{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T16:13:46Z","timestamp":1787501626409,"version":"build-2736575974"},"reference-count":38,"publisher":"MDPI AG","issue":"11","license":[{"start":{"date-parts":[[2022,5,27]],"date-time":"2022-05-27T00:00:00Z","timestamp":1653609600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Science Committee of the Ministry of Education and Science of the Republic of Kazakhstan","award":["\u0410\u042008855433"],"award-info":[{"award-number":["\u0410\u042008855433"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>An efficient method of producing quinine derivatives via reaction of acylation with 4,5-dichloroisothiazole-3-, 5-arylisoxazole-3-, adamantane- and hydrochlorides of pyridine-3- and pyridine-4-carbonyl chlorides was developed. All synthesized compounds were tested for antiviral, antimicrobial and analgesic activity. The most pronounced antibacterial activity was shown by the compounds 2e, 3b, 3c and 3e with isoxazole and pyridine fragments. It was found that most of the tested compounds showed significant analgesic activity reducing the pain response of animals to the irritating effect of acetic acid.<\/jats:p>","DOI":"10.3390\/molecules27113476","type":"journal-article","created":{"date-parts":[[2022,5,29]],"date-time":"2022-05-29T23:43:03Z","timestamp":1653867783000},"page":"3476","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Quinine Esters with 1,2-Azole, Pyridine and Adamantane Fragments"],"prefix":"10.3390","volume":"27","author":[{"given":"Gulim K.","family":"Mukusheva","sequence":"first","affiliation":[{"name":"Karaganda Buketov University, Karaganda 100024, Kazakhstan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aigerym R.","family":"Zhasymbekova","sequence":"additional","affiliation":[{"name":"Karaganda Buketov University, Karaganda 100024, Kazakhstan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roza B.","family":"Seidakhmetova","sequence":"additional","affiliation":[{"name":"Karaganda Buketov University, Karaganda 100024, Kazakhstan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oralgazy A.","family":"Nurkenov","sequence":"additional","affiliation":[{"name":"Institute of Organic Synthesis and Coal Chemistry of the Republic of Kazakhstan, Karaganda 100008, Kazakhstan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0803-8623","authenticated-orcid":false,"given":"Ekaterina A.","family":"Akishina","sequence":"additional","affiliation":[{"name":"Institute of Physical Organic Chemistry, National Academy of Sciences of Belarus, 220072 Minsk, Belarus"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7823-3208","authenticated-orcid":false,"given":"Sergey K.","family":"Petkevich","sequence":"additional","affiliation":[{"name":"Institute of Physical Organic Chemistry, National Academy of Sciences of Belarus, 220072 Minsk, Belarus"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Evgenij A.","family":"Dikusar","sequence":"additional","affiliation":[{"name":"Institute of Physical Organic Chemistry, National Academy of Sciences of Belarus, 220072 Minsk, Belarus"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vladimir I.","family":"Potkin","sequence":"additional","affiliation":[{"name":"Institute of Physical Organic Chemistry, National Academy of Sciences of Belarus, 220072 Minsk, Belarus"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,5,27]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1186\/1475-2875-10-144","article-title":"Quinine, an old anti-malarial drug in a modern world: Role in the treatment of malaria","volume":"10","author":"Achan","year":"2011","journal-title":"Malar. 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