{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T05:35:09Z","timestamp":1790055309686,"version":"4.0.1"},"reference-count":73,"publisher":"MDPI AG","issue":"1","license":[{"start":{"date-parts":[[2021,12,31]],"date-time":"2021-12-31T00:00:00Z","timestamp":1640908800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100002261","name":"Russian Foundation for Basic Research","doi-asserted-by":"publisher","award":["20-34-90014"],"award-info":[{"award-number":["20-34-90014"]}],"id":[{"id":"10.13039\/501100002261","id-type":"DOI","asserted-by":"publisher"}]},{"name":"state assignment of the SSC RAS","award":["AAAA-A19-119040390083-6"],"award-info":[{"award-number":["AAAA-A19-119040390083-6"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>The effect of a reduced deuterium (D) content in the incubation medium on the survival of cultured neurons in vitro and under glucose deprivation was studied. In addition, we studied the effect of a decrease in the deuterium content in the rat brain on oxidative processes in the nervous tissue, its antioxidant protection, and training of rats in the T-shaped maze test under hypoxic conditions. For experiments with cultures of neurons, 7\u20138-day cultures of cerebellar neurons were used. Determination of the rate of neuronal death in cultures was carried out using propidium iodide. Acute hypoxia with hypercapnia was simulated in rats by placing them in sealed vessels with a capacity of 1 L. The effect on oxidative processes in brain tissues was assessed by changes in the level of free radical oxidation and malondialdehyde. The effect on the antioxidant system of the brain was assessed by the activity of catalase. The study in the T-maze was carried out in accordance with the generally accepted methodology, the skill of alternating right-sided and left-sided loops on positive reinforcement was developed. This work has shown that a decrease in the deuterium content in the incubation medium to a level of \u2212357\u2030 has a neuroprotective effect, increasing the survival rate of cultured neurons under glucose deprivation. When exposed to hypoxia, a preliminary decrease in the deuterium content in the rat brain to \u2212261\u2030 prevents the development of oxidative stress in their nervous tissue and preserves the learning ability of animals in the T-shaped maze test at the level of the control group. A similar protective effect during the modification of the 2H\/1H internal environment of the body by the consumption of DDW can potentially be used for the prevention of pathological conditions associated with the development of oxidative stress with damage to the central nervous system.<\/jats:p>","DOI":"10.3390\/molecules27010243","type":"journal-article","created":{"date-parts":[[2022,1,3]],"date-time":"2022-01-03T20:49:38Z","timestamp":1641242978000},"page":"243","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":24,"title":["Reduction of Deuterium Level Supports Resistance of Neurons to Glucose Deprivation and Hypoxia: Study in Cultures of Neurons and on Animals"],"prefix":"10.3390","volume":"27","author":[{"given":"Alexandr","family":"Kravtsov","sequence":"first","affiliation":[{"name":"Department of Radiophysics and Nanothechnology, Physics Faculty, Kuban State University, 350040 Krasnodar, Russia"},{"name":"South Scientific Center of the Russian Academy of Sciences, Laboratory of Problems of Stable Isotope Spreading in Living Systems, 344006 Rostov-on-Don, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stanislav","family":"Kozin","sequence":"additional","affiliation":[{"name":"Department of Radiophysics and Nanothechnology, Physics Faculty, Kuban State University, 350040 Krasnodar, Russia"},{"name":"South Scientific Center of the Russian Academy of Sciences, Laboratory of Problems of Stable Isotope Spreading in Living Systems, 344006 Rostov-on-Don, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2262-4549","authenticated-orcid":false,"given":"Alexandr","family":"Basov","sequence":"additional","affiliation":[{"name":"Department of Radiophysics and Nanothechnology, Physics Faculty, Kuban State University, 350040 Krasnodar, Russia"},{"name":"Department of Fundamental and Clinical Biochemistry, Kuban State Medical University, 350063 Krasnodar, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elena","family":"Butina","sequence":"additional","affiliation":[{"name":"Department of Technology of Fats, Cosmetics, Commodity Science, Processes and Devices, Kuban State Technological University, 350072 Krasnodar, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mikhail","family":"Baryshev","sequence":"additional","affiliation":[{"name":"Department of Radiophysics and Nanothechnology, Physics Faculty, Kuban State University, 350040 Krasnodar, Russia"},{"name":"South Scientific Center of the Russian Academy of Sciences, Laboratory of Problems of Stable Isotope Spreading in Living Systems, 344006 Rostov-on-Don, Russia"},{"name":"Department of Technology of Fats, Cosmetics, Commodity Science, Processes and Devices, Kuban State Technological University, 350072 Krasnodar, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1323-0828","authenticated-orcid":false,"given":"Vadim","family":"Malyshko","sequence":"additional","affiliation":[{"name":"South Scientific Center of the Russian Academy of Sciences, Laboratory of Problems of Stable Isotope Spreading in Living Systems, 344006 Rostov-on-Don, Russia"},{"name":"Department of Fundamental and Clinical Biochemistry, Kuban State Medical University, 350063 Krasnodar, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arkady","family":"Moiseev","sequence":"additional","affiliation":[{"name":"Department of Organization and Support of Scientific Activities, Kuban State Agrarian University, 350044 Krasnodar, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9452-0132","authenticated-orcid":false,"given":"Anna","family":"Elkina","sequence":"additional","affiliation":[{"name":"Department of Radiophysics and Nanothechnology, Physics Faculty, Kuban State University, 350040 Krasnodar, Russia"},{"name":"South Scientific Center of the Russian Academy of Sciences, Laboratory of Problems of Stable Isotope Spreading in Living Systems, 344006 Rostov-on-Don, Russia"},{"name":"Department of Physics, K.G. Razumovsky Moscow State University of Technologies and Management (The First Cossack University), 109004 Moscow, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stepan","family":"Dzhimak","sequence":"additional","affiliation":[{"name":"Department of Radiophysics and Nanothechnology, Physics Faculty, Kuban State University, 350040 Krasnodar, Russia"},{"name":"South Scientific Center of the Russian Academy of Sciences, Laboratory of Problems of Stable Isotope Spreading in Living Systems, 344006 Rostov-on-Don, Russia"},{"name":"The V.M. Gorbatov Federal Research Center for Food Systems of the Russian Academy of Sciences, Experimental Clinic\u2014Laboratory of Biologically Active Substances of Animal Origin, 109316 Moscow, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2021,12,31]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1007\/s12223-019-00740-0","article-title":"Deuterium and its impact on living organisms","volume":"64","year":"2019","journal-title":"Folia Microbiol."},{"key":"ref_2","doi-asserted-by":"crossref","unstructured":"Basov, A., Fedulova, L., Baryshev, M., and Dzhimak, S. (2019). Deuterium-depleted water influence on the isotope 2H\/1H regulation in body and individual adaptation. Nutrients, 11.","DOI":"10.3390\/nu11081903"},{"key":"ref_3","doi-asserted-by":"crossref","unstructured":"Basov, A., Fedulova, L., Vasilevskaya, E., and Dzhimak, S. (2019). 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