{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T15:50:40Z","timestamp":1791474640778,"version":"4.3.4"},"reference-count":147,"publisher":"MDPI AG","issue":"3","license":[{"start":{"date-parts":[[2022,2,2]],"date-time":"2022-02-02T00:00:00Z","timestamp":1643760000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004281","name":"National Science Center","doi-asserted-by":"publisher","award":["2018\/30\/E\/ST5\/00242"],"award-info":[{"award-number":["2018\/30\/E\/ST5\/00242"]}],"id":[{"id":"10.13039\/501100004281","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>Late-stage modification of drug molecules is a fast method to introduce diversity into the already biologically active scaffold. A notable number of analogs of mefloquine, chloroquine, and hydroxychloroquine have been synthesized, starting from the readily available active pharmaceutical ingredient (API). In the current review, all the modifications sites and reactivity types are summarized and provide insight into the chemistry of these molecules. The approaches include the introduction of simple groups and functionalities. Coupling to other drugs, polymers, or carriers afforded hybrid compounds or conjugates with either easily hydrolyzable or more chemically inert bonds. The utility of some of the compounds was tested in antiprotozoal, antibacterial, and antiproliferative assays, as well as in enantiodifferentiation experiments.<\/jats:p>","DOI":"10.3390\/molecules27031003","type":"journal-article","created":{"date-parts":[[2022,2,3]],"date-time":"2022-02-03T05:42:33Z","timestamp":1643866953000},"page":"1003","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":70,"title":["A Review of Modifications of Quinoline Antimalarials: Mefloquine and (hydroxy)Chloroquine"],"prefix":"10.3390","volume":"27","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5074-4719","authenticated-orcid":false,"given":"Dawid J.","family":"Kucharski","sequence":"first","affiliation":[{"name":"Department of Organic and Medicinal Chemistry, Wroc\u0142aw University of Technology, Wyspia\u0144skiego 27, 50-370 Wroc\u0142aw, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michalina K.","family":"Jaszczak","sequence":"additional","affiliation":[{"name":"Department of Organic and Medicinal Chemistry, Wroc\u0142aw University of Technology, Wyspia\u0144skiego 27, 50-370 Wroc\u0142aw, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7139-8568","authenticated-orcid":false,"given":"Przemys\u0142aw J.","family":"Boraty\u0144ski","sequence":"additional","affiliation":[{"name":"Department of Organic and Medicinal Chemistry, Wroc\u0142aw University of Technology, Wyspia\u0144skiego 27, 50-370 Wroc\u0142aw, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,2,2]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1723","DOI":"10.1007\/s00044-020-02604-6","article-title":"A Review of Antimalarial Activity of Two or Three Nitrogen Atoms Containing Heterocyclic Compounds","volume":"29","author":"Chugh","year":"2020","journal-title":"Med. 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