{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T15:44:08Z","timestamp":1787240648884,"version":"build-2736575974"},"reference-count":177,"publisher":"MDPI AG","issue":"1","license":[{"start":{"date-parts":[[2021,12,30]],"date-time":"2021-12-30T00:00:00Z","timestamp":1640822400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>MicroRNAs (miRNAs) are a class of small (20\u201324 nucleotides), highly conserved, non-coding RNA molecules whose main function is the post-transcriptional regulation of gene expression through sequence-specific manners, such as mRNA degradation or translational repression. Since these key regulatory molecules are implicated in several biological processes, their altered expression affects the preservation of cellular homeostasis and leads to the development of a wide range of pathologies. Over the last few years, relevant investigations have elucidated that miRNAs participate in different stages of bone growth and development. Moreover, the abnormal expression of these RNA molecules in bone cells and tissues has been significantly associated with the progression of numerous bone diseases, including osteoporosis, osteosarcoma, osteonecrosis and bone metastasis, among others. In fact, miRNAs regulate multiple pathological mechanisms, including altering either osteogenic or osteoblast differentiation, metastasis, osteosarcoma cell proliferation, and bone loss. Therefore, in this present review, aiming to impulse the research arena of the biological implications of miRNA transcriptome in bone diseases and to explore their potentiality as a theragnostic target, we summarize the recent findings associated with the clinical significance of miRNAs in these ailments.<\/jats:p>","DOI":"10.3390\/molecules27010211","type":"journal-article","created":{"date-parts":[[2021,12,30]],"date-time":"2021-12-30T23:29:07Z","timestamp":1640906947000},"page":"211","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":41,"title":["The Emerging Role of MicroRNAs in Bone Diseases and Their Therapeutic Potential"],"prefix":"10.3390","volume":"27","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6342-4842","authenticated-orcid":false,"given":"Luis Alberto","family":"Bravo V\u00e1zquez","sequence":"first","affiliation":[{"name":"Tecnologico de Monterrey, School of Engineering and Sciences, Campus Quer\u00e9taro, Av. Epigmenio Gonz\u00e1lez, No. 500 Fracc. San Pablo, Quer\u00e9taro 76130, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariana Yunuen","family":"Moreno Becerril","sequence":"additional","affiliation":[{"name":"Tecnologico de Monterrey, School of Engineering and Sciences, Campus Quer\u00e9taro, Av. Epigmenio Gonz\u00e1lez, No. 500 Fracc. San Pablo, Quer\u00e9taro 76130, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erick Octavio","family":"Mora Hern\u00e1ndez","sequence":"additional","affiliation":[{"name":"Tecnologico de Monterrey, School of Engineering and Sciences, Campus Mexico City, Calle del Puente, No. 222 Col. Ejidos de Huipulco, Tlalpan, Mexico City 14380, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriela Garc\u00eda de","family":"Le\u00f3n Carmona","sequence":"additional","affiliation":[{"name":"Tecnologico de Monterrey, School of Engineering and Sciences, Campus Quer\u00e9taro, Av. Epigmenio Gonz\u00e1lez, No. 500 Fracc. San Pablo, Quer\u00e9taro 76130, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda Emilia","family":"Aguirre Padilla","sequence":"additional","affiliation":[{"name":"Tecnologico de Monterrey, School of Engineering and Sciences, Campus Quer\u00e9taro, Av. Epigmenio Gonz\u00e1lez, No. 500 Fracc. San Pablo, Quer\u00e9taro 76130, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samik","family":"Chakraborty","sequence":"additional","affiliation":[{"name":"Division of Nephrology, Boston Children\u2019s Hospital, Harvard Medical School, Boston, MA 02115, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anindya","family":"Bandyopadhyay","sequence":"additional","affiliation":[{"name":"International Rice Research Institute, Manila 4031, Philippines"},{"name":"Reliance Industries Ltd., Navi Mumbai 400701, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5024-7261","authenticated-orcid":false,"given":"Sujay","family":"Paul","sequence":"additional","affiliation":[{"name":"Tecnologico de Monterrey, School of Engineering and Sciences, Campus Quer\u00e9taro, Av. Epigmenio Gonz\u00e1lez, No. 500 Fracc. San Pablo, Quer\u00e9taro 76130, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2021,12,30]]},"reference":[{"key":"ref_1","first-page":"421746","article-title":"Biology of Bone Tissue: Structure, Function, and Factors That Influence Bone Cells","volume":"2015","author":"Sasso","year":"2015","journal-title":"BioMed Res. Int."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"776","DOI":"10.7150\/ijbs.27063","article-title":"Bone function, dysfunction and its role in diseases including critical illness","volume":"15","author":"Su","year":"2019","journal-title":"Int. J. Biol. Sci."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"668","DOI":"10.1096\/fba.2020-00058","article-title":"Current advances in regulation of bone homeostasis","volume":"2","year":"2020","journal-title":"FASEB BioAdv."},{"key":"ref_4","doi-asserted-by":"crossref","unstructured":"Chindamo, G., Sapino, S., Peira, E., Chirio, D., Gonzalez, M.C., and Gallarate, M. (2020). Bone Diseases: Current Approach and Future Perspectives in Drug Delivery Systems for Bone Targeted Therapeutics. Nanomaterials, 10.","DOI":"10.3390\/nano10050875"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"e34","DOI":"10.15190\/d.2014.26","article-title":"Key principles of miRNA involvement in human diseases","volume":"2","author":"Giza","year":"2014","journal-title":"Discoveries"},{"key":"ref_6","first-page":"253","article-title":"MicroRNAs: Their discovery, biogenesis, function and potential use as biomarkers in non-invasive prenatal diagnostics","volume":"2","author":"Ladomery","year":"2011","journal-title":"Int. J. Mol. Epidemiol. Genet."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.mrfmmm.2011.03.009","article-title":"MicroRNA history: Discovery, recent applications, and next frontiers","volume":"717","author":"Almeida","year":"2011","journal-title":"Mutat. Res. Mol. Mech. Mutagen."},{"key":"ref_8","doi-asserted-by":"crossref","unstructured":"Matsuyama, H., and Suzuki, H.I. (2020). Systems and Synthetic microRNA Biology: From Biogenesis to Disease Pathogenesis. Int. J. Mol. Sci., 21.","DOI":"10.3390\/ijms21010132"},{"key":"ref_9","doi-asserted-by":"crossref","unstructured":"Condrat, C.E., Thompson, D.C., Barbu, M.G., Bugnar, O.L., Boboc, A., Cretoiu, D., Suciu, N., Cretoiu, S.M., and Voinea, S.C. (2020). miRNAs as Biomarkers in Disease: Latest Findings Regarding Their Role in Diagnosis and Prognosis. Cells, 9.","DOI":"10.3390\/cells9020276"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/j.jare.2020.08.012","article-title":"Therapeutic advances of miRNAs: A preclinical and clinical update","volume":"28","author":"Chakraborty","year":"2021","journal-title":"J. Adv. Res."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/j.biochi.2021.05.015","article-title":"Roles of microRNAs in carbohydrate and lipid metabolism disorders and their therapeutic potential","volume":"187","author":"Paul","year":"2021","journal-title":"Biochimie"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"108763","DOI":"10.1016\/j.abb.2021.108763","article-title":"Roles of microRNAs in chronic pediatric diseases and their use as potential biomarkers: A review","volume":"699","author":"Paul","year":"2021","journal-title":"Arch. Biochem. Biophys."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"510","DOI":"10.1007\/s13205-020-02498-6","article-title":"Human microRNAs in host\u2013parasite interaction: A review","volume":"10","author":"Paul","year":"2020","journal-title":"3 Biotech"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1007\/s11064-019-02917-y","article-title":"MicroRNAs and Child Neuropsychiatric Disorders: A Brief Review","volume":"45","author":"Paul","year":"2019","journal-title":"Neurochem. Res."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"1040","DOI":"10.1007\/s13577-021-00540-0","article-title":"Current insight into the functions of microRNAs in common human hair loss disorders: A mini review","volume":"34","author":"Paul","year":"2021","journal-title":"Hum. Cell"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"198631","DOI":"10.1016\/j.virusres.2021.198631","article-title":"The role of microRNAs in solving COVID-19 puzzle from infection to therapeutics: A mini-review","volume":"308","author":"Paul","year":"2022","journal-title":"Virus Res."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1007\/s00198-017-4241-7","article-title":"Effects of endogenous hypercortisolism on bone mRNA and microRNA expression in humans","volume":"29","author":"Belaya","year":"2018","journal-title":"Osteoporos. Int."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"1191","DOI":"10.1007\/s00198-016-3847-5","article-title":"MicroRNAs in bone diseases","volume":"28","author":"Gennari","year":"2017","journal-title":"Osteoporos. Int."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"116068","DOI":"10.1016\/j.bone.2021.116068","article-title":"Osteoporosis, fracture, osteoarthritis & sarcopenia: A systematic review of circulating microRNA association","volume":"152","author":"Jones","year":"2021","journal-title":"Bone"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"115787","DOI":"10.1016\/j.bone.2020.115787","article-title":"Circulating miRNAs in bone health and disease","volume":"145","author":"Grillari","year":"2021","journal-title":"Bone"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"427","DOI":"10.2174\/1389202916666150817202425","article-title":"miRNAs in Bone Development","volume":"16","author":"Papaioannou","year":"2015","journal-title":"Curr. Genom."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1002\/ddr.21260","article-title":"MicroRNAs in Bone Balance and Osteoporosis","volume":"76","author":"Chen","year":"2015","journal-title":"Drug Dev. Res."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"20","DOI":"10.2174\/2211536611302010004","article-title":"MiRNAs in Bone Diseases","volume":"2","author":"Moore","year":"2013","journal-title":"MicroRNA"},{"key":"ref_24","first-page":"175","article-title":"Extracellular\/Circulating MicroRNAs: Release Mechanisms, Functions and Challenges","volume":"10","author":"Sohel","year":"2016","journal-title":"Achiev. Life Sci."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"1030","DOI":"10.1002\/jcp.27127","article-title":"Emerging role of circulating microRNA in the diagnosis of human infectious diseases","volume":"234","author":"Ojha","year":"2019","journal-title":"J. Cell. Physiol."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"626","DOI":"10.3389\/fgene.2019.00626","article-title":"Circulating MicroRNAs in Cancer: Potential and Challenge","volume":"10","author":"Cui","year":"2019","journal-title":"Front. Genet."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"165847","DOI":"10.1016\/j.bbadis.2020.165847","article-title":"Identifying circulating miRNA biomarkers for early diagnosis and monitoring of lung cancer","volume":"1866","author":"Zhang","year":"2020","journal-title":"Biochim. Biophys. Acta (BBA) Mol. Basis Dis."},{"key":"ref_28","doi-asserted-by":"crossref","unstructured":"Gherman, A., Balacescu, L., Gheorghe-Cetean, S., Vlad, C., Balacescu, O., Irimie, A., and Lisencu, C. (2020). Current and New Predictors for Treatment Response in Metastatic Colorectal Cancer. The Role of Circulating miRNAs as Biomarkers. Int. J. Mol. Sci., 21.","DOI":"10.3390\/ijms21062089"},{"key":"ref_29","doi-asserted-by":"crossref","unstructured":"Sidorkiewicz, I., Niemira, M., Maliszewska, K., Erol, A., Bielska, A., Szalkowska, A., Adamska-Patruno, E., Szczerbinski, L., Gorska, M., and Kretowski, A. (2020). Circulating miRNAs as a Predictive Biomarker of the Progression from Prediabetes to Diabetes: Outcomes of a 5-Year Prospective Observational Study. J. Clin. Med., 9.","DOI":"10.3390\/jcm9072184"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"1262","DOI":"10.1007\/s11427-015-4969-2","article-title":"The role of circulating miRNAs in multiple myeloma","volume":"58","author":"Zhang","year":"2015","journal-title":"Sci. China Life Sci."},{"key":"ref_31","doi-asserted-by":"crossref","unstructured":"Donati, S., Ciuffi, S., Palmini, G., and Brandi, M.L. (2020). Circulating miRNAs: A New Opportunity in Bone Fragility. Biomolecules, 10.","DOI":"10.3390\/biom10060927"},{"key":"ref_32","doi-asserted-by":"crossref","unstructured":"Bottani, M., Banfi, G., and Lombardi, G. (2020). The Clinical Potential of Circulating miRNAs as Biomarkers: Present and Future Applications for Diagnosis and Prognosis of Age-Associated Bone Diseases. Biomolecules, 10.","DOI":"10.3390\/biom10040589"},{"key":"ref_33","doi-asserted-by":"crossref","unstructured":"Bottani, M., Banfi, G., and Lombardi, G. (2019). Circulating miRNAs as Diagnostic and Prognostic Biomarkers in Common Solid Tumors: Focus on Lung, Breast, Prostate Cancers, and Osteosarcoma. J. Clin. Med., 8.","DOI":"10.3390\/jcm8101661"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"101479","DOI":"10.1016\/j.mcp.2019.101479","article-title":"MiRNA-483\u20135p is involved in the pathogenesis of osteoporosis by promoting osteoclast differentiation","volume":"49","author":"Li","year":"2020","journal-title":"Mol. Cell. Probes"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"586","DOI":"10.1080\/13880209.2019.1657153","article-title":"MiR-152 influences osteoporosis through regulation of osteoblast differentiation by targeting RICTOR","volume":"57","author":"Feng","year":"2019","journal-title":"Pharm. Biol."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"2271","DOI":"10.1007\/s00198-020-05497-8","article-title":"Is there a role for menopausal hormone therapy in the management of postmenopausal osteoporosis?","volume":"31","author":"Rozenberg","year":"2020","journal-title":"Osteoporos. Int."},{"key":"ref_37","doi-asserted-by":"crossref","unstructured":"Mazziotta, C., Lanzillotti, C., Iaquinta, M., Taraballi, F., Torreggiani, E., Rotondo, J., Ot\u00f2n-Gonzalez, L., Mazzoni, E., Frontini, F., and Bononi, I. (2021). MicroRNAs Modulate Signaling Pathways in Osteogenic Differentiation of Mesenchymal Stem Cells. Int. J. Mol. Sci., 22.","DOI":"10.3390\/ijms22052362"},{"key":"ref_38","first-page":"6394","article-title":"MicroRNA-449b-5p promotes the progression of osteoporosis by inhibiting osteogenic differentiation of BMSCs via targeting Satb2","volume":"23","author":"Li","year":"2019","journal-title":"Eur. Rev. Med. Pharmacol. Sci."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"BSR20181108","DOI":"10.1042\/BSR20181108","article-title":"miR-206 inhibits osteogenic differentiation of bone marrow mesenchymal stem cells by targetting glutaminase","volume":"39","author":"Chen","year":"2019","journal-title":"Biosci. Rep."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"115104","DOI":"10.1016\/j.bone.2019.115104","article-title":"MicroRNA levels in bone and blood change during bisphosphonate and teriparatide therapy in an animal model of postmenopausal osteoporosis","volume":"131","author":"Kocijan","year":"2020","journal-title":"Bone"},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1007\/s11626-019-00344-5","article-title":"miR-363-3p is activated by MYB and regulates osteoporosis pathogenesis via PTEN\/PI3K\/AKT signaling pathway","volume":"55","author":"Li","year":"2019","journal-title":"Vitr. Cell. Dev. Biol. Anim."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/bs.ctdb.2016.12.005","article-title":"Estrogen Hormone Biology","volume":"125","author":"Hamilton","year":"2017","journal-title":"Curr. Top. Dev. Biol."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"181","DOI":"10.3389\/fgene.2020.00181","article-title":"MicroRNA Alterations for Diagnosis, Prognosis, and Treatment of Osteoporosis: A Comprehensive Review and Computational Functional Survey","volume":"11","author":"Hu","year":"2020","journal-title":"Front. Genet."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"1217","DOI":"10.1002\/jcb.24471","article-title":"Down-regulation of miR-21 biogenesis by estrogen action contributes to osteoclastic apoptosis","volume":"114","author":"Sugatani","year":"2013","journal-title":"J. Cell. Biochem."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"1539","DOI":"10.3892\/mmr.2017.6168","article-title":"Estrogen stimulates osteoprotegerin expression via the suppression of miR-145 expression in MG-63 cells","volume":"15","author":"Jia","year":"2017","journal-title":"Mol. Med. Rep."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"187","DOI":"10.4103\/jmh.jmh_284_20","article-title":"Postmenopausal hormone therapy and its association with breast cancer","volume":"11","author":"Syal","year":"2020","journal-title":"J. Mid-Life Health"},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1007\/s10549-010-0972-2","article-title":"Let-7 family miRNAs regulate estrogen receptor alpha signaling in estrogen receptor positive breast cancer","volume":"127","author":"Zhao","year":"2011","journal-title":"Breast Cancer Res. Treat."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1186\/s12575-018-0082-9","article-title":"microRNA Regulation in Estrogen Receptor-Positive Breast Cancer and Endocrine Therapy","volume":"20","author":"Howard","year":"2018","journal-title":"Biol. Proced. Online"},{"key":"ref_49","first-page":"7789","article-title":"MicroRNA-148a inhibition protects against ovariectomy-induced osteoporosis through PI3K\/AKT signaling by estrogen receptor \u03b1","volume":"17","author":"Xiao","year":"2018","journal-title":"Mol. Med. Rep."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"8421","DOI":"10.1038\/s41598-018-26525-y","article-title":"Circulating microRNAs as potential diagnostic biomarkers for osteoporosis","volume":"8","author":"Mandourah","year":"2018","journal-title":"Sci. Rep."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1139\/bcb-2017-0243","article-title":"Reduced miR-144-3p expression in serum and bone mediates osteoporosis pathogenesis by targeting RANK","volume":"96","author":"Wang","year":"2018","journal-title":"Biochem. Cell Biol."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1093\/abbs\/gmy006","article-title":"MiRNA-133a is involved in the regulation of postmenopausal osteoporosis through promoting osteoclast differentiation","volume":"50","author":"Li","year":"2018","journal-title":"Acta Biochim. Biophys. Sin."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"9863","DOI":"10.1073\/pnas.1018493108","article-title":"A program of microRNAs controls osteogenic lineage progression by targeting transcription factor Runx2","volume":"108","author":"Zhang","year":"2011","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"783","DOI":"10.1007\/s10616-017-0183-3","article-title":"Generation of PTEN knockout bone marrow mesenchymal stem cell lines by CRISPR\/Cas9-mediated genome editing","volume":"70","author":"Shen","year":"2018","journal-title":"Cytotechnology"},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"705","DOI":"10.1038\/s41419-019-1942-1","article-title":"MicroRNA-29a represses osteoclast formation and protects against osteoporosis by regulating PCAF-mediated RANKL and CXCL12","volume":"10","author":"Lian","year":"2019","journal-title":"Cell Death Dis."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"109378","DOI":"10.1016\/j.biopha.2019.109378","article-title":"Suppression of miR-451a accelerates osteogenic differentiation and inhibits bone loss via Bmp6 signaling during osteoporosis","volume":"120","author":"Lu","year":"2019","journal-title":"Biomed. Pharmacother."},{"key":"ref_57","first-page":"6791","article-title":"MicroRNA-579-3p promotes the progression of osteoporosis by inhibiting osteogenic differentiation of mesenchymal stem cells through regulating Sirt1","volume":"23","author":"Luo","year":"2019","journal-title":"Eur. Rev. Med. Pharmacol. Sci."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"108960","DOI":"10.1016\/j.biopha.2019.108960","article-title":"MicroRNA-200a-3p accelerates the progression of osteoporosis by targeting glutaminase to inhibit osteogenic differentiation of bone marrow mesenchymal stem cells","volume":"116","author":"Lv","year":"2019","journal-title":"Biomed. Pharmacother."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"790","DOI":"10.1016\/j.bbrc.2019.09.058","article-title":"LncRNA MSC-AS1 promotes osteogenic differentiation and alleviates osteoporosis through sponging microRNA-140\u20135p to upregulate BMP2","volume":"519","author":"Zhang","year":"2019","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_60","first-page":"29","article-title":"Down-regulation of miR-339 promotes differentiation of BMSCs and alleviates osteoporosis by targeting DLX5","volume":"23","author":"Zhou","year":"2019","journal-title":"Eur. Rev. Med. Pharmacol. Sci."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1007\/s11626-019-00405-9","article-title":"miR-140-3p exhibits repressive functions on preosteoblast viability and differentiation by downregulating MCF2L in osteoporosis","volume":"56","author":"Mao","year":"2020","journal-title":"Vitr. Cell. Dev. Biol. Anim."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"814","DOI":"10.1016\/j.omtn.2020.07.023","article-title":"Inhibition of Circulating miR-194-5p Reverses Osteoporosis through Wnt5a\/\u03b2-Catenin-Dependent Induction of Osteogenic Differentiation","volume":"21","author":"Mi","year":"2020","journal-title":"Mol. Ther. Nucleic Acids"},{"key":"ref_63","first-page":"1","article-title":"MicroRNA-1286 inhibits osteogenic differentiation of mesenchymal stem cells to promote the progression of osteoporosis via regulating FZD4 expression","volume":"24","author":"Zhou","year":"2020","journal-title":"Eur. Rev. Med. Pharmacol. Sci."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"111074","DOI":"10.1016\/j.mce.2020.111074","article-title":"Kaempferol promotes BMSC osteogenic differentiation and improves osteoporosis by downregulating miR-10a-3p and upregulating CXCL12","volume":"520","author":"Liu","year":"2021","journal-title":"Mol. Cell. Endocrinol."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1016\/j.bone.2019.02.013","article-title":"Deregulated miRNAs in bone health: Epigenetic roles in osteoporosis","volume":"122","author":"Bellavia","year":"2019","journal-title":"Bone"},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1186\/s12938-021-00860-0","article-title":"Osteosarcoma: A review of current and future therapeutic approaches","volume":"20","author":"Zhao","year":"2021","journal-title":"Biomed. Eng. Online"},{"key":"ref_67","doi-asserted-by":"crossref","unstructured":"Czarnecka, A.M., Synoradzki, K., Firlej, W., Bartnik, E., Sobczuk, P., Fiedorowicz, M., Grieb, P., and Rutkowski, P. (2020). Molecular Biology of Osteosarcoma. Cancers, 12.","DOI":"10.3390\/cancers12082130"},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1007\/s40744-016-0050-2","article-title":"Osteosarcoma Overview","volume":"4","author":"Lindsey","year":"2017","journal-title":"Rheumatol. Ther."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"359739","DOI":"10.1155\/2012\/359739","article-title":"MicroRNA Involvement in Osteosarcoma","volume":"2012","author":"Kobayashi","year":"2012","journal-title":"Sarcoma"},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"69","DOI":"10.3389\/fped.2015.00069","article-title":"MicroRNAs and Potential Targets in Osteosarcoma: Review","volume":"3","author":"Sampson","year":"2015","journal-title":"Front. Pediatr."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1016\/j.omtn.2017.12.010","article-title":"MicroRNA-300 Regulates the Ubiquitination of PTEN through the CRL4BDCAF13 E3 Ligase in Osteosarcoma Cells","volume":"10","author":"Chen","year":"2018","journal-title":"Mol. Ther. Nucleic Acids"},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"2003","DOI":"10.3892\/etm.2017.4204","article-title":"MicroRNA-93 promotes cell proliferation by directly targeting P21 in osteosarcoma cells","volume":"13","author":"He","year":"2017","journal-title":"Exp. Ther. Med."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"12064","DOI":"10.1007\/s11356-018-1331-9","article-title":"MicroRNA-411 promoted the osteosarcoma progression by suppressing MTSS1 expression","volume":"25","author":"Xu","year":"2018","journal-title":"Environ. Sci. Pollut. Res."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"997","DOI":"10.1016\/j.biopha.2018.08.059","article-title":"MiR-1284 enhances sensitivity of cervical cancer cells to cisplatin via downregulating HMGB1","volume":"107","author":"Chen","year":"2018","journal-title":"Biomed. Pharmacother."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"3965","DOI":"10.2147\/OTT.S191015","article-title":"MiR-1284 suppresses gastric cancer progression by targeting EIF4A1","volume":"12","author":"Wei","year":"2019","journal-title":"OncoTargets Ther."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"BSR20171675","DOI":"10.1042\/BSR20171675","article-title":"miRNA-1284, a regulator of HMGB1, inhibits cell proliferation and migration in osteosarcoma","volume":"38","author":"Lv","year":"2018","journal-title":"Biosci. Rep."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/j.jbo.2018.05.001","article-title":"Diagnostic and prognostic values of blood microRNA-Let7A for osteosarcoma","volume":"12","author":"Hua","year":"2018","journal-title":"J. Bone Oncol."},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"669","DOI":"10.3389\/fonc.2019.00669","article-title":"Crosstalk Between Long Non-coding RNAs, Micro-RNAs and mRNAs: Deciphering Molecular Mechanisms of Master Regulators in Cancer","volume":"9","year":"2019","journal-title":"Front. Oncol."},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1159\/000495239","article-title":"Long Noncoding RNA SNHG16 Promotes Cell Proliferation by Sponging MicroRNA-205 and Upregulating ZEB1 Expression in Osteosarcoma","volume":"51","author":"Zhu","year":"2018","journal-title":"Cell. Physiol. Biochem."},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1080\/15384101.2015.1006048","article-title":"ZEB1: At the crossroads of epithelial-mesenchymal transition, metastasis and therapy resistance","volume":"14","author":"Zhang","year":"2015","journal-title":"Cell Cycle"},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1016\/j.gene.2018.08.078","article-title":"MicroRNA-1301 inhibits migration and invasion of osteosarcoma cells by targeting BCL9","volume":"679","author":"Wang","year":"2018","journal-title":"Gene"},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"976","DOI":"10.1007\/s10147-019-01433-x","article-title":"A four serum-miRNA panel serves as a potential diagnostic biomarker of osteosarcoma","volume":"24","author":"Huang","year":"2019","journal-title":"Int. J. Clin. Oncol."},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"936","DOI":"10.1080\/21691401.2016.1196456","article-title":"Integrated bioinformatics analysis of miRNA expression in osteosarcoma","volume":"45","author":"Wang","year":"2016","journal-title":"Artif. Cells Nanomed. Biotechnol."},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"4761064","DOI":"10.1155\/2018\/4761064","article-title":"Identification of Key Genes and miRNAs in Osteosarcoma Patients with Chemoresistance by Bioinformatics Analysis","volume":"2018","author":"Xie","year":"2018","journal-title":"BioMed Res. Int."},{"key":"ref_85","doi-asserted-by":"crossref","unstructured":"Ram Kumar, R.M., Boro, A., and Fuchs, B. (2016). Involvement and Clinical Aspects of MicroRNA in Osteosarcoma. Int. J. Mol. Sci., 17.","DOI":"10.3390\/ijms17060877"},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"8129","DOI":"10.1002\/jcp.29467","article-title":"Identification of potential miRNA biomarkers for traumatic osteonecrosis of femoral head","volume":"235","author":"Liu","year":"2020","journal-title":"J. Cell. Physiol."},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"1813","DOI":"10.12659\/MSM.909655","article-title":"MicroRNA Expression Profiling of Bone Marrow Mesenchymal Stem Cells in Steroid-Induced Osteonecrosis of the Femoral Head Associated with Osteogenesis","volume":"24","author":"Wang","year":"2018","journal-title":"Med. Sci. Monit."},{"key":"ref_88","first-page":"4053","article-title":"MiR-181d promotes steroid-induced osteonecrosis of the femoral head by targeting SMAD3 to inhibit osteogenic differentiation of hBMSCs","volume":"22","author":"Xie","year":"2018","journal-title":"Eur. Rev. Med. Pharmacol. Sci."},{"key":"ref_89","first-page":"4594","article-title":"MicroRNA-186-5p mediates osteoblastic differentiation and cell viability by targeting CXCL13 in non-traumatic osteonecrosis","volume":"20","author":"Xu","year":"2019","journal-title":"Mol. Med. Rep."},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"127","DOI":"10.5625\/lar.2011.27.2.127","article-title":"Traumatic and Non-traumatic Osteonecrosis in the Femoral Head of a Rabbit Model","volume":"27","author":"Hwang","year":"2011","journal-title":"Lab. Anim. Res."},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"601763","DOI":"10.1155\/2012\/601763","article-title":"The Pathogenesis of Nontraumatic Osteonecrosis","volume":"2012","author":"Seamon","year":"2012","journal-title":"Arthritis"},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"965","DOI":"10.1007\/s00198-018-04826-2","article-title":"Epidemiology of osteonecrosis among older adults in Sweden","volume":"30","author":"Bergman","year":"2019","journal-title":"Osteoporos. Int."},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1007\/s12178-015-9277-8","article-title":"Pathophysiology and risk factors for osteonecrosis","volume":"8","author":"Shah","year":"2015","journal-title":"Curr. Rev. Musculoskelet. Med."},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"42638","DOI":"10.18632\/oncotarget.17333","article-title":"Differential expression of miR-195-5p in collapse of steroid-induced osteonecrosis of the femoral head","volume":"8","author":"Li","year":"2017","journal-title":"Oncotarget"},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1007\/s12020-011-9580-0","article-title":"Glucocorticoid-induced osteonecrosis","volume":"41","author":"Weinstein","year":"2012","journal-title":"Endocrine"},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"1112","DOI":"10.1016\/j.biopha.2018.10.166","article-title":"MiR-217 promotes cell proliferation and osteogenic differentiation of BMSCs by targeting DKK1 in steroid-associated osteonecrosis","volume":"109","author":"Dai","year":"2019","journal-title":"Biomed. Pharmacother."},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"841","DOI":"10.1016\/j.omtn.2019.09.030","article-title":"AAV-Anti-miR-214 Prevents Collapse of the Femoral Head in Osteonecrosis by Regulating Osteoblast and Osteoclast Activities","volume":"18","author":"Wang","year":"2019","journal-title":"Mol. Ther. Nucleic Acids"},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1186\/s11671-019-3221-6","article-title":"Upregulating MicroRNA-410 or Downregulating Wnt-11 Increases Osteoblasts and Reduces Osteoclasts to Alleviate Osteonecrosis of the Femoral Head","volume":"14","author":"Yin","year":"2019","journal-title":"Nanoscale Res. Lett."},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"187","DOI":"10.2147\/CIA.S289479","article-title":"Identifying the Potential Differentially Expressed miRNAs and mRNAs in Osteonecrosis of the Femoral Head Based on Integrated Analysis","volume":"16","author":"Hao","year":"2021","journal-title":"Clin. Interv. Aging"},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"145128","DOI":"10.1016\/j.gene.2020.145128","article-title":"Preliminary study of icariin indicating prevention of steroid-induced osteonecrosis of femoral head by regulating abnormal expression of miRNA-335 and protecting the functions of bone microvascular endothelial cells in rats","volume":"766","author":"Yue","year":"2021","journal-title":"Gene"},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"e12405","DOI":"10.1111\/cpr.12405","article-title":"Emerging roles of MicroRNAs in osteonecrosis of the femoral head","volume":"51","author":"Li","year":"2018","journal-title":"Cell Prolif."},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"834","DOI":"10.1002\/cncr.11132","article-title":"Mechanisms of osteolytic bone metastases in breast carcinoma","volume":"97","author":"Mundy","year":"2003","journal-title":"Cancer"},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1615\/CritRevOncog.v18.i1-2.40","article-title":"On the Origin of Cancer Metastasis","volume":"18","author":"Seyfried","year":"2013","journal-title":"Crit. Rev. Oncog."},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"a031252","DOI":"10.1101\/cshperspect.a031252","article-title":"The Biology of Bone Metastasis","volume":"8","author":"Esposito","year":"2018","journal-title":"Cold Spring Harb. Perspect. Med."},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"2609","DOI":"10.1158\/1535-7163.MCT-07-0234","article-title":"Molecular Biology of Bone Metastasis","volume":"6","author":"Kingsley","year":"2007","journal-title":"Mol. Cancer Ther."},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/j.critrevonc.2017.04.008","article-title":"Systematic review and meta-analysis on the proportion of patients with breast cancer who develop bone metastases","volume":"115","author":"Body","year":"2017","journal-title":"Crit. Rev. Oncol. Hematol."},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"3279","DOI":"10.1007\/s00520-013-1887-3","article-title":"Natural history of skeletal-related events in patients with breast, lung, or prostate cancer and metastases to bone: A 15-year study in two large US health systems","volume":"21","author":"Oster","year":"2013","journal-title":"Support. Care Cancer"},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"1936","DOI":"10.1111\/bph.14836","article-title":"Non-coding RNAs in bone remodelling and bone metastasis: Mechanisms of action and translational relevance","volume":"178","author":"Puppo","year":"2021","journal-title":"Br. J. Pharmacol."},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"e2572","DOI":"10.1038\/cddis.2017.15","article-title":"MicroRNA-466 inhibits tumor growth and bone metastasis in prostate cancer by direct regulation of osteogenic transcription factor RUNX2","volume":"8","author":"Colden","year":"2018","journal-title":"Cell Death Dis."},{"key":"ref_110","first-page":"81","article-title":"Downregulation of miR-19a-3p promotes invasion, migration and bone metastasis via activating TGF-\u03b2 signaling in prostate cancer","volume":"39","author":"Wa","year":"2018","journal-title":"Oncol. Rep."},{"key":"ref_111","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/j.omtn.2019.01.004","article-title":"miR-582-3p and miR-582-5p Suppress Prostate Cancer Metastasis to Bone by Repressing TGF-\u03b2 Signaling","volume":"16","author":"Huang","year":"2019","journal-title":"Mol. Ther. Nucleic Acids"},{"key":"ref_112","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1016\/S0092-8674(03)00432-X","article-title":"Mechanisms of TGF-\u03b2 Signaling from Cell Membrane to the Nucleus","volume":"113","author":"Shi","year":"2003","journal-title":"Cell"},{"key":"ref_113","doi-asserted-by":"crossref","first-page":"865","DOI":"10.1093\/carcin\/bgz191","article-title":"Regulation of cell\u2013cell adhesion in prostate cancer cells by microRNA-96 through upregulation of E-Cadherin and EpCAM","volume":"41","author":"Voss","year":"2020","journal-title":"Carcinogenesis"},{"key":"ref_114","doi-asserted-by":"crossref","first-page":"3199","DOI":"10.1101\/gad.1486806","article-title":"Cadherins in development: Cell adhesion, sorting, and tissue morphogenesis","volume":"20","author":"Halbleib","year":"2006","journal-title":"Genes Dev."},{"key":"ref_115","doi-asserted-by":"crossref","first-page":"955","DOI":"10.1038\/bjc.2014.366","article-title":"EpCAM is overexpressed in local and metastatic prostate cancer, suppressed by chemotherapy and modulated by MET-associated miRNA-200c\/205","volume":"111","author":"Massoner","year":"2014","journal-title":"Br. J. Cancer"},{"key":"ref_116","doi-asserted-by":"crossref","first-page":"40487","DOI":"10.1038\/srep40487","article-title":"Osteoclastic miR-214 targets TRAF3 to contribute to osteolytic bone metastasis of breast cancer","volume":"7","author":"Liu","year":"2017","journal-title":"Sci. Rep."},{"key":"ref_117","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1186\/s12943-017-0746-0","article-title":"microRNA-124 inhibits bone metastasis of breast cancer by repressing Interleukin-11","volume":"17","author":"Cai","year":"2018","journal-title":"Mol. Cancer"},{"key":"ref_118","first-page":"2376","article-title":"Serum microRNA-139-5p is downregulated in lung cancer patients with lytic bone metastasis","volume":"39","author":"Xu","year":"2018","journal-title":"Oncol. Rep."},{"key":"ref_119","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1186\/1476-4598-13-124","article-title":"microRNA-139-5p exerts tumor suppressor function by targeting NOTCH1 in colorectal cancer","volume":"13","author":"Zhang","year":"2014","journal-title":"Mol. Cancer"},{"key":"ref_120","doi-asserted-by":"crossref","first-page":"1010428317705761","DOI":"10.1177\/1010428317705761","article-title":"MicroRNA-34a inhibits tumor invasion and metastasis in osteosarcoma partly by effecting C-IAP2 and Bcl-2","volume":"39","author":"Wen","year":"2017","journal-title":"Tumor Biol."},{"key":"ref_121","doi-asserted-by":"crossref","first-page":"2204","DOI":"10.1073\/pnas.1717363115","article-title":"Cancer-secreted hsa-miR-940 induces an osteoblastic phenotype in the bone metastatic microenvironment via targeting ARHGAP1 and FAM134A","volume":"115","author":"Hashimoto","year":"2018","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_122","doi-asserted-by":"crossref","first-page":"611054","DOI":"10.3389\/fonc.2020.611054","article-title":"The Potential Roles of Exosomal miR-214 in Bone Metastasis of Lung Adenocarcinoma","volume":"10","author":"Zhang","year":"2021","journal-title":"Front. Oncol."},{"key":"ref_123","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1186\/s12943-019-0959-5","article-title":"Hypoxic BMSC-derived exosomal miRNAs promote metastasis of lung cancer cells via STAT3-induced EMT","volume":"18","author":"Zhang","year":"2019","journal-title":"Mol. Cancer"},{"key":"ref_124","doi-asserted-by":"crossref","first-page":"5687","DOI":"10.1002\/cam4.2454","article-title":"Breast cancer cell-derived exosomal miR-20a-5p promotes the proliferation and differentiation of osteoclasts by targeting SRCIN1","volume":"8","author":"Guo","year":"2019","journal-title":"Cancer Med."},{"key":"ref_125","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1007\/s10585-020-10062-y","article-title":"Correlation of exosomal microRNA clusters with bone metastasis in non-small cell lung cancer","volume":"38","author":"Yang","year":"2021","journal-title":"Clin. Exp. Metastasis"},{"key":"ref_126","doi-asserted-by":"crossref","first-page":"1429","DOI":"10.7150\/thno.45351","article-title":"Breast cancer exosomes contribute to pre-metastatic niche formation and promote bone metastasis of tumor cells","volume":"11","author":"Yuan","year":"2021","journal-title":"Theranostics"},{"key":"ref_127","doi-asserted-by":"crossref","first-page":"5196","DOI":"10.1038\/s41467-021-25473-y","article-title":"Exosomal miR-19a and IBSP cooperate to induce osteolytic bone metastasis of estrogen receptor-positive breast cancer","volume":"12","author":"Wu","year":"2021","journal-title":"Nat. Commun."},{"key":"ref_128","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1016\/j.jbo.2016.04.002","article-title":"The role of microRNAs in bone metastasis","volume":"5","author":"Zoni","year":"2016","journal-title":"J. Bone Oncol."},{"key":"ref_129","doi-asserted-by":"crossref","first-page":"279","DOI":"10.3892\/ijmm.2016.2839","article-title":"miR-628-3p regulates osteoblast differentiation by targeting RUNX2: Possible role in atrophic non-union","volume":"39","author":"Chen","year":"2017","journal-title":"Int. J. Mol. Med."},{"key":"ref_130","doi-asserted-by":"crossref","first-page":"1","DOI":"10.5704\/MOJ.1907.001","article-title":"Fracture Non-Union: A Review of Clinical Challenges and Future Research Needs","volume":"13","author":"Stewart","year":"2019","journal-title":"Malays. Orthop. J."},{"key":"ref_131","doi-asserted-by":"crossref","first-page":"1144","DOI":"10.1302\/0301-620X.97B8.34966","article-title":"Profiling microRNA expression in fracture nonunions: Potential role of microRNAs in nonunion formation studied in a rat model","volume":"97-B","author":"Waki","year":"2015","journal-title":"Bone Jt. J."},{"key":"ref_132","doi-asserted-by":"crossref","first-page":"470","DOI":"10.1038\/s41419-019-1693-z","article-title":"miR-381 modulates human bone mesenchymal stromal cells (BMSCs) osteogenesis via suppressing Wnt signaling pathway during atrophic nonunion development","volume":"10","author":"Long","year":"2019","journal-title":"Cell Death Dis."},{"key":"ref_133","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1186\/s13018-020-01685-8","article-title":"miR-1323 suppresses bone mesenchymal stromal cell osteogenesis and fracture healing via inhibiting BMP4\/SMAD4 signaling","volume":"15","author":"Xie","year":"2020","journal-title":"J. Orthop. Surg. Res."},{"key":"ref_134","doi-asserted-by":"crossref","first-page":"e21653","DOI":"10.1097\/MD.0000000000021653","article-title":"Experimental study of expression profile and specific role of human microRNAs in regulating atrophic bone nonunion","volume":"99","author":"Wei","year":"2020","journal-title":"Medicine"},{"key":"ref_135","doi-asserted-by":"crossref","unstructured":"Kaneto, C.M., Lima, P.S., Zanette, D.L., Prata, K.L., Pina Neto, J.M., de Paula, F.J., and Silva Jr, W.A. (2014). COL1A1 and miR-29b show lower expression levels during osteoblast differentiation of bone marrow stromal cells from Osteogenesis Imperfecta patients. BMC Med. Genet., 15.","DOI":"10.1186\/1471-2350-15-45"},{"key":"ref_136","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1016\/j.bone.2017.02.004","article-title":"Genetic causes and mechanisms of Osteogenesis Imperfecta","volume":"102","author":"Lim","year":"2017","journal-title":"Bone"},{"key":"ref_137","doi-asserted-by":"crossref","first-page":"1105","DOI":"10.1016\/j.biopha.2016.08.025","article-title":"Ossotide promotes cell differentiation of human osteoblasts from osteogenesis imperfecta patients by up-regulating miR-145","volume":"83","author":"Sun","year":"2016","journal-title":"Biomed. Pharmacother."},{"key":"ref_138","first-page":"81","article-title":"Serum microRNA is a promising biomarker for osteogenesis imperfecta","volume":"1","author":"Wang","year":"2012","journal-title":"Intractable Rare Dis. Res."},{"key":"ref_139","doi-asserted-by":"crossref","first-page":"1933","DOI":"10.1182\/blood-2011-12-400085","article-title":"Transplanted bone marrow mononuclear cells and MSCs impart clinical benefit to children with osteogenesis imperfecta through different mechanisms","volume":"120","author":"Otsuru","year":"2012","journal-title":"Blood"},{"key":"ref_140","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1016\/j.jcyt.2017.09.012","article-title":"Extracellular vesicles released from mesenchymal stromal cells stimulate bone growth in osteogenesis imperfecta","volume":"20","author":"Otsuru","year":"2018","journal-title":"Cytotherapy"},{"key":"ref_141","first-page":"1027","article-title":"Diagnosis and management of osteomyelitis","volume":"84","author":"Hatzenbuehler","year":"2011","journal-title":"Am. Fam. Physician"},{"key":"ref_142","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/j.jor.2016.10.004","article-title":"Osteomyelitis: Recent advances in pathophysiology and therapeutic strategies","volume":"14","author":"Birt","year":"2017","journal-title":"J. Orthop."},{"key":"ref_143","doi-asserted-by":"crossref","first-page":"2804","DOI":"10.1002\/jcb.25225","article-title":"The Role of MicroRNA, miR-24, and Its Target CHI3L1 in Osteomyelitis Caused by Staphylococcus aureus","volume":"116","author":"Jin","year":"2015","journal-title":"J. Cell. Biochem."},{"key":"ref_144","doi-asserted-by":"crossref","first-page":"e00362-19","DOI":"10.1128\/MCB.00362-19","article-title":"Long Noncoding RNA FAM83H-AS1 Modulates SpA-Inhibited Osteogenic Differentiation in Human Bone Mesenchymal Stem Cells","volume":"40","author":"Wu","year":"2020","journal-title":"Mol. Cell. Biol."},{"key":"ref_145","doi-asserted-by":"crossref","first-page":"7282","DOI":"10.1111\/jcmm.15294","article-title":"Cladophora glomerata enriched by biosorption with Mn(II) ions alleviates lipopolysaccharide-induced osteomyelitis-like model in MC3T3-E1, and 4B12 osteoclastogenesis","volume":"24","author":"Bourebaba","year":"2020","journal-title":"J. Cell. Mol. Med."},{"key":"ref_146","doi-asserted-by":"crossref","first-page":"1018","DOI":"10.1016\/j.jmii.2020.08.002","article-title":"Tumor necrosis factor-\u03b1 promotes Staphylococcus aureus-induced osteomyelitis through downregulating endothelial nitric oxide synthase","volume":"54","author":"Ma","year":"2021","journal-title":"J. Microbiol. Immunol. Infect."},{"key":"ref_147","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/j.mayocp.2015.11.007","article-title":"Multiple Myeloma: Diagnosis and Treatment","volume":"91","author":"Rajkumar","year":"2016","journal-title":"Mayo Clin. Proc."},{"key":"ref_148","doi-asserted-by":"crossref","first-page":"e538","DOI":"10.1016\/S1470-2045(14)70442-5","article-title":"International Myeloma Working Group updated criteria for the diagnosis of multiple myeloma","volume":"15","author":"Rajkumar","year":"2014","journal-title":"Lancet Oncol."},{"key":"ref_149","doi-asserted-by":"crossref","unstructured":"Handa, H., Murakami, Y., Ishihara, R., Kimura-Masuda, K., and Masuda, Y. (2019). The Role and Function of microRNA in the Pathogenesis of Multiple Myeloma. Cancers, 11.","DOI":"10.3390\/cancers11111738"},{"key":"ref_150","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1016\/j.bbrc.2011.09.063","article-title":"Overexpression of microRNA-29b induces apoptosis of multiple myeloma cells through down regulating Mcl-1","volume":"414","author":"Zhang","year":"2011","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_151","doi-asserted-by":"crossref","first-page":"17579","DOI":"10.1038\/srep17579","article-title":"Delivery of miR-34a by chitosan\/PLGA nanoplexes for the anticancer treatment of multiple myeloma","volume":"5","author":"Cosco","year":"2015","journal-title":"Sci. Rep."},{"key":"ref_152","doi-asserted-by":"crossref","first-page":"1601","DOI":"10.1007\/s00432-019-02896-1","article-title":"Clinical significance of circulatory microRNA-203 in serum as novel potential diagnostic marker for multiple myeloma","volume":"145","author":"Gupta","year":"2019","journal-title":"J. Cancer Res. Clin."},{"key":"ref_153","doi-asserted-by":"crossref","unstructured":"Yu, M., Yu, J., Zhang, Y., Sun, X., Sun, R., Xia, M., Li, S., and Cui, X. (2021). A novel circRNA-miRNA-mRNA network revealed exosomal circ-ATP10A as a biomarker for multiple myeloma angiogenesis. Bioengineered.","DOI":"10.1080\/21655979.2021.2012553"},{"key":"ref_154","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1186\/s43141-021-00138-x","article-title":"Epigenetic effects toward new insights as potential therapeutic target in B-thalassemia","volume":"19","author":"Eltaweel","year":"2021","journal-title":"J. Genet. Eng. Biotechnol."},{"key":"ref_155","doi-asserted-by":"crossref","first-page":"102523","DOI":"10.1016\/j.bcmd.2020.102523","article-title":"MicroRNA expression patterns in HbE\/\u03b2-thalassemia patients: The passwords to unlock fetal hemoglobin expression in \u03b2-hemoglobinopathies","volume":"87","author":"Das","year":"2021","journal-title":"Blood Cells Mol. Dis."},{"key":"ref_156","doi-asserted-by":"crossref","first-page":"3909","DOI":"10.1007\/s11033-020-05483-7","article-title":"miR-30a regulates \u03b3-globin expression in erythoid precursors of intermedia thalassemia through targeting BCL11A","volume":"47","author":"Gholampour","year":"2020","journal-title":"Mol. Biol. Rep."},{"key":"ref_157","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1016\/j.amjms.2021.02.011","article-title":"MicroRNAs in \u03b2-thalassemia","volume":"362","author":"Wang","year":"2021","journal-title":"Am. J. Med. Sci."},{"key":"ref_158","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1080\/03630269.2019.1628043","article-title":"Anemia Severity in \u03b2-Thalassemia Correlates with Elevated Levels of microRNA-125b in Activated Phagocytic Monocytes","volume":"43","author":"Kuno","year":"2019","journal-title":"Hemoglobin"},{"key":"ref_159","doi-asserted-by":"crossref","first-page":"337","DOI":"10.3389\/fendo.2019.00337","article-title":"Recent Advances in the Genetics of Fractures in Osteoporosis","volume":"10","author":"Koromani","year":"2019","journal-title":"Front. Endocrinol."},{"key":"ref_160","doi-asserted-by":"crossref","first-page":"1147","DOI":"10.1111\/bcp.13803","article-title":"Genetic approaches to metabolic bone diseases","volume":"85","author":"Hannan","year":"2019","journal-title":"Br. J. Clin. Pharmacol."},{"key":"ref_161","doi-asserted-by":"crossref","first-page":"115760","DOI":"10.1016\/j.bone.2020.115760","article-title":"The role of microRNAs in bone development","volume":"143","author":"Hensley","year":"2021","journal-title":"Bone"},{"key":"ref_162","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1016\/j.mce.2017.06.008","article-title":"Vitamin D endocrinology of bone mineralization","volume":"453","year":"2017","journal-title":"Mol. Cell. Endocrinol."},{"key":"ref_163","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1615\/CritRevEukaryotGeneExpr.2013007147","article-title":"Vitamin D and microRNAs in bone","volume":"23","author":"Lisse","year":"2013","journal-title":"Crit. Rev. Eukaryot. Gene Expr."},{"key":"ref_164","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1016\/j.jbo.2016.05.001","article-title":"miRNA-223 is a potential diagnostic and prognostic marker for osteosarcoma","volume":"5","author":"Dong","year":"2016","journal-title":"J. Bone Oncol."},{"key":"ref_165","doi-asserted-by":"crossref","first-page":"15861","DOI":"10.1038\/s41598-017-16113-x","article-title":"miRNAs in bone tissue correlate to bone mineral density and circulating miRNAs are gender independent in osteoporotic patients","volume":"7","author":"Kelch","year":"2017","journal-title":"Sci. Rep."},{"key":"ref_166","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1186\/s40659-020-00309-z","article-title":"The roles of miRNA, lncRNA and circRNA in the development of osteoporosis","volume":"53","author":"Yang","year":"2020","journal-title":"Biol. Res."},{"key":"ref_167","doi-asserted-by":"crossref","first-page":"111942","DOI":"10.1016\/j.biopha.2021.111942","article-title":"Contribution of miRNAs and lncRNAs in osteogenesis and related disorders","volume":"142","author":"Abak","year":"2021","journal-title":"Biomed. Pharmacother."},{"key":"ref_168","doi-asserted-by":"crossref","first-page":"S140","DOI":"10.4103\/2230-8210.104023","article-title":"Metabolic bone disease: Newer perspectives","volume":"16","author":"Bhansali","year":"2012","journal-title":"Indian J. Endocrinol. Metab."},{"key":"ref_169","doi-asserted-by":"crossref","first-page":"478","DOI":"10.3389\/fgene.2019.00478","article-title":"The Potential for microRNA Therapeutics and Clinical Research","volume":"10","author":"Hanna","year":"2019","journal-title":"Front. Genet."},{"key":"ref_170","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1111\/apt.13432","article-title":"Miravirsen dosing in chronic hepatitis C patients results in decreased microRNA-122 levels without affecting other microRNAs in plasma","volume":"43","author":"Ottosen","year":"2016","journal-title":"Aliment. Pharmacol. Ther."},{"key":"ref_171","doi-asserted-by":"crossref","first-page":"699","DOI":"10.1111\/jvh.13282","article-title":"Randomized clinical trials towards a single-visit cure for chronic hepatitis C: Oral GSK2878175 and injectable RG-101 in chronic hepatitis C patients and long-acting injectable GSK2878175 in healthy participants","volume":"27","author":"Deng","year":"2020","journal-title":"J. Viral Hepat."},{"key":"ref_172","doi-asserted-by":"crossref","first-page":"1630","DOI":"10.1038\/s41416-020-0802-1","article-title":"Phase 1 study of MRX34, a liposomal miR-34a mimic, in patients with advanced solid tumours","volume":"122","author":"Hong","year":"2020","journal-title":"Br. J. Cancer"},{"key":"ref_173","doi-asserted-by":"crossref","first-page":"109548","DOI":"10.1016\/j.cellsig.2020.109548","article-title":"Modulation of polycystic kidney disease by non-coding RNAs","volume":"71","author":"Ramalingam","year":"2020","journal-title":"Cell. Signal."},{"key":"ref_174","doi-asserted-by":"crossref","first-page":"4148","DOI":"10.1038\/s41467-019-11918-y","article-title":"Discovery and preclinical evaluation of anti-miR-17 oligonucleotide RGLS4326 for the treatment of polycystic kidney disease","volume":"10","author":"Lee","year":"2019","journal-title":"Nat. Commun."},{"key":"ref_175","doi-asserted-by":"crossref","first-page":"761","DOI":"10.1172\/JCI84424","article-title":"Targeting noncoding RNAs in disease","volume":"127","author":"Adams","year":"2017","journal-title":"J. Clin. Investig."},{"key":"ref_176","doi-asserted-by":"crossref","unstructured":"Leimena, C., and Qiu, H. (2018). Non-Coding RNA in the Pathogenesis, Progression and Treatment of Hypertension. Int. J. Mol. Sci., 19.","DOI":"10.3390\/ijms19040927"},{"key":"ref_177","first-page":"961","article-title":"Insights into role of microRNAs in cardiac development, cardiac diseases, and developing novel therapies","volume":"23","author":"Arabian","year":"2020","journal-title":"Iran. J. Basic Med. Sci."}],"container-title":["Molecules"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1420-3049\/27\/1\/211\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T07:55:50Z","timestamp":1760169350000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1420-3049\/27\/1\/211"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,12,30]]},"references-count":177,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2022,1]]}},"alternative-id":["molecules27010211"],"URL":"https:\/\/doi.org\/10.3390\/molecules27010211","relation":{},"ISSN":["1420-3049"],"issn-type":[{"value":"1420-3049","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,12,30]]}}}