{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T06:54:55Z","timestamp":1790492095835,"version":"4.1.0"},"reference-count":44,"publisher":"MDPI AG","issue":"24","license":[{"start":{"date-parts":[[2021,12,9]],"date-time":"2021-12-09T00:00:00Z","timestamp":1639008000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Yunnan Provincial Science and Technology Department - Applied Basic Research Joint Special Funds of Yunnan University of Traditional Chinese Medicine","award":["2017FF117"],"award-info":[{"award-number":["2017FF117"]}]},{"name":"Yunnan Provincial Science and Technology Department Applied Basic Research Joint Special Funds of Yunnan University of Traditional Chinese Medicine","award":["2017FF116"],"award-info":[{"award-number":["2017FF116"]}]},{"name":"GAIN (Axencia Galega de Innovaci\u00f3n)","award":["IN607A2019\/01"],"award-info":[{"award-number":["IN607A2019\/01"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>Schisandrin A (SCH) is a natural bioactive phytonutrient that belongs to the lignan derivatives found in Schisandra chinensis fruit. This study aims to investigate the impact of SCH on promoting neural progenitor cell (NPC) regeneration for avoiding stroke ischemic injury. The promoting effect of SCH on NPCs was evaluated by photothrombotic model, immunofluorescence, cell line culture of NPCs, and Western blot assay. The results showed that neuron-specific class III beta-tubulin (Tuj1) was positive with Map2 positive nerve fibers in the ischemic area after using SCH. In addition, Nestin and SOX2 positive NPCs were significantly (p &lt; 0.05) increased in the penumbra and core. Further analysis identified that SCH can regulate the expression level of cell division control protein 42 (Cdc42). In conclusion, our findings suggest that SCH enhanced NPCs proliferation and differentiation possible by Cdc42 to regulated cytoskeletal rearrangement and polarization of cells, which provides new hope for the late recovery of stroke.<\/jats:p>","DOI":"10.3390\/molecules26247466","type":"journal-article","created":{"date-parts":[[2021,12,9]],"date-time":"2021-12-09T21:46:58Z","timestamp":1639086418000},"page":"7466","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":35,"title":["The Antioxidant Phytochemical Schisandrin A Promotes Neural Cell Proliferation and Differentiation after Ischemic Brain Injury"],"prefix":"10.3390","volume":"26","author":[{"given":"Wentian","family":"Zong","sequence":"first","affiliation":[{"name":"Kunming Health Vocational College, Kunming 650607, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8174-4145","authenticated-orcid":false,"given":"Mostafa","family":"Gouda","sequence":"additional","affiliation":[{"name":"College of Biosystems Engineering and Food Science, Zhejiang University, Hangzhou 310058, China"},{"name":"Department of Nutrition & Food Science, National Research Centre, Giza 12622, Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Enli","family":"Cai","sequence":"additional","affiliation":[{"name":"College of Nursing, Yunnan University of Chinese Medicine, Kunming 650500, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruofeng","family":"Wang","sequence":"additional","affiliation":[{"name":"College of health, Yunnan Technology and Business University, Kunming 651701, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weijie","family":"Xu","sequence":"additional","affiliation":[{"name":"Kunming Health Vocational College, Kunming 650607, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuming","family":"Wu","sequence":"additional","affiliation":[{"name":"College of Nursing, Yunnan University of Chinese Medicine, Kunming 650500, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paulo E. S.","family":"Munekata","sequence":"additional","affiliation":[{"name":"Centro Tecnol\u00f3gico de la Carne de Galicia, R\u00faa Galicia No. 4, Parque Tecnol\u00f3gico de Galicia, San Cibrao das Vi\u00f1as, 32900 Ourense, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7725-9294","authenticated-orcid":false,"given":"Jos\u00e9 M.","family":"Lorenzo","sequence":"additional","affiliation":[{"name":"Centro Tecnol\u00f3gico de la Carne de Galicia, R\u00faa Galicia No. 4, Parque Tecnol\u00f3gico de Galicia, San Cibrao das Vi\u00f1as, 32900 Ourense, Spain"},{"name":"\u00c1rea de Tecnolog\u00eda de los Alimentos, Facultad de Ciencias de Ourense, Universidad de Vigo, 32004 Ourense, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2021,12,9]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1443","DOI":"10.1016\/S0140-6736(20)31374-X","article-title":"Stroke systems of care in low-income and middle-income countries: Challenges and opportunities","volume":"396","author":"Pandian","year":"2020","journal-title":"Lancet"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"101211","DOI":"10.1016\/j.arr.2020.101211","article-title":"The role of nrf2 in neural stem\/progenitors cells: From maintaining stemness and self-renewal to promoting differentiation capability and facilitating therapeutic application in neurodegenerative disease","volume":"65","author":"Kahroba","year":"2021","journal-title":"Ageing Res. 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