{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T19:26:37Z","timestamp":1790364397250,"version":"4.1.0"},"reference-count":37,"publisher":"MDPI AG","issue":"9","license":[{"start":{"date-parts":[[2022,4,25]],"date-time":"2022-04-25T00:00:00Z","timestamp":1650844800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003693","name":"Korea Institute of Science and Technology","doi-asserted-by":"publisher","award":["2E31881"],"award-info":[{"award-number":["2E31881"]}],"id":[{"id":"10.13039\/501100003693","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Republic of Korea, the Rural Development Administration under Cooperative Research Program for Agriculture Science &amp; Technology Development","award":["PJ013335"],"award-info":[{"award-number":["PJ013335"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>Black soybean has been used in traditional medicine to treat inflammatory diseases, cancer, and diabetes and as a nutritional source since ancient times. We found that Korean black soybean cultivar A63 has more cyanidin-3-O-glucoside, (C3G), procyanidin B2 (PB2), and epicatechin (EPC) contents than other cultivars and has beneficial effects on cell viability and anti-oxidation. Given the higher concentration of anthocyanidins and their strong anti-oxidant activity, we predicted that A63 extract could relieve inflammatory disease symptoms, including those of atopic dermatitis (AD). Here, we evaluated the anti-AD activity of A63 extract in an oxazolone (OXA)-induced mouse model. A63 extract treatment significantly reduced epidermal thickness and inflammatory cell infiltration, downregulated the expression of AD gene markers, including Interleukin (IL)-4 and IL-5, and restored damaged skin barrier tissues. Furthermore, A63 extract influenced the activation of the signal transducer and activator of transcription (STAT) 3 and STAT6, extracellular regulatory kinase (ERK), and c-Jun N-terminal kinase (JNK) signaling pathways, which play a crucial role in the development of AD. Altogether, our results suggest that A63 can ameliorate AD-like skin inflammation by inhibiting inflammatory cytokine production and STAT3\/6 and Mitogen-activated protein kinase (MAPK) signaling and restoring skin barrier function.<\/jats:p>","DOI":"10.3390\/molecules27092751","type":"journal-article","created":{"date-parts":[[2022,4,26]],"date-time":"2022-04-26T02:14:39Z","timestamp":1650939279000},"page":"2751","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Extract from Black Soybean Cultivar A63 Extract Ameliorates Atopic Dermatitis-like Skin Inflammation in an Oxazolone-Induced Murine Model"],"prefix":"10.3390","volume":"27","author":[{"given":"Banzragch","family":"Dorjsembe","sequence":"first","affiliation":[{"name":"Smart Farm Research Center, Korea Institute of Science and Technology (KIST), Gangneung 25451, Korea"},{"name":"Division of Bio-Medical Science and Technology, KIST School, Korea University of Science and Technology (UST), Daejeon 34113, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7805-0521","authenticated-orcid":false,"given":"Chu Won","family":"Nho","sequence":"additional","affiliation":[{"name":"Smart Farm Research Center, Korea Institute of Science and Technology (KIST), Gangneung 25451, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yongsoo","family":"Choi","sequence":"additional","affiliation":[{"name":"Natural Product Research Center, Korea Institute of Science and Technology (KIST), Gangneung 25451, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2535-2761","authenticated-orcid":false,"given":"Jin-Chul","family":"Kim","sequence":"additional","affiliation":[{"name":"Natural Product Research Center, Korea Institute of Science and Technology (KIST), Gangneung 25451, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,4,25]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1185\/03007990903512156","article-title":"Atopic dermatitis: A review of topical treatment options","volume":"26","author":"Simpson","year":"2010","journal-title":"Curr. 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