{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,3]],"date-time":"2026-03-03T13:12:56Z","timestamp":1772543576429,"version":"3.50.1"},"reference-count":26,"publisher":"MDPI AG","issue":"7","license":[{"start":{"date-parts":[[2022,3,25]],"date-time":"2022-03-25T00:00:00Z","timestamp":1648166400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Inha University Research Grant","award":["N\/A"],"award-info":[{"award-number":["N\/A"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>A novel melanoblast stimulator (1) was isolated from Dimocarpus longan. Its analogs were also synthesized to support a new furan-based melanoblast stimulator scaffold for treating vitiligo. Isolated 5-(hydroxymethyl)furfural (HMF, 1) is a well-known compound in the food industry. Surprisingly, the melanogenic activity of HMF (1) was discovered here for the first time. Both HMF and its synthetic analog (16) promote the differentiation and migration of melanoblasts in vitro. Typically, stimulator (1) upregulated MMP2 expression, which promoted the migration of melanoblasts in vitro.<\/jats:p>","DOI":"10.3390\/molecules27072135","type":"journal-article","created":{"date-parts":[[2022,3,27]],"date-time":"2022-03-27T21:29:36Z","timestamp":1648416576000},"page":"2135","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Isolation of a Melanoblast Stimulator from Dimocarpus longan, Its Structural Modification, and Structure\u2013Activity Relationships for Vitiligo"],"prefix":"10.3390","volume":"27","author":[{"given":"Jae-Won","family":"Song","sequence":"first","affiliation":[{"name":"Department of Chemistry and Chemical Engineering, Inha University, Incheon 22212, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sunju","family":"Choi","sequence":"additional","affiliation":[{"name":"Department of Biological Engineering, Inha University, Incheon 22212, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gayeong","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Biological Engineering, Inha University, Incheon 22212, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hyang Bok","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Biological Engineering, Inha University, Incheon 22212, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P. Sankara","family":"Rao","sequence":"additional","affiliation":[{"name":"Department of Chemistry and Chemical Engineering, Inha University, Incheon 22212, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4995-9533","authenticated-orcid":false,"given":"Jeonghyun","family":"Shin","sequence":"additional","affiliation":[{"name":"Department of Dermatology, School of Medicine, Inha University, Incheon 22212, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eun Ki","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Biological Engineering, Inha University, Incheon 22212, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3272-0745","authenticated-orcid":false,"given":"Dong-Gyu","family":"Cho","sequence":"additional","affiliation":[{"name":"Department of Chemistry and Chemical Engineering, Inha University, Incheon 22212, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2022,3,25]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1016\/S0140-6736(14)60763-7","article-title":"Vitiligo","volume":"386","author":"Ezzedine","year":"2015","journal-title":"Lancet"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"15011","DOI":"10.1038\/nrdp.2015.11","article-title":"Vitiligo","volume":"1","author":"Picardo","year":"2015","journal-title":"Nat. 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