{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T16:00:22Z","timestamp":1791907222655,"version":"4.3.4"},"reference-count":237,"publisher":"MDPI AG","issue":"24","license":[{"start":{"date-parts":[[2021,12,17]],"date-time":"2021-12-17T00:00:00Z","timestamp":1639699200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>Oxidative stress is the leading player in the onset and development of various diseases. The Keap1-Nrf2 pathway is a pivotal antioxidant system that preserves the cells\u2019 redox balance. It decreases inflammation in which the nuclear trans-localization of Nrf2 as a transcription factor promotes various antioxidant responses in cells. Through some other directions and regulatory proteins, this pathway plays a fundamental role in preventing several diseases and reducing their complications. Regulation of the Nrf2 pathway occurs on transcriptional and post-transcriptional levels, and these regulations play a significant role in its activity. There is a subtle correlation between the Nrf2 pathway and the pivotal signaling pathways, including PI3 kinase\/AKT\/mTOR, NF-\u03baB and HIF-1 factors. This demonstrates its role in the development of various diseases. Curcumin is a yellow polyphenolic compound from Curcuma longa with multiple bioactivities, including antioxidant, anti-inflammatory, anti-tumor, and anti-viral activities. Since hyperglycemia and increased reactive oxygen species (ROS) are the leading causes of common diabetic complications, reducing the generation of ROS can be a fundamental approach to dealing with these complications. Curcumin can be considered a potential treatment option by creating an efficient therapeutic to counteract ROS and reduce its detrimental effects. This review discusses Nrf2 pathway regulation at different levels and its correlation with other important pathways and proteins in the cell involved in the progression of diabetic complications and targeting these pathways by curcumin.<\/jats:p>","DOI":"10.3390\/molecules26247658","type":"journal-article","created":{"date-parts":[[2021,12,20]],"date-time":"2021-12-20T02:50:18Z","timestamp":1639968618000},"page":"7658","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":61,"title":["The Potential Role of Curcumin in Modulating the Master Antioxidant Pathway in Diabetic Hypoxia-Induced Complications"],"prefix":"10.3390","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1492-1252","authenticated-orcid":false,"given":"Somayyeh","family":"Ghareghomi","sequence":"first","affiliation":[{"name":"Institute of Biochemistry and Biophysics, University of Tehran, Tehran 1417466191, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2924-9101","authenticated-orcid":false,"given":"Mahdie","family":"Rahban","sequence":"additional","affiliation":[{"name":"Institute of Biochemistry and Biophysics, University of Tehran, Tehran 1417466191, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5777-6577","authenticated-orcid":false,"given":"Zainab","family":"Moosavi-Movahedi","sequence":"additional","affiliation":[{"name":"Chemistry and Chemical Engineering Research Center of Iran, Tehran 1496813151, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4819-8613","authenticated-orcid":false,"given":"Mehran","family":"Habibi-Rezaei","sequence":"additional","affiliation":[{"name":"School of Biology, College of Science, University of Tehran, Tehran 1417466191, Iran"},{"name":"Center of Excellence in NanoBiomedicine, University of Tehran, Tehran 1417466191, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4530-8706","authenticated-orcid":false,"given":"Luciano","family":"Saso","sequence":"additional","affiliation":[{"name":"Department of Physiology and Pharmacology \u201cVittorio Erspamer,\u201d Sapienza University of Rome, 00185 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ali Akbar","family":"Moosavi-Movahedi","sequence":"additional","affiliation":[{"name":"Institute of Biochemistry and Biophysics, University of Tehran, Tehran 1417466191, Iran"},{"name":"UNESCO Chair on Interdisciplinary Research in Diabetes, University of Tehran, Tehran 1417466191, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2021,12,17]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1245049","DOI":"10.1155\/2016\/1245049","article-title":"Role of ROS and RNS Sources in Physiological and Pathological Conditions","volume":"2016","author":"Reed","year":"2016","journal-title":"Oxid. Med. Cell. Longev."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1007\/s12291-014-0446-0","article-title":"Free radicals: Properties, sources, targets, and their implication in various diseases","volume":"30","author":"Phaniendra","year":"2015","journal-title":"Indian J. Clin. Biochem."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"7266","DOI":"10.3390\/molecules15107266","article-title":"The Nrf2 System as a Potential Target for the Development of Indirect Antioxidants","volume":"15","author":"Jung","year":"2010","journal-title":"Molecules"},{"key":"ref_4","doi-asserted-by":"crossref","unstructured":"Saha, S., Buttari, B., Panieri, E., Profumo, E., and Saso, L. (2020). An overview of Nrf2 signaling pathway and its role in inflammation. Molecules, 25.","DOI":"10.3390\/molecules25225474"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1097\/00041552-200311000-00004","article-title":"Oxidative stress in uremia","volume":"12","author":"Himmelfarb","year":"2003","journal-title":"Curr. Opin. Nephrol. Hypertens."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"1524","DOI":"10.1046\/j.1523-1755.2002.00600.x","article-title":"The elephant in uremia: Oxidant stress as a unifying concept of cardiovascular disease in uremia","volume":"62","author":"Himmelfarb","year":"2002","journal-title":"Kidney Int."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/j.trsl.2008.11.007","article-title":"Impaired antioxidant activity of high-density lipoprotein in chronic kidney disease","volume":"153","author":"Moradi","year":"2009","journal-title":"Transl. Res."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1016\/j.semnephrol.2004.06.026","article-title":"Oxidative stress in uremia: Nature, mechanisms, and potential consequences","volume":"24","author":"Vaziri","year":"2004","journal-title":"Semin. Nephrol."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1038\/ki.2009.177","article-title":"In vitro stimulation of HDL anti-inflammatory activity and inhibition of LDL pro-inflammatory activity in the plasma of patients with end-stage renal disease by an apoA-1 mimetic peptide","volume":"76","author":"Vaziri","year":"2009","journal-title":"Kidney Int."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1038\/s41580-020-0230-3","article-title":"Reactive oxygen species (ROS) as pleiotropic physiological signalling agents","volume":"21","author":"Sies","year":"2020","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"694","DOI":"10.3389\/fphys.2020.00694","article-title":"Lifestyle, Oxidative Stress, and Antioxidants: Back and Forth in the Pathophysiology of Chronic Diseases","volume":"11","author":"Zucca","year":"2020","journal-title":"Front. Physiol."},{"key":"ref_12","first-page":"7","article-title":"Current status of diabetes in India and need for novel therapeutic agents","volume":"58","author":"Ramachandran","year":"2010","journal-title":"J. Assoc. Physicians India"},{"key":"ref_13","unstructured":"Atlas, D. (2015). International diabetes federation. IDF Diabetes Atlas, International Diabetes Federation. [7th ed.]."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/j.tem.2020.11.002","article-title":"Nrf2: The Master and Captain of Beta Cell Fate","volume":"32","author":"Katz","year":"2021","journal-title":"Trends Endocrinol. Metab."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1016\/j.abb.2019.05.008","article-title":"Intensification of serum albumin amyloidogenesis by a glycation-peroxidation loop (GPL)","volume":"668","author":"Farzadfard","year":"2019","journal-title":"Arch. Biochem. Biophys."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"1401","DOI":"10.1016\/j.jnutbio.2015.08.001","article-title":"The complexity of the Nrf2 pathway: Beyond the antioxidant response","volume":"26","author":"Huang","year":"2015","journal-title":"J. Nutr. Biochem."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/j.freeradbiomed.2020.03.023","article-title":"Beyond repression of Nrf2: An update on Keap1","volume":"157","author":"Kopacz","year":"2020","journal-title":"Free Radic. Biol. Med."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1089\/ars.2005.7.385","article-title":"Molecular mechanisms activating the Nrf2-Keap1 pathway of antioxidant gene regulation","volume":"7","author":"Kobayashi","year":"2005","journal-title":"Antioxid. Redox Signal."},{"key":"ref_19","first-page":"312","article-title":"Regulation of Nrf2 Signaling","volume":"8","author":"Li","year":"2019","journal-title":"React. Oxyg Species"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1016\/j.advenzreg.2006.01.007","article-title":"Nrf2-Keap1 regulation of cellular defense mechanisms against electrophiles and reactive oxygen species","volume":"46","author":"Kobayashi","year":"2006","journal-title":"Adv. Enzym. Regul."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"1526","DOI":"10.1055\/s-0028-1088302","article-title":"Nrf2 as a master redox switch in turning on the cellular signaling involved in the induction of cytoprotective genes by some chemopreventive phytochemicals","volume":"74","author":"Surh","year":"2008","journal-title":"Planta Med."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"1937","DOI":"10.1039\/c1np00051a","article-title":"Multitargeting by curcumin as revealed by molecular interaction studies","volume":"28","author":"Gupta","year":"2011","journal-title":"Nat. Prod. Rep."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"1062","DOI":"10.1002\/mnfr.200700316","article-title":"Curcumin and the cellular stress response in free radical-related diseases","volume":"52","author":"Calabrese","year":"2008","journal-title":"Mol. Nutr. Food Res."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1007\/s12035-011-8168-2","article-title":"Neuroprotection by spice-derived nutraceuticals: You are what you eat!","volume":"44","author":"Kannappan","year":"2011","journal-title":"Mol. Neurobiol."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"2166","DOI":"10.1016\/j.lwt.2011.05.023","article-title":"Beta casein-micelle as a nano vehicle for solubility enhancement of curcumin; food industry application","volume":"44","author":"Esmaili","year":"2011","journal-title":"Lwt-Food Sci. Technol."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/j.abb.2017.06.018","article-title":"Destructive effect of non-enzymatic glycation on catalase and remediation via curcumin","volume":"630","author":"Taghavi","year":"2017","journal-title":"Arch. Biochem. Biophys."},{"key":"ref_27","doi-asserted-by":"crossref","unstructured":"Panieri, E., Telkoparan-Akillilar, P., Suzen, S., and Saso, L. (2020). The NRF2\/KEAP1 axis in the regulation of tumor metabolism: Mechanisms and therapeutic perspectives. Biomolecules, 10.","DOI":"10.3390\/biom10050791"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1006\/bbrc.1997.6943","article-title":"An Nrf2\/small Maf heterodimer mediates the induction of phase II detoxifying enzyme genes through antioxidant response elements","volume":"236","author":"Itoh","year":"1997","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1002\/mc.20465","article-title":"Molecular mechanisms of Nrf2-mediated antioxidant response","volume":"48","author":"Li","year":"2009","journal-title":"Mol. Carcinog."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"3097","DOI":"10.1158\/0008-5472.CAN-12-3386","article-title":"RXR\u03b1 inhibits the NRF2-ARE signaling pathway through a direct interaction with the Neh7 domain of NRF2","volume":"73","author":"Wang","year":"2013","journal-title":"Cancer Res."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"2226","DOI":"10.1016\/j.jasms.2007.09.015","article-title":"Sites of alkylation of human Keap1 by natural chemoprevention agents","volume":"18","author":"Luo","year":"2007","journal-title":"J. Am. Soc. Mass Spectrom."},{"key":"ref_32","first-page":"9372182","article-title":"Activators and Inhibitors of NRF2: A Review of Their Potential for Clinical Development","volume":"2019","author":"Manda","year":"2019","journal-title":"Oxid. Med. Cell. Longev."},{"key":"ref_33","doi-asserted-by":"crossref","unstructured":"Rahban, M., Habibi-Rezaei, M., Mazaheri, M., Saso, L., and Moosavi-Movahedi, A.A. (2020). Anti-Viral Potential and Modulation of Nrf2 by Curcumin: Pharmacological Implications. Antioxidants, 9.","DOI":"10.3390\/antiox9121228"},{"key":"ref_34","doi-asserted-by":"crossref","unstructured":"Emanuele, S., Celesia, A., D\u2019Anneo, A., Lauricella, M., Carlisi, D., De Blasio, A., and Giuliano, M. (2021). The Good and Bad of Nrf2: An Update in Cancer and New Perspectives in COVID-19. Int. J. Mol. Sci., 22.","DOI":"10.3390\/ijms22157963"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"1912","DOI":"10.1126\/science.1075762","article-title":"The protein kinase complement of the human genome","volume":"298","author":"Manning","year":"2002","journal-title":"Science"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"e1822","DOI":"10.1038\/cddis.2015.183","article-title":"Protein kinase R-like ER kinase and its role in endoplasmic reticulum stress-decided cell fate","volume":"6","author":"Liu","year":"2015","journal-title":"Cell Death Dis."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1038\/nrm829","article-title":"The unfolded protein response in nutrient sensing and differentiation","volume":"3","author":"Kaufman","year":"2002","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1186\/1475-2840-12-158","article-title":"Protein kinase RNA-like endoplasmic reticulum kinase (PERK) signaling pathway plays a major role in reactive oxygen species (ROS)-mediated endoplasmic reticulum stress-induced apoptosis in diabetic cardiomyopathy","volume":"12","author":"Liu","year":"2013","journal-title":"Cardiovasc. Diabetol."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1038\/nrm2847","article-title":"PKC and the control of localized signal dynamics","volume":"11","author":"Rosse","year":"2010","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"44675","DOI":"10.1074\/jbc.M307633200","article-title":"Phosphorylation of Nrf2 at Ser40 by protein kinase C in response to antioxidants leads to the release of Nrf2 from INrf2, but is not required for Nrf2 stabilization\/accumulation in the nucleus and transcriptional activation of antioxidant response element-mediated NAD (P) H: Quinone oxidoreductase-1 gene expression","volume":"278","author":"Bloom","year":"2003","journal-title":"J. Biol. Chem."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1042\/bj20021469","article-title":"Protein kinase CK2: Structure, regulation and role in cellular decisions of life and death","volume":"369","author":"Litchfield","year":"2003","journal-title":"Biochem. J."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1002\/jbt.20212","article-title":"Phosphorylation of Nrf2 in the transcription activation domain by casein kinase 2 (CK2) is critical for the nuclear translocation and transcription activation function of Nrf2 in IMR-32 neuroblastoma cells","volume":"22","author":"Apopa","year":"2008","journal-title":"J. Biochem. Mol. Toxicol."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"112185","DOI":"10.1016\/j.ecoenv.2021.112185","article-title":"Dose-and time-effects responses of Nonylphenol on oxidative stress in rat through the Keap1-Nrf2 signaling pathway","volume":"216","author":"Ke","year":"2021","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"1797","DOI":"10.1016\/j.freeradbiomed.2007.03.001","article-title":"Molecular mechanism of human Nrf2 activation and degradation: Role of sequential phosphorylation by protein kinase CK2","volume":"42","author":"Pi","year":"2007","journal-title":"Free Radica. Biol. Med."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1146\/annurev.cellbio.13.1.513","article-title":"Cellular functions regulated by Src family kinases","volume":"13","author":"Thomas","year":"1997","journal-title":"Annu. Rev. Cell Dev. Biol."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"12132","DOI":"10.1074\/jbc.M511198200","article-title":"Phosphorylation of tyrosine 568 controls nuclear export of Nrf2","volume":"281","author":"Jain","year":"2006","journal-title":"J. Biol. Chem."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"686","DOI":"10.1016\/j.bbamcr.2019.01.011","article-title":"c-Src regulates Nrf2 activity through PKC\u03b4 after oxidant stimulus","volume":"1866","author":"Mota","year":"2019","journal-title":"Biochim. Biophys. Acta Mol. Cell Res."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"28821","DOI":"10.1074\/jbc.M111.255042","article-title":"Src subfamily kinases regulate nuclear export and degradation of transcription factor Nrf2 to switch off Nrf2-mediated antioxidant activation of cytoprotective gene expression","volume":"286","author":"Niture","year":"2011","journal-title":"J. Biol. Chem."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"16502","DOI":"10.1074\/jbc.M611336200","article-title":"GSK-3\u03b2 acts upstream of Fyn kinase in regulation of nuclear export and degradation of NF-E2 related factor 2","volume":"282","author":"Jain","year":"2007","journal-title":"J. Biol. Chem."},{"key":"ref_50","unstructured":"Chackalamannil, S., Rotella, D., and Ward, S.E. (2017). 7.10-Inhibiting Kinases in the CNS. Comprehensive Medicinal Chemistry III, Elsevier."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"1877","DOI":"10.1038\/cdd.2015.49","article-title":"Astrocyte NMDA receptors\u2019 activity sustains neuronal survival through a Cdk5\u2013Nrf2 pathway","volume":"22","author":"Gonzalez","year":"2015","journal-title":"Cell Death Differ."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"1249","DOI":"10.1172\/JCI29710","article-title":"Diabetic impairments in NO-mediated endothelial progenitor cell mobilization and homing are reversed by hyperoxia and SDF-1\u03b1","volume":"117","author":"Gallagher","year":"2007","journal-title":"J. Clin. Investig."},{"key":"ref_53","doi-asserted-by":"crossref","unstructured":"Sabio, G., and Davis, R.J. (2014). Seminars in immunology. TNF and MAP Kinase Signalling Pathways, Elsevier.","DOI":"10.1016\/j.smim.2014.02.009"},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1016\/S0898-6568(97)00042-9","article-title":"Stress-activated protein kinases: Activation, regulation and function","volume":"9","author":"Paul","year":"1997","journal-title":"Cell. Signal."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"1969","DOI":"10.1101\/gad.1107303","article-title":"Mechanism of p38 MAP kinase activation in vivo","volume":"17","author":"Brancho","year":"2003","journal-title":"Genes Dev."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"1301","DOI":"10.1093\/emboj\/19.6.1301","article-title":"Molecular determinants that mediate selective activation of p38 MAP kinase isoforms","volume":"19","author":"Enslen","year":"2000","journal-title":"Embo J."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"660","DOI":"10.1016\/j.cellsig.2009.11.020","article-title":"Differential activation of p38MAPK isoforms by MKK6 and MKK3","volume":"22","author":"Remy","year":"2010","journal-title":"Cell. Signal."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1007\/s10787-017-0339-y","article-title":"Nrf2: A potential therapeutic target for diabetic neuropathy","volume":"25","author":"Kumar","year":"2017","journal-title":"Inflammopharmacology"},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"1951","DOI":"10.1159\/000491465","article-title":"Nrf2 Pathway in Age-Related Neurological Disorders: Insights into MicroRNAs","volume":"47","author":"Paladino","year":"2018","journal-title":"Cell. Physiol. Biochem. Int. J. Exp. Cell. Physiol. Biochem. Pharmacol."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"841","DOI":"10.1002\/mc.20234","article-title":"Butylated hydroxyanisole regulates ARE-mediated gene expression via Nrf2 coupled with ERK and JNK signaling pathway in HepG2 cells","volume":"45","author":"Yuan","year":"2006","journal-title":"Mol. Carcinog."},{"key":"ref_61","first-page":"40","article-title":"GSK-3: Functional insights from cell biology and animal models","volume":"4","author":"Woodgett","year":"2011","journal-title":"Front. Mol. Neurosci."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"1415","DOI":"10.1016\/j.cell.2007.05.052","article-title":"Systematic discovery of in vivo phosphorylation networks","volume":"129","author":"Linding","year":"2007","journal-title":"Cell"},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1016\/j.biochi.2020.11.015","article-title":"Fundamental insights into the interaction between telomerase\/TERT and intracellular signaling pathways","volume":"181","author":"Ghareghomi","year":"2021","journal-title":"Biochimie"},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"301","DOI":"10.2174\/1389200220666190227224748","article-title":"PI3K\/Akt-Nrf2 and anti-inflammation effect of macrolides in chronic obstructive pulmonary disease","volume":"20","author":"Sun","year":"2019","journal-title":"Curr. Drug Metab."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"6076","DOI":"10.1007\/s12035-017-0798-6","article-title":"Natural dietary supplementation of anthocyanins via PI3K\/Akt\/Nrf2\/HO-1 pathways mitigate oxidative stress, neurodegeneration, and memory impairment in a mouse model of Alzheimer\u2019s disease","volume":"55","author":"Ali","year":"2018","journal-title":"Mol. Neurobiol."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"14841","DOI":"10.1074\/jbc.M513737200","article-title":"Glycogen synthase kinase-3\u03b2 inhibits the xenobiotic and antioxidant cell response by direct phosphorylation and nuclear exclusion of the transcription factor Nrf2","volume":"281","author":"Salazar","year":"2006","journal-title":"J. Biol. Chem."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"3765","DOI":"10.1038\/onc.2012.388","article-title":"Nrf2 is controlled by two distinct \u03b2-TrCP recognition motifs in its Neh6 domain, one of which can be modulated by GSK-3 activity","volume":"32","author":"Chowdhry","year":"2013","journal-title":"Oncogene"},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"31556","DOI":"10.1074\/jbc.M403061200","article-title":"Redox-regulated turnover of Nrf2 is determined by at least two separate protein domains, the redox-sensitive Neh2 degron and the redox-insensitive Neh6 degron","volume":"279","author":"McMahon","year":"2004","journal-title":"J. Biol. Chem."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"3486","DOI":"10.1128\/MCB.00180-12","article-title":"Structural and functional characterization of Nrf2 degradation by the glycogen synthase kinase 3\/\u03b2-TrCP axis","volume":"32","author":"Rada","year":"2012","journal-title":"Mol. Cell. Biol."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"373","DOI":"10.3389\/fgene.2018.00373","article-title":"Molecular Pathways Associated With Methylmercury-Induced Nrf2 Modulation","volume":"9","author":"Unoki","year":"2018","journal-title":"Fron. Genet."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"705","DOI":"10.1016\/j.bcp.2012.11.016","article-title":"The Nrf2 cell defence pathway: Keap1-dependent and-independent mechanisms of regulation","volume":"85","author":"Bryan","year":"2013","journal-title":"Biochem. Pharmacol."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"2658","DOI":"10.1128\/MCB.01639-08","article-title":"Acetylation of Nrf2 by p300\/CBP augments promoter-specific DNA binding of Nrf2 during the antioxidant response","volume":"29","author":"Sun","year":"2009","journal-title":"Mol. Cell. Biol."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"10842","DOI":"10.1074\/jbc.M112475200","article-title":"Signaling molecules of the NF-\u03baB pathway shuttle constitutively between cytoplasm and nucleus","volume":"277","author":"Birbach","year":"2002","journal-title":"J. Biol. Chem."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"394","DOI":"10.1016\/j.redox.2013.07.005","article-title":"Potential therapeutic effects of the simultaneous targeting of the Nrf2 and NF-\u03baB pathways in diabetic neuropathy","volume":"1","author":"Yerra","year":"2013","journal-title":"Redox Biol."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1016\/j.intimp.2015.06.015","article-title":"Sappanone A exhibits anti-inflammatory effects via modulation of Nrf2 and NF-\u03baB","volume":"28","author":"Lee","year":"2015","journal-title":"Int. Immunopharmacol."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1016\/j.bbamcr.2008.01.002","article-title":"NF-\u03baB\/p65 antagonizes Nrf2-ARE pathway by depriving CBP from Nrf2 and facilitating recruitment of HDAC3 to MafK","volume":"1783","author":"Liu","year":"2008","journal-title":"Biochim. Biophys. Acta (Bba)-Mol. Cell Res."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"40725","DOI":"10.1074\/jbc.M111.275495","article-title":"miR-200a regulates Nrf2 activation by targeting Keap1 mRNA in breast cancer cells","volume":"286","author":"Eades","year":"2011","journal-title":"J. Biol. Chem."},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/j.mad.2010.12.004","article-title":"Increased expression of miR-34a and miR-93 in rat liver during aging, and their impact on the expression of Mgst1 and Sirt1","volume":"132","author":"Li","year":"2011","journal-title":"Mech. Ageing Dev."},{"key":"ref_79","first-page":"4338","article-title":"microRNA miR-144 modulates oxidative stress tolerance and associates with anemia severity in sickle cell disease","volume":"116","author":"Sangokoya","year":"2010","journal-title":"Blood J. Am. Soc. Hematol."},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"983","DOI":"10.1007\/s10549-011-1604-1","article-title":"MiR-28 regulates Nrf2 expression through a Keap1-independent mechanism","volume":"129","author":"Yang","year":"2011","journal-title":"Breast Cancer Res. Treat."},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"20922","DOI":"10.1074\/jbc.M112.352336","article-title":"Caveolin-1 inhibits expression of antioxidant enzymes through direct interaction with nuclear erythroid 2 p45-related factor-2 (Nrf2)","volume":"287","author":"Li","year":"2012","journal-title":"J. Biol. Chem."},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"1304","DOI":"10.1016\/j.freeradbiomed.2009.07.035","article-title":"Nrf2: INrf2 (Keap1) signaling in oxidative stress","volume":"47","author":"Kaspar","year":"2009","journal-title":"Free Radic. Biol. Med."},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"944","DOI":"10.1038\/nature04634","article-title":"Reactive oxygen species have a causal role in multiple forms of insulin resistance","volume":"440","author":"Houstis","year":"2006","journal-title":"Nature"},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"104760","DOI":"10.1016\/j.phrs.2020.104760","article-title":"Obesity and NRF2-mediated cytoprotection: Where is the missing link?","volume":"156","author":"Vasileva","year":"2020","journal-title":"Pharmacol. Res."},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1007\/s12012-019-09544-7","article-title":"Association of genetic variations in NRF2, NQO1, HMOX1, and MT with severity of coronary artery disease and related risk factors","volume":"20","author":"Sarutipaiboon","year":"2020","journal-title":"Cardiovasc. Toxicol."},{"key":"ref_86","first-page":"10420","article-title":"Resveratrol attenuates inflammation and oxidative stress induced by myocardial ischemia-reperfusion injury: Role of Nrf2\/ARE pathway","volume":"8","author":"Cheng","year":"2015","journal-title":"Int. J. Clin. Exp. Med."},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1016\/j.freeradbiomed.2019.06.028","article-title":"Antioxidant and antihypertensive responses to oral nitrite involves activation of the Nrf2 pathway","volume":"141","author":"Amaral","year":"2019","journal-title":"Free Radic. Biol. Med."},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1016\/j.freeradbiomed.2021.10.020","article-title":"Thioredoxin reductase-1 levels are associated with NRF2 pathway activation and tumor recurrence in non-small cell lung cancer","volume":"177","author":"Delgobo","year":"2021","journal-title":"Free Radic. Biol. Med."},{"key":"ref_89","doi-asserted-by":"crossref","unstructured":"Suvorova, E.S., Lucas, O., Weisend, C.M., Rollins, M.F., Merrill, G.F., Capecchi, M.R., and Schmidt, E.E. (2009). Cytoprotective Nrf2 pathway is induced in chronically txnrd 1-deficient hepatocytes. PLoS ONE, 4.","DOI":"10.1371\/journal.pone.0006158"},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1016\/j.redox.2016.01.007","article-title":"Cross-talk between two antioxidants, thioredoxin reductase and heme oxygenase-1, and therapeutic implications for multiple myeloma","volume":"8","author":"Raninga","year":"2016","journal-title":"Redox Biol."},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1016\/j.talanta.2018.10.049","article-title":"A new substrate for glutathione reductase: Glutathione coated Ag2S quantum dots","volume":"194","author":"Aydemir","year":"2019","journal-title":"Talanta"},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"3029","DOI":"10.1016\/j.febslet.2005.04.058","article-title":"Role of Nrf2 signaling in regulation of antioxidants and phase 2 enzymes in cardiac fibroblasts: Protection against reactive oxygen and nitrogen species-induced cell injury","volume":"579","author":"Zhu","year":"2005","journal-title":"FEBS Lett."},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"436","DOI":"10.2183\/pjab.92.436","article-title":"CXCL12 protects pancreatic \u03b2-cells from oxidative stress by a Nrf2-induced increase in catalase expression and activity","volume":"92","year":"2016","journal-title":"Proc. Jpn. Acad. Ser. B"},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1007\/s11010-014-2051-1","article-title":"Redox regulation of antioxidant enzymes: Post-translational modulation of catalase and glutathione peroxidase activity by resveratrol in diabetic rat liver","volume":"393","author":"Sadi","year":"2014","journal-title":"Mol. Cell. Biochem."},{"key":"ref_95","first-page":"e8394","article-title":"Activation of Nrf2-antioxidant response element mediated glutamate cysteine ligase expression in hepatoma cell line by homocysteine","volume":"13","author":"Mani","year":"2013","journal-title":"Hepa. Mon."},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"458","DOI":"10.1016\/j.aohep.2019.11.010","article-title":"NRF-2 and nonalcoholic fatty liver disease","volume":"19","year":"2020","journal-title":"Ann. Hepatol."},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"2987249","DOI":"10.1155\/2018\/2987249","article-title":"Characterization of the antioxidant effects of \u03b3-oryzanol: Involvement of the Nrf2 pathway","volume":"2018","author":"Rungratanawanich","year":"2018","journal-title":"Oxid. Med. Cell. Longev."},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"466","DOI":"10.1016\/j.freeradbiomed.2015.06.039","article-title":"Glutathione S-transferase pi expression regulates the Nrf2-dependent response to hormetic diselenides","volume":"88","author":"Bartolini","year":"2015","journal-title":"Free Radic. Biol. Med."},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"139","DOI":"10.3892\/mco.2017.1129","article-title":"The role of peroxiredoxins in cancer","volume":"6","author":"Nicolussi","year":"2017","journal-title":"Mol. Clin. Oncol."},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1016\/j.lfs.2016.02.022","article-title":"Molecular mechanisms underlying chemopreventive potential of curcumin: Current challenges and future perspectives","volume":"148","author":"Kumar","year":"2016","journal-title":"Life Sci."},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"D498","DOI":"10.1093\/nar\/gkaa1025","article-title":"BRENDA, the ELIXIR core data resource in 2021: New developments and updates","volume":"49","author":"Chang","year":"2021","journal-title":"Nucleic Acids Res."},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"941","DOI":"10.1007\/s12031-014-0449-6","article-title":"Sulfiredoxin-1 attenuates oxidative stress via Nrf2\/ARE pathway and 2-Cys Prdxs after oxygen-glucose deprivation in astrocytes","volume":"55","author":"Zhou","year":"2015","journal-title":"J. Mol. Neurosci."},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1146\/annurev.pharmtox.43.100901.140229","article-title":"Regulatory mechanisms controlling gene expression mediated by the antioxidant response element","volume":"43","author":"Nguyen","year":"2003","journal-title":"Annu. Rev. Pharmacol. Toxicol."},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"699","DOI":"10.1016\/j.freeradbiomed.2021.06.031","article-title":"Role of chemopreventive phytochemicals in NRF2-mediated redox homeostasis in humans","volume":"172","author":"Chun","year":"2021","journal-title":"Free Radic. Biol. Med."},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1146\/annurev.pharmtox.010909.105600","article-title":"Mechanisms of Cell Protection by Heme Oxygenase-1","volume":"50","author":"Gozzelino","year":"2010","journal-title":"Annu. Rev. Pharmacol. Toxicol."},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1111\/j.1471-4159.2008.05648.x","article-title":"Induction of sulfiredoxin expression and reduction of peroxiredoxin hyperoxidation by the neuroprotective Nrf2 activator 3H-1,2-dithiole-3-thione","volume":"107","author":"Soriano","year":"2008","journal-title":"J. Neurochem."},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1007\/s00011-018-1151-x","article-title":"A review on heme oxygenase-1 induction: Is it a necessary evil","volume":"67","author":"Waza","year":"2018","journal-title":"Inflamm. Res."},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/j.tips.2015.09.003","article-title":"Translational Significance of Heme Oxygenase in Obesity and Metabolic Syndrome","volume":"37","author":"Abraham","year":"2016","journal-title":"Trends Pharmacol. Sci."},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"101950","DOI":"10.1016\/j.redox.2021.101950","article-title":"The diverse functionality of NQO1 and its roles in redox control","volume":"41","author":"Ross","year":"2021","journal-title":"Redox Biol."},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/j.cotox.2017.10.005","article-title":"NQO1 in protection against oxidative stress","volume":"7","author":"Ross","year":"2018","journal-title":"Curr. Opin. Toxicol."},{"key":"ref_111","doi-asserted-by":"crossref","first-page":"524","DOI":"10.4103\/1735-5362.272561","article-title":"Possible antioxidant mechanism of coenzyme Q10 in diabetes: Impact on Sirt1\/Nrf2 signaling pathways","volume":"14","author":"Samimi","year":"2019","journal-title":"Res. Pharm Sci"},{"key":"ref_112","doi-asserted-by":"crossref","first-page":"846","DOI":"10.1016\/j.ijbiomac.2020.11.149","article-title":"Strategies to expand the therapeutic potential of superoxide dismutase by exploiting delivery approaches","volume":"168","author":"Rosa","year":"2021","journal-title":"Int. J. Biol. Macromol."},{"key":"ref_113","first-page":"287","article-title":"First line defence antioxidants-superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GPX): Their fundamental role in the entire antioxidant defence grid","volume":"54","author":"Ighodaro","year":"2018","journal-title":"Alex. J. Med."},{"key":"ref_114","doi-asserted-by":"crossref","first-page":"1303","DOI":"10.1681\/ASN.2008080844","article-title":"Reduction of Renal Superoxide Dismutase in Progressive Diabetic Nephropathy","volume":"20","author":"Fujita","year":"2009","journal-title":"J. Am. Soc. Nephrol."},{"key":"ref_115","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1080\/10715760100300281","article-title":"Manganese superoxide dismutase in disease","volume":"34","author":"Cruthirds","year":"2001","journal-title":"Free Radic. Res."},{"key":"ref_116","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1016\/j.freeradbiomed.2009.05.018","article-title":"Regulation of superoxide dismutase genes: Implications in disease","volume":"47","author":"Miao","year":"2009","journal-title":"Free Radic. Biol. Med."},{"key":"ref_117","doi-asserted-by":"crossref","first-page":"313","DOI":"10.3109\/10715760903494168","article-title":"Oxidative damage of mitochondrial DNA in diabetes and its protection by manganese superoxide dismutase","volume":"44","author":"Zhong","year":"2010","journal-title":"Free Radic. Res."},{"key":"ref_118","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1007\/s10565-020-09517-5","article-title":"Glutathione S-transferase P influences the Nrf2-dependent response of cellular thiols to seleno-compounds","volume":"36","author":"Bartolini","year":"2020","journal-title":"Cell Biol. Toxicol."},{"key":"ref_119","doi-asserted-by":"crossref","first-page":"517","DOI":"10.5999\/aps.2013.40.5.517","article-title":"Expression of extracellular superoxide dismutase protein in diabetes","volume":"40","author":"Kim","year":"2013","journal-title":"Arch. Plast. Surg."},{"key":"ref_120","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1016\/j.bbapap.2009.10.010","article-title":"Post-translational modifications of superoxide dismutase","volume":"1804","author":"Yamakura","year":"2010","journal-title":"Biochim. Biophys. Acta Proteins Proteom."},{"key":"ref_121","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1016\/j.bbrc.2010.03.083","article-title":"Thioredoxin and thioredoxin reductase: Current research with special reference to human disease","volume":"396","author":"Holmgren","year":"2010","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_122","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1016\/j.bbagen.2009.01.014","article-title":"Focus on mammalian thioredoxin reductases\u2014important selenoproteins with versatile functions","volume":"1790","year":"2009","journal-title":"Biochim. Biophys. Acta Gen. Subj."},{"key":"ref_123","doi-asserted-by":"crossref","first-page":"R1004","DOI":"10.1152\/ajpregu.00011.2020","article-title":"Peroxiredoxin 1 plays a primary role in protecting pancreatic \u03b2-cells from hydrogen peroxide and peroxynitrite","volume":"318","author":"Stancill","year":"2020","journal-title":"Am. J. Physiol. Regul. Integr. Comp. Physiol."},{"key":"ref_124","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1016\/S1665-2681(19)32099-X","article-title":"The importance of redox state in liver damage","volume":"3","author":"Cesaratto","year":"2004","journal-title":"Ann. Hepatol."},{"key":"ref_125","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1089\/ars.2007.9.25","article-title":"Thioredoxin and related molecules\u2013from biology to health and disease","volume":"9","author":"Lillig","year":"2007","journal-title":"Antioxid. Redox Signal."},{"key":"ref_126","doi-asserted-by":"crossref","first-page":"714370","DOI":"10.3389\/fcell.2021.714370","article-title":"Physiological signaling functions of reactive oxygen species in stem cells: From flies to man","volume":"9","author":"Sinenko","year":"2021","journal-title":"Front. Cell Dev. Biol."},{"key":"ref_127","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1089\/ars.2017.7290","article-title":"The role of sirtuins in antioxidant and redox signaling","volume":"28","author":"Singh","year":"2018","journal-title":"Antioxid. Redox Signal."},{"key":"ref_128","doi-asserted-by":"crossref","first-page":"498","DOI":"10.1089\/ars.2019.7905","article-title":"Regulatory phenomena in the glutathione peroxidase superfamily","volume":"33","year":"2020","journal-title":"Antioxid. Redox Signal."},{"key":"ref_129","doi-asserted-by":"crossref","first-page":"823","DOI":"10.1089\/ars.2015.6378","article-title":"TrxR1 as a potent regulator of the Nrf2-Keap1 response system","volume":"23","author":"Cebula","year":"2015","journal-title":"Antioxid. Redox Signal."},{"key":"ref_130","doi-asserted-by":"crossref","first-page":"L545","DOI":"10.1152\/ajplung.00214.2018","article-title":"The thioredoxin reductase inhibitor auranofin induces heme oxygenase-1 in lung epithelial cells via Nrf2-dependent mechanisms","volume":"315","author":"Dunigan","year":"2018","journal-title":"Am. J. Physiol-Lung Cell. Mol. Physiol."},{"key":"ref_131","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/j.freeradbiomed.2015.04.036","article-title":"The emerging role of Nrf2 in mitochondrial function","volume":"88","author":"Abramov","year":"2015","journal-title":"Free Radic. Biol. Med."},{"key":"ref_132","doi-asserted-by":"crossref","first-page":"484","DOI":"10.1016\/S0076-6879(85)13062-4","article-title":"Glutathione reductase","volume":"113","author":"Carlberg","year":"1985","journal-title":"Methods Enzymol."},{"key":"ref_133","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1016\/j.tox.2006.06.008","article-title":"Glutathione peroxidase and glutathione reductase activities are partially responsible for determining the susceptibility of cells to oxidative stress","volume":"226","author":"Yang","year":"2006","journal-title":"Toxicology"},{"key":"ref_134","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1016\/j.mam.2008.05.005","article-title":"Regulation of glutathione synthesis","volume":"30","author":"Lu","year":"2009","journal-title":"Mol. Asp. Med."},{"key":"ref_135","doi-asserted-by":"crossref","first-page":"e17","DOI":"10.1017\/S1462399409001094","article-title":"The Nrf2\u2013ARE cytoprotective pathway in astrocytes","volume":"11","author":"Vargas","year":"2009","journal-title":"Expert Rev. Mol. Med."},{"key":"ref_136","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1146\/annurev.pharmtox.46.120604.141046","article-title":"Cell survival responses to environmental stresses via the Keap1-Nrf2-ARE pathway","volume":"47","author":"Kensler","year":"2007","journal-title":"Annu. Rev. Pharmacol. Toxicol."},{"key":"ref_137","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1165\/rcmb.2005-0325OC","article-title":"Glutathione peroxidase 2, the major cigarette smoke\u2013inducible isoform of GPX in lungs, is regulated by Nrf2","volume":"35","author":"Singh","year":"2006","journal-title":"Am. J. Respir. Cell Mol. Biol."},{"key":"ref_138","doi-asserted-by":"crossref","first-page":"44765","DOI":"10.1074\/jbc.M208704200","article-title":"Electrophile response element-mediated induction of the cystine\/glutamate exchange transporter gene expression","volume":"277","author":"Sasaki","year":"2002","journal-title":"J. Biol. Chem."},{"key":"ref_139","doi-asserted-by":"crossref","first-page":"1248","DOI":"10.1172\/JCI200421146","article-title":"Genetic ablation of Nrf2 enhances susceptibility to cigarette smoke\u2013induced emphysema in mice","volume":"114","author":"Rangasamy","year":"2004","journal-title":"J. Clin. Investig."},{"key":"ref_140","doi-asserted-by":"crossref","first-page":"984","DOI":"10.1172\/JCI25790","article-title":"Nrf2 is a critical regulator of the innate immune response and survival during experimental sepsis","volume":"116","author":"Thimmulappa","year":"2016","journal-title":"J. Clin. Investig."},{"key":"ref_141","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1016\/j.freeradbiomed.2008.10.040","article-title":"Nrf2-regulated glutathione recycling independent of biosynthesis is critical for cell survival during oxidative stress","volume":"46","author":"Harvey","year":"2009","journal-title":"Free Radic. Biol. Med."},{"key":"ref_142","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1016\/j.ijbiomac.2016.11.050","article-title":"Studies to reveal the nature of interactions between catalase and curcumin using computational methods and optical techniques","volume":"95","author":"Ghadari","year":"2017","journal-title":"Int. J. Biol. Macromol."},{"key":"ref_143","doi-asserted-by":"crossref","first-page":"590","DOI":"10.1134\/S0003683808060069","article-title":"Use of cadmium hydroxide gel for isolation of extracellular catalases from Penicillium piceum and characterization of purified enzymes","volume":"44","author":"Eremin","year":"2008","journal-title":"Appl. Biochem. Microbiol."},{"key":"ref_144","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1016\/j.abb.2012.02.005","article-title":"Acatalasemia and diabetes mellitus","volume":"525","author":"Nagy","year":"2012","journal-title":"Arch. Biochem. Biophys."},{"key":"ref_145","doi-asserted-by":"crossref","first-page":"1839","DOI":"10.2337\/diacare.24.10.1839","article-title":"Blood Catalase Deficiency and Diabetes in Hungary","volume":"24","author":"Lenkey","year":"2001","journal-title":"Diabetes Care"},{"key":"ref_146","doi-asserted-by":"crossref","unstructured":"Lee, D.-Y., Song, M.-Y., and Kim, E.-H. (2021). Role of Oxidative Stress and Nrf2\/KEAP1 Signaling in Colorectal Cancer: Mechanisms and Therapeutic Perspectives with Phytochemicals. Antioxidants, 10.","DOI":"10.3390\/antiox10050743"},{"key":"ref_147","doi-asserted-by":"crossref","first-page":"2565","DOI":"10.2337\/db12-0248","article-title":"Catalase prevents maternal diabetes\u2013induced perinatal programming via the Nrf2\u2013HO-1 defense system","volume":"61","author":"Chang","year":"2012","journal-title":"Diabetes"},{"key":"ref_148","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1146\/annurev-pharmtox-011112-140320","article-title":"Role of nrf2 in oxidative stress and toxicity","volume":"53","author":"Ma","year":"2013","journal-title":"Annu. Rev. Pharmacol. Toxicol."},{"key":"ref_149","doi-asserted-by":"crossref","first-page":"3483","DOI":"10.2337\/db13-1830","article-title":"Catalase overexpression prevents nuclear factor erythroid 2\u2013related factor 2 stimulation of renal angiotensinogen gene expression, hypertension, and kidney injury in diabetic mice","volume":"63","author":"Abdo","year":"2014","journal-title":"Diabetes"},{"key":"ref_150","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1016\/j.freeradbiomed.2015.06.017","article-title":"Regulation of catalase expression in healthy and cancerous cells","volume":"87","author":"Glorieux","year":"2015","journal-title":"Free Radic. Biol. Med."},{"key":"ref_151","doi-asserted-by":"crossref","first-page":"C385","DOI":"10.1152\/ajpcell.00485.2010","article-title":"Hypoxia. 2. Hypoxia regulates cellular metabolism","volume":"300","author":"Wheaton","year":"2011","journal-title":"Am. J. Physiol.-Cell Physiol."},{"key":"ref_152","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1016\/j.cca.2008.05.002","article-title":"Regulation of gene expression by hypoxia: Integration of the HIF-transduced hypoxic signal at the hypoxia-responsive element","volume":"395","author":"Kaluz","year":"2008","journal-title":"Clin. Chim. Acta"},{"key":"ref_153","first-page":"2629","article-title":"Factor inhibiting HIF-1 (FIH-1) modulates protein interactions of apoptosis-stimulating p53 binding protein 2 (ASPP2)","volume":"126","author":"Janke","year":"2013","journal-title":"J. Cell Sci."},{"key":"ref_154","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1042\/bj20021162","article-title":"Hypoxia-inducible factor asparaginyl hydroxylase (FIH-1) catalyses hydroxylation at the \u03b2-carbon of asparagine-803","volume":"367","author":"McNEILL","year":"2002","journal-title":"Biochem. J."},{"key":"ref_155","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1056\/NEJMra1011165","article-title":"Oxygen sensing, homeostasis, and disease","volume":"365","author":"Semenza","year":"2011","journal-title":"N. Engl. J. Med."},{"key":"ref_156","doi-asserted-by":"crossref","first-page":"8592348","DOI":"10.1155\/2019\/8592348","article-title":"Potential applications of NRF2 inhibitors in cancer therapy","volume":"2019","author":"Panieri","year":"2019","journal-title":"Oxidative Med. Cell. Longev."},{"key":"ref_157","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1016\/j.cca.2015.07.009","article-title":"Natural Nrf2 activators in diabetes","volume":"448","year":"2015","journal-title":"Clin. Chim. Acta"},{"key":"ref_158","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1097\/nen.0b013e31802d6da9","article-title":"Expression of Nrf2 in neurodegenerative diseases","volume":"66","author":"Ramsey","year":"2007","journal-title":"J. Neuropathol. Exp. Neurol."},{"key":"ref_159","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/srep39123","article-title":"Brusatol inhibits HIF-1 signaling pathway and suppresses glucose uptake under hypoxic conditions in HCT116 cells","volume":"6","author":"Lu","year":"2016","journal-title":"Sci. Rep."},{"key":"ref_160","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1161\/CIRCULATIONAHA.107.687947","article-title":"MicroRNAs in the human heart: A clue to fetal gene reprogramming in heart failure","volume":"116","author":"Thum","year":"2007","journal-title":"Circulation"},{"key":"ref_161","doi-asserted-by":"crossref","first-page":"101210","DOI":"10.1016\/j.redox.2019.101210","article-title":"Impairment of HIF-1\u03b1-mediated metabolic adaption by NRF2-silencing in breast cancer cells","volume":"24","author":"Lee","year":"2019","journal-title":"Redox Biol."},{"key":"ref_162","doi-asserted-by":"crossref","first-page":"13593","DOI":"10.1038\/ncomms13593","article-title":"NQO1 inhibits proteasome-mediated degradation of HIF-1\u03b1","volume":"7","author":"Oh","year":"2016","journal-title":"Nat. Commun."},{"key":"ref_163","doi-asserted-by":"crossref","first-page":"13505","DOI":"10.1073\/pnas.0906670106","article-title":"The molecular basis for impaired hypoxia-induced VEGF expression in diabetic tissues","volume":"106","author":"Thangarajah","year":"2009","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_164","doi-asserted-by":"crossref","first-page":"858","DOI":"10.1038\/nm1075","article-title":"Progenitor cell trafficking is regulated by hypoxic gradients through HIF-1 induction of SDF-1","volume":"10","author":"Ceradini","year":"2004","journal-title":"Nat. Med."},{"key":"ref_165","doi-asserted-by":"crossref","first-page":"10930","DOI":"10.1074\/jbc.M707451200","article-title":"Decreasing intracellular superoxide corrects defective ischemia-induced new vessel formation in diabetic mice","volume":"283","author":"Ceradini","year":"2008","journal-title":"J. Biol. Chem."},{"key":"ref_166","doi-asserted-by":"crossref","first-page":"1899","DOI":"10.2337\/diabetes.48.10.1899","article-title":"Vascular endothelial growth factor and diabetes: The agonist versus antagonist paradox","volume":"48","author":"Duh","year":"1999","journal-title":"Diabetes"},{"key":"ref_167","first-page":"1","article-title":"Regulation of redox signaling in HIF-1-dependent tumor angiogenesis","volume":"2021","author":"Manuelli","year":"2021","journal-title":"FEBS J."},{"key":"ref_168","doi-asserted-by":"crossref","first-page":"3088","DOI":"10.1158\/0008-5472.CAN-15-1584","article-title":"NRF2 intensifies host defense systems to prevent lung carcinogenesis, but after tumor initiation accelerates malignant cell growth","volume":"76","author":"Satoh","year":"2016","journal-title":"Cancer Res."},{"key":"ref_169","doi-asserted-by":"crossref","unstructured":"Toth, R.K., and Warfel, N.A. (2017). Strange bedfellows: Nuclear factor, erythroid 2-like 2 (Nrf2) and hypoxia-inducible factor 1 (HIF-1) in tumor hypoxia. Antioxidants, 6.","DOI":"10.3390\/antiox6020027"},{"key":"ref_170","doi-asserted-by":"crossref","first-page":"1094","DOI":"10.1016\/j.neurobiolaging.2005.06.004","article-title":"Increased levels of 4-hydroxynonenal and acrolein, neurotoxic markers of lipid peroxidation, in the brain in Mild Cognitive Impairment and early Alzheimer\u2019s disease","volume":"27","author":"Williams","year":"2006","journal-title":"Neurobiol. Aging"},{"key":"ref_171","doi-asserted-by":"crossref","unstructured":"Singh, A., Kukreti, R., Saso, L., and Kukreti, S. (2019). Oxidative stress: A key modulator in neurodegenerative diseases. Molecules, 24.","DOI":"10.3390\/molecules24081583"},{"key":"ref_172","doi-asserted-by":"crossref","first-page":"15168","DOI":"10.1021\/ja054041c","article-title":"Formation and stabilization model of the 42-mer A\u03b2 radical: Implications for the long-lasting oxidative stress in Alzheimer\u2019s disease","volume":"127","author":"Murakami","year":"2005","journal-title":"J. Am. Chem. Soc."},{"key":"ref_173","doi-asserted-by":"crossref","first-page":"1152","DOI":"10.1212\/01.WNL.0000156156.13641.BA","article-title":"Evidence of increased oxidative damage in subjects with mild cognitive impairment","volume":"64","author":"Keller","year":"2005","journal-title":"Neurology"},{"key":"ref_174","doi-asserted-by":"crossref","first-page":"427318","DOI":"10.1155\/2014\/427318","article-title":"Oxidative stress in Alzheimer\u2019s disease: Why did antioxidant therapy fail?","volume":"2014","author":"Persson","year":"2014","journal-title":"Oxid. Med. Cell. Longev."},{"key":"ref_175","doi-asserted-by":"crossref","first-page":"108515","DOI":"10.1016\/j.jnutbio.2020.108515","article-title":"Curcumin reverses diabetic nephropathy in streptozotocin-induced diabetes in rats by inhibition of PKC\u03b2\/p66Shc axis and activation of FOXO-3a","volume":"87","author":"ALTamimi","year":"2021","journal-title":"J. Nutr. Biochem."},{"key":"ref_176","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1016\/j.jtcme.2016.05.005","article-title":"Biological activities of curcuminoids, other biomolecules from turmeric and their derivatives\u2013A review","volume":"7","author":"Amalraj","year":"2017","journal-title":"J. Tradit. Complement. Med."},{"key":"ref_177","doi-asserted-by":"crossref","first-page":"514","DOI":"10.3389\/fgene.2019.00514","article-title":"Curcumin as an alternative epigenetic modulator: Mechanism of action and potential effects","volume":"10","author":"Hassan","year":"2019","journal-title":"Front. Genet."},{"key":"ref_178","doi-asserted-by":"crossref","first-page":"660712","DOI":"10.3389\/fonc.2021.660712","article-title":"Curcumin Regulates Cancer Progression: Focus on ncRNAs and Molecular Signaling Pathways","volume":"11","author":"Wang","year":"2021","journal-title":"Front. Oncol."},{"key":"ref_179","first-page":"469","article-title":"Curcumin attenuates the expression of IL-1beta, IL-6, and TNF-alpha as well as cyclin E in TNF-alpha-treated HaCaT cells; NF-kappaB and MAPKs as potential upstream targets","volume":"19","author":"Cho","year":"2007","journal-title":"Int. J. Mol. Med."},{"key":"ref_180","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1016\/j.phrs.2016.03.026","article-title":"Curcumin downregulates human tumor necrosis factor-\u03b1 levels: A systematic review and meta-analysis ofrandomized controlled trials","volume":"107","author":"Sahebkar","year":"2016","journal-title":"Pharmacol. Res."},{"key":"ref_181","doi-asserted-by":"crossref","unstructured":"Yahfoufi, N., Alsadi, N., Jambi, M., and Matar, C. (2018). The Immunomodulatory and Anti-Inflammatory Role of Polyphenols. Nutrients, 10.","DOI":"10.3390\/nu10111618"},{"key":"ref_182","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1080\/08923973.2018.1474921","article-title":"Curcumin reduces the expression of interleukin 1\u03b2 and the production of interleukin 6 and tumor necrosis factor alpha by M1 macrophages from patients with Behcet\u2019s disease","volume":"40","author":"Palizgir","year":"2018","journal-title":"Immunopharmacol. Immunotoxicol."},{"key":"ref_183","doi-asserted-by":"crossref","unstructured":"Moosavi-Movahedi, A.A. (2021). Lifestyle in the Regulation of Diabetic Disorders. Rationality and Scientific Lifestyle for Health, Springer.","DOI":"10.1007\/978-3-030-74326-0"},{"key":"ref_184","unstructured":"World Health Organization (2016). Global Report on Diabetes."},{"key":"ref_185","doi-asserted-by":"crossref","first-page":"1315","DOI":"10.1056\/NEJM198805193182007","article-title":"Advanced glycosylation end products in tissue and the biochemical basis of diabetic complications","volume":"318","author":"Brownlee","year":"1988","journal-title":"N. Engl. J. Med."},{"key":"ref_186","doi-asserted-by":"crossref","first-page":"1521","DOI":"10.1161\/01.ATV.14.10.1521","article-title":"Cellular receptors for advanced glycation end products. Implications for induction of oxidant stress and cellular dysfunction in the pathogenesis of vascular lesions","volume":"14","author":"Schmidt","year":"1994","journal-title":"Arterioscler. Thromb. J. Vasc. Biol."},{"key":"ref_187","doi-asserted-by":"crossref","first-page":"1395","DOI":"10.1172\/JCI118175","article-title":"Advanced glycation endproducts interacting with their endothelial receptor induce expression of vascular cell adhesion molecule-1 (VCAM-1) in cultured human endothelial cells and in mice. A potential mechanism for the accelerated vasculopathy of diabetes","volume":"96","author":"Schmidt","year":"1995","journal-title":"J. Clin. Investig."},{"key":"ref_188","doi-asserted-by":"crossref","first-page":"419","DOI":"10.3109\/07853899608999102","article-title":"Advanced glycation end-products and atherosclerosis","volume":"28","author":"Vlassara","year":"1996","journal-title":"Ann. Med."},{"key":"ref_189","doi-asserted-by":"crossref","first-page":"3213","DOI":"10.1161\/CIRCULATIONAHA.106.679597","article-title":"Diabetic cardiomyopathy revisited","volume":"115","author":"Boudina","year":"2007","journal-title":"Circulation"},{"key":"ref_190","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1177\/1479164115579006","article-title":"Diabetic cardiomyopathy: An expression of stage B heart failure with preserved ejection fraction","volume":"12","author":"Lam","year":"2015","journal-title":"Diabetes Vasc. Dis. Res."},{"key":"ref_191","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1186\/1743-7075-8-35","article-title":"Curcumin ameliorates macrophage infiltration by inhibiting NF-\u03baB activation and proinflammatory cytokines in streptozotocin induced-diabetic nephropathy","volume":"8","author":"Soetikno","year":"2011","journal-title":"Nutr. Metab."},{"key":"ref_192","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1089\/ars.2008.2140","article-title":"Curcumin supplementation lowers TNF-\u03b1, IL-6, IL-8, and MCP-1 secretion in high glucose-treated cultured monocytes and blood levels of TNF-\u03b1, IL-6, MCP-1, glucose, and glycosylated hemoglobin in diabetic rats","volume":"11","author":"Jain","year":"2009","journal-title":"Antioxid. Redox Signal."},{"key":"ref_193","doi-asserted-by":"crossref","unstructured":"Yu, W., Wu, J., Cai, F., Xiang, J., Zha, W., Fan, D., Guo, S., Ming, Z., and Liu, C. (2012). Curcumin alleviates diabetic cardiomyopathy in experimental diabetic rats. PLoS ONE, 7.","DOI":"10.1371\/journal.pone.0052013"},{"key":"ref_194","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1002\/jbt.21562","article-title":"Curcumin Ameliorates Streptozotocin-Induced Heart Injury in Rats","volume":"28","author":"Harisa","year":"2014","journal-title":"J. Biochem. Mol. Toxicol."},{"key":"ref_195","doi-asserted-by":"crossref","first-page":"604","DOI":"10.1016\/j.ejps.2012.04.018","article-title":"Curcumin prevents diabetic cardiomyopathy in streptozotocin-induced diabetic rats: Possible involvement of PKC\u2013MAPK signaling pathway","volume":"47","author":"Soetikno","year":"2012","journal-title":"Eur. J. Pharm. Sci."},{"key":"ref_196","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1177\/0003319709356424","article-title":"The effect of curcumin on insulin release in rat-isolated pancreatic islets","volume":"61","author":"Wassef","year":"2010","journal-title":"Angiology"},{"key":"ref_197","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1186\/1758-5996-5-13","article-title":"Signaling mechanisms of a water soluble curcumin derivative in experimental type 1 diabetes with cardiomyopathy","volume":"5","author":"Aziz","year":"2013","journal-title":"Diabetol. Metab. Syndr."},{"key":"ref_198","doi-asserted-by":"crossref","first-page":"4158591","DOI":"10.1155\/2016\/4158591","article-title":"Curcumin protects neonatal rat cardiomyocytes against high glucose-induced apoptosis via PI3K\/Akt signalling pathway","volume":"2016","author":"Yu","year":"2016","journal-title":"J. Diabetes Res."},{"key":"ref_199","doi-asserted-by":"crossref","first-page":"1203","DOI":"10.1111\/jcmm.12267","article-title":"Inhibition of JNK by compound C66 prevents pathological changes of the aorta in STZ-induced diabetes","volume":"18","author":"Liu","year":"2014","journal-title":"J. Cell. Mol. Med."},{"key":"ref_200","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1056\/NEJMra021678","article-title":"retinopathy D","volume":"350","author":"Frank","year":"2004","journal-title":"Diabet. Retin. N. Engl. J. Med."},{"key":"ref_201","doi-asserted-by":"crossref","first-page":"556","DOI":"10.2337\/dc11-1909","article-title":"Global prevalence and major risk factors of diabetic retinopathy","volume":"35","author":"Yau","year":"2012","journal-title":"Diabetes Care"},{"key":"ref_202","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1007\/s592-001-8076-6","article-title":"Diabetes-induced elevations in retinal oxidative stress, protein kinase C and nitric oxide are interrelated","volume":"38","author":"Kowluru","year":"2001","journal-title":"Acta Diabetol."},{"key":"ref_203","doi-asserted-by":"crossref","first-page":"1615","DOI":"10.2337\/diabetes.54.6.1615","article-title":"The pathobiology of diabetic complications: A unifying mechanism","volume":"54","author":"Brownlee","year":"2005","journal-title":"Diabetes"},{"key":"ref_204","doi-asserted-by":"crossref","first-page":"061038","DOI":"10.1155\/2007\/61038","article-title":"The polyol pathway as a mechanism for diabetic retinopathy: Attractive, elusive, and resilient","volume":"2007","author":"Lorenzi","year":"2007","journal-title":"Exp. Diabetes Res."},{"key":"ref_205","doi-asserted-by":"crossref","first-page":"11059","DOI":"10.1073\/pnas.89.22.11059","article-title":"Preferential elevation of protein kinase C isoform beta II and diacylglycerol levels in the aorta and heart of diabetic rats: Differential reversibility to glycemic control by islet cell transplantation","volume":"89","author":"Inoguchi","year":"1992","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_206","doi-asserted-by":"crossref","first-page":"3941","DOI":"10.1167\/iovs.13-11598","article-title":"Transcription factor Nrf2-mediated antioxidant defense system in the development of diabetic retinopathy","volume":"54","author":"Zhong","year":"2013","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"key":"ref_207","first-page":"2962","article-title":"Abnormalities of retinal metabolism in diabetes or galactosemia: ATPases and glutathione","volume":"35","author":"Kern","year":"1994","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"key":"ref_208","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/j.freeradbiomed.2014.07.001","article-title":"Epigenetic modifications of Nrf2-mediated glutamate\u2013cysteine ligase: Implications for the development of diabetic retinopathy and the metabolic memory phenomenon associated with its continued progression","volume":"75","author":"Mishra","year":"2014","journal-title":"Free Radic. Biol. Med."},{"key":"ref_209","doi-asserted-by":"crossref","first-page":"1073","DOI":"10.1016\/j.bcp.2011.07.065","article-title":"Pharmacodynamics of curcumin as DNA hypomethylation agent in restoring the expression of Nrf2 via promoter CpGs demethylation","volume":"82","author":"Khor","year":"2011","journal-title":"Biochem. Pharmacol."},{"key":"ref_210","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1080\/15569527.2017.1354218","article-title":"Protective effects of melatonin and memantine in human retinal pigment epithelium (ARPE-19) cells against 2-ethylpyridine-induced oxidative stress: Implications for age-related macular degeneration","volume":"37","author":"Bardak","year":"2018","journal-title":"Cutan. Ocul. Toxicol."},{"key":"ref_211","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1111\/jphp.12691","article-title":"Anti-apoptotic effects of Curcuma longa L. extract and its curcuminoids against blue light-induced cytotoxicity in A2E-laden human retinal pigment epithelial cells","volume":"69","author":"Park","year":"2017","journal-title":"J. Pharm. Pharmacol."},{"key":"ref_212","first-page":"901","article-title":"Curcumin protects retinal pigment epithelial cells against oxidative stress via induction of heme oxygenase-1 expression and reduction of reactive oxygen","volume":"18","author":"Woo","year":"2012","journal-title":"Mol. Vis."},{"key":"ref_213","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1016\/j.resp.2018.09.008","article-title":"Intonation of Nrf2 and Hif1-\u03b1 pathway by curcumin prophylaxis: A potential strategy to augment survival signaling under hypoxia","volume":"258","author":"Mathew","year":"2018","journal-title":"Respir. Physiol. Neurobiol."},{"key":"ref_214","doi-asserted-by":"crossref","first-page":"1775","DOI":"10.1007\/s11033-018-4323-4","article-title":"Curcumin confers hepatoprotection against AFB 1-induced toxicity via activating autophagy and ameliorating inflammation involving Nrf2\/HO-1 signaling pathway","volume":"45","author":"Muhammad","year":"2018","journal-title":"Mol. Biol. Rep."},{"key":"ref_215","doi-asserted-by":"crossref","first-page":"17295","DOI":"10.1002\/jcp.28347","article-title":"Curcumin prevents high glucose damage in retinal pigment epithelial cells through ERK1\/2-mediated activation of the Nrf2\/HO-1 pathway","volume":"234","author":"Bucolo","year":"2019","journal-title":"J. Cell. Physiol."},{"key":"ref_216","doi-asserted-by":"crossref","first-page":"4158591","DOI":"10.1155\/2014\/315494","article-title":"Role of nutrient-sensing signals in the pathogenesis of diabetic nephropathy","volume":"2014","author":"Kume","year":"2014","journal-title":"Biomed. Res. Int."},{"key":"ref_217","doi-asserted-by":"crossref","first-page":"164","DOI":"10.2337\/diacare.28.1.164","article-title":"Diabetic nephropathy: Diagnosis, prevention, and treatment","volume":"28","author":"Gross","year":"2005","journal-title":"Diabetes Care"},{"key":"ref_218","doi-asserted-by":"crossref","first-page":"3055","DOI":"10.2337\/db11-0807","article-title":"Therapeutic potential of Nrf2 activators in streptozotocin-induced diabetic nephropathy","volume":"60","author":"Zheng","year":"2011","journal-title":"Diabetes"},{"key":"ref_219","doi-asserted-by":"crossref","first-page":"664","DOI":"10.3349\/ymj.2016.57.3.664","article-title":"Protective effects of curcumin on renal oxidative stress and lipid metabolism in a rat model of type 2 diabetic nephropathy","volume":"57","author":"Kim","year":"2016","journal-title":"Yonsei Med. J."},{"key":"ref_220","doi-asserted-by":"crossref","first-page":"1649","DOI":"10.1002\/mnfr.201200540","article-title":"Curcumin alleviates oxidative stress, inflammation, and renal fibrosis in remnant kidney through the N rf2\u2013keap1 pathway","volume":"57","author":"Soetikno","year":"2013","journal-title":"Mol. Nutr. Food Res."},{"key":"ref_221","doi-asserted-by":"crossref","first-page":"1655","DOI":"10.1002\/mnfr.201100080","article-title":"Curcumin attenuates diabetic nephropathy by inhibiting PKC-\u03b1 and PKC-\u03b21 activity in streptozotocin-induced type I diabetic rats","volume":"55","author":"Soetikno","year":"2011","journal-title":"Mol. Nutr. Food Res."},{"key":"ref_222","doi-asserted-by":"crossref","first-page":"887","DOI":"10.1042\/bj20021619","article-title":"Curcumin activates the haem oxygenase-1 gene via regulation of Nrf2 and the antioxidant-responsive element","volume":"371","author":"Balogun","year":"2003","journal-title":"Biochem. J."},{"key":"ref_223","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1002\/biof.1072","article-title":"Molecular mechanisms of hypolipidemic effects of curcumin","volume":"39","author":"Zingg","year":"2013","journal-title":"Biofactors"},{"key":"ref_224","doi-asserted-by":"crossref","first-page":"F1146","DOI":"10.1152\/ajprenal.90732.2008","article-title":"Curcumin ameliorates renal failure in 5\/6 nephrectomized rats: Role of inflammation","volume":"296","author":"Ghosh","year":"2009","journal-title":"Am. J. Physiol.-Ren. Physiol."},{"key":"ref_225","doi-asserted-by":"crossref","first-page":"1516985","DOI":"10.1155\/2017\/1516985","article-title":"Curcumin ameliorates diabetic nephropathy by suppressing NLRP3 inflammasome signaling","volume":"2017","author":"Lu","year":"2017","journal-title":"Biomed. Res. Int."},{"key":"ref_226","doi-asserted-by":"crossref","unstructured":"Tanase, D.M., Gosav, E.M., Neculae, E., Costea, C.F., Ciocoiu, M., Hurjui, L.L., Tarniceriu, C.C., Maranduca, M.A., Lacatusu, C.M., and Floria, M. (2020). Role of gut microbiota on onset and progression of microvascular complications of type 2 diabetes (T2DM). Nutrients, 12.","DOI":"10.3390\/nu12123719"},{"key":"ref_227","doi-asserted-by":"crossref","first-page":"60","DOI":"10.2174\/138945008783431718","article-title":"Pro-inflammatory mechanisms in diabetic neuropathy: Focus on the nuclear factor kappa B pathway","volume":"9","author":"Cameron","year":"2008","journal-title":"Curr. Drug Targets"},{"key":"ref_228","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1172\/JCI11916","article-title":"NF-\u03baB in neuronal plasticity and neurodegenerative disorders","volume":"107","author":"Mattson","year":"2001","journal-title":"J. Clin. Investig."},{"key":"ref_229","doi-asserted-by":"crossref","first-page":"386","DOI":"10.1006\/exnr.2001.7677","article-title":"Pro-and anti-inflammatory cytokine gene expression in rat sciatic nerve chronic constriction injury model of neuropathic pain","volume":"169","author":"Okamoto","year":"2001","journal-title":"Exp. Neurol."},{"key":"ref_230","doi-asserted-by":"crossref","first-page":"368","DOI":"10.1111\/j.1749-6632.2002.tb02108.x","article-title":"Oxidative stress and programmed cell death in diabetic neuropathy","volume":"959","author":"Vincent","year":"2002","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"ref_231","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1016\/S1734-1140(09)70111-2","article-title":"Role of NF-\u03baB in the pathogenesis of diabetes and its associated complications","volume":"61","author":"Patel","year":"2009","journal-title":"Pharmacol. Rep."},{"key":"ref_232","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1016\/j.ejphar.2006.03.006","article-title":"Curcumin attenuates thermal hyperalgesia in a diabetic mouse model of neuropathic pain","volume":"536","author":"Sharma","year":"2006","journal-title":"Eur. J. Pharmacol."},{"key":"ref_233","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1002\/ptr.2070","article-title":"Effect of insulin and its combination with resveratrol or curcumin in attenuation of diabetic neuropathic pain: Participation of nitric oxide and TNF-alpha","volume":"21","author":"Sharma","year":"2007","journal-title":"Phytother. Res."},{"key":"ref_234","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1016\/j.neuropharm.2017.11.007","article-title":"A novel curcumin derivative for the treatment of diabetic neuropathy","volume":"129","author":"Daugherty","year":"2018","journal-title":"Neuropharmacology"},{"key":"ref_235","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/j.neulet.2013.12.019","article-title":"Curcumin ameliorated diabetic neuropathy partially by inhibition of NADPH oxidase mediating oxidative stress in the spinal cord","volume":"560","author":"Zhao","year":"2014","journal-title":"Neurosci. Lett."},{"key":"ref_236","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/j.nlm.2015.05.001","article-title":"Curcumin alleviates cisplatin-induced learning and memory impairments","volume":"123","author":"Oz","year":"2015","journal-title":"Neurobiol. Learn. Mem."},{"key":"ref_237","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1248\/bpb.b19-00862","article-title":"Curcumin alleviates oxaliplatin-induced peripheral neuropathic pain through inhibiting oxidative stress-mediated activation of NF-\u03baB and mitigating inflammation","volume":"43","author":"Zhang","year":"2020","journal-title":"Biol. Pharm. 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