{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,11]],"date-time":"2026-05-11T02:06:16Z","timestamp":1778465176381,"version":"3.51.4"},"reference-count":48,"publisher":"MDPI AG","issue":"10","license":[{"start":{"date-parts":[[2022,5,17]],"date-time":"2022-05-17T00:00:00Z","timestamp":1652745600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Khon Kaen University Research Fund","award":["KKU-YN60-012"],"award-info":[{"award-number":["KKU-YN60-012"]}]},{"name":"Khon Kaen University Research Fund","award":["573500"],"award-info":[{"award-number":["573500"]}]},{"name":"Khon Kaen University Research Fund","award":["580077"],"award-info":[{"award-number":["580077"]}]},{"name":"Khon Kaen University Research Fund","award":["580039"],"award-info":[{"award-number":["580039"]}]},{"name":"Khon Kaen University Research Fund","award":["KKU-NRCT (Graduate) 016\/2560"],"award-info":[{"award-number":["KKU-NRCT (Graduate) 016\/2560"]}]},{"name":"Graduate Research Fund Academic Year 2017 from National Research Council of Thailand (NRCT)","award":["KKU-YN60-012"],"award-info":[{"award-number":["KKU-YN60-012"]}]},{"name":"Graduate Research Fund Academic Year 2017 from National Research Council of Thailand (NRCT)","award":["573500"],"award-info":[{"award-number":["573500"]}]},{"name":"Graduate Research Fund Academic Year 2017 from National Research Council of Thailand (NRCT)","award":["580077"],"award-info":[{"award-number":["580077"]}]},{"name":"Graduate Research Fund Academic Year 2017 from National Research Council of Thailand (NRCT)","award":["580039"],"award-info":[{"award-number":["580039"]}]},{"name":"Graduate Research Fund Academic Year 2017 from National Research Council of Thailand (NRCT)","award":["KKU-NRCT (Graduate) 016\/2560"],"award-info":[{"award-number":["KKU-NRCT (Graduate) 016\/2560"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>Dipterocarpus alatus Roxb. ex G. Don is widely found in Southeast Asia. Its oleo-resin has reportedly been used in biodiesel production. Two different biodiesel production processes produce resinous byproducts, namely degumming (DG) and distillation (DT). Gas chromatography-mass spectrometry identified sesquiterpenes and triterpenes in oleo-resin, DG, and DT; and long-chain hydrocarbons in oleo-resin. High-performance liquid chromatography detected dipterocarpol as a marker compound, with the highest to lowest amounts detected in DG, DT, and oleo-resin, respectively. Oleo-resin, DG, and DT exerted more cytotoxicity than dipterocarpol, and melphalan, a chemotherapeutic drug. Oleo-resin, DG, and DT exerted cytotoxicity to a different degree in T cell leukemia (Jurkat), cervical adenocarcinoma (HeLa), and human hepatocellular carcinoma (HepG2) cells, while the highest selectivity was found in the Jurkat cells compared to the non-cancer Vero cells. Dipterocarpol exhibited the highest cytotoxicity in HepG2 cells and the lowest cytotoxicity in Jurkat cells. Oleo-resin, DG, and DT induced apoptosis in Jurkat cells. In oleo-resin, DG, and DT, dipterocarpol and other compounds may act in synergy leading to cytotoxicity and an apoptosis-inducing effect. Oleo-resin, DG, and DT could be potential sources for anticancer agents. Dipterocarpol could serve as a biomarker for follow ups on the anticancer activity of a sample from D. alatus.<\/jats:p>","DOI":"10.3390\/molecules27103187","type":"journal-article","created":{"date-parts":[[2022,5,17]],"date-time":"2022-05-17T08:34:29Z","timestamp":1652776469000},"page":"3187","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Dipterocarpol in Oleoresin of Dipterocarpus alatus Attributed to Cytotoxicity and Apoptosis-Inducing Effect"],"prefix":"10.3390","volume":"27","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5069-2071","authenticated-orcid":false,"given":"Ploenthip","family":"Puthongking","sequence":"first","affiliation":[{"name":"Division of Pharmaceutical Chemistry, Faculty of Pharmaceutical Sciences, Khon Kaen University, Khon Kaen 40002, Thailand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2212-232X","authenticated-orcid":false,"given":"Chawalit","family":"Yongram","sequence":"additional","affiliation":[{"name":"Division of Cannabis Health Science, College of Allied Health Sciences, Suansunandha Rajabhat University, Samut Songkhram 75000, Thailand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0651-0787","authenticated-orcid":false,"given":"Somporn","family":"Katekaew","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, Faculty of Science, Khon Kaen University, Khon Kaen 40002, Thailand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8697-0718","authenticated-orcid":false,"given":"Bunleu","family":"Sungthong","sequence":"additional","affiliation":[{"name":"Integrative Pharmaceuticals and Innovation of Pharmaceutical Technology Research Unit, Faculty of Pharmacy, Mahasarakham University, Maha Sarakham 44150, Thailand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0810-8425","authenticated-orcid":false,"given":"Natthida","family":"Weerapreeyakul","sequence":"additional","affiliation":[{"name":"Division of Pharmaceutical Chemistry, Faculty of Pharmaceutical Sciences, Khon Kaen University, Khon Kaen 40002, Thailand"},{"name":"The Research Institute for Human High Performance and Health Promotion, Khon Kaen University, Khon Kaen 40002, Thailand"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2022,5,17]]},"reference":[{"key":"ref_1","unstructured":"Langenheim, J.H. 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