{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T22:21:32Z","timestamp":1792621292571,"version":"4.5.0"},"reference-count":234,"publisher":"MDPI AG","issue":"1","license":[{"start":{"date-parts":[[2022,1,4]],"date-time":"2022-01-04T00:00:00Z","timestamp":1641254400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>Endophytic fungi are microorganisms that exist almost ubiquitously inside the various tissues of living plants where they act as an important reservoir of diverse bioactive compounds. Recently, endophytic fungi have drawn tremendous attention from researchers; their isolation, culture, purification, and characterization have revealed the presence of around 200 important and diverse compounds including anticancer agents, antibiotics, antifungals, antivirals, immunosuppressants, and antimycotics. Many of these anticancer compounds, such as paclitaxel, camptothecin, vinblastine, vincristine, podophyllotoxin, and their derivatives, are currently being used clinically for the treatment of various cancers (e.g., ovarian, breast, prostate, lung cancers, and leukemias). By increasing the yield of specific compounds with genetic engineering and other biotechnologies, endophytic fungi could be a promising, prolific source of anticancer drugs. In the future, compounds derived from endophytic fungi could increase treatment availability and cost effectiveness. This comprehensive review includes the putative anticancer compounds from plant-derived endophytic fungi discovered from 1990 to 2020 with their source endophytic fungi and host plants as well as their antitumor activity against various cell lines.<\/jats:p>","DOI":"10.3390\/molecules27010296","type":"journal-article","created":{"date-parts":[[2022,1,7]],"date-time":"2022-01-07T03:46:27Z","timestamp":1641527187000},"page":"296","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":77,"title":["Putative Anticancer Compounds from Plant-Derived Endophytic Fungi: A Review"],"prefix":"10.3390","volume":"27","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7766-5321","authenticated-orcid":false,"given":"Md.","family":"Hridoy","sequence":"first","affiliation":[{"name":"Department of Pharmacy, University of Dhaka, Dhaka 1000, Bangladesh"},{"name":"Department of Pharmaceutical Sciences, School of Pharmacy, Temple University, Philadelphia, PA 19140, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Md. Zobayer Hossain","family":"Gorapi","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, University of Asia Pacific, Dhaka 1215, Bangladesh"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sadia","family":"Noor","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, University of Asia Pacific, Dhaka 1215, Bangladesh"},{"name":"Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Dhaka, Dhaka 1000, Bangladesh"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nargis Sultana","family":"Chowdhury","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Manarat International University, Dhaka 1343, Bangladesh"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8585-263X","authenticated-orcid":false,"given":"Md. Mustafizur","family":"Rahman","sequence":"additional","affiliation":[{"name":"Pharmacy Discipline, Khulna University, Khulna 9208, Bangladesh"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isabella","family":"Muscari","sequence":"additional","affiliation":[{"name":"Department of Medicine and Surgery, University of Perugia, 06132 Perugia, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesco","family":"Masia","sequence":"additional","affiliation":[{"name":"Department of Medicine and Surgery, University of Perugia, 06132 Perugia, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sabrina","family":"Adorisio","sequence":"additional","affiliation":[{"name":"Department of Medicine and Surgery, Foligno Nursing School and Section of Pharmacology, University of Perugia, Piazzale Severi, S. Andrea delle Fratte, 06129 Perugia, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1792-9468","authenticated-orcid":false,"given":"Domenico V.","family":"Delfino","sequence":"additional","affiliation":[{"name":"Department of Medicine and Surgery, Foligno Nursing School and Section of Pharmacology, University of Perugia, Piazzale Severi, S. Andrea delle Fratte, 06129 Perugia, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2190-2591","authenticated-orcid":false,"given":"Md. Abdul","family":"Mazid","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, University of Dhaka, Dhaka 1000, Bangladesh"},{"name":"Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Dhaka, Dhaka 1000, Bangladesh"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,1,4]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Verma, V.C., and Gange, A.C. (2014). Endophytic Fungi: Novel Sources of Anticancer Molecules. Advances in Endophytic Research, Springer.","DOI":"10.1007\/978-81-322-1575-2"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1021\/np058128n","article-title":"Natural Products from Plant-Associated Microorganisms: Distribution, Structural Diversity, Bioactivity, and Implications of Their Occurrence","volume":"69","author":"Gunatilaka","year":"2006","journal-title":"J. Nat. Prod."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"753","DOI":"10.1039\/b609472b","article-title":"Biology and Chemistry of Endophytes","volume":"23","author":"Zhang","year":"2006","journal-title":"Nat. Prod. Rep."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s13225-010-0034-4","article-title":"Fungal Endophytes from Higher Plants: A Prolific Source of Phytochemicals and Other Bioactive Natural Products","volume":"41","author":"Aly","year":"2010","journal-title":"Fungal Divers."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1080\/17429140801886293","article-title":"Endophytes: Exploiting Biodiversity for the Improvement of Natural Product-Based Drug Discovery","volume":"3","author":"Staniek","year":"2008","journal-title":"J. Plant Interact."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1126\/science.8097061","article-title":"Taxol and Taxane Production by Taxomyces Andreanae, an Endophytic Fungus of Pacific Yew","volume":"260","author":"Stierle","year":"1993","journal-title":"Sci.-N. Y. THEN Wash."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"861","DOI":"10.1016\/j.toxrep.2016.10.005","article-title":"Cytotoxic and Antibacterial Naphthoquinones from an Endophytic Fungus, Cladosporium sp.","volume":"3","author":"Khan","year":"2016","journal-title":"Toxicol. Rep."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"970","DOI":"10.1016\/j.toxrep.2018.08.016","article-title":"Endophytic Fusarium Solani: A Rich Source of Cytotoxic and Antimicrobial Napthaquinone and Aza-Anthraquinone Derivatives","volume":"5","author":"Khan","year":"2018","journal-title":"Toxicol. Rep."},{"key":"ref_9","doi-asserted-by":"crossref","unstructured":"Adorisio, S., Fierabracci, A., Muscari, I., Liberati, A.M., Cannarile, L., Thuy, T.T., Sung, T.V., Sohrab, H., Hasan, C.M., and Ayroldi, E. (2019). Fusarubin and Anhydrofusarubin Isolated from a Cladosporium Species Inhibit Cell Growth in Human Cancer Cell Lines. Toxins, 11.","DOI":"10.3390\/toxins11090503"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/j.phytochem.2009.09.030","article-title":"Endophytic Fungal Strains of Fusarium Solani, from Apodytes Dimidiata E. Mey. Ex Arn (Icacinaceae) Produce Camptothecin, 10-Hydroxycamptothecin and 9-Methoxycamptothecin","volume":"71","author":"Shweta","year":"2010","journal-title":"Phytochemistry"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"1717","DOI":"10.1021\/np0502802","article-title":"An Endophytic Fungus from Nothapodytes Foetida That Produces Camptothecin","volume":"68","author":"Puri","year":"2005","journal-title":"J. Nat. Prod."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"1121","DOI":"10.1021\/np060174f","article-title":"Endophyte Fungal Isolates from Podophyllum Peltatum Produce Podophyllotoxin","volume":"69","author":"Eyberger","year":"2006","journal-title":"J. Nat. Prod."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"1019","DOI":"10.1111\/j.1365-2672.2009.04285.x","article-title":"Aspergillus Fumigatus Fresenius, an Endophytic Fungus from Juniperus Communis L. Horstmann as a Novel Source of the Anticancer pro-Drug Deoxypodophyllotoxin","volume":"107","author":"Kusari","year":"2009","journal-title":"J. Appl. Microbiol."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1016\/S1074-5521(97)90325-2","article-title":"Glucosylation of the Peptide Leucinostatin A, Produced by an Endophytic Fungus of European Yew, May Protect the Host from Leucinostatin Toxicity","volume":"4","author":"Strobel","year":"1997","journal-title":"Chem. Biol."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1038\/ja.2014.103","article-title":"Allantopyrone A, an \u03b1-Pyrone Metabolite from an Endophytic Fungus, Inhibits the Tumor Necrosis Factor \u03b1-Induced Nuclear Factor \u039aB Signaling Pathway","volume":"68","author":"Yokoigawa","year":"2015","journal-title":"J. Antibiot."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"972","DOI":"10.1021\/np070447m","article-title":"Cytotoxic Metabolites from the Fungal Endophyte Alternaria sp. and Their Subsequent Detection in Its Host Plant Polygonum Senegalense","volume":"71","author":"Aly","year":"2008","journal-title":"J. Nat. Prod."},{"key":"ref_17","first-page":"329","article-title":"Demonstration of the Lapachol as a Potential Drug for Reducing Cancer Metastasis","volume":"13","author":"Balassiano","year":"2005","journal-title":"Oncol. Rep."},{"key":"ref_18","first-page":"129","article-title":"First Report of Anticancer Agent, Lapachol Producing Endophyte, Aspergillus Niger of Tabebuia Argentea and Its in Vitro Cytotoxicity Assays","volume":"9","author":"Govindappa","year":"2014","journal-title":"Bangladesh J. Pharmacol."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"2169","DOI":"10.1271\/bbb.70103","article-title":"Induction of Egr-1 Is Associated with Anti-Metastatic and Anti-Invasive Ability of \u03b2-Lapachone in Human Hepatocarcinoma Cells","volume":"71","author":"KIM","year":"2007","journal-title":"Biosci. Biotechnol. Biochem."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1016\/j.phrs.2005.02.004","article-title":"Down-Regulation of Cyclooxygenase-2 and Telomerase Activity by \u03b2-Lapachone in Human Prostate Carcinoma Cells","volume":"51","author":"Lee","year":"2005","journal-title":"Pharmacol. Res."},{"key":"ref_21","first-page":"3643","article-title":"Antimicrobial and Antioxidant Activities of Endophytes from Tabebuia Argentea and Identification of Anticancer Agent (Lapachol)","volume":"5","author":"Sadananda","year":"2011","journal-title":"J. Med. Plants Res."},{"key":"ref_22","first-page":"1876","article-title":"Induction of Apoptosis in MCF-7:WS8 Breast Cancer Cells by \u03b2-Lapachone","volume":"58","author":"Wuerzberger","year":"1998","journal-title":"Cancer Res."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"2840","DOI":"10.3390\/md12052840","article-title":"Three New Resveratrol Derivatives from the Mangrove Endophytic Fungus Alternaria sp.","volume":"12","author":"Wang","year":"2014","journal-title":"Mar. Drugs"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"832","DOI":"10.3390\/md9050832","article-title":"Three Bianthraquinone Derivatives from the Mangrove Endophytic Fungus Alternaria sp. ZJ9-6B from the South China Sea","volume":"9","author":"Huang","year":"2011","journal-title":"Mar. Drugs"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1016\/j.phytochem.2013.12.001","article-title":"Capsaicin Production by Alternaria Alternata, an Endophytic Fungus from Capsicum Annum; LC\u2013ESI\u2013MS\/MS Analysis","volume":"98","author":"Devari","year":"2014","journal-title":"Phytochemistry"},{"key":"ref_26","first-page":"337","article-title":"Endophytic Fungi from Miquelia Dentata Bedd., Produce the Anti-Cancer Alkaloid, Camptothecine","volume":"20","author":"Shweta","year":"2013","journal-title":"Phytomed. Int. J. Phytother. Phytopharm."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1007\/s13213-017-1263-5","article-title":"Isolation and Characterization of Anticancer Flavone Chrysin (5,7-Dihydroxy Flavone)-Producing Endophytic Fungi from Passiflora Incarnata L. Leaves","volume":"67","author":"Seetharaman","year":"2017","journal-title":"Ann. Microbiol."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/j.fitote.2014.09.015","article-title":"Bioactive Metabolites from the Endophytic Fungus Alternaria Alternata","volume":"99","author":"Wang","year":"2014","journal-title":"Fitoterapia"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1016\/j.cclet.2011.11.021","article-title":"A New Isocoumarin from Metabolites of the Endophytic Fungus Alternaria Tenuissima (Nees & T. Nees: Fr.) Wiltshire","volume":"23","author":"Fang","year":"2012","journal-title":"Chin. Chem. Lett."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"1384","DOI":"10.1080\/14786419.2015.1025230","article-title":"Chemical Investigation of Metabolites Produced by an Endophytic Aspergillus sp. Isolated from Limonia Acidissima","volume":"29","author":"Siriwardane","year":"2015","journal-title":"Nat. Prod. Res."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1111\/j.1574-695X.2002.tb00602.x","article-title":"Brefeldin A, a Cytotoxin Produced by Paecilomyces sp. and Aspergillus Clavatus Isolated from Taxus Mairei and Torreya Grandis","volume":"34","author":"Wang","year":"2002","journal-title":"FEMS Immunol. Med. Microbiol."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"753","DOI":"10.1021\/np800700e","article-title":"Bioactive Alkaloids from Endophytic Aspergillus Fumigatus","volume":"72","author":"Ge","year":"2009","journal-title":"J. Nat. Prod."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"1424","DOI":"10.3390\/molecules20011424","article-title":"An Alkaloid and a Steroid from the Endophytic Fungus Aspergillus Fumigatus","volume":"20","author":"Liang","year":"2015","journal-title":"Molecules"},{"key":"ref_34","first-page":"391","article-title":"Antioxidant and Antitumor Activity of a New Sesquiterpene Isolated from Endophytic Fungus Aspergillus Glaucus","volume":"5.2","author":"Asker","year":"2013","journal-title":"Int. J. PharmTech Res."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"1787","DOI":"10.1021\/np200381u","article-title":"Nigerapyrones A-H, \u03b1-Pyrone Derivatives from the Marine Mangrove-Derived Endophytic Fungus Aspergillus Niger MA-132","volume":"74","author":"Liu","year":"2011","journal-title":"J. Nat. Prod."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/j.femsle.2004.10.005","article-title":"Endophytic Naphthopyrone Metabolites Are Co-Inhibitors of Xanthine Oxidase, SW1116 Cell and Some Microbial Growths","volume":"241","author":"Song","year":"2004","journal-title":"FEMS Microbiol. Lett."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"5479","DOI":"10.1021\/jo990277l","article-title":"Sequoiatones A and B: Novel Antitumor Metabolites Isolated from a Redwood Endophyte","volume":"64","author":"Stierle","year":"1999","journal-title":"J. Org. Chem."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"4966","DOI":"10.1021\/jo0340253","article-title":"Sequoiamonascins A\u2013D: Novel Anticancer Metabolites Isolated from a Redwood Endophyte","volume":"68","author":"Stierle","year":"2003","journal-title":"J. Org. Chem."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1007\/s11274-017-2228-3","article-title":"Bioactive Compounds of Aspergillus Terreus\u2014F7, an Endophytic Fungus from Hyptis Suaveolens (L.) Poit","volume":"33","author":"Brissow","year":"2017","journal-title":"World J. Microbiol. Biotechnol."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"1334","DOI":"10.3389\/fmicb.2017.01334","article-title":"Isolation and Characterization of \u201cTerrein\u201d an Antimicrobial and Antitumor Compound from Endophytic Fungus Aspergillus Terreus (JAS-2) Associated from Achyranthus Aspera Varanasi, India","volume":"8","author":"Goutam","year":"2017","journal-title":"Front. Microbiol."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"1236","DOI":"10.1021\/np401017g","article-title":"Cytotoxic Alkylated Hydroquinone, Phenol, and Cyclohexenone Derivatives from Aspergillus Violaceofuscus Gasperini","volume":"77","author":"Myobatake","year":"2014","journal-title":"J. Nat. Prod."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"717","DOI":"10.1007\/s11274-007-9530-4","article-title":"Taxol, an Anticancer Drug Produced by an Endophytic Fungus Bartalinia Robillardoides Tassi, Isolated from a Medicinal Plant, Aegle Marmelos Correa Ex Roxb","volume":"24","author":"Gangadevi","year":"2008","journal-title":"World J. Microbiol. Biotechnol."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"1361","DOI":"10.1021\/np060190c","article-title":"Depsidones from the Endophytic Fungus BCC 8616","volume":"69","author":"Pittayakhajonwut","year":"2006","journal-title":"J. Nat. Prod."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"2151","DOI":"10.1021\/np400988a","article-title":"Bioactive Spirobisnaphthalenes from the Endophytic Fungus Berkleasmium sp.","volume":"77","author":"Shan","year":"2014","journal-title":"J. Nat. Prod."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"1081","DOI":"10.3390\/md10051081","article-title":"Pullularins E and F, Two New Peptides from the Endophytic Fungus Bionectria Ochroleuca Isolated from the Mangrove Plant Sonneratia Caseolaris","volume":"10","author":"Ebrahim","year":"2012","journal-title":"Mar. Drugs"},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"1455","DOI":"10.1080\/14786419.2015.1062760","article-title":"Anticancer Activity of Ophiobolin A, Isolated from the Endophytic Fungus Bipolaris Setariae","volume":"30","author":"Bhatia","year":"2016","journal-title":"Nat. Prod. Res."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"3584","DOI":"10.1021\/jf500054f","article-title":"Secondary Metabolites from the Endophytic Botryosphaeria Dothidea of Melia Azedarach and Their Antifungal, Antibacterial, Antioxidant, and Cytotoxic Activities","volume":"62","author":"Xiao","year":"2014","journal-title":"J. Agric. Food Chem."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1016\/j.phytochem.2009.09.024","article-title":"Botryorhodines A\u2013D, Antifungal and Cytotoxic Depsidones from Botryosphaeria Rhodina, an Endophyte of the Medicinal Plant Bidens Pilosa","volume":"71","author":"Abdou","year":"2010","journal-title":"Phytochemistry"},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"873","DOI":"10.1021\/np4009688","article-title":"Guanacastane Diterpenoids from the Plant Endophytic Fungus Cercospora sp.","volume":"77","author":"Feng","year":"2014","journal-title":"J. Nat. Prod."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1016\/j.phytochem.2013.07.025","article-title":"Ceriponols A-K, Tremulane Sesquitepenes from Ceriporia Lacerate HS-ZJUT-C13A, a Fungal Endophyte of Huperzia Serrata","volume":"95","author":"Ying","year":"2013","journal-title":"Phytochemistry"},{"key":"ref_51","first-page":"229","article-title":"Bioactive Secondary Metabolites from the Endophytic Fungus Chaetomium sp. Isolated from Salvia Officinalis Growing in Morocco","volume":"13","author":"Debbab","year":"2009","journal-title":"Biotechnol. Agron. Soc. Environ."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1016\/j.fitote.2017.06.021","article-title":"Secondary Metabolites from Endophytic Fungus Chaetomium sp. Induce Colon Cancer Cell Apoptotic Death","volume":"121","author":"Wang","year":"2017","journal-title":"Fitoterapia"},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"9294","DOI":"10.1038\/srep09294","article-title":"Indole Diketopiperazines from Endophytic Chaetomium Sp 88194 Induce Breast Cancer Cell Apoptotic Death","volume":"5","author":"Wang","year":"2015","journal-title":"Sci. Rep."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"5709","DOI":"10.1021\/ol062257t","article-title":"Chaetominine, a Cytotoxic Alkaloid Produced by Endophytic Chaetomium sp. IFB-E015","volume":"8","author":"Jiao","year":"2006","journal-title":"Org. Lett."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1021\/np058095b","article-title":"Search for Hsp90 Inhibitors with Potential Anticancer Activity: Isolation and SAR Studies of Radicicol and Monocillin I from Two Plant-Associated Fungi of the Sonoran Desert","volume":"69","author":"Turbyville","year":"2006","journal-title":"J. Nat. Prod."},{"key":"ref_56","first-page":"364","article-title":"Bioactive Metabolites from Chaetomium Globosum L18, an Endophytic Fungus in the Medicinal Plant Curcuma Wenyujin","volume":"19","author":"Wang","year":"2012","journal-title":"Phytomed. Int. J. Phytother. Phytopharm."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1021\/np050515+","article-title":"Chaetoglobosin U, a Cytochalasan Alkaloid from Endophytic Chaetomium Globosum IFB-E019","volume":"69","author":"Ding","year":"2006","journal-title":"J. Nat. Prod."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"724","DOI":"10.1021\/np058014b","article-title":"Globosumones A- C, Cytotoxic Orsellinic Acid Esters from the Sonoran Desert Endophytic Fungus Chaetomium Globosum 1","volume":"68","author":"Bashyal","year":"2005","journal-title":"J. Nat. Prod."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"3734","DOI":"10.1021\/jf500390h","article-title":"Chaetoglobosins from Chaetomium Globosum, an Endophytic Fungus in Ginkgo Biloba, and Their Phytotoxic and Cytotoxic Activities","volume":"62","author":"Li","year":"2014","journal-title":"J. Agric. Food Chem."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1042\/BA20070243","article-title":"Taxol Production by Pestalotiopsis Terminaliae, an Endophytic Fungus of Terminalia Arjuna (Arjun Tree)","volume":"52","author":"Gangadevi","year":"2009","journal-title":"Biotechnol. Appl. Biochem."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1007\/s00284-008-9270-1","article-title":"An Endophytic Taxol-Producing Fungus from Taxus Media, Cladosporium Cladosporioides MD2","volume":"59","author":"Zhang","year":"2009","journal-title":"Curr. Microbiol."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1016\/j.saa.2014.11.036","article-title":"Anti-Proliferative Effect of Fungal Taxol Extracted from Cladosporium Oxysporum against Human Pathogenic Bacteria and Human Colon Cancer Cell Line HCT 15","volume":"138","author":"Manikandan","year":"2015","journal-title":"Spectrochim. Acta A Mol. Biomol. Spectrosc."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"6627","DOI":"10.7314\/APJCP.2014.15.16.6627","article-title":"Fungal Taxol Extracted from Cladosporium Oxysporum Induces Apoptosis in T47D Human Breast Cancer Cell Line","volume":"15","author":"Raj","year":"2014","journal-title":"Asian Pac. J. Cancer Prev."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1002\/elsc.201000119","article-title":"In Vitro Screening of Taxol, an Anticancer Drug Produced by the Fungus, Colletotrichum Capsici","volume":"11","author":"Kumaran","year":"2011","journal-title":"Eng. Life Sci."},{"key":"ref_65","first-page":"16379","article-title":"A New Endophytic Taxol-and Baccatin III-Producing Fungus Isolated from Taxus Chinensis Var. Mairei","volume":"10","author":"Wang","year":"2011","journal-title":"Afr. J. Biotechnol."},{"key":"ref_66","first-page":"57","article-title":"A New Macrolide Isolated from the Endophytic Fungus Colletotrichum sp.","volume":"6","author":"Bungihan","year":"2013","journal-title":"Philipp. Sci. Lett."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"1823","DOI":"10.1016\/j.bmcl.2015.03.059","article-title":"New Cytochalasins from Medicinal Macrofungus Crodyceps Taii and Their Inhibitory Activities against Human Cancer Cells","volume":"25","author":"Li","year":"2015","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"9699","DOI":"10.1021\/jo201755v","article-title":"Bioactive Nonanolide Derivatives Isolated from the Endophytic Fungus Cytospora sp.","volume":"76","author":"Lu","year":"2011","journal-title":"J. Org. Chem."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1038\/ja.2016.109","article-title":"Diapolic Acid A\u2013B from an Endophytic Fungus, Diaporthe Terebinthifolii Depicting Antimicrobial and Cytotoxic Activity","volume":"70","author":"Yedukondalu","year":"2017","journal-title":"J. Antibiot."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"1720","DOI":"10.1021\/np900316x","article-title":"\u03b3-Lactones and Ent-Eudesmane Sesquiterpenes from the Endophytic Fungus Eutypella sp. BCC 13199","volume":"72","author":"Isaka","year":"2009","journal-title":"J. Nat. Prod."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"777","DOI":"10.1016\/j.fitote.2011.04.002","article-title":"Chemical Constituents from Endophytic Fungus Fusarium Oxysporum","volume":"82","author":"Wang","year":"2011","journal-title":"Fitoterapia"},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"S1081","DOI":"10.1016\/S2221-1691(12)60365-7","article-title":"Taxol Producing Mangrove Endophytic Fungi Fusarium Oxysporum from Rhizophora Annamalayana","volume":"2","author":"Elavarasi","year":"2012","journal-title":"Asian Pac. J. Trop. Biomed."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1016\/j.jbiosc.2010.06.007","article-title":"Taxol Promising Fungal Endophyte, Pestalotiopsis Species Isolated from Taxus Cuspidata","volume":"110","author":"Kumaran","year":"2010","journal-title":"J. Biosci. Bioeng."},{"key":"ref_74","doi-asserted-by":"crossref","unstructured":"Palem, P.P.C., Kuriakose, G.C., and Jayabaskaran, C. (2015). An Endophytic Fungus, Talaromyces Radicus, Isolated from Catharanthus Roseus, Produces Vincristine and Vinblastine, Which Induce Apoptotic Cell Death. PLoS ONE, 10.","DOI":"10.1371\/journal.pone.0144476"},{"key":"ref_75","first-page":"805","article-title":"Preliminary Study on the Isolation of Endophytic Fungus of Catharanthus Roseus and Its Fermentation to Produce Products of Therapeutic Value","volume":"31","author":"Zhang","year":"2000","journal-title":"Chin. Tradit. Herb. Drugs"},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"868","DOI":"10.1016\/j.toxicon.2006.02.012","article-title":"Cytotoxicity of Enniatins A, A1, B, B1, B2 and B3 from Fusarium Avenaceum","volume":"47","author":"Ivanova","year":"2006","journal-title":"Toxicon Off. J. Int. Soc. Toxinology"},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1021\/np060394t","article-title":"Search for Cell Motility and Angiogenesis Inhibitors with Potential Anticancer Activity: Beauvericin and Other Constituents of Two Endophytic Strains of Fusarium Oxysporum","volume":"70","author":"Zhan","year":"2007","journal-title":"J. Nat. Prod."},{"key":"ref_78","first-page":"335","article-title":"New Potential Cytotoxic and Antitumor Substances I. In Vitro Effect of Bikaverin and Its Derivatives on Cells of Certain Tumors","volume":"22","author":"Fuska","year":"1975","journal-title":"Neoplasma"},{"key":"ref_79","first-page":"2493","article-title":"Fusarium Solani, P1, a New Endophytic Podophyllotoxin-Producing Fungus from Roots of Podophyllum Hexandrum","volume":"6","author":"Nadeem","year":"2012","journal-title":"Afr. J. Microbiol. Res."},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1021\/np800455b","article-title":"An Endophytic Fungus from Camptotheca Acuminata That Produces Camptothecin and Analogues","volume":"72","author":"Kusari","year":"2009","journal-title":"J. Nat. Prod."},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"838","DOI":"10.1111\/j.1365-2184.2009.00636.x","article-title":"Ecology-Based Screen Identifies New Metabolites from a Cordyceps-Colonizing Fungus as Cancer Cell Proliferation Inhibitors and Apoptosis Inducers","volume":"42","author":"Chen","year":"2009","journal-title":"Cell Prolif."},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/j.phytol.2011.11.010","article-title":"Tricycloalternarene Derivatives from the Endophytic Fungus Guignardia Bidwellii PSU-G11","volume":"5","author":"Sommart","year":"2012","journal-title":"Phytochem. Lett."},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"22900","DOI":"10.3390\/molecules201219890","article-title":"Guignardones P\u2013S, New Meroterpenoids from the Endophytic Fungus Guignardia Mangiferae A348 Derived from the Medicinal Plant Smilax Glabra","volume":"20","author":"Sun","year":"2015","journal-title":"Molecules"},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1111\/jam.12195","article-title":"Hypocrea Lixii, Novel Endophytic Fungi Producing Anticancer Agent Cajanol, Isolated from Pigeon Pea (Cajanus Cajan [L.] Millsp.)","volume":"115","author":"Zhao","year":"2013","journal-title":"J. Appl. Microbiol."},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1021\/np0604127","article-title":"Cytotoxic Benzo [j] Fluoranthene Metabolites from Hypoxylon Truncatum IFB-18, an Endophyte of Artemisia Annua","volume":"70","author":"Gu","year":"2007","journal-title":"J. Nat. Prod."},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1007\/s12272-001-1201-x","article-title":"Cytotoxic Activities of Trichothecenes Isolated from an Endophytic Fungus Belonging to Order Hypocreales","volume":"31","author":"Chinworrungsee","year":"2008","journal-title":"Arch. Pharm. Res."},{"key":"ref_87","first-page":"1428","article-title":"Isolation and Detection of Taxol, an Anticancer Drug Produced from Lasiodiplodia Theobromae, an Endophytic Fungus of the Medicinal Plant Morinda Citrifolia","volume":"10","author":"Pandi","year":"2011","journal-title":"Afr. J. Biotechnol."},{"key":"ref_88","first-page":"P671","article-title":"Resorcylic Lactones from Lasiodiplodia Theobromae (MUB65), a Fungal Endophyte Isolated from Myracrodruon Urundeuva","volume":"82","author":"Sobreira","year":"2016","journal-title":"Planta Med."},{"key":"ref_89","first-page":"79","article-title":"Preliminary Study of a Vincristine-Proudcing Endophytic Fungus Isolated from Leaves of Catharanthus Roseus","volume":"35","author":"Yang","year":"2004","journal-title":"Chin. Tradit. Herb. Drugs"},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"2059","DOI":"10.1021\/ol060434k","article-title":"Spiro-Mamakone A:\u2009 A Unique Relative of the Spirobisnaphthalene Class of Compounds","volume":"8","author":"Blunt","year":"2006","journal-title":"Org. Lett."},{"key":"ref_91","first-page":"835","article-title":"Chemical Constituents of the New Endophytic Fungus Mycosphaerella sp. Nov. and Their Anti-Parasitic Activity","volume":"6","author":"Moreno","year":"2011","journal-title":"Nat. Prod. Commun."},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1021\/np300806a","article-title":"Arundinols A\u2013C and Arundinones A and B from the Plant Endophytic Fungus Microsphaeropsis Arundinis","volume":"76","author":"Luo","year":"2013","journal-title":"J. Nat. Prod."},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"741","DOI":"10.1021\/np300792t","article-title":"Mycoleptodiscins A and B, Cytotoxic Alkaloids from the Endophytic Fungus Mycoleptodiscus sp. F0194","volume":"76","author":"Ortega","year":"2013","journal-title":"J. Nat. Prod."},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"2504","DOI":"10.1016\/j.bmcl.2014.04.016","article-title":"Myrotheciumones: Bicyclic Cytotoxic Lactones Isolated from an Endophytic Fungus of Ajuga Decumbens","volume":"24","author":"Lin","year":"2014","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"652","DOI":"10.1038\/ja.2016.86","article-title":"New Cytotoxic Trichothecene Macrolide Epimers from Endophytic Myrothecium Roridum IFB-E012","volume":"69","author":"Shen","year":"2016","journal-title":"J. Antibiot."},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1134\/S0003683808020130","article-title":"An Endophytic Neurospora sp. from Nothapodytes Foetida Producing Camptothecin","volume":"44","author":"Rehman","year":"2008","journal-title":"Appl. Biochem. Microbiol."},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"920","DOI":"10.1002\/hlca.200900307","article-title":"A New Isofuranonaphthalenone and Benzopyrans from the Endophytic Fungus Nodulisporium sp. A4 from Aquilaria Sinensis","volume":"93","author":"Wu","year":"2010","journal-title":"Helv. Chim. Acta"},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"2941","DOI":"10.1002\/cbdv.201000011","article-title":"Chemical Constituents of Papulaspora Immersa, an Endophyte from Smallanthus Sonchifolius (Asteraceae), and Their Cytotoxic Activity","volume":"7","author":"Pessoa","year":"2010","journal-title":"Chem. Biodivers."},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"1400","DOI":"10.1016\/j.phytochem.2011.04.016","article-title":"Isopimarane Diterpene Glycosides, Isolated from Endophytic Fungus Paraconiothyrium sp. MY-42","volume":"72","author":"Shiono","year":"2011","journal-title":"Phytochemistry"},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"746","DOI":"10.1021\/np5009569","article-title":"Bisabolane Sesquiterpenoids from the Plant Endophytic Fungus Paraconiothyrium Brasiliense","volume":"78","author":"Liu","year":"2015","journal-title":"J. Nat. Prod."},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"1291","DOI":"10.1080\/14786419.2011.569502","article-title":"A New Furanocoumarin from the Mangrove Endophytic Fungus Penicillium sp. (ZH16)","volume":"26","author":"Huang","year":"2012","journal-title":"Nat. Prod. Res."},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1248\/cpb.56.217","article-title":"Penicillenols from Penicillium sp. GQ-7, an Endophytic Fungus Associated with Aegiceras Corniculatum","volume":"56","author":"Lin","year":"2008","journal-title":"Chem. Pharm. Bull."},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"1273","DOI":"10.1016\/j.phytochem.2007.10.030","article-title":"Polyketides from Penicillium sp. JP-1, an Endophytic Fungus Associated with the Mangrove Plant Aegiceras Corniculatum","volume":"69","author":"Lin","year":"2008","journal-title":"Phytochemistry"},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"1544","DOI":"10.1080\/14786419.2014.924932","article-title":"Penifupyrone, a New Cytotoxic Funicone Derivative from the Endophytic Fungus Penicillium sp. HSZ-43","volume":"28","author":"Chen","year":"2014","journal-title":"Nat. Prod. Res."},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"978","DOI":"10.1007\/s12272-013-0268-2","article-title":"Two New Meroterpenoids Produced by the Endophytic Fungus Penicillium sp. SXH-65","volume":"37","author":"Sun","year":"2014","journal-title":"Arch. Pharm. Res."},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"70595","DOI":"10.1039\/C5RA13735G","article-title":"Cytotoxic Metabolites from the Endophytic Fungus Penicillium Chermesinum: Discovery of a Cysteine-Targeted Michael Acceptor as a Pharmacophore for Fragment-Based Drug Discovery, Bioconjugation and Click Reactions","volume":"5","author":"Darsih","year":"2015","journal-title":"RSC Adv."},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"1099","DOI":"10.1021\/np4001366","article-title":"Alkaloids and Polyketides from Penicillium Citrinum, an Endophyte Isolated from the Moroccan Plant Ceratonia Siliqua","volume":"76","author":"Ebrahim","year":"2013","journal-title":"J. Nat. Prod."},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"1541","DOI":"10.1248\/cpb.59.1541","article-title":"Two New Terpenoids from Endophytic Fungus Periconia sp. F-31","volume":"59","author":"Ge","year":"2011","journal-title":"Chem. Pharm. Bull."},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"2686","DOI":"10.1016\/j.phytochem.2006.09.005","article-title":"Aromatic Compounds Produced by Periconia Atropurpurea, an Endophytic Fungus Associated with Xylopia Aromatica","volume":"67","author":"Teles","year":"2006","journal-title":"Phytochemistry"},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"662","DOI":"10.1021\/np800748u","article-title":"Chromones from the Endophytic Fungus Pestalotiopsis sp. Isolated from the Chinese Mangrove Plant Rhizophora Mucronata","volume":"72","author":"Xu","year":"2009","journal-title":"J. Nat. Prod."},{"key":"ref_111","doi-asserted-by":"crossref","first-page":"1785","DOI":"10.1039\/b924169h","article-title":"Pestalactams A\u2013C: Novel Caprolactams from the Endophytic Fungus Pestalotiopsis sp.","volume":"8","author":"Davis","year":"2010","journal-title":"Org. Biomol. Chem."},{"key":"ref_112","doi-asserted-by":"crossref","unstructured":"Wu, L.-S., Jia, M., Chen, L., Zhu, B., Dong, H.-X., Si, J.-P., Peng, W., and Han, T. (2015). Cytotoxic and Antifungal Constituents Isolated from the Metabolites of Endophytic Fungus DO14 from Dendrobium Officinale. Molecules, 21.","DOI":"10.3390\/molecules21010014"},{"key":"ref_113","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1016\/j.fitote.2013.01.010","article-title":"Pestaloficiols Q\u2013S from the Plant Endophytic Fungus Pestalotiopsis Fici","volume":"85","author":"Liu","year":"2013","journal-title":"Fitoterapia"},{"key":"ref_114","first-page":"374","article-title":"Cytotoxic Isoprenylated Epoxycyclohexanediols from the Plant Endophyte Pestalotiopsis Fici","volume":"9","author":"LIU","year":"2011","journal-title":"Chin. J. Nat. Med."},{"key":"ref_115","doi-asserted-by":"crossref","first-page":"1482","DOI":"10.1021\/np900308s","article-title":"Isoprenylated Chromone Derivatives from the Plant Endophytic Fungus Pestalotiopsis Fici","volume":"72","author":"Liu","year":"2009","journal-title":"J. Nat. Prod."},{"key":"ref_116","doi-asserted-by":"crossref","first-page":"8554","DOI":"10.3390\/molecules17078554","article-title":"Two New Oxysporone Derivatives from the Fermentation Broth of the Endophytic Plant Fungus Pestalotiopsis Karstenii Isolated from Stems of Camellia Sasanqua","volume":"17","author":"Luo","year":"2012","journal-title":"Molecules"},{"key":"ref_117","first-page":"950","article-title":"Isolation of Taxol, an Anticancer Drug Produced by the Endophytic Fungus, Phoma Betae","volume":"11","author":"Kumaran","year":"2012","journal-title":"Afr. J. Biotechnol."},{"key":"ref_118","first-page":"112","article-title":"Efficiency of Fungal Taxol on Human Liver Carcinoma Cell Lines","volume":"1","author":"Rajendran","year":"2013","journal-title":"Am. J. Res. Commun."},{"key":"ref_119","doi-asserted-by":"crossref","first-page":"3232","DOI":"10.1021\/jo960471x","article-title":"Torreyanic Acid:\u2009 A Selectively Cytotoxic Quinone Dimer from the Endophytic Fungus Pestalotiopsis Microspora","volume":"61","author":"Lee","year":"1996","journal-title":"J. Org. Chem."},{"key":"ref_120","doi-asserted-by":"crossref","first-page":"2079","DOI":"10.1099\/00221287-146-8-2079","article-title":"Induction of the Sexual Stage of Pestalotiopsis Microspora, a Taxol-Producing Fungus","volume":"146","author":"Metz","year":"2000","journal-title":"Microbiology"},{"key":"ref_121","doi-asserted-by":"crossref","first-page":"S1159","DOI":"10.1016\/S2221-1691(12)60378-5","article-title":"In Vitro Studies on Anticancer Activity of Fungal Taxol against Human Breast Cancer Cell Line MCF-7 Cells","volume":"2","author":"Vennila","year":"2012","journal-title":"Asian Pac. J. Trop. Biomed."},{"key":"ref_122","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1038\/ja.2012.14","article-title":"Photipyrones A and B, New Pyrone Derivatives from the Plant Endophytic Fungus Pestalotiopsis Photiniae","volume":"65","author":"Ding","year":"2012","journal-title":"J. Antibiot."},{"key":"ref_123","doi-asserted-by":"crossref","first-page":"942","DOI":"10.1021\/np900084d","article-title":"Photinides A\u2013F, Cytotoxic Benzofuranone-Derived \u03b3-Lactones from the Plant Endophytic Fungus Pestalotiopsis Photiniae","volume":"72","author":"Ding","year":"2009","journal-title":"J. Nat. Prod."},{"key":"ref_124","doi-asserted-by":"crossref","first-page":"95307","DOI":"10.1039\/C5RA18121F","article-title":"Phialomustin A\u2013D, New Antimicrobial and Cytotoxic Metabolites from an Endophytic Fungus, Phialophora Mustea","volume":"5","author":"Nalli","year":"2015","journal-title":"RSC Adv."},{"key":"ref_125","doi-asserted-by":"crossref","first-page":"627","DOI":"10.12980\/APJTB.4.2014APJTB-2014-0030","article-title":"Polyketide and Benzopyran Compounds of an Endophytic Fungus Isolated from C Innamomum Mollissimum: Biological Activity and Structure","volume":"4","author":"Santiago","year":"2014","journal-title":"Asian Pac. J. Trop. Biomed."},{"key":"ref_126","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1007\/s10600-009-9446-3","article-title":"Chemistry and Cytotoxic Activities of Polyketides Produced by the Mangrove Endophytic Fungus Phomopsis SP. ZSU-H76","volume":"45","author":"Huang","year":"2009","journal-title":"Chem. Nat. Compd."},{"key":"ref_127","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1007\/s10600-013-0497-0","article-title":"A New Xanthone O-Glycoside from the Mangrove Endophytic Fungus Phomopsis sp.","volume":"49","author":"Huang","year":"2013","journal-title":"Chem. Nat. Compd."},{"key":"ref_128","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1016\/j.fitote.2014.05.001","article-title":"Phomopsidone A, a Novel Depsidone Metabolite from the Mangrove Endophytic Fungus Phomopsis sp. A123","volume":"96","author":"Zhang","year":"2014","journal-title":"Fitoterapia"},{"key":"ref_129","doi-asserted-by":"crossref","first-page":"1015","DOI":"10.1021\/np010006h","article-title":"Phomoxanthones A and B, Novel Xanthone Dimers from the Endophytic Fungus Phomopsis Species","volume":"64","author":"Isaka","year":"2001","journal-title":"J. Nat. Prod."},{"key":"ref_130","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1021\/np900650c","article-title":"Oblongolides from the Endophytic Fungus Phomopsis sp. BCC 9789","volume":"73","author":"Bunyapaiboonsri","year":"2010","journal-title":"J. Nat. Prod."},{"key":"ref_131","doi-asserted-by":"crossref","unstructured":"Jouda, J.-B., Tamokou, J.-D., Mbazoa, C.D., Douala-Meli, C., Sarkar, P., Bag, P.K., and Wandji, J. (2016). Antibacterial and Cytotoxic Cytochalasins from the Endophytic Fungus Phomopsis sp. Harbored in Garcinia Kola (Heckel) Nut. BMC Complement. Altern. Med., 16.","DOI":"10.1186\/s12906-016-1454-9"},{"key":"ref_132","doi-asserted-by":"crossref","first-page":"1006","DOI":"10.1021\/np010020u","article-title":"Dicerandrols, New Antibiotic and Cytotoxic Dimers Produced by the Fungus Phomopsis Longicolla Isolated from an Endangered Mint","volume":"64","author":"Wagenaar","year":"2001","journal-title":"J. Nat. Prod."},{"key":"ref_133","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1021\/np070600c","article-title":"Sesquiterpene Quinones and Related Metabolites from Phyllosticta Spinarum, a Fungal Strain Endophytic in Platycladus Orientalis of the Sonoran Desert (1)","volume":"71","author":"Wijeratne","year":"2008","journal-title":"J. Nat. Prod."},{"key":"ref_134","doi-asserted-by":"crossref","first-page":"784","DOI":"10.1002\/cbdv.200800103","article-title":"Anti-Inflammatory and Anticancer Activity of Ergoflavin Isolated from an Endophytic Fungus","volume":"6","author":"Deshmukh","year":"2009","journal-title":"Chem. Biodivers."},{"key":"ref_135","doi-asserted-by":"crossref","first-page":"1712","DOI":"10.1021\/np900302w","article-title":"Spirobisnaphthalene Analogues from the Endophytic Fungus Preussia sp.","volume":"72","author":"Chen","year":"2009","journal-title":"J. Nat. Prod."},{"key":"ref_136","doi-asserted-by":"crossref","first-page":"1692","DOI":"10.1021\/np0002942","article-title":"Three New Cytochalasins Produced by an Endophytic Fungus in the Genus Rhinocladiella","volume":"63","author":"Wagenaar","year":"2000","journal-title":"J. Nat. Prod."},{"key":"ref_137","doi-asserted-by":"crossref","first-page":"1271","DOI":"10.3390\/md12031271","article-title":"Spirobisnaphthalenes from the Mangrove-Derived Fungus Rhytidhysteron sp. AS21B","volume":"12","author":"Pudhom","year":"2014","journal-title":"Mar. Drugs"},{"key":"ref_138","doi-asserted-by":"crossref","first-page":"2022","DOI":"10.1021\/acs.jnatprod.6b00327","article-title":"Bioactive Dibenzo-\u03b1-Pyrone Derivatives from the Endophytic Fungus Rhizopycnis Vagum Nitaf22","volume":"79","author":"Lai","year":"2016","journal-title":"J. Nat. Prod."},{"key":"ref_139","doi-asserted-by":"crossref","first-page":"2878","DOI":"10.1016\/j.bmc.2017.02.054","article-title":"Identification of Spirobisnaphthalene Derivatives with Anti-Tumor Activities from the Endophytic Fungus Rhytidhysteron Rufulum AS21B","volume":"25","author":"Siridechakorn","year":"2017","journal-title":"Bioorg. Med. Chem."},{"key":"ref_140","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1002\/ejoc.201402984","article-title":"Biosynthetically Distinct Cytotoxic Polyketides from Setophoma Terrestris","volume":"2015","author":"Figueroa","year":"2015","journal-title":"Eur. J. Org. Chem."},{"key":"ref_141","doi-asserted-by":"crossref","first-page":"2052","DOI":"10.1021\/np2000864","article-title":"Smardaesidins A\u2013G, Isopimarane and 20-Nor-Isopimarane Diterpenoids from Smardaea sp., a Fungal Endophyte of the Moss Ceratodon Purpureus","volume":"74","author":"Wang","year":"2011","journal-title":"J. Nat. Prod."},{"key":"ref_142","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1111\/j.1574-6968.2011.02488.x","article-title":"Isolation and Characterization of Stemphylium Sedicola SBU-16 as a New Endophytic Taxol-Producing Fungus from Taxus Baccata Grown in Iran","volume":"328","author":"Mirjalili","year":"2012","journal-title":"FEMS Microbiol. Lett."},{"key":"ref_143","doi-asserted-by":"crossref","first-page":"626","DOI":"10.1021\/np8004997","article-title":"Bioactive Metabolites from the Endophytic Fungus Stemphylium Globuliferum Isolated from Mentha Pulegium","volume":"72","author":"Debbab","year":"2009","journal-title":"J. Nat. Prod."},{"key":"ref_144","doi-asserted-by":"crossref","first-page":"3850","DOI":"10.1016\/j.bmc.2013.04.024","article-title":"Anticancer Effect of Altersolanol A, a Metabolite Produced by the Endophytic Fungus Stemphylium Globuliferum, Mediated by Its pro-Apoptotic and Anti-Invasive Potential via the Inhibition of NF-\u039aB Activity","volume":"21","author":"Teiten","year":"2013","journal-title":"Bioorg. Med. Chem."},{"key":"ref_145","first-page":"453","article-title":"Secondary Metabolites and Biological Activities of Talaromyces sp. LGT-2, an Endophytic Fungus from Tripterygium Wilfordii","volume":"15","author":"Zhao","year":"2016","journal-title":"Iran. J. Pharm. Res. IJPR"},{"key":"ref_146","doi-asserted-by":"crossref","first-page":"1230","DOI":"10.1021\/np200164k","article-title":"Cytotoxic Norsesquiterpene Peroxides from the Endophytic Fungus Talaromyces Flavus Isolated from the Mangrove Plant Sonneratia Apetala","volume":"74","author":"Li","year":"2011","journal-title":"J. Nat. Prod."},{"key":"ref_147","doi-asserted-by":"crossref","first-page":"1825","DOI":"10.1021\/np9002977","article-title":"Light-Independent Metabolomics of Endophytic Thielavia Subthermophila Provides Insight into Microbial Hypericin Biosynthesis","volume":"72","author":"Kusari","year":"2009","journal-title":"J. Nat. Prod."},{"key":"ref_148","doi-asserted-by":"crossref","first-page":"494","DOI":"10.1016\/j.jbiotec.2005.10.015","article-title":"The Endophytic Fungus Trametes Hirsuta as a Novel Alternative Source of Podophyllotoxin and Related Aryl Tetralin Lignans","volume":"122","author":"Puri","year":"2006","journal-title":"J. Biotechnol."},{"key":"ref_149","doi-asserted-by":"crossref","first-page":"2516","DOI":"10.1002\/ejoc.201200053","article-title":"Trichoderones A and B: Two Pentacyclic Cytochalasans from the Plant Endophytic Fungus Trichoderma Gamsii","volume":"2012","author":"Ding","year":"2012","journal-title":"Eur. J. Org. Chem."},{"key":"ref_150","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1186\/2043-7129-2-8","article-title":"Isolation, Purification and Characterization of Trichothecinol-A Produced by Endophytic Fungus Trichothecium sp. and Its Antifungal, Anticancer and Antimetastatic Activities","volume":"2","author":"Taware","year":"2014","journal-title":"Sustain. Chem. Process."},{"key":"ref_151","doi-asserted-by":"crossref","first-page":"1005","DOI":"10.1021\/np100103j","article-title":"Cytotoxic Nor-Chamigrane and Chamigrane Endoperoxides from a Basidiomycetous Fungus","volume":"73","author":"Chokpaiboon","year":"2010","journal-title":"J. Nat. Prod."},{"key":"ref_152","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1021\/np100030x","article-title":"Eremophilane-Type Sesquiterpenes from the Fungus Xylaria sp. BCC 21097","volume":"73","author":"Isaka","year":"2010","journal-title":"J. Nat. Prod."},{"key":"ref_153","doi-asserted-by":"crossref","first-page":"1620","DOI":"10.1021\/np0701069","article-title":"Antimalarial Benzoquinones from an Endophytic Fungus, Xylaria sp.","volume":"70","author":"Tansuwan","year":"2007","journal-title":"J. Nat. Prod."},{"key":"ref_154","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1016\/j.phytochem.2015.08.010","article-title":"Sesquiterpenes and Other Constituents of Xylaria sp. NC1214, a Fungal Endophyte of the Moss Hypnum sp.","volume":"118","author":"Wei","year":"2015","journal-title":"Phytochemistry"},{"key":"ref_155","doi-asserted-by":"crossref","first-page":"10962","DOI":"10.1021\/jf503846z","article-title":"Characterization of Cytochalasins from the Endophytic Xylaria sp. and Their Biological Functions","volume":"62","author":"Zhang","year":"2014","journal-title":"J. Agric. Food Chem."},{"key":"ref_156","doi-asserted-by":"crossref","first-page":"2033","DOI":"10.1080\/14786419.2015.1017724","article-title":"Antimalarial and Cytotoxic Constituents of Xylaria Cf. Cubensis PK108","volume":"29","author":"Sawadsitang","year":"2015","journal-title":"Nat. Prod. Res."},{"key":"ref_157","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1002\/hlca.201000220","article-title":"Three New Triterpenes from Xylarialean sp. A45, an Endophytic Fungus from Annona Squamosa L.","volume":"94","author":"Lin","year":"2011","journal-title":"Helv. Chim. Acta"},{"key":"ref_158","doi-asserted-by":"crossref","first-page":"2444","DOI":"10.4161\/cc.8.15.9170","article-title":"Secalonic Acid D Induced Leukemia Cell Apoptosis and Cell Cycle Arrest of G(1) with Involvement of GSK-3beta\/Beta-Catenin\/c-Myc Pathway","volume":"8","author":"Zhang","year":"2009","journal-title":"Cell Cycle Georget. Tex"},{"key":"ref_159","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1016\/j.fitote.2017.10.021","article-title":"Induction of New Metabolites from the Endophytic Fungus Bionectria sp. through Bacterial Co-Culture","volume":"124","author":"Kamdem","year":"2018","journal-title":"Fitoterapia"},{"key":"ref_160","doi-asserted-by":"crossref","first-page":"786","DOI":"10.1016\/j.bmc.2017.12.049","article-title":"Fusarithioamide B, a New Benzamide Derivative from the Endophytic Fungus Fusarium Chlamydosporium with Potent Cytotoxic and Antimicrobial Activities","volume":"26","author":"Ibrahim","year":"2018","journal-title":"Bioorg. Med. Chem."},{"key":"ref_161","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1007\/s00284-017-1418-4","article-title":"Identification of a New Uncompetitive Inhibitor of Adenosine Deaminase from Endophyte Aspergillus Niger sp.","volume":"75","author":"Zhang","year":"2018","journal-title":"Curr. Microbiol."},{"key":"ref_162","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1038\/s41429-018-0037-z","article-title":"Spiciferone Analogs from an Endophytic Fungus Phoma Betae Collected from Desert Plants in West China","volume":"71","author":"Tan","year":"2018","journal-title":"J. Antibiot."},{"key":"ref_163","first-page":"2944","article-title":"Investigations on secondary metabolites of endophyte Diaporthe sp. hosted in Tylophora ovata","volume":"43","author":"Liu","year":"2018","journal-title":"Zhongguo Zhong Yao Za Zhi Zhongguo Zhongyao Zazhi China J. Chin. Mater. Medica"},{"key":"ref_164","doi-asserted-by":"crossref","first-page":"2217","DOI":"10.1016\/j.bmcl.2018.04.018","article-title":"Valproic Acid Induces Three Novel Cytotoxic Secondary Metabolites in Diaporthe sp., an Endophytic Fungus from Datura Inoxia Mill","volume":"28","author":"Sharma","year":"2018","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"ref_165","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1111\/jam.13764","article-title":"New Cytochalasin from Rosellinia Sanctae-Cruciana, an Endophytic Fungus of Albizia Lebbeck","volume":"125","author":"Sharma","year":"2018","journal-title":"J. Appl. Microbiol."},{"key":"ref_166","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1016\/j.fitote.2018.05.020","article-title":"Metabolites from the Endophytic Fungus Cylindrocarpon sp. Isolated from Tropical Plant Sapium Ellipticum","volume":"128","author":"Kamdem","year":"2018","journal-title":"Fitoterapia"},{"key":"ref_167","doi-asserted-by":"crossref","first-page":"1247","DOI":"10.1007\/s00284-018-1517-x","article-title":"Antimicrobial and Cytotoxic Properties of Bioactive Metabolites Produced by Streptomyces Cavourensis YBQ59 Isolated from Cinnamomum Cassia Prels in Yen Bai Province of Vietnam","volume":"75","author":"Vu","year":"2018","journal-title":"Curr. Microbiol."},{"key":"ref_168","doi-asserted-by":"crossref","first-page":"2360","DOI":"10.1080\/14786419.2017.1410810","article-title":"Secondary Metabolites from the Colletotrichum Gloeosporioides A12, an Endophytic Fungus Derived from Aquilaria Sinensis","volume":"32","author":"Liu","year":"2018","journal-title":"Nat. Prod. Res."},{"key":"ref_169","doi-asserted-by":"crossref","unstructured":"Ouyang, J., Mao, Z., Guo, H., Xie, Y., Cui, Z., Sun, J., Wu, H., Wen, X., Wang, J., and Shan, T. (2018). Mollicellins O\u2013R, Four New Depsidones Isolated from the Endophytic Fungus Chaetomium sp. Eef-10. Molecules, 23.","DOI":"10.3390\/molecules23123218"},{"key":"ref_170","doi-asserted-by":"crossref","first-page":"2968","DOI":"10.1080\/14786419.2017.1395431","article-title":"Cytotoxic Constituents from the Mangrove Endophytic Pestalotiopsis sp. Induce G0\/G1 Cell Cycle Arrest and Apoptosis in Human Cancer Cells","volume":"32","author":"Zhou","year":"2018","journal-title":"Nat. Prod. Res."},{"key":"ref_171","doi-asserted-by":"crossref","first-page":"1412","DOI":"10.1021\/acs.jnatprod.8b00723","article-title":"Indole Diterpenoids from an Endophytic Penicillium sp.","volume":"82","author":"Ariantari","year":"2019","journal-title":"J. Nat. Prod."},{"key":"ref_172","doi-asserted-by":"crossref","first-page":"152830","DOI":"10.1016\/j.phymed.2019.152830","article-title":"Anticancer Potential of NF-\u039aB Targeting Apoptotic Molecule \u201cFlavipin\u201d Isolated from Endophytic Chaetomium Globosum","volume":"61","author":"Kumaresan","year":"2019","journal-title":"Phytomedicine"},{"key":"ref_173","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/j.phytol.2018.11.012","article-title":"Cytotoxic Polyketides from Endophytic Fungus Phoma Bellidis Harbored in Ttricyrtis Maculate","volume":"29","author":"Wang","year":"2019","journal-title":"Phytochem. Lett."},{"key":"ref_174","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1080\/14786419.2019.1627348","article-title":"Dithiodiketopiperazine Derivatives from Endophytic Fungi Trichoderma Harzianum and Epicoccum Nigrum","volume":"35","author":"Harwoko","year":"2021","journal-title":"Nat. Prod. Res."},{"key":"ref_175","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/j.fitote.2018.11.010","article-title":"Cytotoxic Seco-Cytochalasins from an Endophytic Aspergillus sp. Harbored in Pinellia Ternata Tubers","volume":"132","author":"Xin","year":"2019","journal-title":"Fitoterapia"},{"key":"ref_176","doi-asserted-by":"crossref","first-page":"16035","DOI":"10.1039\/C9RA02647A","article-title":"Cytotoxic Metabolites from the Endophytic Fungus Chaetomium Globosum 7951","volume":"9","author":"Wang","year":"2019","journal-title":"RSC Adv."},{"key":"ref_177","doi-asserted-by":"crossref","first-page":"28754","DOI":"10.1039\/C9RA04747F","article-title":"Cytotoxic and Antimicrobial Indole Alkaloids from an Endophytic Fungus Chaetomium sp. SYP-F7950 of Panax Notoginseng","volume":"9","author":"Peng","year":"2019","journal-title":"RSC Adv."},{"key":"ref_178","doi-asserted-by":"crossref","first-page":"1752","DOI":"10.1021\/acs.jnatprod.8b00918","article-title":"Ascomylactams A\u2013C, Cytotoxic 12- or 13-Membered-Ring Macrocyclic Alkaloids Isolated from the Mangrove Endophytic Fungus Didymella sp. CYSK-4, and Structure Revisions of Phomapyrrolidones A and C","volume":"82","author":"Chen","year":"2019","journal-title":"J. Nat. Prod."},{"key":"ref_179","doi-asserted-by":"crossref","first-page":"12913","DOI":"10.1039\/C9RA01956A","article-title":"Heptaketides from the Endophytic Fungus Pleosporales sp. F46 and Their Antifungal and Cytotoxic Activities","volume":"9","author":"Li","year":"2019","journal-title":"RSC Adv."},{"key":"ref_180","doi-asserted-by":"crossref","unstructured":"Kumarihamy, M., Ferreira, D., Croom, E.M., Sahu, R., Tekwani, B.L., Duke, S.O., Khan, S., Techen, N., and Nanayakkara, N.P.D. (2019). Antiplasmodial and Cytotoxic Cytochalasins from an Endophytic Fungus, Nemania sp. UM10M, Isolated from a Diseased Torreya Taxifolia Leaf. Molecules, 24.","DOI":"10.3390\/molecules24040777"},{"key":"ref_181","doi-asserted-by":"crossref","first-page":"10660","DOI":"10.1021\/acs.jafc.9b04254","article-title":"Cytotoxic Indolyl Diketopiperazines from the Aspergillus sp. GZWMJZ-258, Endophytic with the Medicinal and Edible Plant Garcinia Multiflora","volume":"67","author":"He","year":"2019","journal-title":"J. Agric. Food Chem."},{"key":"ref_182","doi-asserted-by":"crossref","first-page":"104253","DOI":"10.1016\/j.fitote.2019.104253","article-title":"Cytotoxic 19,20-Epoxycytochalasans from Endophytic Fungus Xylaria Cf. Curta","volume":"137","author":"Wang","year":"2019","journal-title":"Fitoterapia"},{"key":"ref_183","doi-asserted-by":"crossref","first-page":"957","DOI":"10.1055\/a-0853-7793","article-title":"dos S.; Junior, J.M.B.; Bauab, T.M.; Ara\u00fajo, A.R.; Carlos, I.Z.; Vilegas, W.; Santos, L.C. dos New Benzaldehyde and Benzopyran Compounds from the Endophytic Fungus Paraphaeosphaeria sp. F03 and Their Antimicrobial and Cytotoxic Activities","volume":"85","author":"Junior","year":"2019","journal-title":"Planta Med."},{"key":"ref_184","doi-asserted-by":"crossref","first-page":"851","DOI":"10.1080\/10286020.2018.1495197","article-title":"Three New \u03b1-Pyrone Derivatives from the Plant Endophytic Fungus Penicillium Ochrochloronthe and Their Antibacterial, Antifungal, and Cytotoxic Activities","volume":"21","author":"Zhao","year":"2019","journal-title":"J. Asian Nat. Prod. Res."},{"key":"ref_185","doi-asserted-by":"crossref","first-page":"103046","DOI":"10.1016\/j.bioorg.2019.103046","article-title":"Cytotoxic and Neuroprotective Activities of Constituents from Alternaria Alternate, a Fungal Endophyte of Psidium Littorale","volume":"90","author":"Xu","year":"2019","journal-title":"Bioorg. Chem."},{"key":"ref_186","doi-asserted-by":"crossref","first-page":"326","DOI":"10.1007\/s12272-018-1019-1","article-title":"Cytotoxic Isocoumarin Derivatives from the Mangrove Endophytic Fungus Aspergillus sp. HN15-5D","volume":"42","author":"Wu","year":"2019","journal-title":"Arch. Pharm. Res."},{"key":"ref_187","doi-asserted-by":"crossref","first-page":"2840","DOI":"10.1080\/14786419.2019.1675060","article-title":"Two Metabolites Isolated from Endophytic Fungus Coniochaeta sp. F-8 in Ageratina Adenophora Exhibit Antioxidative Activity and Cytotoxicity","volume":"35","author":"Fu","year":"2021","journal-title":"Nat. Prod. Res."},{"key":"ref_188","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1007\/s00044-018-2281-y","article-title":"Isolation, Structural Modification of Macrophin from Endophytic Fungus Phoma Macrostoma and Their Cytotoxic Potential","volume":"28","author":"Nalli","year":"2019","journal-title":"Med. Chem. Res."},{"key":"ref_189","doi-asserted-by":"crossref","first-page":"1503","DOI":"10.1021\/acs.jnatprod.8b01034","article-title":"Cytotoxic Trichothecene Macrolides Produced by the Endophytic Myrothecium Roridum","volume":"82","author":"Shen","year":"2019","journal-title":"J. Nat. Prod."},{"key":"ref_190","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1016\/j.phytol.2019.06.003","article-title":"Cytotoxic Prenylated Indole Alkaloid Produced by the Endophytic Fungus Aspergillus Terreus P63","volume":"32","author":"Gubiani","year":"2019","journal-title":"Phytochem. Lett."},{"key":"ref_191","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1016\/j.fitote.2019.03.020","article-title":"Two Spiroketal Derivatives with an Unprecedented Amino Group and Their Cytotoxicity Evaluation from the Endophytic Fungus Pestalotiopsis Flavidula","volume":"135","author":"Rao","year":"2019","journal-title":"Fitoterapia"},{"key":"ref_192","doi-asserted-by":"crossref","first-page":"3520","DOI":"10.1039\/C8RA10195G","article-title":"Seven New Cytotoxic Phenylspirodrimane Derivatives from the Endophytic Fungus Stachybotrys Chartarum","volume":"9","author":"Zhang","year":"2019","journal-title":"RSC Adv."},{"key":"ref_193","doi-asserted-by":"crossref","first-page":"1870","DOI":"10.1080\/14786419.2018.1478824","article-title":"Isochromanes from Aspergillus Fumigatus, an Endophytic Fungus from Cordyceps Sinensis","volume":"33","author":"Li","year":"2019","journal-title":"Nat. Prod. Res."},{"key":"ref_194","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.phytol.2018.10.014","article-title":"New Secondary Metabolites from the Mangrove-Derived Fungus Aspergillus sp. AV-2","volume":"29","author":"Elissawy","year":"2019","journal-title":"Phytochem. Lett."},{"key":"ref_195","doi-asserted-by":"crossref","unstructured":"Zhang, H.-M., Ju, C.-X., Li, G., Sun, Y., Peng, Y., Li, Y.-X., Peng, X.-P., and Lou, H.-X. (2019). Dimeric 1,4-Benzoquinone Derivatives with Cytotoxic Activities from the Marine-Derived Fungus Penicillium sp. L129. Mar. Drugs, 17.","DOI":"10.3390\/md17070383"},{"key":"ref_196","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1016\/j.phytol.2018.11.021","article-title":"Cytotoxic Butenolides and Diphenyl Ethers from the Endophytic Fungus Pestalotiopsis sp.","volume":"29","author":"Yang","year":"2019","journal-title":"Phytochem. Lett."},{"key":"ref_197","doi-asserted-by":"crossref","first-page":"1534","DOI":"10.1021\/acs.joc.8b02830","article-title":"Emeridones A\u2013F, a Series of 3,5-Demethylorsellinic Acid-Based Meroterpenoids with Rearranged Skeletons from an Endophytic Fungus Emericella sp. TJ29","volume":"84","author":"Li","year":"2019","journal-title":"J. Org. Chem."},{"key":"ref_198","doi-asserted-by":"crossref","first-page":"104260","DOI":"10.1016\/j.fitote.2019.104260","article-title":"Four New Metabolites from the Endophytic Fungus Diaporthe Lithocarpus A740","volume":"137","author":"Liu","year":"2019","journal-title":"Fitoterapia"},{"key":"ref_199","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1016\/j.fitote.2019.02.015","article-title":"Cytotoxic, Antimicrobial and Antiviral Secondary Metabolites Produced by the Plant Pathogenic Fungus Cytospora sp. CCTU A309","volume":"134","author":"Narmani","year":"2019","journal-title":"Fitoterapia"},{"key":"ref_200","first-page":"9","article-title":"Isolation and Structure Elucidation of Secondary Metabolites From an Endophytic Fungus Annulohypoxylon Ilanense","volume":"14","author":"Cheng","year":"2019","journal-title":"Nat. Prod. Commun."},{"key":"ref_201","doi-asserted-by":"crossref","first-page":"1055","DOI":"10.1021\/acs.jnatprod.8b00938","article-title":"Sesquiterpenoids from the Endophytic Fungus Rhinocladiella Similis","volume":"82","author":"Liu","year":"2019","journal-title":"J. Nat. Prod."},{"key":"ref_202","doi-asserted-by":"crossref","first-page":"368","DOI":"10.1016\/j.bioorg.2019.02.005","article-title":"Three New Diterpenes and Two New Sesquiterpenoids from the Endophytic Fungus Trichoderma Koningiopsis A729","volume":"86","author":"Chen","year":"2019","journal-title":"Bioorg. Chem."},{"key":"ref_203","doi-asserted-by":"crossref","first-page":"150952","DOI":"10.1016\/j.tetlet.2019.150952","article-title":"Cytochalasins D1 and C1, Unique Cytochalasans from Endophytic Fungus Xylaria Cf. Curta","volume":"60","author":"Wang","year":"2019","journal-title":"Tetrahedron Lett."},{"key":"ref_204","doi-asserted-by":"crossref","first-page":"2229","DOI":"10.1021\/acs.jnatprod.9b00288","article-title":"Absolute Configuration and Biological Activities of Meroterpenoids from an Endophytic Fungus of Lycium Barbarum","volume":"82","author":"Long","year":"2019","journal-title":"J. Nat. Prod."},{"key":"ref_205","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1016\/j.phytochem.2018.11.007","article-title":"Thiodiketopiperazines with Two Spirocyclic Centers Extracted from Botryosphaeria Mamane, an Endophytic Fungus Isolated from Bixa Orellana L.","volume":"158","author":"Barakat","year":"2019","journal-title":"Phytochemistry"},{"key":"ref_206","doi-asserted-by":"crossref","unstructured":"Guo, L., Lin, J., Niu, S., Liu, S., and Liu, L. (2020). Pestalotiones A\u2013D: Four New Secondary Metabolites from the Plant Endophytic Fungus Pestalotiopsis Theae. Molecules, 25.","DOI":"10.3390\/molecules25030470"},{"key":"ref_207","doi-asserted-by":"crossref","unstructured":"Yu, X., M\u00fcller, W.E.G., Meier, D., Kalscheuer, R., Guo, Z., Zou, K., Umeokoli, B.O., Liu, Z., and Proksch, P. (2020). Polyketide Derivatives from Mangrove Derived Endophytic Fungus Pseudopestalotiopsis Theae. Mar. Drugs, 18.","DOI":"10.3390\/md18020129"},{"key":"ref_208","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1080\/14786419.2018.1489393","article-title":"Terezine E, Bioactive Prenylated Tryptophan Analogue from an Endophyte of Centaurea Stoebe","volume":"34","author":"Abdou","year":"2020","journal-title":"Nat. Prod. Res."},{"key":"ref_209","doi-asserted-by":"crossref","unstructured":"de Oliveira Filho, J.W.G., Andrade, T.d.J.A.d.S., de Lima, R.M.T., Silva, D.H.S., dos Reis, A.C., Santos, J.V.d.O., de Meneses, A.-A.P.M., de Carvalho, R.M., da Mata, A.M.O., and de Alencar, M.V.O.B. (2020). Cytogenotoxic Evaluation of the Acetonitrile Extract, Citrinin and Dicitrinin-A from Penicillium Citrinum. Drug Chem. Toxicol., 1\u201310.","DOI":"10.1080\/01480545.2020.1769642"},{"key":"ref_210","doi-asserted-by":"crossref","unstructured":"Elsbaey, M., Tanaka, C., and Miyamoto, T. (2020). Allantopyrone E, a Rare \u03b1-Pyrone Metabolite from the Mangrove Derived Fungus Aspergillus Versicolor. Nat. Prod. Res., 1\u20135.","DOI":"10.1080\/14786419.2020.1803309"},{"key":"ref_211","doi-asserted-by":"crossref","unstructured":"Wei, C., Deng, Q., Sun, M., and Xu, J. (2020). Cytospyrone and Cytospomarin: Two New Polyketides Isolated from Mangrove Endophytic Fungus, Cytospora sp.. Molecules, 25.","DOI":"10.3390\/molecules25184224"},{"key":"ref_212","doi-asserted-by":"crossref","first-page":"104685","DOI":"10.1016\/j.fitote.2020.104685","article-title":"New Cytotoxic Secondary Metabolites against Human Pancreatic Cancer Cells from the Hypericum Perforatum Endophytic Fungus Aspergillus Terreus","volume":"146","author":"Deng","year":"2020","journal-title":"Fitoterapia"},{"key":"ref_213","doi-asserted-by":"crossref","first-page":"6134","DOI":"10.1080\/14786419.2020.1828410","article-title":"Cytotoxic Xanthones from the Plant Endophytic Fungus Paecilamyces sp. TE-540","volume":"35","author":"Li","year":"2020","journal-title":"Nat. Prod. Res."},{"key":"ref_214","doi-asserted-by":"crossref","first-page":"2919","DOI":"10.1080\/14786419.2019.1598993","article-title":"Two New Secondary Metabolites from the Mangrove Endophytic Fungus Pleosporales sp. SK7","volume":"34","author":"Wen","year":"2020","journal-title":"Nat. Prod. Res."},{"key":"ref_215","doi-asserted-by":"crossref","first-page":"596889","DOI":"10.3389\/fchem.2020.596889","article-title":"Eremophilane-Type Sesquiterpenoids From the Endophytic Fungus Rhizopycnis Vagum and Their Antibacterial, Cytotoxic, and Phytotoxic Activities","volume":"8","author":"Wang","year":"2020","journal-title":"Front. Chem."},{"key":"ref_216","doi-asserted-by":"crossref","first-page":"2796","DOI":"10.3389\/fmicb.2020.600983","article-title":"Induction of New Lactam Derivatives From the Endophytic Fungus Aplosporella Javeedii Through an OSMAC Approach","volume":"11","author":"Gao","year":"2020","journal-title":"Front. Microbiol."},{"key":"ref_217","doi-asserted-by":"crossref","first-page":"104768","DOI":"10.1016\/j.fitote.2020.104768","article-title":"Trichothecene Macrolides from the Endophytic Fungus Paramyrothecium Roridum and Their Cytotoxic Activity","volume":"147","author":"Liu","year":"2020","journal-title":"Fitoterapia"},{"key":"ref_218","doi-asserted-by":"crossref","first-page":"104449","DOI":"10.1016\/j.bioorg.2020.104449","article-title":"Colletotrichalactones A-Ca, Unusual 5\/6\/10-Fused Tricyclic Polyketides Produced by an Endophytic Fungus, Colletotrichum sp. JS-0361","volume":"105","author":"Bang","year":"2020","journal-title":"Bioorganic Chem."},{"key":"ref_219","doi-asserted-by":"crossref","first-page":"2324","DOI":"10.1080\/14786419.2019.1672685","article-title":"Secondary Metabolites from Diaporthe Lithocarpus Isolated from Artocarpus Heterophyllus","volume":"35","author":"Riga","year":"2021","journal-title":"Nat. Prod. Res."},{"key":"ref_220","doi-asserted-by":"crossref","first-page":"3277","DOI":"10.1080\/14786419.2019.1696793","article-title":"Two New Sterol Derivatives Isolated from the Endophytic Fungus Aspergillus Tubingensis YP-2","volume":"35","author":"Yu","year":"2021","journal-title":"Nat. Prod. Res."},{"key":"ref_221","first-page":"454","article-title":"Endophytic Fungi with Antitumor Activities: Their Occurrence and Anticancer Compounds","volume":"42","author":"Chen","year":"2014","journal-title":"Crit. Rev. Microbiol."},{"key":"ref_222","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1021\/acs.jnatprod.5b01055","article-title":"Natural Products as Sources of New Drugs from 1981 to 2014","volume":"79","author":"Newman","year":"2016","journal-title":"J. Nat. Prod."},{"key":"ref_223","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1016\/j.jep.2005.05.011","article-title":"Plants as a Source of Anti-Cancer Agents","volume":"100","author":"Cragg","year":"2005","journal-title":"J. Ethnopharmacol."},{"key":"ref_224","doi-asserted-by":"crossref","first-page":"305","DOI":"10.2174\/1568026033452546","article-title":"Non-Camptothecin DNA Topoisomerase I Inhibitors in Cancer Therapy","volume":"3","author":"Pommier","year":"2003","journal-title":"Curr. Top. Med. Chem."},{"key":"ref_225","doi-asserted-by":"crossref","first-page":"789","DOI":"10.1038\/nrc1977","article-title":"Topoisomerase I Inhibitors: Camptothecins and Beyond","volume":"6","author":"Pommier","year":"2006","journal-title":"Nat. Rev. Cancer"},{"key":"ref_226","doi-asserted-by":"crossref","first-page":"12048","DOI":"10.1073\/pnas.0402111101","article-title":"An Enantioselective, Modular, and General Route to the Cytochalasins: Synthesis of L-696,474 and Cytochalasin B","volume":"101","author":"Haidle","year":"2004","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_227","first-page":"173","article-title":"Alkaloids of Vinca Rosea (Catharanthus Roseus). IX. Extraction and Characterization of Leurosidine and Leurocristine","volume":"24","author":"Svoboda","year":"1961","journal-title":"Subj. Strain Bibliogr."},{"key":"ref_228","doi-asserted-by":"crossref","first-page":"810","DOI":"10.1002\/ijc.24915","article-title":"Leucinostatin A Inhibits Prostate Cancer Growth through Reduction of Insulin-like Growth Factor-I Expression in Prostate Stromal Cells","volume":"126","author":"Kawada","year":"2010","journal-title":"Int. J. Cancer"},{"key":"ref_229","doi-asserted-by":"crossref","first-page":"1173","DOI":"10.1021\/acs.jnatprod.6b00610","article-title":"Cytotoxic Naphthoquinone and Azaanthraquinone Derivatives from an Endophytic Fusarium Solani","volume":"80","author":"Chowdhury","year":"2017","journal-title":"J. Nat. Prod."},{"key":"ref_230","doi-asserted-by":"crossref","first-page":"1208","DOI":"10.1039\/c1np00008j","article-title":"Anticancer Compounds Derived from Fungal Endophytes; Their Importance and Future Challenges","volume":"28","author":"Kharwar","year":"2011","journal-title":"Nat. Prod. Rep."},{"key":"ref_231","doi-asserted-by":"crossref","first-page":"2325","DOI":"10.1021\/ja00738a045","article-title":"Plant Antitumor Agents. VI. Isolation and Structure of Taxol, a Novel Antileukemic and Antitumor Agent from Taxus Brevifolia","volume":"93","author":"Wani","year":"1971","journal-title":"J. Am. Chem. Soc."},{"key":"ref_232","doi-asserted-by":"crossref","unstructured":"Cragg, G.M., Kingston, D.G.I., and Newman, D.J. (2012). Anticancer Agents from Natural Products, CRC Press. [2nd ed.].","DOI":"10.1201\/b11185"},{"key":"ref_233","doi-asserted-by":"crossref","unstructured":"Zhang, P., Li, X., Yuan, X.-L., Du, Y.-M., Wang, B.-G., and Zhang, Z.-F. (2018). Antifungal Prenylated Diphenyl Ethers from Arthrinium Arundinis, an Endophytic Fungus Isolated from the Leaves of Tobacco (Nicotiana Tabacum L.). Molecules, 23.","DOI":"10.3390\/molecules23123179"},{"key":"ref_234","doi-asserted-by":"crossref","first-page":"104652","DOI":"10.1016\/j.fitote.2020.104652","article-title":"Sesterterpenes and Macrolide Derivatives from the Endophytic Fungus Aplosporella Javeedii","volume":"146","author":"Gao","year":"2020","journal-title":"Fitoterapia"}],"container-title":["Molecules"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1420-3049\/27\/1\/296\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,13]],"date-time":"2025-10-13T13:26:57Z","timestamp":1760362017000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1420-3049\/27\/1\/296"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,1,4]]},"references-count":234,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2022,1]]}},"alternative-id":["molecules27010296"],"URL":"https:\/\/doi.org\/10.3390\/molecules27010296","relation":{},"ISSN":["1420-3049"],"issn-type":[{"value":"1420-3049","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,1,4]]}}}