{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,17]],"date-time":"2026-03-17T05:17:59Z","timestamp":1773724679701,"version":"3.50.1"},"reference-count":48,"publisher":"MDPI AG","issue":"3","license":[{"start":{"date-parts":[[2022,1,22]],"date-time":"2022-01-22T00:00:00Z","timestamp":1642809600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"the Key Research and Development Program of Zhejiang Province","award":["No. 2022C03016"],"award-info":[{"award-number":["No. 2022C03016"]}]},{"name":"the Zhejiang Provincial Natural Science Foundation of China","award":["No. LY17C140003"],"award-info":[{"award-number":["No. LY17C140003"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>To discover an efficient and convenient method to synthesize C2-arylacylated benzothiazoles as potential drug scaffolds, a novel [bis(trifluoroacetoxy)iodo]benzene(PIFA)\/KOH synergistically promoted direct ring-opening C2-arylacylation reaction of 2H-benzothiazoles with aryl methyl ketones has been developed. Various substrates were tolerated under optimized conditions affording the C2-arylacylation products in 70\u201395% yields for 38 examples. A plausible mechanism was also proposed based on a series of controlled experiments.<\/jats:p>","DOI":"10.3390\/molecules27030726","type":"journal-article","created":{"date-parts":[[2022,1,23]],"date-time":"2022-01-23T20:34:40Z","timestamp":1642970080000},"page":"726","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["A Novel PIFA\/KOH Promoted Approach to Synthesize C2-arylacylated Benzothiazoles as Potential Drug Scaffolds"],"prefix":"10.3390","volume":"27","author":[{"given":"Xiao-Tong","family":"Sun","sequence":"first","affiliation":[{"name":"College of Chemical Engineering, Zhejiang University of Technology, Hangzhou 310014, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhi-Gang","family":"Hu","sequence":"additional","affiliation":[{"name":"College of Chemical Engineering, Zhejiang University of Technology, Hangzhou 310014, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhen","family":"Huang","sequence":"additional","affiliation":[{"name":"College of Chemical Engineering, Zhejiang University of Technology, Hangzhou 310014, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ling-Li","family":"Zhou","sequence":"additional","affiliation":[{"name":"College of Chemical Engineering, Zhejiang University of Technology, Hangzhou 310014, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5513-6421","authenticated-orcid":false,"given":"Jian-Quan","family":"Weng","sequence":"additional","affiliation":[{"name":"College of Chemical Engineering, Zhejiang University of Technology, Hangzhou 310014, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2022,1,22]]},"reference":[{"key":"ref_1","first-page":"37","article-title":"Oxidative routes to the heterocyclic cores of benzothiazole natural products","volume":"27","author":"Blunt","year":"2016","journal-title":"Synlett"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"314","DOI":"10.2174\/1389557520666200820133252","article-title":"Advancement in pharmacological activities of benzothiazole and its derivatives: An up to date review","volume":"21","author":"Sumit","year":"2021","journal-title":"Mini-Rev. 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