year":"2021","journal-title":"Drug Des. Dev. Ther."},{"key":"ref_230","first-page":"1995","article-title":"Hispidulin exhibits potent anticancer activity in vitro and in vivo through activating ER stress in non-small-cell lung cancer cells","volume":"43","author":"Lv","year":"2020","journal-title":"Oncol. Rep."},{"key":"ref_231","doi-asserted-by":"crossref","first-page":"1039","DOI":"10.3892\/ijmm.2020.4645","article-title":"Liriopesides B induces apoptosis and cell cycle arrest in human non-small cell lung cancer cells","volume":"46","author":"Sheng","year":"2020","journal-title":"Int. J. Mol. Med."}],"container-title":["Molecules"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1420-3049\/26\/24\/7459\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T07:44:25Z","timestamp":1760168665000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1420-3049\/26\/24\/7459"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,12,9]]},"references-count":231,"journal-issue":{"issue":"24","published-online":{"date-parts":[[2021,12]]}},"alternative-id":["molecules26247459"],"URL":"https:\/\/doi.org\/10.3390\/molecules26247459","relation":{},"ISSN":["1420-3049"],"issn-type":[{"value":"1420-3049","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,12,9]]}}}