{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T04:57:52Z","timestamp":1787029072132,"version":"build-2736575974"},"reference-count":112,"publisher":"MDPI AG","issue":"8","license":[{"start":{"date-parts":[[2022,4,17]],"date-time":"2022-04-17T00:00:00Z","timestamp":1650153600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Romanian Ministry of Research, Innovation and Digitalization","award":["PFE-14 (ID 546)"],"award-info":[{"award-number":["PFE-14 (ID 546)"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>Although conventional medicine, chemical drug synthesis and pharmaceutical research are advancing at a rapid pace, nature remains a major supplier of biological molecules. Natural bioactive compounds are studied closely especially as an alternative to the limitations of conventional therapy in many diseases, melanoma being one of them. Malignant melanoma is a highly aggressive type of cancer, and the current methods of treatment used are cryotherapy, external surgery, radiation therapy, chemotherapy, photodynamic therapy, biological therapy, and targeted drug therapy. Unfortunately, these treatment methods are often inefficient, extremely expensive and cause many side effects, which is why focusing on melanoma chemoprevention and adjuvant therapy with natural herbal phytoconstituents is an emerging strategy to prevent, cure or treat melanoma. This review aims to examine the latest discoveries in terms of potential natural bioactive compounds that possess important activity against the development and spread of murine melanoma cancer. In particular, the use of different phytochemicals such as phenolic acids, flavonoids, anthocyanins, terpenoids, essential oils and carotenoids in vitro and in vivo models will be discussed. These data are helpful in guiding researchers in the direction of studying phytonutrients with important effects in the prevention and treatment of melanoma.<\/jats:p>","DOI":"10.3390\/molecules27082585","type":"journal-article","created":{"date-parts":[[2022,4,19]],"date-time":"2022-04-19T01:03:01Z","timestamp":1650330181000},"page":"2585","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":25,"title":["Recent Advances in the Antiproliferative and Proapoptotic Activity of Various Plant Extracts and Constituents against Murine Malignant Melanoma"],"prefix":"10.3390","volume":"27","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8940-9651","authenticated-orcid":false,"given":"Daria-Antonia","family":"Dumitra\u0219","sequence":"first","affiliation":[{"name":"Department of Biochemistry, University of Agricultural Sciences and Veterinary Medicine, M\u0103n\u0103\u015ftur no. 3\u20135, 400372 Cluj-Napoca, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0622-0963","authenticated-orcid":false,"given":"Sanda","family":"Andrei","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, University of Agricultural Sciences and Veterinary Medicine, M\u0103n\u0103\u015ftur no. 3\u20135, 400372 Cluj-Napoca, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,4,17]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1038\/s41573-020-00114-z","article-title":"Natural products in drug discovery: Advances and opportunities","volume":"20","author":"Atanasov","year":"2021","journal-title":"Nat. Rev. Drug Discov."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"3670","DOI":"10.1016\/j.bbagen.2013.02.008","article-title":"Natural products: A continuing source of novel drug leads","volume":"1830","author":"Cragg","year":"2013","journal-title":"Biochim. Biophys. Acta"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"11679","DOI":"10.3390\/molecules190811679","article-title":"Review of natural compounds for potential skin cancer treatment","volume":"19","author":"Chinembiri","year":"2014","journal-title":"Molecules"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1007\/s11418-016-0992-2","article-title":"Screening of promising chemotherapeutic candidates from plants extracts","volume":"70","author":"Kinjo","year":"2016","journal-title":"J. Nat. Med."},{"key":"ref_5","unstructured":"(2022, February 10). Skin Cancer Facts & Statistics. Available online: https:\/\/www.skincancer.org\/skin-cancer-information\/skin-cancer-facts\/."},{"key":"ref_6","unstructured":"(2022, January 18). Key Statistics for Melanoma Skin Cancer. Available online: https:\/\/www.cancer.org\/cancer\/melanoma-skin-cancer\/about\/key-statistics.html."},{"key":"ref_7","doi-asserted-by":"crossref","unstructured":"Nishiya, A.T., Massoco, C.O., Felizzola, C.R., Perlmann, E., Batschinski, K., Tedardi, M.V., Garcia, J.S., Mendon\u00e7a, P.P., Teixeira, T.F., and Dagli, M.L.Z. (2016). Comparative Aspects of Canine Melanoma. Vet. Sci., 3.","DOI":"10.3390\/vetsci3010007"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"631","DOI":"10.2174\/1871520617666171121142522","article-title":"Natural compounds in the chemoprevention of malignant melanoma","volume":"18","author":"Danciu","year":"2018","journal-title":"Anti-Cancer Agents Med. Chem."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"978","DOI":"10.1111\/j.1365-4632.2010.04474.x","article-title":"Review: Ultraviolet radiation and skin cancer","volume":"49","author":"Narayanan","year":"2010","journal-title":"Int. J. Dermatol."},{"key":"ref_10","doi-asserted-by":"crossref","unstructured":"Gastaldello, G., Cazeloto, A., Ferreira, J., Rodrigues, D., Bastos, J., Campo, V., Zoccal, K., and Tef\u00e9-Silva, C. (2021). Green Propolis Compounds (Baccharin and p-Coumaric Acid) Show Beneficial Effects in Mice for Melanoma Induced by B16f10. Medicines, 8.","DOI":"10.3390\/medicines8050020"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"36114","DOI":"10.1038\/srep36114","article-title":"Jolkinolide B induces apoptosis and inhibits tumor growth in mouse melanoma B16F10 cells by altering glycolysis","volume":"6","author":"Gao","year":"2016","journal-title":"Sci. Rep."},{"key":"ref_12","doi-asserted-by":"crossref","unstructured":"Santhanam, R.K., Ahmad, S., Abas, F., Ismail, I.S., Rukayadi, Y., Akhtar, M.T., and Shaari, K. (2016). Bioactive constituents of Zanthoxylum rhetsa bark and its cytotoxic potential against B16-F10 melanoma cancer and normal human dermal fibroblast (HDF) cell lines. Molecules, 21.","DOI":"10.3390\/molecules21060652"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"5703","DOI":"10.7314\/APJCP.2015.16.14.5703","article-title":"Anti proliferative properties of Melissa ofcinalis in diferent human cancer cells","volume":"16","author":"Modaeinama","year":"2015","journal-title":"Asian Pacifc J. Cancer Prev."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"12424","DOI":"10.3390\/ijms160612424","article-title":"Induction of Apoptosis in Endometrial Cancer (Ishikawa) Cells by Pogostemon cablin Aqueous Extract (PCAE)","volume":"16","author":"Tsai","year":"2015","journal-title":"Int. J. Mol. Sci."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"13105","DOI":"10.3748\/wjg.v20.i36.13105","article-title":"Xiaotan Sanjie decoction attenuates tumor angiogenesis by manipulating Notch-1-regulated proliferation of gastric cancer stem-like cells","volume":"20","author":"Yan","year":"2014","journal-title":"World J. Gastroenterol."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/1472-6882-14-353","article-title":"Anti-angiogenic potential of an ethanol extract of Annona atemoya seeds in vitro and in vivo","volume":"14","author":"Yi","year":"2014","journal-title":"BMC Complement. Altern. Med."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1515\/JBCPP.2010.21.4.295","article-title":"Extract of Xylopia aethiopica (Annonaceae) protects against gammaradiation induced testicular damage in Wistar rats","volume":"21","author":"Adaramoye","year":"2010","journal-title":"J. Basic Clin. Physiol. Pharmacol."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1016\/j.etp.2010.05.005","article-title":"Dried fruit extract from Xylopia aethiopica (Annonaceae) protects Wistar albino rats from adverse efects of whole body radiation","volume":"63","author":"Adaramoye","year":"2011","journal-title":"Exp. Toxicol. Pathol."},{"key":"ref_19","doi-asserted-by":"crossref","unstructured":"Diaconeasa, Z., \u0218tirbu, I., Xiao, J., Leopold, N., Ayvaz, Z., Danciu, C., Ayvaz, H., St\u01cenil\u01ce, A., Nistor, M., and Socaciu, C. (2020). Anthocyanins, Vibrant Color Pigments, and Their Role in Skin Cancer Prevention. Biomedicines, 8.","DOI":"10.3390\/biomedicines8090336"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1021\/acs.jnatprod.5b01055","article-title":"Natural products as sources of new drugs from 1981 to 2014","volume":"79","author":"Newman","year":"2016","journal-title":"J. Nat. Prod."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"1614","DOI":"10.3389\/fphar.2019.01614","article-title":"Phytochemicals in Cancer Treatment: From Preclinical Studies to Clinical Practice","volume":"10","author":"Choudhari","year":"2019","journal-title":"Front. Pharmacol."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2016\/2853543","article-title":"Biofunctional activities of Equisetum ramosissimum extract: Protective effects against oxidation, melanoma, and melanogenesis","volume":"2016","author":"Li","year":"2016","journal-title":"Oxidative Med. Cell. Longev."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1515\/pjfns-2016-0006","article-title":"Biological activities and nutraceutical potentials of water extracts from different parts of Cynomorium coccineum L. (Maltese Mushroom)","volume":"66","author":"Zucca","year":"2016","journal-title":"Pol. J. Food Nutr. Sci."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"130937","DOI":"10.1016\/j.foodchem.2021.130937","article-title":"Drying methods influence the physicochemical and functional properties of seed-used pumpkin","volume":"369","author":"Chao","year":"2021","journal-title":"Food Chem."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"956","DOI":"10.3892\/ijo.2013.2001","article-title":"Antioxidant extracts of African medicinal plants induce cell cycle arrest and differentiation in B16F10 melanoma cells","volume":"43","author":"Gismondi","year":"2013","journal-title":"Int. J. Oncol."},{"key":"ref_26","doi-asserted-by":"crossref","unstructured":"Hanganu, D., Niculae, M., Ielciu, I., Olah, N.-K., Munteanu, M., Burtescu, R., \u0218tefan, R., Olar, L., Pall, E., and Andrei, S. (2021). Chemical Profile, Cytotoxic Activity and Oxidative Stress Reduction of Different Syringa vulgaris L. Extracts. Molecules, 26.","DOI":"10.3390\/molecules26113104"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"875","DOI":"10.1007\/s10495-020-01643-z","article-title":"The delay in cell death caused by the induction of autophagy by P2Et extract is essential for the generation of immunogenic signals in melanoma cells","volume":"25","author":"Prieto","year":"2020","journal-title":"Apoptosis"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/j.toxicon.2021.04.026","article-title":"hierchuntica extract exacerbates genotoxic, cytotoxic, apoptotic and oxidant effects in B16F10 melanoma cells","volume":"198","author":"Gokce","year":"2021","journal-title":"Toxicon"},{"key":"ref_29","doi-asserted-by":"crossref","unstructured":"Yoo, T.-K., Kim, J.-S., and Hyun, T.K. (2020). Polyphenolic Composition and Anti-Melanoma Activity of White Forsythia (Abeliophyllum distichum Nakai) Organ Extracts. Plants, 9.","DOI":"10.3390\/plants9060757"},{"key":"ref_30","doi-asserted-by":"crossref","unstructured":"Huang, H.-C., Wang, S.-S., Tsai, T.-C., Ko, W.-P., and Chang, T.-M. (2020). Phoenix dactylifera L. Seed Extract Exhibits Antioxidant Effects and Attenuates Melanogenesis in B16F10 Murine Melanoma Cells by Downregulating PKA Signaling. Antioxidants, 9.","DOI":"10.3390\/antiox9121270"},{"key":"ref_31","doi-asserted-by":"crossref","unstructured":"Nanni, V., Di Marco, G., Sacchetti, G., Canini, A., and Gismondi, A. (2020). Oregano phytocomplex induces programmed cell death in melanoma lines via mitochondria and DNA damage. Foods, 9.","DOI":"10.3390\/foods9101486"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"11699","DOI":"10.3390\/molecules200711699","article-title":"Redox-active profile characterization of Remirea maritima extracts and its cytotoxic effect in mouse fibroblasts (L929) and melanoma (B16F10) cells","volume":"20","author":"Santos","year":"2015","journal-title":"Molecules"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.phymed.2018.06.008","article-title":"Hydroalcoholic extract of Spartium junceum L. flowers inhibits growth and melanogenesis in B16-F10 cells by inducing senescence","volume":"46","author":"Nanni","year":"2018","journal-title":"Phytomedicine"},{"key":"ref_34","first-page":"311","article-title":"Phenolic compounds from Viscum album tinctures enhanced antitumor activity in melanoma murine cancer cells","volume":"3","author":"Oliveira","year":"2018","journal-title":"Saudi Pharm. J."},{"key":"ref_35","doi-asserted-by":"crossref","unstructured":"Ju, H.J., Kim, K.C., Kim, H., Kim, J.-S., and Hyun, T.K. (2021). Variability of polyphenolic compounds and biological activities among Perilla frutescens var. crispa genotypes. Horticulturae, 7.","DOI":"10.3390\/horticulturae7100404"},{"key":"ref_36","first-page":"117","article-title":"Antiangiogenic and antiproliferative effects of black pomegranate peel extract on melanoma cell line","volume":"10","author":"Dana","year":"2015","journal-title":"Res. Pharm. Sci."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1271\/bbb.120562","article-title":"Separation of the antioxidant compound quercitrin from Lindera obtusiloba Blume and its antimelanogenic effect on B16F10 melanoma cells","volume":"77","author":"Hong","year":"2013","journal-title":"Biosci. Biotechnol. Biochem."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"460","DOI":"10.1002\/cbf.2919","article-title":"Phytochemical potential of Daphne gnidium in inhibiting growth of melanoma cells and enhancing melanogenesis of B16-F0 melanoma","volume":"31","author":"Chaabane","year":"2013","journal-title":"Cell Biochem. Funct."},{"key":"ref_39","doi-asserted-by":"crossref","unstructured":"Rugin\u0103, D., Hanganu, D., Diaconeasa, Z., T\u0103b\u0103ran, F., Coman, C., Leopold, L., Bunea, A., and Pintea, A. (2017). Antiproliferative and apoptotic potential of cyanidin-based anthocyanins on melanoma cells. Int. J. Mol. Sci., 18.","DOI":"10.3390\/ijms18050949"},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"1325308","DOI":"10.1080\/16546628.2017.1325308","article-title":"Antiproliferative and proapoptotic activities of anthocyanin and anthocyanidin extracts from blueberry fruits on B16-F10 melanoma cells","volume":"61","author":"Wang","year":"2017","journal-title":"Food Nutr. Res."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"436","DOI":"10.1016\/j.phytochem.2013.06.018","article-title":"Anthocyanin determination in blueberry extracts from various cultivars and their antiproliferative and apoptotic properties in B16-F10 metastatic murine melanoma cells","volume":"95","author":"Bunea","year":"2013","journal-title":"Phytochemistry"},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"2352","DOI":"10.3390\/ijms16022352","article-title":"Antiproliferative and antioxidant properties of anthocyanin rich extracts from blueberry and blackcurrant juice","volume":"16","author":"Diaconeasa","year":"2015","journal-title":"Int. J. Mol. Sci."},{"key":"ref_43","doi-asserted-by":"crossref","unstructured":"Fofaria, N.M., Kim, S.-H., and Srivastava, S.K. (2014). Piperine causes G1 phase cell cycle arrest and apoptosis in melanoma cells through checkpoint kinase-1 activation. PLoS ONE, 9.","DOI":"10.1371\/journal.pone.0094298"},{"key":"ref_44","doi-asserted-by":"crossref","unstructured":"Wikiera, A., Grabacka, M., Byczy\u0144ski, \u0141., Stodolak, B., and Mika, M. (2021). Enzymatically Extracted Apple Pectin Possesses Antioxidant and Antitumor Activity. Molecules, 26.","DOI":"10.3390\/molecules26051434"},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"2447","DOI":"10.3892\/or.2014.3103","article-title":"Polysaccharide from Inonotus obliquus inhibits migration and invasion in B16-F10 cells by suppressing MMP-2 and MMP-9 via downregulation of NF-\u03baB signaling pathway","volume":"31","author":"Lee","year":"2014","journal-title":"Oncol. Rep."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1007\/s11418-015-0933-5","article-title":"Callicarpa longissima extract, carnosol-rich, potently inhibits melanogenesis in B16F10 melanoma cells","volume":"70","author":"Yamahara","year":"2015","journal-title":"J. Nat. Med."},{"key":"ref_47","doi-asserted-by":"crossref","unstructured":"Prasedya, E.S., Ardiana, N., Padmi, H., Ilhami, B.T.K., Martyasari, N.W.R., Sunarwidhi, A.L., Nikmatullah, A., Widyastuti, S., Sunarpi, H., and Frediansyah, A. (2021). The The Antiproliferative and Apoptosis-Inducing Effects of the Red Macroalgae Gelidium latifolium Extract against Melanoma Cells. Molecules, 26.","DOI":"10.3390\/molecules26216568"},{"key":"ref_48","doi-asserted-by":"crossref","unstructured":"Mokhtari, K., P\u00e9rez-Jim\u00e9nez, A., Garc\u00eda-Salguero, L., Lupi\u00e1\u00f1ez, J.A., and Rufino-Palomares, E. (2020). Unveiling the Differential Antioxidant Activity of Maslinic Acid in Murine Melanoma Cells and in Rat Embryonic Healthy Cells Following Treatment with Hydrogen Peroxide. Molecules, 25.","DOI":"10.20944\/preprints202008.0077.v1"},{"key":"ref_49","first-page":"112","article-title":"The cytotoxicity of dacarbazine potentiated by sea cucumber saponin in resistant B16F10 melanoma cells through apoptosis induction","volume":"8","author":"Baharara","year":"2016","journal-title":"Avicenna J. Med. Biotechnol."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"29","DOI":"10.5564\/mjas.v21i02.902","article-title":"Anti-Cancer Effect Of Plantago Depressa Ethanolic Extract In B16f10 Skin Cancer Cells","volume":"21","author":"AY","year":"2017","journal-title":"Mong. J. Agric. Sci."},{"key":"ref_51","first-page":"1495","article-title":"Effects of standardized Cannabis sativa extract and ionizing radiation in melanoma cells in vitro","volume":"16","author":"Vaseghi","year":"2018","journal-title":"J. Cancer Res. Ther."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"9477","DOI":"10.3390\/molecules18089477","article-title":"Chemical Composition and Cytotoxicity Evaluation of Essential Oil from Leaves of Casearia Sylvestris, Its Main Compound \u03b1-Zingiberene and Derivatives","volume":"18","author":"Bou","year":"2013","journal-title":"Molecules"},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/j.biopha.2014.11.010","article-title":"Compounds isolated from the aerial part of Crataegus azarolus inhibit growth of B16F10 melanoma cells and exert a potent inhibition of the melanin synthesis","volume":"69","author":"Mustapha","year":"2015","journal-title":"Biomed. Pharmacother."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"635","DOI":"10.5897\/JMPR2016.6156","article-title":"Antitumor activity of Pachycereus marginatus (DC.) Britton Rose extracts against murine lymphoma L5178Y-R and skin melanoma B16F10 cells","volume":"10","author":"Mario","year":"2016","journal-title":"J. Med. Plants Res."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"6511","DOI":"10.1007\/s13277-015-4492-x","article-title":"In vitro and in vivo anti-melanoma effects of Daphne gnidium aqueous extract via activation of the immune system","volume":"37","author":"Chaabane","year":"2016","journal-title":"Tumor Biol."},{"key":"ref_56","first-page":"18856","article-title":"Antitumoral effect of lobelia inflata in an experimental mouse model of melanoma","volume":"25","author":"Zoccal","year":"2020","journal-title":"Biomed. J. Sci. Tech. Res."},{"key":"ref_57","doi-asserted-by":"crossref","unstructured":"Str\u00fch, C.M., J\u00e4ger, S., Kersten, A., Schempp, C.M., Scheffler, A., and Martin, S.F. (2013). Triterpenoids amplify anti-tumoral effects of mistletoe extracts on murine B16. f10 melanoma in vivo. PLoS ONE, 8.","DOI":"10.1371\/journal.pone.0062168"},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s41241-017-0039-3","article-title":"In vivo antitumor potential of extracts from different parts of Bauhinia variegata linn. Against b16f10 melanoma tumour model in c57bl\/6 mice","volume":"37","author":"Pandey","year":"2017","journal-title":"Appl. Cancer Res."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"1683","DOI":"10.1002\/ijc.30224","article-title":"Curcumin: A new candidate for melanoma therapy?","volume":"139","author":"Mirzaei","year":"2016","journal-title":"Int. J. Cancer"},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1111\/iep.12351","article-title":"Screening of plants from the Brazilian Atlantic Forest led to the identification of Athenaea velutina (Solanaceae) as a novel source of antimetastatic agents","volume":"101","author":"Almeida","year":"2020","journal-title":"Int. J. Exp. Pathol."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1016\/j.jep.2012.09.017","article-title":"In vitro and in vivo anticancer effects of Lithospermum erythrorhizon extract on B16F10 murine melanoma","volume":"144","author":"Rajasekar","year":"2012","journal-title":"J. Ethnopharmacol."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1089\/jmf.2013.3138","article-title":"Lipid-soluble ginseng extract inhibits invasion and metastasis of B16F10 melanoma cells","volume":"18","author":"Yun","year":"2015","journal-title":"J. Med. Food"},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1097\/CMR.0000000000000240","article-title":"Antitumoral, antioxidant, and antimelanogenesis potencies of Hawthorn, a potential natural agent in the treatment of melanoma","volume":"26","author":"Mustapha","year":"2016","journal-title":"Melanoma Res."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1080\/21691401.2018.1452021","article-title":"Effects of nano-encapsulated curcumin-chrysin on telomerase, MMPs and TIMPs gene expression in mouse B16F10 melanoma tumour model","volume":"46","author":"Tavakoli","year":"2018","journal-title":"Artif. Cells Nanomed. Biotechnol."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"3228","DOI":"10.1002\/ptr.6497","article-title":"Citrus unshiu peel suppress the metastatic potential of murine melanoma B16F10 cells in vitro and in vivo","volume":"33","author":"Choi","year":"2019","journal-title":"Phytotherapy Res."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"23","DOI":"10.5582\/bst.2019.01230","article-title":"Suppression of tumor growth and metastasis by ethanol extract of Angelica dahurica Radix in murine melanoma B16F10 cells","volume":"14","author":"Hwangbo","year":"2020","journal-title":"Biosci. Trends"},{"key":"ref_67","doi-asserted-by":"crossref","unstructured":"Zheng, S.-W., Xiao, S.-Y., Wang, J., Hou, W., and Wang, Y.-P. (2019). Inhibitory effects of ginsenoside Ro on the growth of B16F10 melanoma via its metabolites. Molecules, 24.","DOI":"10.3390\/molecules24162985"},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"1171","DOI":"10.1142\/S0192415X19500605","article-title":"Juniperus communis suppresses melanoma tumorigenesis by inhibiting tumor growth and inducing apoptosis","volume":"47","author":"Gao","year":"2019","journal-title":"Am. J. Chin. Med."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"112545","DOI":"10.1016\/j.jep.2020.112545","article-title":"Himachalol induces apoptosis in B16-F10 murine melanoma cells and protects against skin carcinogenesis","volume":"253","author":"Shebaby","year":"2020","journal-title":"J. Ethnopharmacol."},{"key":"ref_70","doi-asserted-by":"crossref","unstructured":"Pop, T.D., and Diaconeasa, Z. (2021). Recent advances in phenolic metabolites and skin cancer. Int. J. Mol. Sci., 22.","DOI":"10.3390\/ijms22189707"},{"key":"ref_71","doi-asserted-by":"crossref","unstructured":"Uscanga-Palomeque, A.C., Zapata-Benavides, P., Saavedra-Alonso, S., Zamora-\u00c1vila, D.E., Franco-Molina, M.A., Arellano-Rodr\u00edguez, M., Manilla-Mu\u00f1oz, E., Mart\u00ednez-Torres, A.C., Trejo-\u00c1vila, L.M., and Rodr\u00edguez-Padilla, C. (2019). Inhibitory effect of Cuphea aequipetala extracts on murine B16F10 melanoma in vitro and in vivo. BioMed Res. Int., 2019.","DOI":"10.1155\/2019\/8560527"},{"key":"ref_72","doi-asserted-by":"crossref","unstructured":"Cao, C., Su, Y., Gao, Y., Luo, C., Yin, L., Zhao, Y., Chen, H., and Xu, A. (2018). Ginkgo biloba exocarp extract inhibits the metastasis of B16-F10 melanoma involving PI3K\/akt\/NF-\u03baB\/MMP-9 signaling pathway. Evid. Based Complementary Altern. Med., 2018.","DOI":"10.1155\/2018\/4969028"},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"S363","DOI":"10.4103\/0973-1296.133284","article-title":"Pyrostegia venusta heptane extract containing saturated aliphatic hydrocarbons induces apoptosis on B16F10-Nex2 melanoma cells and displays antitumor activity in vivo","volume":"10","author":"Figueiredo","year":"2014","journal-title":"Pharmacogn. Mag."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"5130","DOI":"10.3390\/md11125130","article-title":"Fucoxanthin: A marine carotenoid exerting anti-cancer effects by affecting multiple mechanisms","volume":"11","author":"Kumar","year":"2013","journal-title":"Mar. Drugs"},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/j.etap.2012.10.002","article-title":"Inhibition of tumor growth in vitro and in vivo by fucoxanthin against melanoma B16F10 cells","volume":"35","author":"Kim","year":"2013","journal-title":"Environ. Toxicol. Pharmacol."},{"key":"ref_76","doi-asserted-by":"crossref","unstructured":"Amaral, V.S.G.D., Santos, S.A.C.S., De Andrade, P.C., Nowatzki, J., J\u00fanior, N.S., De Medeiros, L.N., Gitirana, L.B., Pascutti, P.G., Almeida, V.H., and Monteiro, R.Q. (2020). Pisum sativum Defensin 1 Eradicates Mouse Metastatic Lung Nodules from B16F10 Melanoma Cells. Int. J. Mol. Sci., 21.","DOI":"10.3390\/ijms21082662"},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3892\/ijfn.2020.9","article-title":"Polyphenols in cancer prevention: New insights (Review)","volume":"1","author":"Briguglio","year":"2020","journal-title":"Int. J. Funct. Nutr."},{"key":"ref_78","doi-asserted-by":"crossref","unstructured":"Amararathna, M., Johnston, M.R., and Rupasinghe, H.P.V. (2016). Plant Polyphenols as Chemopreventive Agents for Lung Cancer. Int. J. Mol. Sci., 17.","DOI":"10.3390\/ijms17081352"},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"964","DOI":"10.1080\/01635581.2012.717677","article-title":"The risk of lung cancer related to dietary intake of flavonoids","volume":"64","author":"Christensen","year":"2012","journal-title":"Nutr. Cancer"},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"9236","DOI":"10.3390\/ijms16059236","article-title":"In Vitro and in Vivo Antitumoral Effects of Combinations of Polyphenols, or Polyphenols and Anticancer Drugs: Perspectives on Cancer Treatment","volume":"16","author":"Fantini","year":"2015","journal-title":"Int. J. Mol. Sci."},{"key":"ref_81","doi-asserted-by":"crossref","unstructured":"Philips, N., Richardson, R., Siomyk, H., Bynum, D., and Gonzalez, S. (2021). \u201cSkin cancer, polyphenols, and oxidative stress\u201d or Counteraction of oxidative stress, inflammation, signal transduction pathways, and extracellular matrix remodeling that mediate skin carcinogenesis by polyphenols. Cancer, Academic Press.","DOI":"10.1016\/B978-0-12-819547-5.00039-0"},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"104584","DOI":"10.1016\/j.phrs.2019.104584","article-title":"Advances on natural polyphenols as anticancer agents for skin cancer","volume":"151","author":"Sajadimajd","year":"2020","journal-title":"Pharmacol. Res."},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/j.yclnex.2015.09.001","article-title":"The value of flavonoids for the human nutrition: Short review and perspectives","volume":"3","author":"Hoensch","year":"2015","journal-title":"Clin. Nutr. Exp."},{"key":"ref_84","doi-asserted-by":"crossref","unstructured":"Domaszewska-Szostek, A., Puzianowska-Ku\u017anicka, M., and Kury\u0142owicz, A. (2021). Flavonoids in Skin Senescence Prevention and Treatment. Int. J. Mol. Sci., 22.","DOI":"10.3390\/ijms22136814"},{"key":"ref_85","first-page":"737","article-title":"A review on plant flavonoids as potential anticancer agents","volume":"25","author":"Kapoor","year":"2021","journal-title":"Curr. Org. Chem."},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1016\/j.lfs.2015.11.030","article-title":"Effect of apigenin-7-glucoside, genkwanin and naringenin on tyrosinase activity and melanin synthesis in B16F10 melanoma cells","volume":"144","author":"Bouzaiene","year":"2016","journal-title":"Life Sci."},{"key":"ref_87","first-page":"195","article-title":"Anti-Angiogenic effects of pomegranate Peel extract (Punica Granatum L.) on human umbilical vein endothelial cells","volume":"30","author":"Dana","year":"2012","journal-title":"J. Isfahan Med. Sch."},{"key":"ref_88","doi-asserted-by":"crossref","unstructured":"Gon\u00e7alves, A.C., Nunes, A.R., Falc\u00e3o, A., Alves, G., and Silva, L.R. (2021). Dietary Effects of Anthocyanins in Human Health: A Comprehensive Review. Pharmaceuticals, 14.","DOI":"10.3390\/ph14070690"},{"key":"ref_89","first-page":"1","article-title":"Discovery, Development, and Design of Anthocyanins-Inspired Anticancer Agents-A Comprehensive Review","volume":"21","author":"Majhi","year":"2021","journal-title":"Anti-Cancer Agents Med. Chem."},{"key":"ref_90","doi-asserted-by":"crossref","unstructured":"Liu, J., Zhou, H., Song, L., Yang, Z., Qiu, M., Wang, J., and Shi, S. (2021). Anthocyanins: Promising Natural Products with Diverse Pharmacological Activities. Molecules, 26.","DOI":"10.3390\/molecules26133807"},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1002\/med.21346","article-title":"Therapeutic potential of steroidal alkaloids in cancer and other diseases","volume":"36","author":"Jiang","year":"2015","journal-title":"Med. Res. Rev."},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1142\/S0192415X16500269","article-title":"The anti-oxidant and antitumor properties of plant polysaccharides","volume":"44","author":"Jiao","year":"2016","journal-title":"Am. J. Chin. Med."},{"key":"ref_93","doi-asserted-by":"crossref","unstructured":"Joshee, N., Dhekney, S., and Parajuli, P. (2019). Therapeutic and Medicinal Uses of Terpenes. Medicinal Plants, Springer.","DOI":"10.1007\/978-3-030-31269-5"},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/j.canlet.2009.04.033","article-title":"Lupeol, a novel anti-inflammatory and anti-cancer dietary triterpene","volume":"285","author":"Saleem","year":"2009","journal-title":"Cancer Lett."},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"3149362","DOI":"10.1155\/2018\/3149362","article-title":"Anticancer Properties of Essential Oils and Other Natural Products","volume":"2018","author":"Blowman","year":"2018","journal-title":"Evid. Based Complement. Altern. Med."},{"key":"ref_96","first-page":"591","article-title":"Anticancer activity of essential oils and their chemical components\u2014A review","volume":"4","author":"Bayala","year":"2014","journal-title":"Am. J. Cancer Res."},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"154106","DOI":"10.1155\/2014\/154106","article-title":"Essential oils and their constituents as anticancer agents: A mechanistic view","volume":"2014","author":"Gautam","year":"2014","journal-title":"BioMed Res. Int."},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1016\/j.apjtb.2015.05.007","article-title":"Essential oils used in aromatherapy: A systemic review","volume":"5","author":"Ali","year":"2015","journal-title":"Asian Pac. J. Trop. Biomed."},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1016\/j.fct.2012.12.036","article-title":"Chemical composition and anticancer activity of essential oils of Mediterranean sage (Salvia officinalis L.) grown in different environmental conditions","volume":"55","author":"Russo","year":"2013","journal-title":"Food Chem. Toxicol."},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1016\/j.bjp.2015.02.009","article-title":"Cytotoxicity screening of essential oils in cancer cell lines","volume":"25","author":"Alves","year":"2015","journal-title":"Rev. Bras. Farmacogn."},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"750","DOI":"10.1007\/s43450-021-00200-2","article-title":"Cannabis Extracts and Their Cytotoxic Effects on Human Erythrocytes, Fibroblasts, and Murine Melanoma","volume":"31","author":"Milanez","year":"2021","journal-title":"Rev. Bras. Farmacogn."},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"361","DOI":"10.3892\/ijmm.2012.1224","article-title":"Antimetastatic effect of polysaccharide isolated from Colocasia esculenta is exerted through immunostimulation","volume":"31","author":"Park","year":"2013","journal-title":"Int. J. Mol. Med."},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"1170","DOI":"10.1039\/C4NP00130C","article-title":"Natural products with therapeutic potential in melanoma metastasis","volume":"32","author":"Alqathama","year":"2015","journal-title":"Nat. Prod. Rep."},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"6925","DOI":"10.7314\/APJCP.2013.14.11.6925","article-title":"PAMAM dendrimers augment inhibitory effects of curcumin on cancer cell proliferation: Possible inhibition of telomerase","volume":"14","author":"Mollazade","year":"2013","journal-title":"Asian Pac. J. Cancer Prev."},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"8931","DOI":"10.7314\/APJCP.2014.15.20.8931","article-title":"Comparison between effects of free curcumin and curcumin loaded NIPAAm-MAA nanoparticles on telomerase and PinX1 gene expression in lung cancer cells","volume":"15","author":"Badrzadeh","year":"2014","journal-title":"Asian Pac. J. Cancer Prev."},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"912","DOI":"10.5897\/AJB09.904","article-title":"The inhibitory effect of Curcuma longa extract on telomerase activity in A549 lung cancer cell line","volume":"9","author":"Pourhassan","year":"2010","journal-title":"Afr. J. Biotechnol."},{"key":"ref_107","first-page":"134","article-title":"The comparison between effects of free curcumin and curcumin loaded PLGA-PEG on telomerase and TRF1 expressions in calu-6 lung cancer cell line","volume":"4","author":"Taheri","year":"2014","journal-title":"Int. J. Biosci."},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"735","DOI":"10.3109\/21691401.2014.982803","article-title":"PNIPAAm-MAA nanoparticles as delivery vehicles for curcumin against MCF-7 breast cancer cells","volume":"44","author":"Zeighamian","year":"2014","journal-title":"Artif. Cells Nanomed. Biotechnol."},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/j.cbi.2017.11.022","article-title":"Chrysin, a natural and biologically active flavonoid suppresses tumor growth of mouse B16F10 melanoma cells: In vitro and In vivo study","volume":"283","author":"Sassi","year":"2018","journal-title":"Chem. Interact."},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"1127","DOI":"10.1002\/mc.22355","article-title":"Sohlh2 inhibits human ovarian cancer cell invasion and metastasis by transcriptional inactivation of MMP9","volume":"55","author":"Zhang","year":"2016","journal-title":"Mol. Carcinog."},{"key":"ref_111","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1016\/j.semcancer.2017.11.008","article-title":"Matrix Metalloproteinases: A challenging paradigm of cancer management","volume":"56","author":"Alaseem","year":"2019","journal-title":"Semin. Cancer Biol."},{"key":"ref_112","doi-asserted-by":"crossref","first-page":"580","DOI":"10.1016\/j.bbrc.2013.09.019","article-title":"Marine algal fucoxanthin inhibits the metastatic potential of cancer cells","volume":"439","author":"Chung","year":"2013","journal-title":"Biochem. Biophys. Res. 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