{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T11:10:02Z","timestamp":1785409802583,"version":"3.56.0"},"reference-count":56,"publisher":"MDPI AG","issue":"1","license":[{"start":{"date-parts":[[2021,12,22]],"date-time":"2021-12-22T00:00:00Z","timestamp":1640131200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>The work considers for the first time the preparation of sorbents based on hypercrosslinked polysterene (HCP) and chelating agent N,N,N\u2032,N\u2032-tetraoctyl diglycolamide (TODGA) by impregnation in the supercritical (SC) CO2 medium. Such sorbents can be applied for further isolation and separation of lanthanides, actinides and other metals. They are usually prepared by impregnation in toxic organic solvents (e.g., methanol, dichloromethane). Our study shows that application of SC CO2 instead of organic solvents can significantly speed up the impregnation, perfom it in one stage and make the process more eco-friendly. At the same time, the obtained sorbents are close in their parameters to the classical ones. This article presents the results of measuring the TODGA adsorption isotherms on two HCP sorbents (MN202 and MN270) on a wide range of SC fluid parameters. Adsorption measurements were carried out using on-line supercritical fluid chromatography and gravimetry. Based on the sorption capacity parameter, MN202 sorbent was selected as the better carrier for TODGA. An impregnation temperature increase within the range 313\u2013343 K in isochoric conditions (\u03c1 = 0.780 g\/mL) reduces the maximum of TODGA adsorption from ~0.68 mmol\/g to ~0.49 mmol\/g.<\/jats:p>","DOI":"10.3390\/molecules27010031","type":"journal-article","created":{"date-parts":[[2021,12,23]],"date-time":"2021-12-23T02:01:19Z","timestamp":1640224879000},"page":"31","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Adsorption of N,N,N\u2032,N\u2032-Tetraoctyl Diglycolamide on Hypercrosslinked Polysterene from a Supercritical Carbon Dioxide Medium"],"prefix":"10.3390","volume":"27","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7151-678X","authenticated-orcid":false,"given":"Mikhail","family":"Kostenko","sequence":"first","affiliation":[{"name":"Kurnakov Institute of General and Inorganic Chemistry, Russian Academy of Sciences, Leninsky Prospect 31, 119071 Moscow, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olga","family":"Parenago","sequence":"additional","affiliation":[{"name":"Kurnakov Institute of General and Inorganic Chemistry, Russian Academy of Sciences, Leninsky Prospect 31, 119071 Moscow, Russia"},{"name":"Chemistry Department, Moscow State University, Leninskie Gory 1, Bldg. 3, 119234 Moscow, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2021,12,22]]},"reference":[{"key":"ref_1","first-page":"717","article-title":"\u042d\u043ac\u0442pa\u043a\u0446\u0438o\u043d\u043do-xpo\u043ca\u0442o\u0433pa\u03c6\u0438\u0447ec\u043aoe \u0432\u044b\u0434e\u043be\u043d\u0438e \u043deo\u0434\u0438\u043ca \u0438\u0437 a\u0437o\u0442\u043do\u043a\u0438c\u043b\u044bx pac\u0442\u0432opo\u0432 c \u043fp\u0438\u043ce\u043de\u043d\u0438e\u043c cop\u0431e\u043d\u0442o\u0432, \u0438\u043c\u043fpe\u0433\u043d\u0438po\u0432a\u043d\u043d\u044bx N,N,N\u2032,N\u2032-\u0442e\u0442pao\u043a\u0442\u0438\u043b\u0434\u0438\u0433\u043b\u0438\u043ao\u043b\u044ca\u043c\u0438\u0434o\u043c","volume":"18","author":"Baulin","year":"2018","journal-title":"Sorbtsionnye i Khromatograficheskie Protsessy"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"2457","DOI":"10.1021\/ie302603q","article-title":"Synthesis of N,N,N\u2032,N\u2032-Tetraoctyl-3-Oxapentane-1,5-Diamide (TODGA) and Its Steam Thermolysis-Nitrolysis as a Nuclear Waste Solvent Minimization Method","volume":"52","author":"Dicholkar","year":"2013","journal-title":"Ind. Eng. Chem. Res."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1007\/s10967-010-0641-2","article-title":"Extraction Behavior of Cerium by Tetraoctyldiglycolamide from Nitric Acid Solutions","volume":"286","author":"Metwally","year":"2010","journal-title":"J. Radioanal. Nucl. Chem."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1007\/s10967-017-5317-8","article-title":"Extraction of Trivalent Americium and Europium with TODGA Homologs from HNO3 Solution","volume":"313","author":"Wang","year":"2017","journal-title":"J. Radioanal. Nucl. Chem."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1081\/SEI-200066296","article-title":"N,N,N\u2032,N\u2032-Tetraoctyl Diglycolamide (TODGA): A Promising Extractant for Actinide-Partitioning from High-Level Waste (HLW)","volume":"23","author":"Ansari","year":"2005","journal-title":"Solvent Extr. Ion. Exch."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"1223","DOI":"10.1080\/18811248.2011.9711810","article-title":"Adsorption Characteristics of Trivalent Rare Earths and Chemical Stability of a Silica-Based Macroporous TODGA Adsorbent in HNO3 Solution","volume":"48","author":"Xu","year":"2011","journal-title":"J. Nucl. Sci. Technol."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1016\/j.proche.2012.10.064","article-title":"Optimizing Composition of TODGA\/SiO2-P Adsorbent for Extraction Chromatography Process","volume":"7","author":"Watanabe","year":"2012","journal-title":"Procedia Chem."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"1043","DOI":"10.1007\/s10967-012-1878-8","article-title":"A Novel Partitioning Process for Treatment of High Level Liquid Waste Using Macroporous Silica-Based Adsorbents","volume":"295","author":"Kim","year":"2013","journal-title":"J. Radioanal. Nucl. Chem."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"1220","DOI":"10.1246\/cl.130476","article-title":"Chromatographic Separation Behaviors of Am, Cm, and Eu onto TODGA and DOODA(C8) Adsorbents with Hydrophilic Ligand\u2013Nitric Acid Eluents","volume":"42","author":"Usuda","year":"2013","journal-title":"Chem. Lett."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"11290","DOI":"10.1038\/s41598-017-11879-6","article-title":"Effect of HNO3 Concentration on a Novel Silica-Based Adsorbent for Separating Pd(II) from Simulated High Level Liquid Waste","volume":"7","author":"Ge","year":"2017","journal-title":"Sci. Rep."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"3352","DOI":"10.1016\/j.net.2021.04.009","article-title":"Adsorption and Separation Behaviors of Y(III) and Sr(II) in Acid Solution by a Porous Silica Based Adsorbent","volume":"53","author":"Wu","year":"2021","journal-title":"Nucl. Eng. Technol."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1081\/SEI-200049898","article-title":"Novel Extraction Chromatographic Resins Based on Tetraalkyldiglycolamides: Characterization and Potential Applications","volume":"23","author":"Horwitz","year":"2005","journal-title":"Solvent Extr. Ion Exch."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1016\/j.talanta.2018.01.020","article-title":"Adsorption Behavior of Thorium on N,N,N\u2032,N\u2032-Tetraoctyldiglycolamide (TODGA) Impregnated Graphene Aerogel","volume":"181","author":"Chen","year":"2018","journal-title":"Talanta"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1134\/S1066362216010094","article-title":"Chemical Durability and Radiation Resistance of Sorbents Based on N,N,N\u2032,N\u2032-Tetra-n-Octyldiglycolamide","volume":"58","author":"Milyutin","year":"2016","journal-title":"Radiochemistry"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/S0021-9673(01)01583-7","article-title":"Hypercross-Linked Polystyrene and Its Potentials for Liquid Chromatography: A Mini-Review","volume":"965","author":"Davankov","year":"2002","journal-title":"J. Chromatogr. A"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1021\/ie00040a029","article-title":"Supercritical Adsorption and Desorption Behavior of DDT on Activated Carbon Using Carbon Dioxide","volume":"34","author":"Macnaughton","year":"1995","journal-title":"Ind. Eng. Chem. Res."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"2197","DOI":"10.1081\/SS-100105913","article-title":"Adsorption And Desorption Of M -Xylene From Supercritical Carbon Dioxide On Activated Carbon","volume":"36","author":"Benkhedda","year":"2001","journal-title":"Sep. Sci. Technol."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/j.fluid.2013.01.014","article-title":"Measurements and Dubinin\u2013Astakhov Correlation of Adsorption Equilibria of Toluene, Acetone, n-Hexane, n-Decane and Methanol Solutes in Supercritical Carbon Dioxide on Activated Carbon at Temperature from 313 to 353 K and at Pressure from 4.2 to 15.0 MPa","volume":"344","author":"Ushiki","year":"2013","journal-title":"Fluid Phase Equilibria"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/j.chroma.2016.03.006","article-title":"A Closer Study of Methanol Adsorption and Its Impact on Solute Retentions in Supercritical Fluid Chromatography","volume":"1442","author":"Glenne","year":"2016","journal-title":"J. Chromatogr. A"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1016\/j.chroma.2013.09.007","article-title":"Determination of Adsorption Isotherms in Supercritical Fluid Chromatography","volume":"1312","author":"Enmark","year":"2013","journal-title":"J. Chromatogr. A"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1016\/j.chroma.2013.08.063","article-title":"Determination of the Adsorption Isotherm of the Naproxen Enantiomers on (S,S)-Whelk-O1 in Supercritical Fluid Chromatography","volume":"1314","author":"Kamarei","year":"2013","journal-title":"J. Chromatogr. A"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/j.chroma.2013.08.028","article-title":"Effects of the Back Pressure and the Temperature on the Finite Layer Thickness of the Adsorbed Phase Layer in Supercritical Fluid Chromatography","volume":"1309","author":"Vajda","year":"2013","journal-title":"J. Chromatogr. A"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/j.chroma.2014.05.070","article-title":"Investigation of Plateau Methods for Adsorption Isotherm Determination in Supercritical Fluid Chromatography","volume":"1354","author":"Enmark","year":"2014","journal-title":"J. Chromatogr. A"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1016\/j.chroma.2013.06.075","article-title":"Modifier Adsorption in Supercritical Fluid Chromatography onto Silica Surface","volume":"1305","author":"Vajda","year":"2013","journal-title":"J. Chromatogr. A"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/j.chroma.2013.07.113","article-title":"Surface Excess Isotherms of Organic Solvent Mixtures in a System Made of Liquid Carbon Dioxide and a Silicagel Surface","volume":"1308","author":"Vajda","year":"2013","journal-title":"J. Chromatogr. A"},{"key":"ref_26","doi-asserted-by":"crossref","unstructured":"Singh, J.K., and Verma, N. (2019). Aqueous Phase Adsorption: Theory, Simulations and Experiments, Taylor & Francis. [1st ed.].","DOI":"10.1201\/9781351272520"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"2064","DOI":"10.1134\/S0036024415110217","article-title":"Monodisperse Microbeads of Hypercrosslinked Polystyrene for Liquid and Supercritical Fluid Chromatography","volume":"89","author":"Tsyurupa","year":"2015","journal-title":"Russ. J. Phys. Chem."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"8521","DOI":"10.1021\/la0345587","article-title":"Adsorption of Drugs on Silica Aerogels","volume":"19","author":"Smirnova","year":"2003","journal-title":"Langmuir"},{"key":"ref_29","doi-asserted-by":"crossref","unstructured":"Lovskaya, D., and Menshutina, N. (2020). Alginate-Based Aerogel Particles as Drug Delivery Systems: Investigation of the Supercritical Adsorption and In Vitro Evaluations. Materials, 13.","DOI":"10.3390\/ma13020329"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"189","DOI":"10.4236\/aces.2013.33024","article-title":"Supercritical Fluid Adsorption of Domperidone on Silica Aerogel","volume":"3","author":"Caputo","year":"2013","journal-title":"ACES"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"1577","DOI":"10.1134\/S0036023620100125","article-title":"Online Monitoring of Adsorption onto Silica Xerogels and Aerogels from Supercritical Solutions Using Supercritical Fluid Chromatography","volume":"65","author":"Kostenko","year":"2020","journal-title":"Russ. J. Inorg. Chem."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1016\/0378-3812(94)80070-7","article-title":"Solubilities of the Xanthines Caffeine, Theophylline and Theobromine in Supercritical Carbon Dioxide","volume":"95","author":"Johannsen","year":"1994","journal-title":"Fluid Phase Equilibria"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"1530","DOI":"10.1021\/acs.jced.7b00012","article-title":"Determining the Solubility of Nifedipine and Quinine in Supercritical Fluid Carbon Dioxide Using Continuously Stirred Static Solubility Apparatus Interfaced with Online Supercritical Fluid Chromatography","volume":"62","author":"Li","year":"2017","journal-title":"J. Chem. Eng. Data"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"2128","DOI":"10.1021\/acs.jced.6b00081","article-title":"Determining the Solubility of Organic Compounds in Supercritical Carbon Dioxide Using Supercritical Fluid Chromatography Directly Interfaced to Supercritical Fluid Solubility Apparatus","volume":"61","author":"Li","year":"2016","journal-title":"J. Chem. Eng. Data"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1021\/acs.jced.7b00857","article-title":"Measuring the Solubility of Anthracene and Chrysene in Supercritical Fluid Carbon Dioxide Using Static Solubility Apparatus Directly Interfaced Online to Supercritical Fluid Chromatography","volume":"63","author":"Li","year":"2018","journal-title":"J. Chem. Eng. Data"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1039\/a607237b","article-title":"Analysis of Phenols in Water at the Ppb Level Using Direct Supercritical Fluid Extraction of Aqueous Samples Combined On-Line With Supercritical Fluid Chromatography\u2013Mass Spectrometry","volume":"34","author":"Ramsey","year":"1997","journal-title":"Anal. Commun."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"104558","DOI":"10.1016\/j.supflu.2019.104558","article-title":"Determining Phenol Partition Coefficient Values in Water- and Industrial Process Water-Supercritical CO2 Systems Using Direct Aqueous SFE Apparatus Simultaneously Interfaced with on-Line SFC and on-Line HPLC","volume":"152","author":"Li","year":"2019","journal-title":"J. Supercrit. Fluids"},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"104759","DOI":"10.1016\/j.supflu.2020.104759","article-title":"Simultaneous Determination of Partition Coefficients of Three Organic Compounds Distributed as Mixtures between SF-CO2 and Water Using Interfaced SFE-SFC Apparatus","volume":"159","author":"Li","year":"2020","journal-title":"J. Supercrit. Fluids"},{"key":"ref_39","doi-asserted-by":"crossref","unstructured":"Voshkin, A., Solov\u2019ev, V., Kostenko, M., Zakhodyaeva, Y., and Pokrovskiy, O. (2021). A Doubly Green Separation Process: Merging Aqueous Two-Phase Extraction and Supercritical Fluid Extraction. Processes, 9.","DOI":"10.3390\/pr9040727"},{"key":"ref_40","doi-asserted-by":"crossref","unstructured":"Gromov, O.I., Kostenko, M.O., Petrunin, A.V., Popova, A.A., Parenago, O.O., Minaev, N.V., Golubeva, E.N., and Melnikov, M.Y. (2021). Solute Diffusion into Polymer Swollen by Supercritical CO2 by High-Pressure Electron Paramagnetic Resonance Spectroscopy and Chromatography. Polymers, 13.","DOI":"10.3390\/polym13183059"},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"1179","DOI":"10.1007\/s10337-017-3334-y","article-title":"Monitoring the Progress of a Photochemical Reaction Performed in Supercritical Fluid Carbon Dioxide Using a Continuously Stirred Reaction Cell Interfaced to On-Line SFC","volume":"80","author":"Li","year":"2017","journal-title":"Chromatographia"},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1016\/j.supflu.2017.11.002","article-title":"Monitoring the Progress of the Acetylation Reactions of 4-Aminophenol and 2-Aminophenol in Acetonitrile Modified Supercritical Fluid Carbon Dioxide and Pure Acetonitrile Using on-Line Supercritical Fluid Chromatography and on-Line Liquid Chromatography","volume":"133","author":"Li","year":"2018","journal-title":"J. Supercrit. Fluids"},{"key":"ref_43","unstructured":"Linstrom, P. (1997). NIST Chemistry WebBook, NIST Standard Reference Database 69."},{"key":"ref_44","unstructured":"(2021, November 05). Purolite Purolite Product: MacronetTM MN202. Available online: http:\/\/www.purolite.com\/product\/mn202."},{"key":"ref_45","unstructured":"(2021, November 05). Purolite Purolite Product: MacronetTM MN270. Available online: http:\/\/www.purolite.com\/product\/mn270."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"1066","DOI":"10.1016\/j.biortech.2016.05.106","article-title":"Cellulose: A Review as Natural, Modified and Activated Carbon Adsorbent","volume":"216","author":"Suhas","year":"2016","journal-title":"Bioresour. Technol."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"837","DOI":"10.1260\/0263-6174.28.10.837","article-title":"Effect of the Adsorptive Character of Filter Papers on the Concentrations Determined in Studies Involving Heavy Metal Ions","volume":"28","author":"Engin","year":"2010","journal-title":"Adsorpt. Sci. Technol."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"751","DOI":"10.1016\/S0021-9258(18)73780-0","article-title":"The Adsorption of Protein by Filter Paper in the Estimation of Albumin in Blood Serum","volume":"127","author":"Harris","year":"1939","journal-title":"J. Biol. Chem."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"788","DOI":"10.1021\/je000176g","article-title":"Adsorption of Benzene and Toluene from Aqueous Solution onto Granular Activated Carbon","volume":"46","author":"Hindarso","year":"2001","journal-title":"J. Chem. Eng. Data"},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"4763","DOI":"10.1021\/acs.energyfuels.8b00017","article-title":"Comparison of Temperature-Dependent Gas Adsorption Models and Their Application to Shale Gas Reservoirs","volume":"32","author":"Fianu","year":"2018","journal-title":"Energy Fuels"},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1061\/(ASCE)EE.1943-7870.0000131","article-title":"Modeling the Temperature Dependence of Adsorption Equilibriums of VOC(s) onto Activated Carbons","volume":"136","author":"Giraudet","year":"2010","journal-title":"J. Environ. Eng."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1016\/0167-6989(83)90016-8","article-title":"Sorption Properties of Hypercrosslinked Polystyrene Sorbents","volume":"1","author":"Rosenberg","year":"1983","journal-title":"React. Polym. Ion Exch. Sorbents"},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"1553","DOI":"10.1002\/(SICI)1099-0488(20000601)38:11<1553::AID-POLB160>3.0.CO;2-L","article-title":"Unusual Mobility of Hypercrosslinked Polystyrene Networks: Swelling and Dilatometric Studies","volume":"38","author":"Davankov","year":"2000","journal-title":"J. Polym. Sci. Part B Polym. Phys."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1134\/S1995078009090109","article-title":"Hypercrosslinked Polystyrene: The First Nanoporous Polymeric Material","volume":"4","author":"Tsyurupa","year":"2009","journal-title":"Nanotechnol. Russ."},{"key":"ref_55","doi-asserted-by":"crossref","unstructured":"Guiochon, G., Shirazi, D.G., Felinger, A., and Katti, A.M. (2006). Fundamentals of Preparative and Nonlinear Chromatography, Academic Press. [2nd ed.].","DOI":"10.1016\/B978-012370537-2\/50030-8"},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1016\/j.proche.2012.10.026","article-title":"Nitric Acid Extraction into TODGA","volume":"7","author":"Bell","year":"2012","journal-title":"Procedia Chem."}],"container-title":["Molecules"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1420-3049\/27\/1\/31\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T07:51:01Z","timestamp":1760169061000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1420-3049\/27\/1\/31"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,12,22]]},"references-count":56,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2022,1]]}},"alternative-id":["molecules27010031"],"URL":"https:\/\/doi.org\/10.3390\/molecules27010031","relation":{},"ISSN":["1420-3049"],"issn-type":[{"value":"1420-3049","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,12,22]]}}}