{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,18]],"date-time":"2026-03-18T16:14:38Z","timestamp":1773850478096,"version":"3.50.1"},"reference-count":42,"publisher":"MDPI AG","issue":"4","license":[{"start":{"date-parts":[[2022,2,21]],"date-time":"2022-02-21T00:00:00Z","timestamp":1645401600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>Nickel-induced contact dermatitis is a severe allergic reaction to objects or environments that contain nickel. Many nanomaterials have been developed to reduce skin allergies by capturing nickel, but few agents are effective and safe. In this work, mesoporous silica nanoparticles (MSN) were synthesized and decorated with hexa-histidine peptides (denoted as MSN-His6), making it a strong nickel chelator. Subsequently, a dietary polyphenol, chlorogenic acid, was loaded into the mesopores of MSN (denoted as MSN-His6@CGA), realizing the potential of its anti-inflammatory properties. In vitro and in vivo experiments revealed that the synthesized MSN-His6@CGA nanoparticles exhibited more stable and stronger chelation, better biocompatibility, and ideal allergy-relieving ability, whether for environmental metal contamination or for allergic contact dermatitis caused by prolonged nickel exposure. Thus, the application of mesoporous silica-based nanoparticles may represent an ideal approach to alleviate skin allergies by capturing nickel, which would benefit people who suffer from metal-induced contact dermatitis.<\/jats:p>","DOI":"10.3390\/molecules27041430","type":"journal-article","created":{"date-parts":[[2022,2,21]],"date-time":"2022-02-21T20:47:45Z","timestamp":1645476465000},"page":"1430","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Chlorogenic Acid-Loaded Mesoporous Silica Nanoparticles Modified with Hexa-Histidine Peptides Reduce Skin Allergies by Capturing Nickel"],"prefix":"10.3390","volume":"27","author":[{"given":"Tianyu","family":"Wang","sequence":"first","affiliation":[{"name":"College of Food Science and Engineering, Jilin Agriculture University, Changchun 130118, China"},{"name":"College of Food Science and Engineering, Changchun University, Changchun 130012, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liying","family":"Yin","sequence":"additional","affiliation":[{"name":"College of Food Science and Engineering, Changchun University, Changchun 130012, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zheng","family":"Ma","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery, Qilu Hospital, Cheeloo College of Medicine, Shandong University, Jinan 250012, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yanrong","family":"Zhang","sequence":"additional","affiliation":[{"name":"College of Food Science and Engineering, Jilin Agriculture University, Changchun 130118, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2022,2,21]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1007\/164_2016_9","article-title":"Histamine and histamine receptors in allergic dermatitis","volume":"241","author":"Ohtsu","year":"2017","journal-title":"Handb. Exp. Pharmacol."},{"key":"ref_2","first-page":"321","article-title":"Nickel and human health","volume":"13","author":"Zambelli","year":"2013","journal-title":"Interrelat. Between Essent. Met. Ions Life Sci."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1038\/nm.3874","article-title":"Unpleasant memories: Tissue-embedded T cell memory drives skin hypersensitivity","volume":"21","author":"Gebhardt","year":"2015","journal-title":"Nat. Med."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"18517","DOI":"10.1073\/pnas.1215928109","article-title":"T-cell receptor (TCR) interaction with peptides that mimic nickel offers insight into nickel contact allergy","volume":"109","author":"Yin","year":"2012","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1111\/bjd.15628","article-title":"Contact allergy in children with atopic dermatitis: A systematic review","volume":"177","author":"Simonsen","year":"2017","journal-title":"Br. J. Dermatol."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1038\/nri3150","article-title":"Early immune events in the induction of allergic contact dermatitis","volume":"12","author":"Kaplan","year":"2012","journal-title":"Nat. Rev. Immunol."},{"key":"ref_7","doi-asserted-by":"crossref","unstructured":"Rengel, Z. (2004). Heavy metals as essential nutrients. Heavy Metal Stress in Plants, Springer.","DOI":"10.1007\/978-3-662-07743-6_11"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1016\/j.jhazmat.2017.10.063","article-title":"Novel synthesis of cyano-functionalized mesoporous silica nanospheres (MSN) from coal fly ash for removal of toxic metals from wastewater","volume":"345","author":"Wang","year":"2018","journal-title":"J. Hazard. Mater."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/j.matchemphys.2019.01.002","article-title":"New magnetic silica-based hybrid organic-inorganic nanocomposite for the removal of lead(II) and nickel(II) ions from aqueous solutions","volume":"226","author":"Ahmad","year":"2019","journal-title":"Mater. Chem. Phys."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"100105","DOI":"10.1016\/j.wri.2018.100105","article-title":"Modified amorphous silica from a geothermal central as a metal adsorption agent for the regeneration of wastewater","volume":"21","author":"Sandoval","year":"2019","journal-title":"Water Resour. Ind."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"1601125","DOI":"10.1002\/adhm.201601125","article-title":"Synthetic vs natural: Diatoms bioderived porous materials for the next generation of healthcare nanodevices","volume":"6","author":"Rea","year":"2017","journal-title":"Adv. Healthc. Mater."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"3862","DOI":"10.1039\/c3cs35405a","article-title":"Synthesis of mesoporous silica nanoparticles","volume":"42","author":"Wu","year":"2013","journal-title":"Chem. Soc. Rev."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1021\/acsabm.8b00633","article-title":"Identifying a membrane-type 2 matrix metalloproteinase-targeting peptide for human lung cancer detection and targeting chemotherapy with functionalized mesoporous silica","volume":"2","author":"Ren","year":"2019","journal-title":"ACS Appl. Bio Mater."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1038\/nnano.2011.37","article-title":"Nanoparticles reduce nickel allergy by capturing metal ions","volume":"6","author":"Vemula","year":"2011","journal-title":"Nat. Nanotechnol."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/j.jhazmat.2005.09.027","article-title":"Factors affecting adsorption characteristics of Zn2+ on two natural zeolites","volume":"131","author":"Oren","year":"2006","journal-title":"J. Hazard. Mater."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"3412","DOI":"10.1021\/bm500950c","article-title":"Self-assembly of a model peptide incorporating a hexa-histidine sequence attached to an oligo-alanine sequence, and binding to gold NTA\/nickel nanoparticles","volume":"15","author":"Hamley","year":"2014","journal-title":"Biomacromolecules"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"1017","DOI":"10.1038\/nbt0896-1017","article-title":"Enhanced metalloadsorption of bacterial cells displaying poly-His peptides","volume":"14","author":"Sousa","year":"1996","journal-title":"Nat. Biotechnol."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"2083","DOI":"10.1080\/10408398.2019.1630358","article-title":"Delivery of synergistic polyphenol combinations using biopolymer-based systems: Advances in physicochemical properties, stability and bioavailability","volume":"60","author":"Zhang","year":"2020","journal-title":"Crit. Rev. Food Sci. Nutr."},{"key":"ref_19","doi-asserted-by":"crossref","unstructured":"Liu, Y., Kelsang, N., Lu, J., Zhang, Y., Liang, H., Tu, P., Kong, D., and Zhang, Q. (2019). Oxytrodiflavanone A and oxytrochalcoflavanones A,B: New biflavonoids from Oxytropis chiliophylla. Molecules, 24.","DOI":"10.3390\/molecules24081468"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"810","DOI":"10.1016\/j.foodres.2018.09.015","article-title":"Insights into the importance of dietary chrysanthemum flower (Chrysanthemum morifolium cv. Hangju)-wolfberry (Lycium barbarum fruit) combination in antioxidant and anti-inflammatory properties","volume":"116","author":"Zhang","year":"2019","journal-title":"Food Res. Int."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"4826","DOI":"10.1039\/D0FO01168A","article-title":"Protection against developing type 2 diabetes by coffee consumption: Assessment of the role of chlorogenic acid and metabolites on glycaemic responses","volume":"11","author":"Williamson","year":"2020","journal-title":"Food Funct."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/j.biopha.2017.10.064","article-title":"Chlorogenic acid (CGA): A pharmacological review and call for further research","volume":"97","author":"Naveed","year":"2018","journal-title":"Biomed. Pharmacother."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1016\/j.lwt.2015.08.024","article-title":"5-O-Caffeoylquinic acid: A spectroscopic study and biological screening for antimicrobial activity","volume":"65","author":"Bajko","year":"2016","journal-title":"LWT Food Sci. Technol."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"681","DOI":"10.1039\/C8FO01755G","article-title":"Chlorogenic acid relieves lead-induced cognitive impairments and hepato-renal damage via regulating the dysbiosis of the gut microbiota in mice","volume":"10","author":"Cheng","year":"2019","journal-title":"Food Funct."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"122405","DOI":"10.1016\/j.cej.2019.122405","article-title":"Preparation of mesoporous silica materials functionalized with various amino-ligands and investigation of adsorption performances on aromatic acids","volume":"379","author":"Liu","year":"2020","journal-title":"Chem. Eng. J."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"110787","DOI":"10.1016\/j.fct.2019.110787","article-title":"Polyphenols extract from grape pomace. Characterization and valorisation through encapsulation into mesoporous silica-type matrices","volume":"133","author":"Brezoiu","year":"2019","journal-title":"Food Chem. Toxicol."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"185101","DOI":"10.1088\/1361-6528\/ab70fb","article-title":"Antibacterial activity of chlorogenic acid-loaded SiO2 nanoparticles caused by accumulation of reactive oxygen species","volume":"31","author":"Wang","year":"2020","journal-title":"Nanotechnology"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"3978","DOI":"10.1021\/jacs.7b01118","article-title":"Spatial mapping of protein adsorption on mesoporous silica nanoparticles by stochastic optical reconstruction microscopy","volume":"139","author":"Clemments","year":"2017","journal-title":"J. Am. Chem. Soc."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1084\/jem.61.5.643","article-title":"Studies on the sensitization of animals with simple chemical compounds: III. anaphylaxis induced by arsphenamine","volume":"61","author":"Landsteiner","year":"1935","journal-title":"J. Exp. Med."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"710","DOI":"10.1038\/359710a0","article-title":"Ordered mesoporous molecular sieves synthesized by a liquid-crystal template mechanism","volume":"359","author":"Kresge","year":"1992","journal-title":"Nature"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"77","DOI":"10.4155\/ppa-2016-0042","article-title":"Drug delivery via porous silicon: A focused patent review","volume":"6","author":"Kulyavtsev","year":"2017","journal-title":"Pharm. Pat. Anal."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1016\/j.cej.2018.11.087","article-title":"Heavy metal adsorption with zeolites: The role of hierarchical pore architecture","volume":"359","author":"Hong","year":"2019","journal-title":"Chem. Eng. J."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"3192","DOI":"10.1016\/j.jece.2018.04.062","article-title":"Grafting of Amine functional group on silicate based material as adsorbent for water purification: A short review","volume":"6","author":"Wamba","year":"2018","journal-title":"J. Environ. Chem. Eng."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1007\/s40726-020-00152-6","article-title":"Functionalized mesoporous silicon nanomaterials in inorganic soil pollution research: Opportunities for soil protection and advanced chemical imaging","volume":"6","author":"Yang","year":"2020","journal-title":"Curr. Pollut. Rep."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"10764","DOI":"10.1021\/acs.langmuir.5b02158","article-title":"Stealth effect of biomolecular corona on nanoparticle uptake by immune cells","volume":"31","author":"Caracciolo","year":"2015","journal-title":"Langmuir"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1038\/s41565-018-0344-3","article-title":"Immunoglobulin deposition on biomolecule corona determines complement opsonization efficiency of preclinical and clinical nanoparticles","volume":"14","author":"Vu","year":"2019","journal-title":"Nat. Nanotechnol."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"1465","DOI":"10.1016\/j.cell.2018.07.031","article-title":"Cell-penetrating peptide mediates intracellular membrane passage of human papillomavirus L2 protein to trigger retrograde trafficking","volume":"174","author":"Zhang","year":"2018","journal-title":"Cell"},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1038\/nm.3860","article-title":"Common clonal origin of central and resident memory T cells following skin immunization","volume":"21","author":"Gaide","year":"2015","journal-title":"Nat. Med."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"1102","DOI":"10.4049\/jimmunol.0902518","article-title":"CD56highCD16\u2212CD62L\u2212 NK cells accumulate in allergic contact dermatitis and contribute to the expression of allergic responses","volume":"184","author":"Carbone","year":"2010","journal-title":"J. Immunol."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"5089","DOI":"10.1039\/C5NR08753H","article-title":"Cellulose conjugated FITC-labelled mesoporous silica nanoparticles: Intracellular accumulation and stimuli responsive doxorubicin release","volume":"8","author":"Hakeem","year":"2016","journal-title":"Nanoscale"},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"13216","DOI":"10.1021\/ja046275m","article-title":"A polyamidoamine dendrimer-capped mesoporous silica nanosphere-based gene transfection reagent","volume":"126","author":"Radu","year":"2004","journal-title":"J. Am. Chem. Soc."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1034\/j.1398-9995.2003.23790.x","article-title":"A mouse model of the atopic eczema\/dermatitis syndrome by repeated application of a crude extract of house-dust mite Dermatophagoides farinae","volume":"58","author":"Matsuoka","year":"2003","journal-title":"Allergy"}],"container-title":["Molecules"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1420-3049\/27\/4\/1430\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T22:23:44Z","timestamp":1760135024000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1420-3049\/27\/4\/1430"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,2,21]]},"references-count":42,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2022,2]]}},"alternative-id":["molecules27041430"],"URL":"https:\/\/doi.org\/10.3390\/molecules27041430","relation":{},"ISSN":["1420-3049"],"issn-type":[{"value":"1420-3049","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,2,21]]}}}