{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T19:55:29Z","timestamp":1792007729025,"version":"4.4.0"},"reference-count":33,"publisher":"MDPI AG","issue":"10","license":[{"start":{"date-parts":[[2022,5,12]],"date-time":"2022-05-12T00:00:00Z","timestamp":1652313600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100006769","name":"Russian Science Foundation","doi-asserted-by":"publisher","award":["18-73-10035"],"award-info":[{"award-number":["18-73-10035"]}],"id":[{"id":"10.13039\/501100006769","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>A synthetic procedure for the synthesis of azacrown ethers with a combination of pendant arms has been developed and the synthesized ligand, characterized by various techniques, was studied. The prepared benzoazacrown ether with hybrid pendant arms and its complexes with copper and lead cations were studied in terms of biomedical applications. Similarly to a fully acetate analog, the new one binds both cations with close stability constants, despite the decrease in both constants. The calculated geometry of the complexes correlate with the data from X-ray absorption and NMR spectroscopy. Coordination of both cations differs due to the difference between the ionic radii. However, these chelation modes provide effective shielding of cations in both cases, that was shown by the stability of their complexes in the biologically relevant media towards transchelation and transmetallation.<\/jats:p>","DOI":"10.3390\/molecules27103115","type":"journal-article","created":{"date-parts":[[2022,5,12]],"date-time":"2022-05-12T21:46:53Z","timestamp":1652392013000},"page":"3115","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Novel Hybrid Benzoazacrown Ligand as a Chelator for Copper and Lead Cations: What Difference Does Pyridine Make"],"prefix":"10.3390","volume":"27","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2927-7359","authenticated-orcid":false,"given":"Bayirta V.","family":"Egorova","sequence":"first","affiliation":[{"name":"Chemistry Department, Lomonosov Moscow State University, Leninskie Gory, 1, 119991 Moscow, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lyubov S.","family":"Zamurueva","sequence":"additional","affiliation":[{"name":"Chemistry Department, Lomonosov Moscow State University, Leninskie Gory, 1, 119991 Moscow, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4707-3875","authenticated-orcid":false,"given":"Anastasia D.","family":"Zubenko","sequence":"additional","affiliation":[{"name":"A. N. Nesmeyanov Institute of Organoelement Compounds of the Russian Academy of Sciences, Vavilova, 28, GSP-1, 119991 Moscow, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna V.","family":"Pashanova","sequence":"additional","affiliation":[{"name":"A. N. Nesmeyanov Institute of Organoelement Compounds of the Russian Academy of Sciences, Vavilova, 28, GSP-1, 119991 Moscow, Russia"},{"name":"Higher Chemical College, Mendeleev University of Chemistry and Technology of Russia, Miusskaya Sqr., 9, 125047 Moscow, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8891-6862","authenticated-orcid":false,"given":"Artem A.","family":"Mitrofanov","sequence":"additional","affiliation":[{"name":"Chemistry Department, Lomonosov Moscow State University, Leninskie Gory, 1, 119991 Moscow, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna B.","family":"Priselkova","sequence":"additional","affiliation":[{"name":"Skobeltsyn Institute of Nuclear Physics, Lomonosov Moscow State University, Leninskie Gory, 1, 119991 Moscow, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuri V.","family":"Fedorov","sequence":"additional","affiliation":[{"name":"A. N. Nesmeyanov Institute of Organoelement Compounds of the Russian Academy of Sciences, Vavilova, 28, GSP-1, 119991 Moscow, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander L.","family":"Trigub","sequence":"additional","affiliation":[{"name":"National Research Center \u201cKurchatov Institute\u201d, Akademika Kurchatova Sqr., 1, 123098 Moscow, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olga A.","family":"Fedorova","sequence":"additional","affiliation":[{"name":"A. N. Nesmeyanov Institute of Organoelement Compounds of the Russian Academy of Sciences, Vavilova, 28, GSP-1, 119991 Moscow, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stepan N.","family":"Kalmykov","sequence":"additional","affiliation":[{"name":"Chemistry Department, Lomonosov Moscow State University, Leninskie Gory, 1, 119991 Moscow, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,5,12]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1007\/s10967-019-06610-w","article-title":"213Bi production and complexation with new picolinate containing ligands","volume":"321","author":"Sinenko","year":"2019","journal-title":"J. Radioanal. Nucl. 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