{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T14:39:53Z","timestamp":1788878393896,"version":"build-2803163510"},"reference-count":38,"publisher":"MDPI AG","issue":"24","license":[{"start":{"date-parts":[[2021,12,16]],"date-time":"2021-12-16T00:00:00Z","timestamp":1639612800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000780","name":"European Commission","doi-asserted-by":"publisher","award":["European Regional Development Funds (ERDF) Operational Programme of the Valencian Region (2014-2020)"],"award-info":[{"award-number":["European Regional Development Funds (ERDF) Operational Programme of the Valencian Region (2014-2020)"]}],"id":[{"id":"10.13039\/501100000780","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>A GC-HRMS analytical method for the determination of 60 migrant substances, including aldehydes, ketones, phthalates and other plasticizers, phenol derivatives, acrylates, and methacrylates, in plastic food contact materials (FCM) has been developed and validated. The proposed method includes migration tests, according to Commission Regulation (EU) 10\/2011, using four food simulants (A, B, C, and D1), followed by vortex-assisted liquid\u2013liquid extraction (VA-LLE) and GC-Q-Orbitrap HRMS analysis in selected ion monitoring (SIM) mode, with a resolving power of 30,000 FWHM and a mass accuracy \u22645 ppm. The method was validated, showing satisfactory linearity (R2 \u2265 0.98 from 40 to 400 \u00b5g L\u22121), limits of quantification (40 \u00b5g L\u22121), precision (RSD, 0.6\u201312.6%), and relative recovery (81\u2013120%). The proposed method was applied to the analysis of field samples, including an epoxy-coated tin food can, a drinking bottle made of Tritan copolyester, a disposable glass made of polycarbonate, and a baby feeding bottle made of polypropylene, showing that they were in compliance with the current European regulation regarding the studied substances.<\/jats:p>","DOI":"10.3390\/molecules26247640","type":"journal-article","created":{"date-parts":[[2021,12,16]],"date-time":"2021-12-16T21:32:40Z","timestamp":1639690360000},"page":"7640","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Determination of 60 Migrant Substances in Plastic Food Contact Materials by Vortex-Assisted Liquid-Liquid Extraction and GC-Q-Orbitrap HRMS"],"prefix":"10.3390","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6297-5434","authenticated-orcid":false,"given":"Pablo","family":"Miralles","sequence":"first","affiliation":[{"name":"Foundation for the Promotion of Health and Biomedical Research in the Valencian Region (FISABIO), Avinguda Catalunya 21, 46020 Valencia, Spain"},{"name":"Department of Analytical Chemistry, University of Valencia, Avinguda Doctor Moliner 50, 46100 Burjassot, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2817-1453","authenticated-orcid":false,"given":"Vicent","family":"Yus\u00e0","sequence":"additional","affiliation":[{"name":"Foundation for the Promotion of Health and Biomedical Research in the Valencian Region (FISABIO), Avinguda Catalunya 21, 46020 Valencia, Spain"},{"name":"Public Health Laboratory of Valencia, Avinguda Catalunya 21, 46020 Valencia, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yovana","family":"Sanch\u00eds","sequence":"additional","affiliation":[{"name":"Foundation for the Promotion of Health and Biomedical Research in the Valencian Region (FISABIO), Avinguda Catalunya 21, 46020 Valencia, Spain"},{"name":"Public Health Laboratory of Valencia, Avinguda Catalunya 21, 46020 Valencia, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5914-9721","authenticated-orcid":false,"given":"Clara","family":"Coscoll\u00e0","sequence":"additional","affiliation":[{"name":"Foundation for the Promotion of Health and Biomedical Research in the Valencian Region (FISABIO), Avinguda Catalunya 21, 46020 Valencia, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2021,12,16]]},"reference":[{"key":"ref_1","unstructured":"European Commission (2021, December 02). 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