{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T03:02:53Z","timestamp":1792810973252,"version":"4.5.0"},"reference-count":90,"publisher":"MDPI AG","issue":"8","license":[{"start":{"date-parts":[[2022,4,12]],"date-time":"2022-04-12T00:00:00Z","timestamp":1649721600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>Quercetin, an essential plant flavonoid, possesses a variety of pharmacological activities. Extensive literature investigates its antimicrobial activity and possible mechanism of action. Quercetin has been shown to inhibit the growth of different Gram-positive and Gram-negative bacteria as well as fungi and viruses. The mechanism of its antimicrobial action includes cell membrane damage, change of membrane permeability, inhibition of synthesis of nucleic acids and proteins, reduction of expression of virulence factors, mitochondrial dysfunction, and preventing biofilm formation. Quercetin has also been shown to inhibit the growth of various drug-resistant microorganisms, thereby suggesting its use as a potent antimicrobial agent against drug-resistant strains. Furthermore, certain structural modifications of quercetin have sometimes been shown to enhance its antimicrobial activity compared to that of the parent molecule. In this review, we have summarized the antimicrobial activity of quercetin with a special focus on its mechanistic principle. Therefore, this review will provide further insights into the scientific understanding of quercetin\u2019s mechanism of action, and the implications for its use as a clinically relevant antimicrobial agent.<\/jats:p>","DOI":"10.3390\/molecules27082494","type":"journal-article","created":{"date-parts":[[2022,4,12]],"date-time":"2022-04-12T22:48:45Z","timestamp":1649803725000},"page":"2494","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":519,"title":["Antimicrobial Activity of Quercetin: An Approach to Its Mechanistic Principle"],"prefix":"10.3390","volume":"27","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7851-7451","authenticated-orcid":false,"given":"Thi Lan Anh","family":"Nguyen","sequence":"first","affiliation":[{"name":"Biology Department, Franciscan Missionaries of Our Lady University, 5414 Brittany Drive, Baton Rouge, LA 70808, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Debanjana","family":"Bhattacharya","sequence":"additional","affiliation":[{"name":"Biology Department, Franciscan Missionaries of Our Lady University, 5414 Brittany Drive, Baton Rouge, LA 70808, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,4,12]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"12865","DOI":"10.1021\/acsomega.9b00077","article-title":"Antimicrobial Activity of a New Class of Phosphorylated and Modified Flavonoids","volume":"4","author":"Osonga","year":"2019","journal-title":"ACS Omega"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"13","DOI":"10.4081\/mr.2017.6877","article-title":"Antibacterial properties of quercetin","volume":"8","author":"Jaisinghani","year":"2017","journal-title":"Microbiol. 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