{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T13:10:37Z","timestamp":1787836237166,"version":"build-2784847793"},"reference-count":82,"publisher":"MDPI AG","issue":"9","license":[{"start":{"date-parts":[[2022,5,2]],"date-time":"2022-05-02T00:00:00Z","timestamp":1651449600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Medical University of Lublin, Poland","award":["POPW.01.03.00-06-010\/09-00"],"award-info":[{"award-number":["POPW.01.03.00-06-010\/09-00"]}]},{"name":"Operational Program Development of Eastern Poland 2007\u20132013, Priority Axis I, Modern Economy, Operations 1.3. Innovations Promotion","award":["POPW.01.03.00-06-010\/09-00"],"award-info":[{"award-number":["POPW.01.03.00-06-010\/09-00"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>This study aimed to evaluate the phenolic profile and biological activity of the extracts from the leaves and fruits of Cotoneaster nebrodensis and Cotoneaster roseus. Considering that miscellaneous species of Cotoneaster are thought to be healing in traditional Asian medicine, we assumed that this uninvestigated species may reveal significant therapeutic properties. Here, we report the simultaneous assessment of chemical composition as well as biological activities (antioxidant, anti-inflammatory, antibacterial, and cytotoxic properties) of tested species. Complementary LC-MS analysis revealed that polyphenols (especially flavonoids and proanthocyanidins) are the overriding phytochemicals with the greatest significance in tested biological activities. In vitro chemical tests considering biological activities revealed that obtained results showed different values depending on concentration, extraction solvent as well as phenolic content. Biological assays demonstrated that the investigated extracts possessed antibacterial properties and were not cytotoxic toward normal skin fibroblasts. Given the obtained results, we concluded that knowledge of the chemical composition and biological activities of investigated species are important to achieve a better understanding of the utilization of these plants in traditional medicine and be useful for further research in their application to treat various diseases, such as skin disorders.<\/jats:p>","DOI":"10.3390\/molecules27092907","type":"journal-article","created":{"date-parts":[[2022,5,3]],"date-time":"2022-05-03T08:26:35Z","timestamp":1651566395000},"page":"2907","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Can Extracts from the Leaves and Fruits of the Cotoneaster Species Be Considered Promising Anti-Acne Agents?"],"prefix":"10.3390","volume":"27","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3797-4346","authenticated-orcid":false,"given":"Barbara","family":"Krzemi\u0144ska","sequence":"first","affiliation":[{"name":"Department of Pharmaceutical Botany, Medical University of Lublin, 20-093 Lublin, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Micha\u0142 P.","family":"Dybowski","sequence":"additional","affiliation":[{"name":"Department of Chromatography, Faculty of Chemistry, Institute of Chemical Sciences, Maria Curie Sklodowska University in Lublin, 20-031 Lublin, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4236-9087","authenticated-orcid":false,"given":"Katarzyna","family":"Klimek","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Biotechnology, Medical University of Lublin, 20-093 Lublin, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3898-8491","authenticated-orcid":false,"given":"Rafa\u0142","family":"Typek","sequence":"additional","affiliation":[{"name":"Department of Chromatography, Faculty of Chemistry, Institute of Chemical Sciences, Maria Curie Sklodowska University in Lublin, 20-031 Lublin, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0353-123X","authenticated-orcid":false,"given":"Ma\u0142gorzata","family":"Miazga-Karska","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Biotechnology, Medical University of Lublin, 20-093 Lublin, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gra\u017cyna","family":"Ginalska","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Biotechnology, Medical University of Lublin, 20-093 Lublin, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4884-9110","authenticated-orcid":false,"given":"Katarzyna","family":"Dos Santos Szewczyk","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Botany, Medical University of Lublin, 20-093 Lublin, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,5,2]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1007\/s12013-009-9043-x","article-title":"A review of the antioxidant mechanisms of polyphenol compounds related to iron binding","volume":"53","author":"Perron","year":"2009","journal-title":"Cell Biochem. Biophys."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"129488","DOI":"10.1016\/j.foodchem.2021.129488","article-title":"Synthetic phenolic antioxidants: Metabolism, hazards and mechanism of action","volume":"353","author":"Xu","year":"2021","journal-title":"Food Chem."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1021\/acs.chemrestox.1c00348","article-title":"Redox activity of flavonoids: Impact on human health, therapeutics, and chemical safety","volume":"35","author":"Sarkar","year":"2022","journal-title":"Chem. Res. Toxicol."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"274","DOI":"10.53365\/nrfhh\/144880","article-title":"Herbal radioprotectors: A mini-review of the current status","volume":"2","author":"Haritwal","year":"2022","journal-title":"Nat. Resour. Hum. Health"},{"key":"ref_5","doi-asserted-by":"crossref","unstructured":"Paul, A.K., Hossain, M.K., Mahboob, T., Nissapatorn, V., Wilairatana, P., Jahan, R., Jannat, K., Bondhon, T.A., Hasan, A., and de Lourdes Pereira, M. (2022). Does oxidative stress management help alleviation of COVID-19 symptoms in patients experiencing diabetes?. Nutrients, 14.","DOI":"10.3390\/nu14020321"},{"key":"ref_6","first-page":"1","article-title":"Acne mimickers","volume":"42","author":"Kandhari","year":"2021","journal-title":"Egypt J. Dermatol. Venereol."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"151","DOI":"10.3892\/etm.2021.11074","article-title":"Adult female acne: Clinical and therapeutic particularities (review)","volume":"23","author":"Branisteanu","year":"2021","journal-title":"Exp. Ther. Med."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1007\/s00403-019-01968-z","article-title":"Promising plant-derived secondary metabolites for treatment of acne vulgaris: A mechanistic review","volume":"312","author":"Soleymani","year":"2020","journal-title":"Arch. Dermatol. Res."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"411","DOI":"10.3889\/oamjms.2020.5388","article-title":"Maskne: Mask-induced acne flare during Coronavirus disease-19. What is it and how to manage it?","volume":"8","author":"Kosasih","year":"2020","journal-title":"Maced. J. Med. Sci."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"520","DOI":"10.1016\/j.jaad.2020.09.063","article-title":"Diagnostic and management considerations for \u201cmaskne\u201d in the era of COVID-19","volume":"84","author":"Teo","year":"2021","journal-title":"J. Am. Acad. Dermatol."},{"key":"ref_11","doi-asserted-by":"crossref","unstructured":"Alishir, A., and Kim, K.H. (2021). Antioxidant phenylpropanoid glycosides from Ginkgo biloba fruit and identification of a new phenylpropanoid glycoside, Ginkgopanoside. Plants, 10.","DOI":"10.3390\/plants10122702"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/S1473-3099(20)30358-3","article-title":"Universal and targeted varicella vaccination","volume":"21","author":"Bonanni","year":"2021","journal-title":"Lancet"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1111\/dth.13482","article-title":"Systemic isotretinoin therapy in the era of COVID-19","volume":"33","author":"Abdelmaksoud","year":"2020","journal-title":"Dermatol. Ther."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"e13704","DOI":"10.1111\/dth.13704","article-title":"Increased flare of acne caused by long-time mask wearing during COVID-19 pandemic among general population","volume":"33","author":"Han","year":"2020","journal-title":"Dermatol. Ther."},{"key":"ref_15","doi-asserted-by":"crossref","unstructured":"Kicel, A., Michel, P., Owczarek, A., Marchelak, A., Zyzelewicz, D., Budryn, G., Oracz, J., and Olszewska, M.A. (2016). Phenolic profile and antioxidant potential of leaves from selected Cotoneaster Medik. species. Molecules, 21.","DOI":"10.3390\/molecules21060688"},{"key":"ref_16","doi-asserted-by":"crossref","unstructured":"Kicel, A., Kolodziejczyk-Czepas, J., Owczarek, A., Marchelak, A., Sopinska, M., Ciszewski, P., Nowak, P., and Olszewska, M.A. (2018). Polyphenol-rich extracts from Cotoneaster leaves inhibit pro-inflammatory enzymes and protect human plasma components against oxidative stress in vitro. Molecules, 23.","DOI":"10.3390\/molecules23102472"},{"key":"ref_17","doi-asserted-by":"crossref","unstructured":"Krzemi\u0144ska, B., Dybowski, M.P., Klimek, K., Typek, R., Miazga-Karska, M., and Dos Santos Szewczyk, K. (2022). The anti-acne potential and chemical composition of two cultivated Cotoneaster species. Cells, 11.","DOI":"10.3390\/cells11030367"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1016\/j.phytol.2014.09.007","article-title":"Horizontoates A\u2013C: New cholinesterase inhibitors from Cotoneaster horizontalis","volume":"10","author":"Khan","year":"2014","journal-title":"Phytochem. Lett."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"265","DOI":"10.3390\/antiox2040265","article-title":"Antioxidant constituents of Cotoneaster melanocarpus Lodd","volume":"2","author":"Holzer","year":"2013","journal-title":"Antioxidants"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"1775","DOI":"10.1039\/C7FO00330G","article-title":"Chemical constituents, radical scavenging activity and enzyme inhibitory capacity of fruits from Cotoneaster pannosus Franch","volume":"8","author":"Les","year":"2017","journal-title":"Food Funct."},{"key":"ref_21","doi-asserted-by":"crossref","unstructured":"Zengin, G., Uysal, A., Gunes, E., and Aktumsek, A. (2014). Survey of phytochemical composition and biological effects of three extracts from a wild plant (Cotoneaster nummularia Fisch. et Mey.): A potential source for functional food ingredients and drug formulations. PLoS ONE, 9.","DOI":"10.1371\/journal.pone.0113527"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"e12766","DOI":"10.1111\/jfbc.12766","article-title":"Protective effects of Cotoneaster integerrimus on in vitro and ex-vivo models of H2O2-induced lactate dehydrogenase activity in HCT116 cell and on lipopolysaccharide-induced inflammation in rat colon","volume":"43","author":"Zengin","year":"2019","journal-title":"J. Food Biochem."},{"key":"ref_23","first-page":"103","article-title":"Antiplasmodial activity and cytotoxicity of plants used in traditional medicine of Iran for the treatment of fever","volume":"14","author":"Esmaeili","year":"2015","journal-title":"Iran J. Pharm. Res."},{"key":"ref_24","first-page":"2166","article-title":"A phyto pharmacological review on Cotoneaster microphyllus species","volume":"10","author":"Swati","year":"2018","journal-title":"J. Pharm. Sci. Res."},{"key":"ref_25","doi-asserted-by":"crossref","unstructured":"Szewczyk, K., Bogucka-Kocka, A., Vorobets, N., Grzywa-Celi\u0144ska, A., and Granica, S. (2020). Phenolic composition of the leaves of Pyrola rotundifolia L. and their antioxidant and cytotoxic activity. Molecules, 25.","DOI":"10.3390\/molecules25071749"},{"key":"ref_26","first-page":"1","article-title":"Phenolic composition, antioxidant and antimicrobial activity of Cotoneaster Medik. species from Bosnia and Herzegovina","volume":"54","author":"Dizdar","year":"2020","journal-title":"Bull. Chem. Technol. Bosnia Herzeg."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"194","DOI":"10.7783\/KJMCS.2019.27.3.194","article-title":"Comparison of antioxidant and anti-inflammatory activities of methanolic extracts obtained from different parts of Cotoneaster wilsonii Nakai","volume":"27","author":"Yoo","year":"2019","journal-title":"Korean J. Med. Crop Sci."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1016\/j.phytol.2019.02.027","article-title":"Polyphenolic profile, antioxidant activity, and pro-inflammatory enzymes inhibition of leaves, flowers, bark and fruits of Cotoneaster integerrimus: A comparative study","volume":"30","author":"Kicel","year":"2019","journal-title":"Phytochem. Lett."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"1381","DOI":"10.1016\/S0031-9422(06)80133-0","article-title":"Flavonoid glycosides from Cotoneaster thymaefolia","volume":"35","author":"Palme","year":"1994","journal-title":"Phytochem"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1016\/j.indcrop.2016.06.029","article-title":"Insight into anticholinesterase and antioxidant potential of thirty-four Rosaceae samples and phenolic characterization of the active extracts by HPLC","volume":"91","author":"Ekin","year":"2016","journal-title":"Ind. Crops Prod."},{"key":"ref_31","doi-asserted-by":"crossref","unstructured":"Kicel, A., Owczarek, A., Kapusta, P., Kolodziejczyk-Czepas, J., and Olszewska, M.A. (2020). Contribution of individual polyphenols to antioxidant activity of Cotoneaster bullatus and Cotoneaster zabelii leaves\u2014Structural relationships, synergy effects and application for quality control. Antioxidants, 9.","DOI":"10.3390\/antiox9010069"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"1","DOI":"10.5564\/mjc.v20i46.1235","article-title":"Phytochemicals in leaves of Cotoneaster mongolica, their antioxidative, and acetylcholinesterase inhibitory activity","volume":"20","author":"Odontuya","year":"2019","journal-title":"Mong. J. Chem."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"1377","DOI":"10.1071\/CH9741377","article-title":"Isoflavonoids. III. Constituents of Cotoneaster species","volume":"27","author":"Cooke","year":"1974","journal-title":"Aust. J. Chem."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1016\/j.ijpharm.2010.09.035","article-title":"In vitro and in vivo antioxidant properties of chlorogenic acid and caffeic acid","volume":"403","author":"Sato","year":"2011","journal-title":"Int. J. Pharm."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1093\/jn\/131.1.66","article-title":"Chlorogenic acid and caffeic acid are absorbed in humans","volume":"131","author":"Olthof","year":"2001","journal-title":"J. Nutr."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/j.biopha.2017.10.064","article-title":"chlorogenic acid (CGA): A pharmacological review and call for further research","volume":"97","author":"Naveed","year":"2018","journal-title":"Biomed. Pharmacother."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"1219","DOI":"10.1515\/znb-2008-1013","article-title":"Cotonoates A and B, new aromatic esters from Cotoneaster racemiflora","volume":"63","author":"Khan","year":"2008","journal-title":"Z. Naturforsch. B"},{"key":"ref_38","first-page":"620","article-title":"Isolation studies on Cotoneaster racemiflora","volume":"29","author":"Khan","year":"2007","journal-title":"J. Chem. Soc. Pak."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"2421","DOI":"10.1007\/s11738-013-1276-z","article-title":"Antioxidant, anticancer and hepatoprotective activities of Cotoneaster horizontalis Decne extract as well as tocopherol and amygdalin production from in vitro culture","volume":"35","author":"Sokkar","year":"2013","journal-title":"Acta Physiol. Plant."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"1539","DOI":"10.1016\/0031-9422(73)80364-4","article-title":"Cyanogenesis in Cotoneaster-arten","volume":"12","author":"Nahrstedt","year":"1973","journal-title":"Phytochem"},{"key":"ref_41","doi-asserted-by":"crossref","unstructured":"Dzia\u0142o, M., Mierziak, J., Korzun, U., Preisner, M., Szopa, J., and Kulma, A. (2016). The potential of plant phenolics in prevention and therapy of skin disorders. Int. J. Mol. Sci., 17.","DOI":"10.3390\/ijms17020160"},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1002\/jccs.201400180","article-title":"F33O4 magnetic nanoparticles for cinnamic acid extraction from Ramulus Cinnamomi","volume":"62","author":"Huang","year":"2015","journal-title":"J. Chin. Chem. Soc."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"961","DOI":"10.1111\/j.1751-1097.2012.01118.x","article-title":"Caffeic acid and ferulic acid inhibit UVA-induced matrix metalloproteinase-1 through regulation of antioxidant defense system in keratinocyte HaCaT cells","volume":"88","author":"Pluemsamran","year":"2012","journal-title":"Photochem. Photobiol."},{"key":"ref_44","first-page":"98","article-title":"Pharmacological activities of Cotoneaster racemiflorus\u2014A review","volume":"3","year":"2016","journal-title":"Pharm. Chem. J."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"1883","DOI":"10.3892\/or.2012.2000","article-title":"Apoptosis triggered by vitexin in U937 human leukemia cells via a mitochondrial signaling pathway","volume":"28","author":"Lee","year":"2012","journal-title":"Oncol. Rep."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/j.fitote.2015.01.005","article-title":"Inhibitory effects of polyphenols from grape pomace extract on collagenase and elastase activity","volume":"101","author":"Wittenauer","year":"2015","journal-title":"Fitoterapia"},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"1030","DOI":"10.18016\/ksutarimdoga.vi.657560","article-title":"Chemical compositions of essential oil and crude oil of some fruits belonging to Umbelliferae family cultivated in Konya ecological conditions","volume":"23","author":"Ayran","year":"2020","journal-title":"J. Agric. Nat."},{"key":"ref_48","first-page":"602","article-title":"Determination of antioxidant activity of phytochemicals in cellular models by fluorescence\/luminescence methods","volume":"71","author":"Baranowska","year":"2017","journal-title":"Postepy Hig. Med. Dosw."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1016\/j.imu.2017.10.005","article-title":"Antibacterial and antioxidant strategies for acne treatment through plant extracts","volume":"13","author":"Vora","year":"2017","journal-title":"Inform. Med. Unlocked"},{"key":"ref_50","first-page":"135","article-title":"Oxidative stress in acne vulgaris","volume":"23","author":"Sarici","year":"2009","journal-title":"J. Eur. Acad. Dermatol. Venereol."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"502","DOI":"10.1111\/exd.12172","article-title":"Are therapeutic effects of antiacne agents mediated by activation of FoxO1 and inhibition of mTORC1?","volume":"22","author":"Melnik","year":"2013","journal-title":"Exp. Dermatol."},{"key":"ref_52","first-page":"1018","article-title":"Protective effect of alphamangostin against oxidative stress induced-retinal cell death","volume":"6","author":"Fang","year":"2016","journal-title":"Sci. Rep."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1007\/s00403-012-1249-x","article-title":"Polyphenon-60 displays a therapeutic effect on acne by suppression of TLR2 and IL-8 expression via down-regulating the ERK1\/2 pathway","volume":"304","author":"Jung","year":"2012","journal-title":"Arch. Dermatol. Res."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"259","DOI":"10.36468\/pharmaceutical-sciences.506","article-title":"Evaluation of medicinally important constituents of Cotoneaster afghanicus G.Klotz collected from baluchistan region of Pakistan","volume":"81","author":"Bukhari","year":"2019","journal-title":"Indian J. Pharm. Sci."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"1318","DOI":"10.1080\/10942912.2021.1963770","article-title":"Phytochemical isolation and biological screening of Cotoneaster microphyllus","volume":"24","author":"Ali","year":"2021","journal-title":"Int. J. Food Prop."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"979","DOI":"10.1016\/j.phymed.2016.06.011","article-title":"Chemical and biological insights on Cotoneaster integerrimus: A new (-)-epicatechin source for food and medicinal applications","volume":"15","author":"Uysal","year":"2016","journal-title":"Phytomedicine"},{"key":"ref_57","doi-asserted-by":"crossref","unstructured":"McLaughlin, J., Watterson, S., Layton, A.M., Bjourson, A.J., Barnard, E., and McDowell, A. (2019). Propionibacterium acnes and acne vulgaris: New insights from the integration of population genetic, multi-omic, biochemical and host-microbe studies. Microorganisms, 7.","DOI":"10.3390\/microorganisms7050128"},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1016\/j.clindermatol.2008.01.004","article-title":"Flavonoids as components of biologically active cosmeceuticals","volume":"26","author":"Arct","year":"2008","journal-title":"Clin. Dermatol."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1016\/0006-2952(90)90709-T","article-title":"Structure-activity studies of flavonoids as inhibitors of hyaluronidase","volume":"40","author":"Kuppusamy","year":"1990","journal-title":"Biochem Pharmacol."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/S0163-7258(02)00298-X","article-title":"The biochemistry and medical significance of flavonoids","volume":"96","author":"Havsteen","year":"2002","journal-title":"Pharmacol. Ther."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"720","DOI":"10.1002\/ardp.19953281006","article-title":"Anti-elastase and anti-hyaluronidase activities of saponins and sapogenins from Hedera helix, Aesculus hippocastanum, and Ruscus aculeatus: Factors contributing to their efficacy in the treatment of venous insufficiency","volume":"328","author":"Facino","year":"1995","journal-title":"Arch. Pharm."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1002\/ardp.200500216","article-title":"Inhibitory effects of triterpenes and flavonoids on the enzymatic activity of hyaluronic acid splitting enzymes","volume":"339","author":"Hertel","year":"2006","journal-title":"Arch. Pharm."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"4167","DOI":"10.21608\/ejhm.2021.207814","article-title":"Modalities in acne vulgaris treatment: Review article","volume":"85","author":"Toama","year":"2021","journal-title":"Egypt. J. Hosp. Med."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1016\/j.sajb.2018.03.007","article-title":"The biological activities of roots and aerial parts of Alchemilla vulgaris L.","volume":"116","author":"Boroja","year":"2018","journal-title":"S. Afr. J. Bot."},{"key":"ref_65","doi-asserted-by":"crossref","unstructured":"Dos Santos Szewczyk, K.S., Pietrzak, W., Klimek, K., and Gogacz, M. (2022). LC-ESI-MS\/MS dentification of biologically active phenolics in different extracts of Alchemilla acutiloba Opiz. Molecules, 27.","DOI":"10.3390\/molecules27030621"},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1016\/j.clindermatol.2004.03.005","article-title":"Acne and Propionibacterium acnes","volume":"22","author":"Bojar","year":"2004","journal-title":"Clin. Dermatol."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1111\/jdv.14374","article-title":"What is new in the pathophysiology of acne, an overview","volume":"31","author":"Dreno","year":"2017","journal-title":"J. Eur. Acad. Dermatol. Venereol."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1111\/jdv.15043","article-title":"Cutibacterium acnes (Propionibacterium acnes) and acne vulgaris: A brief look at the latest updates","volume":"32","author":"Dreno","year":"2018","journal-title":"J. Eur. Acad. Dermatol. Venereol."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/S1473-3099(15)00527-7","article-title":"Systematic review of antibiotic resistance in acne: An increasing topical and oral threat","volume":"16","author":"Walsh","year":"2016","journal-title":"Lancet Infect. Dis."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"2116","DOI":"10.1080\/14786419.2017.1365068","article-title":"In vitro anti-acne activity of phytoactives from the stem bark of Artocarpus hirsutus Lam. and characterisation of pyranocycloartobiloxanthone A as a mixture of two anomers","volume":"32","author":"Nayak","year":"2018","journal-title":"Nat. Prod. Res."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1080\/08927014.2016.1148141","article-title":"A combination of ellagic acid and tetracycline inhibits biofilm formation and the associated virulence of Propionibacterium acnes in vitro and in vivo","volume":"32","author":"Sivasankar","year":"2016","journal-title":"Biofouling"},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1007\/s10086-013-1388-5","article-title":"Intsia palembanica wood extracts and its isolated compounds as Propionibacterium acnes lipase inhibitor","volume":"60","author":"Batubara","year":"2014","journal-title":"J. Wood Sci."},{"key":"ref_73","first-page":"58","article-title":"Isolation and characterisation of phenolics from the roots of Cotoneaster acuminatus and determination of their antimicrobial activity","volume":"2","author":"Sati","year":"2010","journal-title":"Int. J. Pharm. Pharm. Sci."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"349","DOI":"10.12692\/ijb\/6.2.349-356","article-title":"Antibacterial activity of methanolic extracts from Cotoneaster nummularioides, Cynodon dactylon and Cardaria draba on typical food-borne pathogens","volume":"6","author":"Yaghooti","year":"2015","journal-title":"Int. J. Biosci."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"796","DOI":"10.3390\/antiox9090796","article-title":"Extracts from Cephalaria uralensis (Murray) Roem. & Schult. and Cephalaria gigantea (Ledeb.) Bobrov as potential agents for treatment of acne vulgaris: Chemical characterization and in vitro biological evaluation","volume":"9","author":"Klimek","year":"2020","journal-title":"Antioxidants"},{"key":"ref_76","first-page":"1314","article-title":"Chemical composition and antioxidant activity of essential oil from the aerial parts of Clematis cirrhosa L. (Ranunculaceae) growing in Algeria","volume":"25","author":"Ferchichi","year":"2021","journal-title":"Ann. Rom. Soc. Cell Biol."},{"key":"ref_77","unstructured":"(2011). Polish Pharmacopoeia IX, PTFarm, Polish Pharmaceutical Society."},{"key":"ref_78","first-page":"96","article-title":"Antioxidant properties of the extracts from different parts of broccoli in Taiwan","volume":"9","author":"Guo","year":"2001","journal-title":"J. Food Drug Anal."},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1016\/j.indcrop.2017.11.019","article-title":"Tyrosinase, elastase, hyaluronidase, inhibitory and antioxidant activity of Sri Lankan medicinal plants for novel cosmeceuticals","volume":"111","author":"Liyanaarachchi","year":"2018","journal-title":"Ind. Crop. Prod."},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1093\/ajcp\/45.4_ts.493","article-title":"Antibiotic susceptibility testing by a standardized single method","volume":"45","author":"Bauer","year":"1966","journal-title":"Am. J. Clin. Pathol."},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1016\/j.det.2018.12.001","article-title":"An overview of acne therapy, part 1: Topical therapy, oral antibiotics, laser and light therapy, and dietary interventions","volume":"37","author":"Marson","year":"2019","journal-title":"Dermatol. Clin."},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"1306","DOI":"10.1016\/j.fitote.2012.03.026","article-title":"A review of phytotherapy of acne vulgaris: Perspective of new pharmacological treatments","volume":"83","author":"Azimi","year":"2012","journal-title":"Fitoterapia"}],"container-title":["Molecules"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1420-3049\/27\/9\/2907\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T23:05:30Z","timestamp":1760137530000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1420-3049\/27\/9\/2907"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,5,2]]},"references-count":82,"journal-issue":{"issue":"9","published-online":{"date-parts":[[2022,5]]}},"alternative-id":["molecules27092907"],"URL":"https:\/\/doi.org\/10.3390\/molecules27092907","relation":{},"ISSN":["1420-3049"],"issn-type":[{"value":"1420-3049","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,5,2]]}}}