{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T16:29:03Z","timestamp":1789144143884,"version":"build-2803163510"},"reference-count":390,"publisher":"MDPI AG","issue":"11","license":[{"start":{"date-parts":[[2022,5,25]],"date-time":"2022-05-25T00:00:00Z","timestamp":1653436800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"National Natural Science Foundation of China","award":["81802718"],"award-info":[{"award-number":["81802718"]}]},{"name":"National Natural Science Foundation of China","award":["U1504817"],"award-info":[{"award-number":["U1504817"]}]},{"name":"National Natural Science Foundation of China","award":["2020GGJS038"],"award-info":[{"award-number":["2020GGJS038"]}]},{"name":"National Natural Science Foundation of China","award":["21A310003"],"award-info":[{"award-number":["21A310003"]}]},{"name":"National Natural Science Foundation of China","award":["222102310490"],"award-info":[{"award-number":["222102310490"]}]},{"name":"National Natural Science Foundation of China","award":["222102310495"],"award-info":[{"award-number":["222102310495"]}]},{"name":"Young Backbone Teachers of Institutions of Higher Learning in Henan Province, China","award":["81802718"],"award-info":[{"award-number":["81802718"]}]},{"name":"Young Backbone Teachers of Institutions of Higher Learning in Henan Province, China","award":["U1504817"],"award-info":[{"award-number":["U1504817"]}]},{"name":"Young Backbone Teachers of Institutions of Higher Learning in Henan Province, China","award":["2020GGJS038"],"award-info":[{"award-number":["2020GGJS038"]}]},{"name":"Young Backbone Teachers of Institutions of Higher Learning in Henan Province, China","award":["21A310003"],"award-info":[{"award-number":["21A310003"]}]},{"name":"Young Backbone Teachers of Institutions of Higher Learning in Henan Province, China","award":["222102310490"],"award-info":[{"award-number":["222102310490"]}]},{"name":"Young Backbone Teachers of Institutions of Higher Learning in Henan Province, China","award":["222102310495"],"award-info":[{"award-number":["222102310495"]}]},{"name":"Natural Science Foundation of Education Department of Henan Province, China","award":["81802718"],"award-info":[{"award-number":["81802718"]}]},{"name":"Natural Science Foundation of Education Department of Henan Province, China","award":["U1504817"],"award-info":[{"award-number":["U1504817"]}]},{"name":"Natural Science Foundation of Education Department of Henan Province, China","award":["2020GGJS038"],"award-info":[{"award-number":["2020GGJS038"]}]},{"name":"Natural Science Foundation of Education Department of Henan Province, China","award":["21A310003"],"award-info":[{"award-number":["21A310003"]}]},{"name":"Natural Science Foundation of Education Department of Henan Province, China","award":["222102310490"],"award-info":[{"award-number":["222102310490"]}]},{"name":"Natural Science Foundation of Education Department of Henan Province, China","award":["222102310495"],"award-info":[{"award-number":["222102310495"]}]},{"name":"Foundation of Science &amp; Technology Department of Henan Province, China","award":["81802718"],"award-info":[{"award-number":["81802718"]}]},{"name":"Foundation of Science &amp; Technology Department of Henan Province, China","award":["U1504817"],"award-info":[{"award-number":["U1504817"]}]},{"name":"Foundation of Science &amp; Technology Department of Henan Province, China","award":["2020GGJS038"],"award-info":[{"award-number":["2020GGJS038"]}]},{"name":"Foundation of Science &amp; Technology Department of Henan Province, China","award":["21A310003"],"award-info":[{"award-number":["21A310003"]}]},{"name":"Foundation of Science &amp; Technology Department of Henan Province, China","award":["222102310490"],"award-info":[{"award-number":["222102310490"]}]},{"name":"Foundation of Science &amp; Technology Department of Henan Province, China","award":["222102310495"],"award-info":[{"award-number":["222102310495"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>Hydrogen sulfide (H2S) is an endogenous biologically active gas produced in mammalian tissues. It plays a very critical role in many pathophysiological processes in the body. It can be endogenously produced through many enzymes analogous to the cysteine family, while the exogenous source may involve inorganic sulfide salts. H2S has recently been well investigated with regard to the onset of various carcinogenic diseases such as lung, breast, ovaries, colon cancer, and neurodegenerative disorders. H2S is considered an oncogenic gas, and a potential therapeutic target for treating and diagnosing cancers, due to its role in mediating the development of tumorigenesis. Here in this review, an in-detail up-to-date explanation of the potential role of H2S in different malignancies has been reported. The study summarizes the synthesis of H2S, its roles, signaling routes, expressions, and H2S release in various malignancies. Considering the critical importance of this active biological molecule, we believe this review in this esteemed journal will highlight the oncogenic role of H2S in the scientific community.<\/jats:p>","DOI":"10.3390\/molecules27113389","type":"journal-article","created":{"date-parts":[[2022,5,25]],"date-time":"2022-05-25T05:12:27Z","timestamp":1653455547000},"page":"3389","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":115,"title":["Hydrogen Sulfide Biology and Its Role in Cancer"],"prefix":"10.3390","volume":"27","author":[{"given":"Saadullah","family":"Khattak","sequence":"first","affiliation":[{"name":"Henan International Joint Laboratory for Nuclear Protein Regulation, School of Basic Medical Sciences, Henan University, Kaifeng 475004, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohd Ahmar","family":"Rauf","sequence":"additional","affiliation":[{"name":"Department of Surgery, Miller School of Medicine, University of Miami, Miami, FL 33136, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4380-233X","authenticated-orcid":false,"given":"Nazeer Hussain","family":"Khan","sequence":"additional","affiliation":[{"name":"Henan International Joint Laboratory for Nuclear Protein Regulation, School of Basic Medical Sciences, Henan University, Kaifeng 475004, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qian-Qian","family":"Zhang","sequence":"additional","affiliation":[{"name":"Henan International Joint Laboratory for Nuclear Protein Regulation, School of Basic Medical Sciences, Henan University, Kaifeng 475004, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hao-Jie","family":"Chen","sequence":"additional","affiliation":[{"name":"Henan International Joint Laboratory for Nuclear Protein Regulation, School of Basic Medical Sciences, Henan University, Kaifeng 475004, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5960-0279","authenticated-orcid":false,"given":"Pir","family":"Muhammad","sequence":"additional","affiliation":[{"name":"Henan-Macquarie University Joint Centre for Biomedical Innovation, School of Life Sciences, Henan University, Kaifeng 475004, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammad Azam","family":"Ansari","sequence":"additional","affiliation":[{"name":"Department of Epidemic Disease Research, Institute for Research & Medical Consultations (IRMC), Imam Abdulrahman Bin Faisal University, P.O. Box 1982, Dammam 31441, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammad N.","family":"Alomary","sequence":"additional","affiliation":[{"name":"National Centre for Biotechnology, King Abdulaziz City for Science and Technology (KACST), P.O. Box 6086, Riyadh 11442, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7364-9228","authenticated-orcid":false,"given":"Muhammad","family":"Jahangir","sequence":"additional","affiliation":[{"name":"Department of Psychiatric and Mental Health, Central South University, Changsha 410078, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chun-Yang","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery, The First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, China"},{"name":"Department of General Thoracic Surgery, Hami Central Hospital, Hami 839000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin-Ying","family":"Ji","sequence":"additional","affiliation":[{"name":"Henan International Joint Laboratory for Nuclear Protein Regulation, School of Basic Medical Sciences, Henan University, Kaifeng 475004, China"},{"name":"Kaifeng Key Laboratory of Infection and Biological Safety, School of Basic Medical Sciences, Henan University, Kaifeng 475004, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6739-8437","authenticated-orcid":false,"given":"Dong-Dong","family":"Wu","sequence":"additional","affiliation":[{"name":"Henan International Joint Laboratory for Nuclear Protein Regulation, School of Basic Medical Sciences, Henan University, Kaifeng 475004, China"},{"name":"School of Stomatology, Henan University, Kaifeng 475004, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,5,25]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Zaorska, E., Tomasova, L., Koszelewski, D., Ostaszewski, R., and Ufnal, M. 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