{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T18:45:05Z","timestamp":1788547505195,"version":"build-2803163510"},"reference-count":66,"publisher":"MDPI AG","issue":"6","license":[{"start":{"date-parts":[[2022,3,15]],"date-time":"2022-03-15T00:00:00Z","timestamp":1647302400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"the S &amp; T Program of Hebei","award":["H2021208007"],"award-info":[{"award-number":["H2021208007"]}]},{"name":"Fund of Dean of Huachuang Institute of Areca Research-Hainan","award":["HCBL2020YZ-012"],"award-info":[{"award-number":["HCBL2020YZ-012"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>Hyperlipidemia is a chronic metabolic disease caused by the abnormal metabolism of lipoproteins in the human body. Its main hazard is to accelerate systemic atherosclerosis, which causes cerebrovascular diseases such as coronary heart disease and thrombosis. At the same time, although the current hypolipidemic drugs have a certain therapeutic effect, they have side effects such as liver damage and digestive tract discomfort. Many kinds of polysaccharides from natural resources possess therapeutic effects on hyperlipidemia but still lack a comprehensive understanding. In this paper, the research progress of natural polysaccharides on reducing blood lipids in recent years is reviewed. The pharmacological mechanisms and targets of natural polysaccharides are mainly introduced. The relationship between structure and hypolipidemic activity is also discussed in detail. This review will help to understand the value of polysaccharides in lowering blood lipids and provide guidance for the development and clinical application of new hypolipidemic drugs.<\/jats:p>","DOI":"10.3390\/molecules27061903","type":"journal-article","created":{"date-parts":[[2022,3,16]],"date-time":"2022-03-16T03:36:23Z","timestamp":1647401783000},"page":"1903","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":47,"title":["An Insight into Antihyperlipidemic Effects of Polysaccharides from Natural Resources"],"prefix":"10.3390","volume":"27","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9362-4554","authenticated-orcid":false,"given":"Yong-Shuai","family":"Jing","sequence":"first","affiliation":[{"name":"College of Chemistry and Pharmaceutical Engineering, Hebei University of Science and Technology, 26 Yuxiang Street, Shijiazhuang 050018, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yun-Feng","family":"Ma","sequence":"additional","affiliation":[{"name":"College of Chemistry and Pharmaceutical Engineering, Hebei University of Science and Technology, 26 Yuxiang Street, Shijiazhuang 050018, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fei-Bing","family":"Pan","sequence":"additional","affiliation":[{"name":"Huachuang Institute of Areca Research-Hainan, Haikou 570125, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ming-Song","family":"Li","sequence":"additional","affiliation":[{"name":"College of Chemistry and Pharmaceutical Engineering, Hebei University of Science and Technology, 26 Yuxiang Street, Shijiazhuang 050018, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu-Guang","family":"Zheng","sequence":"additional","affiliation":[{"name":"College of Pharmacy, Hebei University of Chinese Medicine, 3 Xingyuan Road, Shijiazhuang 050200, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lan-Fang","family":"Wu","sequence":"additional","affiliation":[{"name":"College of Pharmacy, Hebei University of Chinese Medicine, 3 Xingyuan Road, Shijiazhuang 050200, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dan-Shen","family":"Zhang","sequence":"additional","affiliation":[{"name":"College of Chemistry and Pharmaceutical Engineering, Hebei University of Science and Technology, 26 Yuxiang Street, Shijiazhuang 050018, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,3,15]]},"reference":[{"key":"ref_1","first-page":"11885","article-title":"Atorvastatin prevents hearing impairment in the presence of hyperlipidemia","volume":"1867","author":"Lee","year":"2020","journal-title":"BBA Mol. 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