{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,19]],"date-time":"2026-03-19T09:29:37Z","timestamp":1773912577805,"version":"3.50.1"},"reference-count":34,"publisher":"MDPI AG","issue":"5","license":[{"start":{"date-parts":[[2022,2,24]],"date-time":"2022-02-24T00:00:00Z","timestamp":1645660800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003593","name":"National Council for Scientific and Technological Development","doi-asserted-by":"publisher","award":["141680\/2018-0"],"award-info":[{"award-number":["141680\/2018-0"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>Diseases caused by viruses are a global threat, resulting in serious medical and social problems for humanity. They are the main contributors to many minor and major outbreaks, epidemics, and pandemics worldwide. Over the years, medicinal plants have been used as a complementary treatment in a range of diseases. In this sense, this review addresses promising antiviral plants from Maraj\u00f3 island, a part of the Amazon region, which is known to present a very wide biodiversity of medicinal plants. The present review has been limited to articles and abstracts available in Scopus, Web of Science, Science Direct, Scielo, PubMed, and Google Scholar, as well as the patent offices in Brazil (INPI), United States (USPTO), Europe (EPO) and World Intellectual Property Organization (WIPO). As a result, some plants from Maraj\u00f3 island were reported to have actions against HIV-1,2, HSV-1,2, SARS-CoV-2, HAV and HBV, Poliovirus, and influenza. Our major conclusion is that plants of the Maraj\u00f3 region show promising perspectives regarding pharmacological potential in combatting future viral diseases.<\/jats:p>","DOI":"10.3390\/molecules27051542","type":"journal-article","created":{"date-parts":[[2022,2,24]],"date-time":"2022-02-24T21:11:07Z","timestamp":1645737067000},"page":"1542","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Antiviral Plants from Maraj\u00f3 Island, Brazilian Amazon: A Narrative Review"],"prefix":"10.3390","volume":"27","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5478-2448","authenticated-orcid":false,"given":"Paulo Wender P.","family":"Gomes","sequence":"first","affiliation":[{"name":"Collaborative Mass Spectrometry Innovation Center, Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California San Diego, San Diego, CA 92122, USA"},{"name":"Laboratory of Liquid Chromatography (Labcrol), Institute of Exact and Natural Sciences, Federal University of Par\u00e1, Belem 66075-110, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luiza","family":"Martins","sequence":"additional","affiliation":[{"name":"Institute of Animal Health and Production (ISPA), Federal Rural University of Amazonia (UFRA), Av. Presidente Tancredo Neves No. 2501, Terra Firme, Belem 66077-830, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emilli","family":"Gomes","sequence":"additional","affiliation":[{"name":"Institute of Health Sciences, Faculty of Nutrition (FANUT), Federal University of Par\u00e1 (UFPA), R. Augusto Corr\u00eaa, 01, Guam\u00e1, Belem 66075-110, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Abra\u00e3o","family":"Muribeca","sequence":"additional","affiliation":[{"name":"Laboratory of Liquid Chromatography (Labcrol), Institute of Exact and Natural Sciences, Federal University of Par\u00e1, Belem 66075-110, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S\u00f4nia","family":"Pamplona","sequence":"additional","affiliation":[{"name":"Laboratory of Liquid Chromatography (Labcrol), Institute of Exact and Natural Sciences, Federal University of Par\u00e1, Belem 66075-110, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2961-5637","authenticated-orcid":false,"given":"Andrea","family":"Komesu","sequence":"additional","affiliation":[{"name":"Department of Marine Sciences (DCMar), Federal University of S\u00e3o Paulo (UNIFESP), R. Carvalho de Mendon\u00e7a, 144, Encruzilhada, Santos 11070-100, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carissa","family":"Bichara","sequence":"additional","affiliation":[{"name":"Laboratory of Liquid Chromatography (Labcrol), Institute of Exact and Natural Sciences, Federal University of Par\u00e1, Belem 66075-110, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0291-0422","authenticated-orcid":false,"given":"Mahendra","family":"Rai","sequence":"additional","affiliation":[{"name":"Biotechnology Department, SGB Amravati University, Amravati 444 602, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Consuelo","family":"Silva","sequence":"additional","affiliation":[{"name":"Laboratory of Liquid Chromatography (Labcrol), Institute of Exact and Natural Sciences, Federal University of Par\u00e1, Belem 66075-110, Brazil"},{"name":"Faculty of Pharmaceutical Sciences, Federal University of Par\u00e1, Belem 66075-110, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9755-4058","authenticated-orcid":false,"given":"Milton","family":"Silva","sequence":"additional","affiliation":[{"name":"Laboratory of Liquid Chromatography (Labcrol), Institute of Exact and Natural Sciences, Federal University of Par\u00e1, Belem 66075-110, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2022,2,24]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"e03217","DOI":"10.1016\/j.heliyon.2020.e03217","article-title":"Coumarin: An emerging antiviral agent","volume":"6","author":"Mishra","year":"2020","journal-title":"Heliyon"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1021\/acscentsci.0c00272","article-title":"Research and Development on Therapeutic Agents and Vaccines for COVID-19 and Related Human Coronavirus Diseases","volume":"6","author":"Liu","year":"2020","journal-title":"ACS Cent. 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