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Research Institute of Jiangsu Vocational College of Medicine","award":["20190404"],"award-info":[{"award-number":["20190404"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>At present, the potential of natural products in new drug development has attracted more and more scientists\u2019 attention, and natural products have become an important source for the treatment of various diseases or important lead compounds. Geniposide, as a novel iridoid glycoside compound, is an active natural product isolated from the herb Gardenia jasminoides Ellis (GJ) for the first time; it is also the main active component of GJ. Recent studies have found that geniposide has multiple pharmacological effects and biological activities, including hepatoprotective activity, an anti-osteoporosis effect, an antitumor effect, an anti-diabetic effect, ananti-myocardial dysfunction effect, a neuroprotective effect, and other protective effects. In this study, the latest research progress of the natural product geniposide is systematically described, and the pharmacological effects, pharmacokinetics, and toxicity of geniposide are also summarized and discussed comprehensively. We also emphasize the major pathways modulated by geniposide, offering new insights into the pharmacological effects of geniposide as a promising drug candidate for multiple disorders.<\/jats:p>","DOI":"10.3390\/molecules27103319","type":"journal-article","created":{"date-parts":[[2022,5,21]],"date-time":"2022-05-21T09:18:08Z","timestamp":1653124688000},"page":"3319","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":71,"title":["Updated Pharmacological Effects, Molecular Mechanisms, and Therapeutic Potential of Natural Product Geniposide"],"prefix":"10.3390","volume":"27","author":[{"given":"Liping","family":"Liu","sequence":"first","affiliation":[{"name":"School of Pharmacy, Jiangsu Vocational College of Medicine, #283 Jiefang South Road, Yancheng 224000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4371-4372","authenticated-orcid":false,"given":"Qin","family":"Wu","sequence":"additional","affiliation":[{"name":"Medical School, Jiangsu Vocational College of Medicine, #283 Jiefang South Road, Yancheng 224000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuping","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Basic Medical Science, Jiangsu Vocational College of Medicine, Yancheng 224005, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guoxiang","family":"Gu","sequence":"additional","affiliation":[{"name":"Medical School, Jiangsu Vocational College of Medicine, #283 Jiefang South Road, Yancheng 224000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Runan","family":"Gao","sequence":"additional","affiliation":[{"name":"School of Pharmacy, Jiangsu Vocational College of Medicine, #283 Jiefang South Road, Yancheng 224000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bo","family":"Peng","sequence":"additional","affiliation":[{"name":"School of Pharmacy, Jiangsu Vocational College of Medicine, #283 Jiefang South Road, Yancheng 224000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yue","family":"Wang","sequence":"additional","affiliation":[{"name":"School of Pharmacy, Jiangsu Vocational College of Medicine, #283 Jiefang South Road, Yancheng 224000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3058-3262","authenticated-orcid":false,"given":"Anbang","family":"Li","sequence":"additional","affiliation":[{"name":"School of Pharmacy, Jiangsu Vocational College of Medicine, #283 Jiefang South Road, Yancheng 224000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jipeng","family":"Guo","sequence":"additional","affiliation":[{"name":"School of Pharmacy, Jiangsu Vocational College of Medicine, #283 Jiefang South Road, Yancheng 224000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinru","family":"Xu","sequence":"additional","affiliation":[{"name":"School of Pharmacy, Jiangsu Vocational College of Medicine, #283 Jiefang South Road, Yancheng 224000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaochen","family":"Shao","sequence":"additional","affiliation":[{"name":"School of Pharmacy, Jiangsu Vocational College of Medicine, #283 Jiefang South Road, Yancheng 224000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lingxing","family":"Li","sequence":"additional","affiliation":[{"name":"School of Pharmacy, Jiangsu Vocational College of Medicine, #283 Jiefang South Road, Yancheng 224000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ya","family":"Shen","sequence":"additional","affiliation":[{"name":"School of Pharmacy, Jiangsu Vocational College of Medicine, #283 Jiefang South Road, Yancheng 224000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jihu","family":"Sun","sequence":"additional","affiliation":[{"name":"Institute of Biotechnology, Jiangsu Vocational College of Medicine, #283 Jiefang South Road, Yancheng 224000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,5,21]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1325","DOI":"10.1111\/bph.13621","article-title":"Curcumin, the golden nutraceutical: Multitargeting for multiple chronic diseases","volume":"174","author":"Kunnumakkara","year":"2017","journal-title":"Brit. 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