{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,20]],"date-time":"2026-02-20T05:14:50Z","timestamp":1771564490976,"version":"3.50.1"},"reference-count":68,"publisher":"MDPI AG","issue":"24","license":[{"start":{"date-parts":[[2021,12,19]],"date-time":"2021-12-19T00:00:00Z","timestamp":1639872000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100008908","name":"University of Messina","doi-asserted-by":"publisher","award":["research and mobility 2017 funds (ARCADIA project)."],"award-info":[{"award-number":["research and mobility 2017 funds (ARCADIA project)."]}],"id":[{"id":"10.13039\/501100008908","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>The interactions of dopamine [2-(3,4-Dihydroxyphenyl)ethylamine, (Dop\u2212)] with cadmium(II), copper(II) and uranyl(VI) were studied in NaCl(aq) at different ionic strengths (0 \u2264 I\/mol dm\u22123 \u2264 1.0) and temperatures (288.15 \u2264 T\/K \u2264 318.15). From the elaboration of the experimental data, it was found that the speciation models are featured by species of different stoichiometry and stability. In particular for cadmium, the formation of only MLH, ML and ML2 (M = Cd2+; L = dopamine) species was obtained. For uranyl(VI) (UO22+), the speciation scheme is influenced by the use of UO2(acetate)2 salt as a chemical; in this case, the formation of ML2, MLOH and the ternary MLAc (Ac = acetate) species in a wide pH range was observed. The most complex speciation model was obtained for the interaction of Cu2+ with dopamine; in this case we observed the formation of the following species: ML2, M2L, M2L2, M2L2(OH)2, M2LOH and ML2OH. These speciation models were determined at each ionic strength and temperature investigated. As a further contribution to this kind of investigation, the ternary interactions of dopamine with UO22+\/Cd2+ and UO22+\/Cu2+ were investigated at I = 0.15 mol dm\u22123 and T = 298.15K. These systems have different speciation models, with the MM\u2019L and M2M\u2019L2OH [M = UO22+; M\u2019 = Cd2+ or Cu2+, L = dopamine] common species; the species of the mixed Cd2+ containing system have a higher stability with respect the Cu2+ containing one. The dependence on the ionic strength of complex formation constants was modelled by using both an extended Debye\u2013H\u00fcckel equation that included the Van\u2019t Hoff term for the calculation of the formation enthalpy change values and the Specific Ion Interaction Theory (SIT). The results highlighted that, in general, the entropy is the driving force of the process. The quantification of the effective sequestering ability of dopamine towards the studied cations was evaluated by using a Boltzmann-type equation and the calculation of pL0.5 parameter. The sequestering ability was quantified at different ionic strengths, temperatures and pHs, and this resulted, in general, that the pL0.5 trend was always: UO22+ &gt; Cu2+ &gt; Cd2+.<\/jats:p>","DOI":"10.3390\/molecules26247679","type":"journal-article","created":{"date-parts":[[2021,12,20]],"date-time":"2021-12-20T02:50:18Z","timestamp":1639968618000},"page":"7679","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["The Effect of Metal Cations on the Aqueous Behavior of Dopamine. Thermodynamic Investigation of the Binary and Ternary Interactions with Cd2+, Cu2+ and UO22+ in NaCl at Different Ionic Strengths and Temperatures"],"prefix":"10.3390","volume":"26","author":[{"given":"Antonio","family":"Gigliuto","sequence":"first","affiliation":[{"name":"Dipartimento di Scienze Chimiche, Biologiche, Farmaceutiche ed Ambientali, Universit\u00e0 degli Studi di Messina, V.le F. Stagno d\u2019Alcontres, 31, I-98166 Messina, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2054-9191","authenticated-orcid":false,"given":"Rosalia Maria","family":"Cigala","sequence":"additional","affiliation":[{"name":"Dipartimento di Scienze Chimiche, Biologiche, Farmaceutiche ed Ambientali, Universit\u00e0 degli Studi di Messina, V.le F. Stagno d\u2019Alcontres, 31, I-98166 Messina, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9023-2897","authenticated-orcid":false,"given":"Anna","family":"Irto","sequence":"additional","affiliation":[{"name":"Dipartimento di Scienze Chimiche, Biologiche, Farmaceutiche ed Ambientali, Universit\u00e0 degli Studi di Messina, V.le F. Stagno d\u2019Alcontres, 31, I-98166 Messina, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria Rosa","family":"Felice","sequence":"additional","affiliation":[{"name":"Dipartimento di Scienze Chimiche, Biologiche, Farmaceutiche ed Ambientali, Universit\u00e0 degli Studi di Messina, V.le F. Stagno d\u2019Alcontres, 31, I-98166 Messina, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4183-2252","authenticated-orcid":false,"given":"Alberto","family":"Pettignano","sequence":"additional","affiliation":[{"name":"Dipartimento di Fisica e Chimica, Universit\u00e0 degli Studi di Palermo, V.le delle Scienze, ed. 17, I-90128 Palermo, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2520-2827","authenticated-orcid":false,"given":"Concetta","family":"De Stefano","sequence":"additional","affiliation":[{"name":"Dipartimento di Scienze Chimiche, Biologiche, Farmaceutiche ed Ambientali, Universit\u00e0 degli Studi di Messina, V.le F. Stagno d\u2019Alcontres, 31, I-98166 Messina, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9143-9582","authenticated-orcid":false,"given":"Francesco","family":"Crea","sequence":"additional","affiliation":[{"name":"Dipartimento di Scienze Chimiche, Biologiche, Farmaceutiche ed Ambientali, Universit\u00e0 degli Studi di Messina, V.le F. Stagno d\u2019Alcontres, 31, I-98166 Messina, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2021,12,19]]},"reference":[{"key":"ref_1","unstructured":"Fellous, J.M., and Suri, R.E. (2002). The Roles of Dopamine, MIT."},{"key":"ref_2","first-page":"1","article-title":"Dopamine. From Parkinson\u2019s disease to fibromyalgia","volume":"13","author":"Holman","year":"2005","journal-title":"Fibrmyalgia Front."},{"key":"ref_3","doi-asserted-by":"crossref","unstructured":"Kabbani, N. (2013). 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