{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T16:52:19Z","timestamp":1792601539587,"version":"4.5.0"},"reference-count":90,"publisher":"MDPI AG","issue":"9","license":[{"start":{"date-parts":[[2022,5,4]],"date-time":"2022-05-04T00:00:00Z","timestamp":1651622400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Open Access Fund of Leibniz Universit\u00e4t Hannover"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>The present study aimed to assess metabolites heterogeneity among four major Cinnamomum species, including true cinnamon (Cinnamomum verum) and less explored species (C. cassia, C. iners, and C. tamala). UPLC-MS led to the annotation of 74 secondary metabolites belonging to different classes, including phenolic acids, tannins, flavonoids, and lignans. A new proanthocyanidin was identified for the first time in C. tamala, along with several glycosylated flavonoid and dicarboxylic fatty acids reported for the first time in cinnamon. Multivariate data analyses revealed, for cinnamates, an abundance in C. verum versus procyandins, dihydro-coumaroylglycosides, and coumarin in C. cassia. A total of 51 primary metabolites were detected using GC-MS analysis encompassing different classes, viz. sugars, fatty acids, and sugar alcohols, with true cinnamon from Malaysia suggested as a good sugar source for diabetic patients. Glycerol in C. tamala, erythritol in C. iners, and glucose and fructose in C. verum from Malaysia were major metabolites contributing to the discrimination among species.<\/jats:p>","DOI":"10.3390\/molecules27092935","type":"journal-article","created":{"date-parts":[[2022,5,4]],"date-time":"2022-05-04T08:21:25Z","timestamp":1651652485000},"page":"2935","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":69,"title":["Comparative Metabolite Fingerprinting of Four Different Cinnamon Species Analyzed via UPLC\u2013MS and GC\u2013MS and Chemometric Tools"],"prefix":"10.3390","volume":"27","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5139-1863","authenticated-orcid":false,"given":"Mohamed A.","family":"Farag","sequence":"first","affiliation":[{"name":"Pharmacognosy Department, College of Pharmacy, Cairo University, Kasr El Aini St., Cairo 11562, Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eman M.","family":"Kabbash","sequence":"additional","affiliation":[{"name":"Phytochemistry Department, National Organization for Drug Control and Research, Giza 12622, Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6892-1995","authenticated-orcid":false,"given":"Ahmed","family":"Mediani","sequence":"additional","affiliation":[{"name":"Institute of Systems Biology (INBIOSIS), Universiti Kebangsaan Malaysia (UKM), Bangi 43600, Selangor, Malaysia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0001-8302","authenticated-orcid":false,"given":"Stefanie","family":"D\u00f6ll","sequence":"additional","affiliation":[{"name":"German Centre for Integrative Biodiversity Research (iDiv) Halle-Jena-Leipzig, Puschstra\u00dfe 4, 04103 Leipzig, Germany"},{"name":"Institute of Biodiversity, Friedrich Schiller University Jena, Dornburger-Str. 159, 07743 Jena, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2413-6925","authenticated-orcid":false,"given":"Tuba","family":"Esatbeyoglu","sequence":"additional","affiliation":[{"name":"Department of Food Development and Food Quality, Institute of Food Science and Human Nutrition, Gottfried Wilhelm Leibniz University Hannover, Am KleinenFelde 30, 30167 Hannover, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sherif M.","family":"Afifi","sequence":"additional","affiliation":[{"name":"Pharmacognosy Department, Faculty of Pharmacy, University of Sadat City, Sadat City 32897, Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,5,4]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1002\/ppp3.10192","article-title":"\u201cCeylon cinnamon\u201d: Much more than just a spice","volume":"3","author":"Suriyagoda","year":"2021","journal-title":"Plants People Planet"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1080\/10408391003699550","article-title":"Chemistry, biogenesis, and biological activities of Cinnamomum zeylanicum","volume":"51","author":"Jayaprakasha","year":"2011","journal-title":"Crit. 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