{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T20:21:28Z","timestamp":1791490888886,"version":"4.3.4"},"reference-count":187,"publisher":"MDPI AG","issue":"6","license":[{"start":{"date-parts":[[2022,3,14]],"date-time":"2022-03-14T00:00:00Z","timestamp":1647216000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"European Union and the European Social Fund","award":["EFOP-3.6.3-VEKOP-16-2017-00008"],"award-info":[{"award-number":["EFOP-3.6.3-VEKOP-16-2017-00008"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>Colorectal cancer (CRC) represents the third type of cancer in incidence and second in mortality worldwide, with the newly diagnosed case number on the rise. Among the diagnosed patients, approximately 70% have no hereditary germ-line mutations or family history of pathology, thus being termed sporadic CRC. Diet and environmental factors are to date considered solely responsible for the development of sporadic CRC; therefore; attention should be directed towards the discovery of preventative actions to combat the CRC initiation, promotion, and progression. Quercetin is a polyphenolic flavonoid plant secondary metabolite with a well-characterized antioxidant activity. It has been extensively reported as an anti-carcinogenic agent in the scientific literature, and the modulated targets of quercetin have been also characterized in the context of CRC, mainly in original research publications. In this fairly comprehensive review, we summarize the molecular targets of quercetin reported to date in in vivo and in vitro CRC models, while also giving background information about the signal transduction pathways that it up- and downregulates. Among the most relevant modulated pathways, the Wnt\/\u03b2-catenin, PI3K\/AKT, MAPK\/Erk, JNK, or p38, p53, and NF-\u03baB have been described. With this work, we hope to encourage further quests in the elucidation of quercetin anti-carcinogenic activity as single agent, as dietary component, or as pharmaconutrient delivered in the form of plant extracts.<\/jats:p>","DOI":"10.3390\/molecules27061873","type":"journal-article","created":{"date-parts":[[2022,3,15]],"date-time":"2022-03-15T02:56:20Z","timestamp":1647312980000},"page":"1873","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":79,"title":["A Comprehensive View on the Quercetin Impact on Colorectal Cancer"],"prefix":"10.3390","volume":"27","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5219-5466","authenticated-orcid":false,"given":"Andreea-Adriana","family":"Neamtu","sequence":"first","affiliation":[{"name":"Doctoral School of Biomedical Sciences, University of Oradea, 410087 Oradea, Romania"},{"name":"Faculty of Medicine, \u201cVasile Goldis\u201d Western University of Arad, 310045 Arad, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Teodor-Andrei","family":"Maghiar","sequence":"additional","affiliation":[{"name":"Doctoral School of Biomedical Sciences, University of Oradea, 410087 Oradea, Romania"},{"name":"Department of Surgical Disciplines, Faculty of Medicine and Pharmacy, University of Oradea, 410081 Oradea, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amina","family":"Alaya","sequence":"additional","affiliation":[{"name":"Doctoral School of Animal Science, Faculty of Agricultural and Food Sciences and Environmental Management, University of Debrecen, H-4032 Debrecen, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5204-6885","authenticated-orcid":false,"given":"Neli-Kinga","family":"Olah","sequence":"additional","affiliation":[{"name":"SC PlantExtrAKT SRL, 407059 R\u0103daia, Romania"},{"name":"Faculty of Pharmacy, \u201cVasile Goldis\u201d Western University of Arad, 310045 Arad, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Violeta","family":"Turcus","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, \u201cVasile Goldis\u201d Western University of Arad, 310045 Arad, Romania"},{"name":"National Institute for Economic Research \u201cCostin C. Kiritescu\u201d of the Romanian Academy\/Centre for Mountain Economy (CE-MONT), 725700 Suceava, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diana","family":"Pelea","sequence":"additional","affiliation":[{"name":"Faculty of Medicine and Pharmacy, University of Oradea, 410081 Oradea, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bogdan Dan","family":"Totolici","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, \u201cVasile Goldis\u201d Western University of Arad, 310045 Arad, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carmen","family":"Neamtu","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, \u201cVasile Goldis\u201d Western University of Arad, 310045 Arad, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adrian Marius","family":"Maghiar","sequence":"additional","affiliation":[{"name":"Department of Surgical Disciplines, Faculty of Medicine and Pharmacy, University of Oradea, 410081 Oradea, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Endre","family":"Mathe","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, \u201cVasile Goldis\u201d Western University of Arad, 310045 Arad, Romania"},{"name":"Institute of Nutrition, Faculty of Agricultural and Food Sciences and Environmental Management, University of Debrecen, H-4032 Debrecen, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,3,14]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"209","DOI":"10.3322\/caac.21660","article-title":"Global cancer statistics 2020: GLOBOCAN Estimates of Incidence and Mortality Worldwide for 36 Cancers in 185 Countries","volume":"71","author":"Sung","year":"2021","journal-title":"CA Cancer J. 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