{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,24]],"date-time":"2026-07-24T16:58:55Z","timestamp":1784912335074,"version":"3.55.0"},"reference-count":40,"publisher":"MDPI AG","issue":"8","license":[{"start":{"date-parts":[[2022,4,12]],"date-time":"2022-04-12T00:00:00Z","timestamp":1649721600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Ministry of Science and Higher Education of the Russian Federation within the framework of state support for the creation and development of World-Class Research Centers \u201cDigital Bi-odesign and Personalized Healthcare\u201d","award":["75-15-2020-913"],"award-info":[{"award-number":["75-15-2020-913"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>We sought to identify the characteristic metabolite profile of blood plasma samples obtained from patients with preeclampsia. Direct high-resolution mass spectrometry was used to analyze samples from 79 pregnant women, 34 of whom had preeclampsia. We performed a comparative analysis of the metabolite profiles and found that they differed between pregnant women with and without preeclampsia. Lipids and sugars were identified as components of the metabolite profile that are likely to be associated with the development of preeclampsia. While PE was established only in the third trimester, a set of metabolites specific for the third trimester, including 2-(acetylamino)-1,5-anhydro-2-deoxy-4-O-b-D-galactopyranosyl-D-arabino-Hex-1-enitol, N-Acetyl-D-glucosaminyldiphosphodolichol, Cer(d18:0\/20:0), and allolithocholic acid, was already traced in the first trimester. These components are also likely involved in lipid metabolism disorders and the development of oxidative stress.<\/jats:p>","DOI":"10.3390\/molecules27082475","type":"journal-article","created":{"date-parts":[[2022,4,12]],"date-time":"2022-04-12T22:48:45Z","timestamp":1649803725000},"page":"2475","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Metabolomic Markers for Predicting Preeclampsia in the First Trimester of Pregnancy: A Retrospective Study"],"prefix":"10.3390","volume":"27","author":[{"given":"Ekaterina V.","family":"Ilgisonis","sequence":"first","affiliation":[{"name":"V.N. Orekhovich Institute of Biomedical Chemistry, 119121 Moscow, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raisa","family":"Shalina","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Pirogov Russian National Research Medical University, Ostrovitianov Str. 1, 117997 Moscow, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nigyar","family":"Kasum-Zade","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Pirogov Russian National Research Medical University, Ostrovitianov Str. 1, 117997 Moscow, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristina G.","family":"Burkova","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Pirogov Russian National Research Medical University, Ostrovitianov Str. 1, 117997 Moscow, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5803-2529","authenticated-orcid":false,"given":"Oxana P.","family":"Trifonova","sequence":"additional","affiliation":[{"name":"V.N. Orekhovich Institute of Biomedical Chemistry, 119121 Moscow, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3003-7595","authenticated-orcid":false,"given":"Dmitry L.","family":"Maslov","sequence":"additional","affiliation":[{"name":"V.N. Orekhovich Institute of Biomedical Chemistry, 119121 Moscow, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4472-2016","authenticated-orcid":false,"given":"Anna L.","family":"Kaysheva","sequence":"additional","affiliation":[{"name":"V.N. Orekhovich Institute of Biomedical Chemistry, 119121 Moscow, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0242-0282","authenticated-orcid":false,"given":"Sergey S.","family":"Markin","sequence":"additional","affiliation":[{"name":"V.N. Orekhovich Institute of Biomedical Chemistry, 119121 Moscow, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,4,12]]},"reference":[{"key":"ref_1","first-page":"87","article-title":"Analysis of Differences in Individual Characteristics, Lifestyle, Nutritional Status and Dieting Patterns in Pregnant Women with Preeclampsian History","volume":"9","author":"Astari","year":"2021","journal-title":"J. Ilmu Keperawatan J. Nurs. Sci."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"e323","DOI":"10.1016\/S2214-109X(14)70227-X","article-title":"Global Causes of Maternal Death: A WHO Systematic Analysis","volume":"2","author":"Say","year":"2014","journal-title":"Lancet Glob. 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