{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T01:52:55Z","timestamp":1791942775343,"version":"4.3.4"},"reference-count":48,"publisher":"MDPI AG","issue":"3","license":[{"start":{"date-parts":[[2022,1,21]],"date-time":"2022-01-21T00:00:00Z","timestamp":1642723200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>Medicinal plant extracts are increasingly considered a major source of innovative medications and healthcare products. This study focused on preparing a polyphenol enriched water extract of Egyptian celery \u201cApium graveolens L., Apiaceae\u201d aerial parts (TAE) in an endeavor to accentuate its antioxidant capacity as well as its antimicrobial activity. (TAE) of celery was partitioned against different organic solvents to yield dichloromethane (DCM), ethyl acetate (EAC), and butanol (BUOH) fractions. (TAE) and the organic fractions thereof besides the remaining mother liquor (ML) were all screened for their antioxidant capacity using various protocols viz. monitoring the reducing amplitudes for ferric ions (FRAP), and radical scavenging potentials of oxygen (ORAC), 2,2\u2019-azino-bis-3-ethylbenzothiazoline-6-sulfonic acid (ABTS), 2,2-diphenyl-1-picrylhydrazyl (DPPH), and metal chelation assays. The examination procedure revealed both (TAE) extract and (DCM) fraction, to pertain the highest antioxidant potentials, where the IC50 of the (TAE) using ABTS and metal chelation assays were ca. 34.52 \u00b1 3.25 and 246.6 \u00b1 5.78 \u00b5g\/mL, respectively. The (DCM) fraction recorded effective results using the FRAP, ORAC, and DPPH assays ca. 233.47 \u00b1 15.14 and 1076 \u00b1 25.73 \u03bcM Trolox equivalents\/mg sample and an IC50 474.4 \u00b1 19.8 \u00b5g\/mL, respectively. Additionally, both (TAE) and (DCM) fraction exerted antimicrobial activities recording inhibition zones (mm) (13.4 \u00b1 1.5) and (12.0 \u00b1 1.0) against Staphylococcus aureus and (11.0 \u00b1 1.2) and (10.0 \u00b1 1.3) against Escherichia coli, respectively, with no anti-fungal activity. Minimum inhibitory concentration (MIC) of (TAE) and (DCM) fraction were 1250 and 2500 \u00b5g\/mL, respectively. UPLC\/ESI\/TOF-MS unveiled the chemical profile of both (TAE) and (DCM) fraction to encompass a myriad of active polyphenolic constituents including phenylpropanoids, coumarins, apigenin, luteolin, and chrysoeriol conjugates.<\/jats:p>","DOI":"10.3390\/molecules27030698","type":"journal-article","created":{"date-parts":[[2022,1,23]],"date-time":"2022-01-23T20:34:40Z","timestamp":1642970080000},"page":"698","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":46,"title":["Antioxidant, Antimicrobial Activities and Characterization of Polyphenol-Enriched Extract of Egyptian Celery (Apium graveolens L., Apiaceae) Aerial Parts via UPLC\/ESI\/TOF-MS"],"prefix":"10.3390","volume":"27","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2654-6557","authenticated-orcid":false,"given":"Ayat M.","family":"Emad","sequence":"first","affiliation":[{"name":"Pharmacognosy Department, Faculty of Pharmacy, October 6 University, Sixth of October City 12511, Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1462-3394","authenticated-orcid":false,"given":"Dalia M.","family":"Rasheed","sequence":"additional","affiliation":[{"name":"Pharmacognosy Department, Faculty of Pharmacy, October 6 University, Sixth of October City 12511, Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6964-2560","authenticated-orcid":false,"given":"Reham F.","family":"El-Kased","sequence":"additional","affiliation":[{"name":"Microbiology & Immunology Department, Faculty of Pharmacy, The British University in Egypt (BUE), Cairo 11837, Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4782-8396","authenticated-orcid":false,"given":"Dina M.","family":"El-Kersh","sequence":"additional","affiliation":[{"name":"Pharmacognosy Department, Faculty of Pharmacy, The British University in Egypt (BUE), Cairo 11837, Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,1,21]]},"reference":[{"key":"ref_1","first-page":"21","article-title":"Use of antioxidants in the prevention and treatment of disease","volume":"10","author":"Kelly","year":"1998","journal-title":"J. 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