{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,5]],"date-time":"2026-09-05T02:45:16Z","timestamp":1788576316742,"version":"build-2803163510"},"reference-count":66,"publisher":"MDPI AG","issue":"7","license":[{"start":{"date-parts":[[2022,3,28]],"date-time":"2022-03-28T00:00:00Z","timestamp":1648425600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Sviluppo di nanotecnologie Orientate alla Rigenerazione e Ricostruzione tissutale, Implantologia e Sensoristica in Odontoiatria\/oculistica (SORRISO);","award":["PON 03 PE_00110_1\/ptd1_000410"],"award-info":[{"award-number":["PON 03 PE_00110_1\/ptd1_000410"]}]},{"name":"\u201cTecnologie abilitanti per la sintesi eco-sostenibile di nuovi materiali per la restaurativa dentale\u201d \u2013 ABILTECH","award":["POR Campania FESR 2014_2020"],"award-info":[{"award-number":["POR Campania FESR 2014_2020"]}]},{"name":"EU funding within the Horizon 2020 Program, under the MSCA-RISE 2016 Project \u201cVAHVISTUS\u201d","award":["Grant 734759"],"award-info":[{"award-number":["Grant 734759"]}]},{"name":"Micro-nanodispositivi veicolanti polifenoli isolati da scarti della filiera olivicola come nuovi integratori alimentari","award":["POR 2014-2020 FESR MISE Prog. n.F\/200004\/01-02\/X45"],"award-info":[{"award-number":["POR 2014-2020 FESR MISE Prog. n.F\/200004\/01-02\/X45"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>The management of periodontitis remains a vital clinical challenge due to the interplay between the microorganisms of the dental biofilm and the host inflammatory response leading to a degenerative process in the surrounding tissues. Quercetin (QUE), a natural flavonol found in many foods, including apples, onions and tea, has exhibited prolonged and strong antibiofilm and anti-inflammatory effects both in vitro and in vivo. However, its clinical application is limited by its poor stability and water solubility, as well as its low bioavailability. Thus, in the present study, electrospun polylactic acid (PLA) nanofibers loaded with different amounts (5\u201310% w\/w) of QUE were produced to rapidly respond to the acidic microenvironment typical of periodontal pockets during periodontal disease. This strategy demonstrated that PLA-QUE membranes can act as a drug reservoir releasing high QUE concentrations in the presence of oral bacterial infection (pH &lt; 5.5), and thus limiting Pseudomonas aeruginosa PAO1 and Streptococcus mutans biofilm maturation. In addition, released QUE exerts antioxidant and anti-inflammatory effects on P. gingivalis Lipopolysaccharide (LPS)-stimulated human gingival fibroblast (HGFs). The reported results confirmed that PLA-QUE membranes could inhibit subgingival biofilm maturation while reducing interleukin release, thereby limiting host inflammatory response. Overall, this study provided an effective pH-sensitive drug delivery system as a promising strategy for treating periodontitis.<\/jats:p>","DOI":"10.3390\/molecules27072205","type":"journal-article","created":{"date-parts":[[2022,3,29]],"date-time":"2022-03-29T21:41:30Z","timestamp":1648590090000},"page":"2205","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":40,"title":["PLA Nanofibers for Microenvironmental-Responsive Quercetin Release in Local Periodontal Treatment"],"prefix":"10.3390","volume":"27","author":[{"given":"Francesca","family":"Di Cristo","sequence":"first","affiliation":[{"name":"Elleva Pharma s.r.l., Via Pietro Castellino 111, 80131 Naples, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8041-2221","authenticated-orcid":false,"given":"Anna","family":"Valentino","sequence":"additional","affiliation":[{"name":"Research Institute on Terrestrial Ecosystems (IRET)\u2014CNR, Via Pietro Castellino 111, 80131 Naples, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ilenia","family":"De Luca","sequence":"additional","affiliation":[{"name":"Research Institute on Terrestrial Ecosystems (IRET)\u2014CNR, Via Pietro Castellino 111, 80131 Naples, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gianfranco","family":"Peluso","sequence":"additional","affiliation":[{"name":"Research Institute on Terrestrial Ecosystems (IRET)\u2014CNR, Via Pietro Castellino 111, 80131 Naples, Italy"},{"name":"Faculty of Medicine and Surgery, Saint Camillus International University of Health Sciences, Via di Sant\u2019Alessandro 8, 00131 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6287-2555","authenticated-orcid":false,"given":"Irene","family":"Bonadies","sequence":"additional","affiliation":[{"name":"Institute for Polymers, Composites and Biomaterials (IPCB-CNR), Via Campi Flegrei 34, 80078 Pozzuoli, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1441-7662","authenticated-orcid":false,"given":"Anna","family":"Calarco","sequence":"additional","affiliation":[{"name":"Research Institute on Terrestrial Ecosystems (IRET)\u2014CNR, Via Pietro Castellino 111, 80131 Naples, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6763-3636","authenticated-orcid":false,"given":"Anna","family":"Di Salle","sequence":"additional","affiliation":[{"name":"Research Institute on Terrestrial Ecosystems (IRET)\u2014CNR, Via Pietro Castellino 111, 80131 Naples, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,3,28]]},"reference":[{"key":"ref_1","first-page":"S5","article-title":"Principles in prevention of periodontal diseases: Consensus report of group 1 of the 11th European Workshop on Periodontology on effective prevention of periodontal and peri-implant diseases","volume":"42","author":"Tonetti","year":"2015","journal-title":"J. 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