{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,20]],"date-time":"2026-03-20T00:00:38Z","timestamp":1773964838930,"version":"3.50.1"},"reference-count":56,"publisher":"MDPI AG","issue":"5","license":[{"start":{"date-parts":[[2022,3,7]],"date-time":"2022-03-07T00:00:00Z","timestamp":1646611200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"European Space Agency Education Office","award":["Spin Your Thesis!"],"award-info":[{"award-number":["Spin Your Thesis!"]}]},{"name":"Romanian Ministry of Research, Innovation and Digitization","award":["16N\/08.02.2019"],"award-info":[{"award-number":["16N\/08.02.2019"]}]},{"name":"Ministry of Research, Innovation and Digitization, CNCS\/CCCDI-UEFISCDI","award":["PD 125\/2020 (PN-III-P1-1.1-PD-2019-1117), PED 465\/2020 (PN-III-P2-2.1-PED-2019-1264) and PED 420\/2020 (PN-III-P2-2.1-PED-2019-5283) within PNCDI III"],"award-info":[{"award-number":["PD 125\/2020 (PN-III-P1-1.1-PD-2019-1117), PED 465\/2020 (PN-III-P2-2.1-PED-2019-1264) and PED 420\/2020 (PN-III-P2-2.1-PED-2019-5283) within PNCDI III"]}]},{"DOI":"10.13039\/501100000844","name":"European Space Agency","doi-asserted-by":"publisher","award":["4000107455\/12\/NL\/PA"],"award-info":[{"award-number":["4000107455\/12\/NL\/PA"]}],"id":[{"id":"10.13039\/501100000844","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>Pharmaceuticals carried into space are subjected to different gravitational conditions. Hypergravity is encountered in the first stage, during spacecraft launching. The stability of medicines represents a critical element of space missions, especially long-duration ones. Therefore, stability studies should be envisaged before the implementation of drugs for future deep space travel, where the available pharmaceuticals would be limited and restocking from Earth would be impossible. Multipurpose drugs should be proposed for this reason, such as phenothiazine derivatives that can be transformed by optical methods into antimicrobial agents. Within this preliminary study, promethazine and thioridazine aqueous solutions were exposed to UV laser radiation that modified their structures and generated a mixture of photoproducts efficient against particular bacteria. Subsequently, they were subjected to 20 g in the European Space Agency\u2019s Large Diameter Centrifuge. The aim was to evaluate the impact of hypergravity on the physico-chemical and spectral properties of unirradiated and laser-irradiated medicine solutions through pH assay, UV-Vis\/FTIR absorption spectroscopy, and thin-layer chromatography. The results revealed no substantial alterations in centrifuged samples when compared to uncentrifuged ones. Due to their stability after high-g episodes, laser-exposed phenothiazines could be considered for future space missions.<\/jats:p>","DOI":"10.3390\/molecules27051728","type":"journal-article","created":{"date-parts":[[2022,3,9]],"date-time":"2022-03-09T01:53:54Z","timestamp":1646790834000},"page":"1728","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Stability Studies of UV Laser Irradiated Promethazine and Thioridazine after Exposure to Hypergravity Conditions"],"prefix":"10.3390","volume":"27","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0097-1996","authenticated-orcid":false,"given":"\u00c1gota","family":"Simon","sequence":"first","affiliation":[{"name":"National Institute for Laser, Plasma and Radiation Physics (INFLPR), Laser Department, Atomi\u0219tilor 409, 077125 M\u0103gurele, Ilfov, Romania"},{"name":"Faculty of Physics, University of Bucharest, Atomi\u0219tilor 405, 077125 M\u0103gurele, Ilfov, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5953-9241","authenticated-orcid":false,"given":"Tatiana","family":"Tozar","sequence":"additional","affiliation":[{"name":"National Institute for Laser, Plasma and Radiation Physics (INFLPR), Laser Department, Atomi\u0219tilor 409, 077125 M\u0103gurele, Ilfov, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4586-7551","authenticated-orcid":false,"given":"Adriana","family":"Smarandache","sequence":"additional","affiliation":[{"name":"National Institute for Laser, Plasma and Radiation Physics (INFLPR), Laser Department, Atomi\u0219tilor 409, 077125 M\u0103gurele, Ilfov, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mihai","family":"Boni","sequence":"additional","affiliation":[{"name":"National Institute for Laser, Plasma and Radiation Physics (INFLPR), Laser Department, Atomi\u0219tilor 409, 077125 M\u0103gurele, Ilfov, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1513-1057","authenticated-orcid":false,"given":"Alexandru","family":"Stoicu","sequence":"additional","affiliation":[{"name":"National Institute for Laser, Plasma and Radiation Physics (INFLPR), Laser Department, Atomi\u0219tilor 409, 077125 M\u0103gurele, Ilfov, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alan","family":"Dowson","sequence":"additional","affiliation":[{"name":"European Space Agency (ESA), European Space Research and Technology Centre (ESTEC), TEC-MMG, Keplerlaan 1, 2201 AZ Noordwijk, The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jack J. 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A.","family":"van Loon","sequence":"additional","affiliation":[{"name":"European Space Agency (ESA), European Space Research and Technology Centre (ESTEC), TEC-MMG, Keplerlaan 1, 2201 AZ Noordwijk, The Netherlands"},{"name":"Dutch Experiment Support Center (DESC), Department of Oral and Maxillofacial Surgery\/Oral Pathology, Amsterdam Bone Center (ABC), Amsterdam UMC Location VU University Medical Center (VUmc) & Academic Centre for Dentistry Amsterdam (ACTA), Gustav Mahlerlaan 3004, 1081 LA Amsterdam, The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1151-9345","authenticated-orcid":false,"given":"Mihail Lucian","family":"Pascu","sequence":"additional","affiliation":[{"name":"National Institute for Laser, Plasma and Radiation Physics (INFLPR), Laser Department, Atomi\u0219tilor 409, 077125 M\u0103gurele, Ilfov, Romania"},{"name":"Faculty of Physics, University of Bucharest, Atomi\u0219tilor 405, 077125 M\u0103gurele, Ilfov, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2022,3,7]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Ortega, H.J., Harm, D.L., and Reschke, M.F. 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