{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T07:03:32Z","timestamp":1788246212924,"version":"build-2803163510"},"reference-count":24,"publisher":"MDPI AG","issue":"5","license":[{"start":{"date-parts":[[2022,2,24]],"date-time":"2022-02-24T00:00:00Z","timestamp":1645660800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Medical Science and Technology Research Accumulation Fund Project of Guangdong Province","award":["B2021430"],"award-info":[{"award-number":["B2021430"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>In this paper, a small series of novel quinoline sulfonamide derivatives was synthesized, and their structure of the target compounds were confirmed by 1H NMR and MS. The screening of the news target compounds\u2019 in vitro cytotoxic activities against tumor cell lines by the MTT method was performed. Among them, compound D13 (N-(4-methoxybenzyl)-2-oxo-N-(3,4,5-trimethoxyphenyl)-1,2,3,4-tetrahydroquinoline-6-sulfonamide exhibited the strongest inhibitory effect on the proliferation of HeLa (IC50: 1.34 \u03bcM), and this value correlated well with the inhibitory activities of the compound against tubulin polymerization (IC50: 6.74 \u03bcM). In summary, a new type of quinoline-sulfonamide derivative with tubulin polymerization inhibitory activity was discovered, and it can be used as a lead compound for further modification.<\/jats:p>","DOI":"10.3390\/molecules27051537","type":"journal-article","created":{"date-parts":[[2022,2,24]],"date-time":"2022-02-24T21:11:07Z","timestamp":1645737067000},"page":"1537","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Discovery of Novel 3,4-Dihydro-2(1H)-Quinolinone Sulfonamide Derivatives as New Tubulin Polymerization Inhibitors with Anti-Cancer Activity"],"prefix":"10.3390","volume":"27","author":[{"given":"Juan","family":"Ma","sequence":"first","affiliation":[{"name":"Pharmaceutical Engineering College of Guangdong Food and Drug Vocational College, Guangzhou 510000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guo-Hua","family":"Gong","sequence":"additional","affiliation":[{"name":"Inner Mongolia Key Laboratory of Mongolian Medicine Pharmacology for Cardio-Cerebral Vascular System, Tongliao 028000, China"},{"name":"Institute of Mongolia and Western Medicinal Treatment, Affiliated Hospital of Inner Mongolia University for Nationalities, Tongliao 028000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,2,24]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"3599","DOI":"10.1098\/rsta.2008.0106","article-title":"Progress in the development of early diagnosis and a drug with unique pharmacology to improve cancer therapy","volume":"366","author":"Lehotzky","year":"2008","journal-title":"Philos. 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