{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T22:46:19Z","timestamp":1790721979853,"version":"4.1.0"},"reference-count":42,"publisher":"MDPI AG","issue":"2","license":[{"start":{"date-parts":[[2022,1,15]],"date-time":"2022-01-15T00:00:00Z","timestamp":1642204800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003141","name":"Consejo Nacional de Ciencia y Tecnolog\u00eda","doi-asserted-by":"publisher","award":["568483"],"award-info":[{"award-number":["568483"]}],"id":[{"id":"10.13039\/501100003141","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>A ferrofluid with 1,2-Benzenediol-coated iron oxide nanoparticles was synthesized and physicochemically analyzed. This colloidal system was prepared following the typical co-precipitation method, and superparamagnetic nanoparticles of 13.5 nm average diameter, 34 emu\/g of magnetic saturation, and 285 K of blocking temperature were obtained. Additionally, the zeta potential showed a suitable colloidal stability for cancer therapy assays and the magneto-calorimetric trails determined a high power absorption density. In addition, the oxidative capability of the ferrofluid was corroborated by performing the Fenton reaction with methylene blue (MB) dissolved in water, where the ferrofluid was suitable for producing reactive oxygen species (ROS), and surprisingly a strong degradation of MB was also observed when it was combined with H2O2. The intracellular ROS production was qualitatively corroborated using the HT-29 human cell line, by detecting the fluorescent rise induced in 2,7-dichlorofluorescein diacetate. In other experiments, cell metabolic activity was measured, and no toxicity was observed, even with concentrations of up to 4 mg\/mL of magnetic nanoparticles (MNPs). When the cells were treated with magnetic hyperthermia, 80% of cells were dead at 43 \u00b0C using 3 mg\/mL of MNPs and applying a magnetic field of 530 kHz with 20 kA\/m amplitude.<\/jats:p>","DOI":"10.3390\/molecules27020544","type":"journal-article","created":{"date-parts":[[2022,1,16]],"date-time":"2022-01-16T20:45:21Z","timestamp":1642365921000},"page":"544","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["A Ferrofluid with Surface Modified Nanoparticles for Magnetic Hyperthermia and High ROS Production"],"prefix":"10.3390","volume":"27","author":[{"given":"Oscar","family":"Cervantes","sequence":"first","affiliation":[{"name":"Centro Universitario de Ciencias Exactas e Ingenier\u00edas, Universidad de Guadalajara, Marcelino Garc\u00eda Barrag\u00e1n 1421, Col. Ol\u00edmpica, Guadalajara C.P. 44430, Jalisco, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0736-642X","authenticated-orcid":false,"given":"Zaira del Rocio","family":"Lopez","sequence":"additional","affiliation":[{"name":"Centro Universitario de la Ci\u00e9nega, Universidad de Guadalajara, Av. Universidad 1115, Col. Linda Vista, Ocotlan C.P. 47810, Jalisco, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Norberto","family":"Casillas","sequence":"additional","affiliation":[{"name":"Centro Universitario de Ciencias Exactas e Ingenier\u00edas, Universidad de Guadalajara, Marcelino Garc\u00eda Barrag\u00e1n 1421, Col. Ol\u00edmpica, Guadalajara C.P. 44430, Jalisco, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Knauth","sequence":"additional","affiliation":[{"name":"Centro Universitario de la Ci\u00e9nega, Universidad de Guadalajara, Av. Universidad 1115, Col. Linda Vista, Ocotlan C.P. 47810, Jalisco, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nayeli","family":"Checa","sequence":"additional","affiliation":[{"name":"Centro Universitario de la Ci\u00e9nega, Universidad de Guadalajara, Av. Universidad 1115, Col. Linda Vista, Ocotlan C.P. 47810, Jalisco, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francisco Apolinar","family":"Cholico","sequence":"additional","affiliation":[{"name":"Centro Universitario de la Ci\u00e9nega, Universidad de Guadalajara, Av. Universidad 1115, Col. Linda Vista, Ocotlan C.P. 47810, Jalisco, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7566-6825","authenticated-orcid":false,"given":"Rodolfo","family":"Hernandez-Guti\u00e9rrez","sequence":"additional","affiliation":[{"name":"Centro de Investigaci\u00f3n y Asistencia en Tecnolog\u00eda y Dise\u00f1o del Estado de Jalisco, A.C. Av. Normalistas 800 Colinas de La Normal, Guadalajara C.P. 44270, Jalisco, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luis Hector","family":"Quintero","sequence":"additional","affiliation":[{"name":"Centro Universitario de Ciencias Econ\u00f3mico Administrativas, Universidad de Guadalajara, Perif\u00e9rico Norte 799, Col. Los Belenes, Zapopan C.P. 45100, Jalisco, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jose Avila","family":"Paz","sequence":"additional","affiliation":[{"name":"Centro Universitario de la Ci\u00e9nega, Universidad de Guadalajara, Av. Universidad 1115, Col. Linda Vista, Ocotlan C.P. 47810, Jalisco, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3334-0082","authenticated-orcid":false,"given":"Mario Eduardo","family":"Cano","sequence":"additional","affiliation":[{"name":"Centro Universitario de la Ci\u00e9nega, Universidad de Guadalajara, Av. Universidad 1115, Col. Linda Vista, Ocotlan C.P. 47810, Jalisco, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,1,15]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"3257","DOI":"10.1039\/C9SM02512J","article-title":"Clickable iron oxide NPs based on catechol derived ligands: Synthesis and characterization","volume":"16","author":"Caro","year":"2020","journal-title":"Soft Matter"},{"key":"ref_2","doi-asserted-by":"crossref","unstructured":"Woo, S., Kim, S., Kim, H., Cheon, Y.W., Yoon, S., Oh, J.H., and Park, J. (2021). Charge-Modulated Synthesis of Highly Stable Iron Oxide Nanoparticles for In Vitro and In Vivo Toxicity Evaluation. 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