{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T04:57:43Z","timestamp":1787029063527,"version":"build-2736575974"},"reference-count":76,"publisher":"MDPI AG","issue":"1","license":[{"start":{"date-parts":[[2021,12,28]],"date-time":"2021-12-28T00:00:00Z","timestamp":1640649600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>Animal chitosan (Chit-A) is gaining more acceptance in daily activities. It is used in a range of products from food supplements for weight loss to even raw materials for producing nanoparticles and hydrogel drug carriers; however, it has low antioxidant activity. Fungal oligochitosan (OChit-F) was identified as a potential substitute for Chit-A. Cunninghamella elegans is a fungus found in the Brazilian savanna (Caatinga) that produces OligoChit-F, which is a relatively poorly studied compound. In this study, 4 kDa OChit-F with a 76% deacetylation degree was extracted from C. elegans. OChit-F showed antioxidant activity similar to that of Chit-A in only one in vitro test (copper chelation) but exhibited higher activity than that of Chit-A in three other tests (reducing power, hydroxyl radical scavenging, and iron chelation). These results indicate that OChit-F is a better antioxidant than Chit-A. In addition, Chit-A significantly increased the formation of calcium oxalate crystals in vitro, particularly those of the monohydrate (COM) type; however, OChit-F had no effect on this process in vitro. In summary, OChit-F had higher antioxidant activity than Chit-A and did not induce the formation of CaOx crystals. Thus, OChit-F can be used as a Chit-A substitute in applications affected by oxidative stress.<\/jats:p>","DOI":"10.3390\/molecules27010171","type":"journal-article","created":{"date-parts":[[2021,12,29]],"date-time":"2021-12-29T02:31:27Z","timestamp":1640745087000},"page":"171","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Oligochitosan Synthesized by Cunninghamella elegans, a Fungus from Caatinga (The Brazilian Savanna) Is a Better Antioxidant than Animal Chitosan"],"prefix":"10.3390","volume":"27","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2022-5659","authenticated-orcid":false,"given":"Weslley Souza","family":"Paiva","sequence":"first","affiliation":[{"name":"Postgraduate Programe in Biotechnology (RENORBIO), Federal University of Rio Grande do Norte (UFRN), Natal 59078-970, Rio Grande do Norte, Brazil"},{"name":"Laborat\u00f3rio de Biotecnologia de Pol\u00edmeros Naturais-BIOPOL, Departament of Biochemistry, Federal University of Rio Grande do Norte (UFRN), Natal 59078-970, Rio Grande do Norte, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francisco Ernesto","family":"de Souza Neto","sequence":"additional","affiliation":[{"name":"Departament of Medicine, Faculdade Nova Esperan\u00e7a, Mossor\u00f3 59628-000, Rio Grande do Norte, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Moacir Fernandes","family":"Queiroz","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio de Biotecnologia de Pol\u00edmeros Naturais-BIOPOL, Departament of Biochemistry, Federal University of Rio Grande do Norte (UFRN), Natal 59078-970, Rio Grande do Norte, Brazil"},{"name":"Biomedicine Departament, Universidade Potiguar, Natal 59056-000, Rio Grande do Norte, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lucas Alighieri Neves Costa","family":"Batista","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio de Biotecnologia de Pol\u00edmeros Naturais-BIOPOL, Departament of Biochemistry, Federal University of Rio Grande do Norte (UFRN), Natal 59078-970, Rio Grande do Norte, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2252-1221","authenticated-orcid":false,"given":"Hugo Alexandre Oliveira","family":"Rocha","sequence":"additional","affiliation":[{"name":"Postgraduate Programe in Biotechnology (RENORBIO), Federal University of Rio Grande do Norte (UFRN), Natal 59078-970, Rio Grande do Norte, Brazil"},{"name":"Biomedicine Departament, Universidade Potiguar, Natal 59056-000, Rio Grande do Norte, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0905-6911","authenticated-orcid":false,"given":"Anabelle Camarotti","family":"de Lima Batista","sequence":"additional","affiliation":[{"name":"Department of Agriculture, Federal University of Para\u00edba (UFPB), Bananeiras 58220-000, Paraiba, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2021,12,28]]},"reference":[{"key":"ref_1","first-page":"47","article-title":"A review on antioxidants and oxidative stress in type-2 diabetes mellitus","volume":"4","author":"Kumar","year":"2017","journal-title":"EJMR"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"906","DOI":"10.1016\/j.ijbiomac.2018.12.134","article-title":"Antioxidant activity of polysaccharides from different sources of ginseng","volume":"15","author":"Chen","year":"2019","journal-title":"Int. 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