{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T18:40:53Z","timestamp":1789497653833,"version":"build-2803163510"},"reference-count":54,"publisher":"MDPI AG","issue":"7","license":[{"start":{"date-parts":[[2022,3,28]],"date-time":"2022-03-28T00:00:00Z","timestamp":1648425600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>In the present study, we investigated the molecular mechanisms of adenosine for its hair growth promoting effect. Adenosine stimulated the Wnt\/\u03b2-catenin pathway by modulating the activity of Gsk3\u03b2 in cultured human dermal papilla cells. It also activated adenosine receptor signaling, increasing intracellular cAMP level, and subsequently stimulating the cAMP mediated cellular energy metabolism. The phosphorylation of CREB, mTOR, and GSK3\u03b2 was increased. Furthermore, the expression of \u03b2-catenin target genes such as Axin2, Lef1, and growth factors (bFGF, FGF7, IGF-1) was also enhanced. The inhibitor study data conducted in Wnt reporter cells and in cultured human dermal papilla cells demonstrated that adenosine stimulates Wnt\/\u03b2-catenin signaling through the activation of the adenosine receptor and Gsk3\u03b2 plays a critical role in transmitting the signals from the adenosine receptor to \u03b2-catenin, possibly via the G\u03b1s\/cAMP\/PKA\/mTOR signaling cascade.<\/jats:p>","DOI":"10.3390\/molecules27072184","type":"journal-article","created":{"date-parts":[[2022,3,29]],"date-time":"2022-03-29T21:41:30Z","timestamp":1648590090000},"page":"2184","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["Anti-Hair Loss Effect of Adenosine Is Exerted by cAMP Mediated Wnt\/\u03b2-Catenin Pathway Stimulation via Modulation of Gsk3\u03b2 Activity in Cultured Human Dermal Papilla Cells"],"prefix":"10.3390","volume":"27","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4785-7090","authenticated-orcid":false,"given":"Jaeyoon","family":"Kim","sequence":"first","affiliation":[{"name":"LG Household & Health Care (LG H&H) R&D Center, 70, Magokjoongang 10-ro, Gangseo-gu, Seoul 07795, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jae Young","family":"Shin","sequence":"additional","affiliation":[{"name":"LG Household & Health Care (LG H&H) R&D Center, 70, Magokjoongang 10-ro, Gangseo-gu, Seoul 07795, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7920-3411","authenticated-orcid":false,"given":"Yun-Ho","family":"Choi","sequence":"additional","affiliation":[{"name":"LG Household & Health Care (LG H&H) R&D Center, 70, Magokjoongang 10-ro, Gangseo-gu, Seoul 07795, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nae Gyu","family":"Kang","sequence":"additional","affiliation":[{"name":"LG Household & Health Care (LG H&H) R&D Center, 70, Magokjoongang 10-ro, Gangseo-gu, Seoul 07795, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9472-9235","authenticated-orcid":false,"given":"Sanghwa","family":"Lee","sequence":"additional","affiliation":[{"name":"LG Household & Health Care (LG H&H) R&D Center, 70, Magokjoongang 10-ro, Gangseo-gu, Seoul 07795, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,3,28]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Effendi, W.I., Nagano, T., Kobayashi, K., and Nishimura, Y. 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