{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,25]],"date-time":"2026-02-25T20:51:05Z","timestamp":1772052665517,"version":"3.50.1"},"reference-count":44,"publisher":"MDPI AG","issue":"9","license":[{"start":{"date-parts":[[2022,4,27]],"date-time":"2022-04-27T00:00:00Z","timestamp":1651017600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"National Key Research and Development Project of China","award":["2018YFE0206300"],"award-info":[{"award-number":["2018YFE0206300"]}]},{"name":"National Key Research and Development Project of China","award":["2020YFD1001400"],"award-info":[{"award-number":["2020YFD1001400"]}]},{"name":"National Key Research and Development Project of China","award":["TD2020C003"],"award-info":[{"award-number":["TD2020C003"]}]},{"name":"National Key Research and Development Project of China","award":["ZDZX202106"],"award-info":[{"award-number":["ZDZX202106"]}]},{"name":"Research Team Project of the Natural Science Foundation of Heilongjiang Province, China","award":["2018YFE0206300"],"award-info":[{"award-number":["2018YFE0206300"]}]},{"name":"Research Team Project of the Natural Science Foundation of Heilongjiang Province, China","award":["2020YFD1001400"],"award-info":[{"award-number":["2020YFD1001400"]}]},{"name":"Research Team Project of the Natural Science Foundation of Heilongjiang Province, China","award":["TD2020C003"],"award-info":[{"award-number":["TD2020C003"]}]},{"name":"Research Team Project of the Natural Science Foundation of Heilongjiang Province, China","award":["ZDZX202106"],"award-info":[{"award-number":["ZDZX202106"]}]},{"name":"Basic Scientific Research Operating Expenses Projects of the Provincial University of Heilongjiang Province","award":["2018YFE0206300"],"award-info":[{"award-number":["2018YFE0206300"]}]},{"name":"Basic Scientific Research Operating Expenses Projects of the Provincial University of Heilongjiang Province","award":["2020YFD1001400"],"award-info":[{"award-number":["2020YFD1001400"]}]},{"name":"Basic Scientific Research Operating Expenses Projects of the Provincial University of Heilongjiang Province","award":["TD2020C003"],"award-info":[{"award-number":["TD2020C003"]}]},{"name":"Basic Scientific Research Operating Expenses Projects of the Provincial University of Heilongjiang Province","award":["ZDZX202106"],"award-info":[{"award-number":["ZDZX202106"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>Accumulating attention has been focused on resistant starch (RS) due to its blood-lipid-lowering activities. However, reports on the potential bioactivities of RS for preventing hyperlipidemia acute pancreatitis (HLAP) are limited. Therefore, in this study, an acute pancreatitis model was set up by feeding a hyperlipidemia diet to rats, and subsequently evaluating the anti-HLAP effect of RS in kidney beans. The results show that the IL-6, IL-1\u03b2, and TNF-\u03b1 of serum in each RS group were decreased by 18.67\u201350.00%, 7.92\u201322.89%, and 8.06\u201334.04%, respectively, compared with the model group (MOD). In addition, the mRNA expression of tight junction protein ZO-1, occludin, and antibacterial peptides CRAMP and DEFB1 of rats in each RS group increased by 26.43\u201360.07%, 229.98\u2013279.90%, 75.80\u2013111.20%, and 77.86\u2013109.07%, respectively. The height of the villi in the small intestine and the thickness of the muscle layer of rats were also increased, while the depth of the crypt decreased. The present study indicates that RS relieves intestinal inflammation, inhibits oxidative stress, and prevents related intestinal barrier damage. These results support the supplementation of RS as an effective nutritional intervention for HLAP and associated intestinal injury.<\/jats:p>","DOI":"10.3390\/molecules27092783","type":"journal-article","created":{"date-parts":[[2022,4,27]],"date-time":"2022-04-27T22:20:20Z","timestamp":1651098020000},"page":"2783","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Beneficial Effect of Kidney Bean Resistant Starch on Hyperlipidemia\u2014Induced Acute Pancreatitis and Related Intestinal Barrier Damage in Rats"],"prefix":"10.3390","volume":"27","author":[{"given":"Zhaohang","family":"Zuo","sequence":"first","affiliation":[{"name":"College of Food Science, Heilongjiang Bayi Agricultural University, Daqing 163319, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shuting","family":"Liu","sequence":"additional","affiliation":[{"name":"College of Food Science, Heilongjiang Bayi Agricultural University, Daqing 163319, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Weiqiao","family":"Pang","sequence":"additional","affiliation":[{"name":"College of Food Science, Heilongjiang Bayi Agricultural University, Daqing 163319, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Baoxin","family":"Lu","sequence":"additional","affiliation":[{"name":"College of Food Science, Heilongjiang Bayi Agricultural University, Daqing 163319, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wei","family":"Sun","sequence":"additional","affiliation":[{"name":"College of Food Science, Heilongjiang Bayi Agricultural University, Daqing 163319, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Naidan","family":"Zhang","sequence":"additional","affiliation":[{"name":"College of Food Science, Heilongjiang Bayi Agricultural University, Daqing 163319, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xinyu","family":"Zhou","sequence":"additional","affiliation":[{"name":"College of Food Science, Heilongjiang Bayi Agricultural University, Daqing 163319, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dongjie","family":"Zhang","sequence":"additional","affiliation":[{"name":"College of Food Science, Heilongjiang Bayi Agricultural University, Daqing 163319, China"},{"name":"National Coarse Cereals Engineering Research Center, Daqing 163319, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ying","family":"Wang","sequence":"additional","affiliation":[{"name":"College of Food Science, Heilongjiang Bayi Agricultural University, Daqing 163319, China"},{"name":"National Coarse Cereals Engineering Research Center, Daqing 163319, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2022,4,27]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/S0140-6736(14)60649-8","article-title":"Acute pancreatitis","volume":"386","author":"Lankisch","year":"2015","journal-title":"Lancet"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"795","DOI":"10.1016\/j.pan.2020.06.005","article-title":"Hypertriglyceridemia and acute pancreatitis","volume":"20","author":"Yang","year":"2020","journal-title":"Pancreatology"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"520","DOI":"10.1016\/j.mayocpiqo.2020.08.015","article-title":"Management of Hypertriglyceridemia-Induced Acute Pancreatitis in a Nondiabetic Patient","volume":"5","author":"Reed","year":"2021","journal-title":"Mayo Clin. 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