{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T19:18:36Z","timestamp":1792005516830,"version":"4.4.0"},"reference-count":45,"publisher":"MDPI AG","issue":"9","license":[{"start":{"date-parts":[[2022,5,8]],"date-time":"2022-05-08T00:00:00Z","timestamp":1651968000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100006769","name":"Russian Science Foundation","doi-asserted-by":"publisher","award":["19-73-10134"],"award-info":[{"award-number":["19-73-10134"]}],"id":[{"id":"10.13039\/501100006769","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>The search for new ways to obtain analogues of the well-known Methylene Blue dye is an important synthetic task. Herein, we proposed and developed an approach to the synthesis of 3-N\u2032-arylaminophenothiazines and asymmetrical 3,7-di(N\u2032-arylamino)phenothiazines. This approach included the optimization of synthetic strategy by quantification analysis of the positive charge distribution in the cation of 3-N\u2032-arylaminophenothiazine derivative. The obtained experimental data are confirmed by DFT studies. Two synthetic routes for asymmetrical phenothiazine diarylamino derivatives were suggested and verified. The developed convenient and versatile synthetic approach makes it easy to obtain aromatic Methylene Blue isostructural analogues with various substituents. As a result, a series of novel 3-N\u2032-arylaminophenothiazines and asymmetrical 3,7-di(N\u2032-arylamino)phenothiazines containing ester, tert-butoxycarbonyl, sulfonic acid, hydroxyl and amine groups were obtained in high yields.<\/jats:p>","DOI":"10.3390\/molecules27093024","type":"journal-article","created":{"date-parts":[[2022,5,8]],"date-time":"2022-05-08T21:31:20Z","timestamp":1652045480000},"page":"3024","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Towards Asymmetrical Methylene Blue Analogues: Synthesis and Reactivity of 3-N\u2032-Arylaminophenothiazines"],"prefix":"10.3390","volume":"27","author":[{"given":"Alena","family":"Khadieva","sequence":"first","affiliation":[{"name":"A.M. Butlerov\u2019 Chemistry Institute, Kazan Federal University, 18 Kremlevskaya Street, 420008 Kazan, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mansur","family":"Rayanov","sequence":"additional","affiliation":[{"name":"A.M. Butlerov\u2019 Chemistry Institute, Kazan Federal University, 18 Kremlevskaya Street, 420008 Kazan, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ksenia","family":"Shibaeva","sequence":"additional","affiliation":[{"name":"A.M. Butlerov\u2019 Chemistry Institute, Kazan Federal University, 18 Kremlevskaya Street, 420008 Kazan, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8200-9433","authenticated-orcid":false,"given":"Alexandr","family":"Piskunov","sequence":"additional","affiliation":[{"name":"G.A. Razuvaev Institute of Organometallic Chemistry, Russian Academy of Sciences, 49 Tropinin Street, 603137 Nizhny Novgorod, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1924-8028","authenticated-orcid":false,"given":"Pavel","family":"Padnya","sequence":"additional","affiliation":[{"name":"A.M. Butlerov\u2019 Chemistry Institute, Kazan Federal University, 18 Kremlevskaya Street, 420008 Kazan, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3019-7866","authenticated-orcid":false,"given":"Ivan","family":"Stoikov","sequence":"additional","affiliation":[{"name":"A.M. Butlerov\u2019 Chemistry Institute, Kazan Federal University, 18 Kremlevskaya Street, 420008 Kazan, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,5,8]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"112341","DOI":"10.1016\/j.ejmech.2020.112341","article-title":"Contemporary Approaches and Future Perspectives of Antibacterial Photodynamic Therapy (APDT) against Methicillin-Resistant Staphylococcus Aureus (MRSA): A Systematic Review","volume":"200","author":"Dharmaratne","year":"2020","journal-title":"Eur. J. Med. Chem."},{"key":"ref_2","doi-asserted-by":"crossref","unstructured":"Lesar, A., Mu\u0161kovi\u0107, M., Begi\u0107, G., Lon\u010dari\u0107, M., Tomi\u0107 Lin\u0161ak, D., Malatesti, N., and Gobin, I. (2020). Cationic Porphyrins as Effective Agents in Photodynamic Inactivation of Opportunistic Plumbing Pathogen Legionella Pneumophila. 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