{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,21]],"date-time":"2026-07-21T00:07:29Z","timestamp":1784592449278,"version":"3.55.0"},"reference-count":121,"publisher":"MDPI AG","issue":"11","license":[{"start":{"date-parts":[[2022,5,28]],"date-time":"2022-05-28T00:00:00Z","timestamp":1653696000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>Cholesterol is essential for normal human health, but elevations in its serum levels have led to the development of various complications, including hypercholesterolemia (HC). Cholesterol accumulation in blood circulation formsplaques on artery walls and worsens the individuals\u2019 health. To overcome this complication, different pharmacological and non-pharmacological approaches are employed to reduce elevated blood cholesterol levels. Atorvastatin and rosuvastatin are the most commonly used drugs, but their prolonged use leads to several acute side effects. In recent decades, the potential benefit of ingesting yogurt on lipid profile has attracted the interest of researchers and medical professionals worldwide. This review aims to give an overview of the current knowledge about HC and the different therapeutic approaches. It also discusses the health benefits of yogurt consumption and highlights the overlooked phyto-enrichment option to enhance the yogurt\u2019s quality. Finally, clinical studies using different phyto-enriched yogurts for HC management are also reviewed. Yogurt has a rich nutritional value, but its processing degrades the content of minerals, vitamins, and other vital constituents with beneficial health effects. The option of enriching yogurt with phytoconstituents has drawn a lot of attention. Different pre-clinical and clinical studies have provided new insights on their benefits on gut microbiota and human health. Thus, the yogurtphyto-enrichment with stanol and \u03b2-glucan have opened new paths in functional food industries and found healthy andeffective alternatives for HC all along with conventional treatment approaches.<\/jats:p>","DOI":"10.3390\/molecules27113479","type":"journal-article","created":{"date-parts":[[2022,5,29]],"date-time":"2022-05-29T23:43:03Z","timestamp":1653867783000},"page":"3479","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Phyto-Enrichment of Yogurt to Control Hypercholesterolemia: A Functional Approach"],"prefix":"10.3390","volume":"27","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5301-484X","authenticated-orcid":false,"given":"Harsh","family":"Kumar","sequence":"first","affiliation":[{"name":"School of Bioengineering & Food Technology, Shoolini University of Biotechnology and Management Sciences, Solan 173229, Himachal Pradesh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1708-6395","authenticated-orcid":false,"given":"Kanchan","family":"Bhardwaj","sequence":"additional","affiliation":[{"name":"School of Biological and Environmental Sciences, Shoolini University of Biotechnology and Management Sciences, Solan 173229, Himachal Pradesh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5934-5201","authenticated-orcid":false,"given":"Nat\u00e1lia","family":"Cruz-Martins","sequence":"additional","affiliation":[{"name":"Department of Biomedicine, Faculty of Medicine, University of Porto, 4200-319 Porto, Portugal"},{"name":"Institute for Research and Innovation in Health (i3S), University of Porto, 4200-135 Porto, Portugal"},{"name":"Institute of Research and Advanced Training in Health Sciences and Technologies (CESPU), Rua Central de Gandra 1317, 4585-116 Gandra PRD, Portugal"},{"name":"TOXRUN-Toxicology Research Unit, University Institute of Health Sciences, CESPU, CRL, 4585-116 Gandra PRD, Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7204-9426","authenticated-orcid":false,"given":"Ruchi","family":"Sharma","sequence":"additional","affiliation":[{"name":"School of Bioengineering & Food Technology, Shoolini University of Biotechnology and Management Sciences, Solan 173229, Himachal Pradesh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6942-4408","authenticated-orcid":false,"given":"Shahida Anusha","family":"Siddiqui","sequence":"additional","affiliation":[{"name":"German Institute of Food Technologies (DIL e.V.), Prof.-von-Klitzing Str. 7, 49610 D-Quakenbr\u00fcck, Germany"},{"name":"Department of Biotechnology and Sustainability, Technical University of Munich, Schulgasse 22, 94315 Straubing, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4791-7388","authenticated-orcid":false,"given":"Daljeet Singh","family":"Dhanjal","sequence":"additional","affiliation":[{"name":"School of Bioengineering and Biosciences, Lovely Professional University, Phagwara 144411, Punjab, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Reena","family":"Singh","sequence":"additional","affiliation":[{"name":"School of Bioengineering and Biosciences, Lovely Professional University, Phagwara 144411, Punjab, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chirag","family":"Chopra","sequence":"additional","affiliation":[{"name":"School of Bioengineering and Biosciences, Lovely Professional University, Phagwara 144411, Punjab, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adriana","family":"Dantas","sequence":"additional","affiliation":[{"name":"School of Bioengineering & Food Technology, Shoolini University of Biotechnology and Management Sciences, Solan 173229, Himachal Pradesh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5321-9450","authenticated-orcid":false,"given":"Rachna","family":"Verma","sequence":"additional","affiliation":[{"name":"School of Biological and Environmental Sciences, Shoolini University of Biotechnology and Management Sciences, Solan 173229, Himachal Pradesh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4434-9146","authenticated-orcid":false,"given":"Noura S.","family":"Dosoky","sequence":"additional","affiliation":[{"name":"Aromatic Plant Research Center, 230 N 1200 E, Suite 100, Lehi, UT 84043, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3485-6408","authenticated-orcid":false,"given":"Dinesh","family":"Kumar","sequence":"additional","affiliation":[{"name":"School of Bioengineering & Food Technology, Shoolini University of Biotechnology and Management Sciences, Solan 173229, Himachal Pradesh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,5,28]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1001\/jama.1995.03530020049031","article-title":"Serum total cholesterol and long-term coronary heart disease mortality in different cultures: Twenty-five-year follow-up of the seven countries study","volume":"274","author":"Verschuren","year":"1995","journal-title":"JAMA"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1001\/jama.284.3.311","article-title":"Relationship of baseline serum cholesterol levels in 3 large cohorts of younger men to long-term coronary, cardiovascular, and all-cause mortality and to longevity","volume":"284","author":"Stamler","year":"2000","journal-title":"JAMA"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"1267","DOI":"10.1016\/S0140-6736(05)67394-1","article-title":"Efficacy and safety of cholesterol-lowering treatment: Prospective meta-analysis of data from 90056 participants in 14 randomised trials of statins","volume":"366","author":"Baigent","year":"2005","journal-title":"Lancet"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1016\/j.recesp.2012.02.005","article-title":"Magnitude and management of hypercholesterolemia in the adult population of Spain, 2008\u20132010: The ENRICA Study","volume":"65","author":"Graciani","year":"2012","journal-title":"Rev. Esp. Cardiol."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.atherosclerosis.2011.06.012","article-title":"ESC\/EAS Guidelines for the management of dyslipidaemias: The Task Force for the management of dyslipidaemias of the European Society of Cardiology (ESC) and the European Atherosclerosis Society (EAS)","volume":"217","author":"Catapano","year":"2011","journal-title":"Atherosclerosis"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1016\/S0140-6736(99)11180-2","article-title":"Estimation of contribution of changes in classic risk factors to trends in coronary-event rates across the WHO MONICA Project populations","volume":"355","author":"Kuulasmaa","year":"2000","journal-title":"Lancet"},{"key":"ref_7","first-page":"988","article-title":"Analyzing the coronary heart disease mortality decline in a Mediterranean population: Spain 1988-2005","volume":"64","author":"Grau","year":"2011","journal-title":"Rev. Esp. Cardiol."},{"key":"ref_8","first-page":"302","article-title":"Critical review and proposals for improvement of the health information systems on cardiovascular diseases in Spain","volume":"131","author":"Banegas","year":"2008","journal-title":"Med. Clin."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s12889-017-4629-5","article-title":"Prevalence, awareness, treatment and control of dyslipidemia in older persons in urban and rural population in the Astana region, Kazakhstan","volume":"17","author":"Supiyev","year":"2017","journal-title":"BMC Public Health"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1161\/01.CIR.0000136583.52681.0D","article-title":"Serum total and lipoprotein cholesterol levels and awareness, treatment, and control of hypercholesterolemia in China","volume":"110","author":"He","year":"2004","journal-title":"Circulation"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"1773","DOI":"10.1001\/jama.294.14.1773","article-title":"Trends in serum lipids and lipoproteins of adults, 1960\u20132002","volume":"294","author":"Carroll","year":"2005","journal-title":"JAMA"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1111\/j.1365-2265.2006.02459.x","article-title":"Levels of dyslipidaemia and improvement in its management in England: Results from the Health Survey for England 2003","volume":"64","author":"Primatesta","year":"2006","journal-title":"Clin. Endocrinol."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"1868","DOI":"10.1016\/j.amjcard.2011.03.047","article-title":"30-year trends in serum lipids among United States adults: Results from the national health and nutrition examination surveys II, III, and 1999\u20132006","volume":"107","author":"Carroll","year":"2011","journal-title":"Am. J. Cardiol."},{"key":"ref_14","unstructured":"Centers for Disease Control and Prevention (CDC) (2011). Vital signs: Prevalence, treatment, and control of high levels of low-density lipoprotein cholesterol\u2014United States, 1999\u20132002 and 2005\u20132008. MMWR Morb. Mortal. Wkly Rep., 60, 109\u2013114."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"92","DOI":"10.2471\/BLT.10.079947","article-title":"High total serum cholesterol, medication coverage and therapeutic control: An analysis of national health examination survey data from eight countries","volume":"89","author":"Roth","year":"2011","journal-title":"Bull. World Health Organ."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"937","DOI":"10.1016\/S0140-6736(04)17018-9","article-title":"Effect of potentially modifiable risk factors associated with myocardial infarction in 52 countries (the INTERHEART study): Case-control study","volume":"364","author":"Yusuf","year":"2004","journal-title":"Lancet"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"902717","DOI":"10.1155\/2012\/902917","article-title":"Cholesterol-lowering probiotics as potential biotherapeutics for metabolic diseases","volume":"2012","author":"Kumar","year":"2012","journal-title":"Exp. Diabetes Res."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2014\/572754","article-title":"Effects of probiotics, prebiotics, and synbiotics on hypercholesterolemia: A review","volume":"572754","author":"Anandharaj","year":"2014","journal-title":"Chin. J. Biol."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"576","DOI":"10.12944\/CRNFSJ.6.3.02","article-title":"Superfoods: Recent data on their role in the prevention of diseases","volume":"6","author":"Proestos","year":"2018","journal-title":"Curr. Res. Nutr. Food Sci. J."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"1944","DOI":"10.1039\/C7FO01792H","article-title":"Effects of superfoods on risk factors of metabolic syndrome: A systematic review of human intervention trials","volume":"9","author":"Plat","year":"2018","journal-title":"Food Funct."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"1235S","DOI":"10.3945\/ajcn.113.073015","article-title":"Yogurt and dairy product consumption to prevent cardiometabolic diseases: Epidemiologic and experimental studies","volume":"99","author":"Astrup","year":"2014","journal-title":"Am. J. Clin. Nutr."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"812","DOI":"10.3945\/an.116.013946","article-title":"Yogurt and cardiometabolic diseases: A critical review of potential mechanisms","volume":"8","author":"Fernandez","year":"2017","journal-title":"Adv. Nutr."},{"key":"ref_23","doi-asserted-by":"crossref","unstructured":"Lordan, R., Tsoupras, A., Mitra, B., and Zabetakis, I. (2018). Dairy fats and cardiovascular disease: Do we really need to be concerned?. Foods, 7.","DOI":"10.3390\/foods7030029"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"506","DOI":"10.1080\/10408398.2017.1383355","article-title":"Health benefits of fermented foods","volume":"59","author":"Sezgin","year":"2019","journal-title":"Crit. Rev. Food Sci. Nutr."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1016\/j.nutres.2012.11.009","article-title":"Yogurt consumption is associated with better diet quality and metabolic profile in American men and women","volume":"33","author":"Wang","year":"2013","journal-title":"Nutr. Res."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"1013","DOI":"10.1017\/S0007114520000227","article-title":"The association between milk consumption and the metabolic syndrome: A cross-sectional study of the residents of Suzhou, China and a meta-analysis","volume":"123","author":"Hidayat","year":"2020","journal-title":"Br. J. Nutr."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1007\/s00394-015-0878-1","article-title":"Association between yogurt consumption, dietary patterns, and cardio-metabolic risk factors","volume":"55","author":"Cormier","year":"2016","journal-title":"Eur. J. Nutr."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"1111","DOI":"10.3945\/ajcn.115.123216","article-title":"Consumption of dairy foods and diabetes incidence: A dose-response meta-analysis of observational studies","volume":"103","author":"Gijsbers","year":"2016","journal-title":"Am. J. Clin. Nutr."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1093\/ajh\/hpx220","article-title":"Regular yogurt intake and risk of cardiovascular disease among hypertensive adults","volume":"31","author":"Buendia","year":"2018","journal-title":"Am. J. Hypertens"},{"key":"ref_30","doi-asserted-by":"crossref","unstructured":"Watanabe, D., Kuranuki, S., Sunto, A., Matsumoto, N., and Nakamura, T. (2018). Daily yogurt consumption improves glucose metabolism and insulin sensitivity in young nondiabetic Japanese subjects with type-2 diabetes risk alleles. Nutrients, 10.","DOI":"10.3390\/nu10121834"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"55","DOI":"10.3389\/fnut.2019.00055","article-title":"Greek yogurt and 12 weeks of exercise training on strength, muscle thickness and body composition in lean, untrained, university-aged males","volume":"6","author":"Bridge","year":"2019","journal-title":"Front. Nutr."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1038\/s41430-018-0166-2","article-title":"The relationship between yogurt consumption, body weight, and metabolic profiles in youth with a familial predisposition to obesity","volume":"73","author":"Panahi","year":"2019","journal-title":"Eur. J. Clin. Nutr."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s12944-017-0488-4","article-title":"Genetic determinants of inherited susceptibility to hypercholesterolemia\u2013a comprehensive literature review","volume":"16","author":"Paththinige","year":"2017","journal-title":"Lipids Health Dis."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1038\/ncpcardio0836","article-title":"Mechanisms of disease: Genetic causes of familial hypercholesterolemia","volume":"4","author":"Soutar","year":"2007","journal-title":"Nat. Clin. Pract. Cardiovasc. Med."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"a993","DOI":"10.1136\/bmj.a993","article-title":"Hypercholesterolaemia and its management","volume":"337","author":"Bhatnagar","year":"2008","journal-title":"BMJ"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"382","DOI":"10.1016\/j.ihj.2017.02.020","article-title":"Recent trends in epidemiology of dyslipidemias in India","volume":"69","author":"Gupta","year":"2017","journal-title":"Indian Heart J."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"461","DOI":"10.2471\/BLT.05.027037","article-title":"Methods for establishing a surveillance system for cardiovascular diseases in Indian industrial populations","volume":"84","author":"Reddy","year":"2006","journal-title":"Bull. World Health Organ."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"c4974","DOI":"10.1136\/bmj.c4974","article-title":"Sociodemographic patterning of non-communicable disease risk factors in rural India: A cross sectional study","volume":"341","author":"Kinra","year":"2010","journal-title":"BMJ"},{"key":"ref_39","first-page":"634","article-title":"Surveillance of cardiovascular disease risk factors in India: The need & scope","volume":"132","author":"Shah","year":"2010","journal-title":"Indian J. Med. Res."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/j.ijcard.2011.06.008","article-title":"Determinants of urban\u2013rural differences in cardiovascular risk factors in middle-aged women in India: A cross-sectional study","volume":"163","author":"Pandey","year":"2013","journal-title":"Int. J. Cardio."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1016\/j.ihj.2014.03.005","article-title":"Cholesterol lipoproteins and prevalence of dyslipidemias in urban Asian Indians: A cross sectional study","volume":"66","author":"Guptha","year":"2014","journal-title":"Indian Heart J."},{"key":"ref_42","doi-asserted-by":"crossref","unstructured":"Joshi, S.R., Anjana, R.M., Deepa, M., Pradeepa, R., Bhansali, A., Dhandania, V.K., and ICMR\u2013INDIAB Collaborative Study Group (2014). Prevalence of dyslipidemia in urban and rural India: The ICMR\u2013INDIAB study. PLoS ONE, 9.","DOI":"10.1371\/journal.pone.0096808"},{"key":"ref_43","first-page":"1","article-title":"The prevalence of hypercholesterolemia and associated risk factors in Al-Kharj population, Saudi Arabia: A cross-sectional survey","volume":"21","author":"Shubair","year":"2021","journal-title":"BMC Cardiovas. Disord."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"e23445","DOI":"10.1097\/MD.0000000000023445","article-title":"Prevalence and management of hypercholesterolemia in France, the Esteban observational study","volume":"99","author":"Blacher","year":"2020","journal-title":"Medicine"},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/1476-511X-4-17","article-title":"Diet, lifestyle factors and hypercholesterolemia in elderly men and women from Cyprus","volume":"4","author":"Polychronopoulos","year":"2005","journal-title":"Lipids Health Dis."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"274","DOI":"10.5001\/omj.2012.69","article-title":"Hypercholesterolemia among apparently healthy university students","volume":"27","author":"Shawar","year":"2012","journal-title":"Oman Med. J."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1177\/1010539510377651","article-title":"Joint prevalence and control of hypercholesterolemia and hypertension in Thailand: Third national health examination survey","volume":"24","author":"Khonputsa","year":"2012","journal-title":"Asia Pac. J. Public Health"},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1016\/0021-9150(95)05615-7","article-title":"Cholesterol levels and prevalence of hypercholesterolemia in a Mexican adult population","volume":"118","year":"1995","journal-title":"Atherosclerosis"},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"1471","DOI":"10.1016\/j.jacl.2018.08.001","article-title":"The prevalence, awareness, and treatment of lipid abnormalities in Iranian adults: Surveillance of risk factors of non-communicable diseases in Iran 2016","volume":"12","author":"Aryan","year":"2018","journal-title":"J. Clin. Lipidol."},{"key":"ref_50","unstructured":"Caroll, M.D., Cheryl, D.F., and Duong, T.N. (2020, December 12). Total and High-density Lipoprotein Cholesterol in Adults: United States, 2015\u20132016, Available online: https:\/\/www.cdc.gov\/nchs\/data\/databriefs\/db290.pdf."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"606","DOI":"10.5551\/jat.42531","article-title":"Associations between socioeconomic status and the prevalence and treatment of hypercholesterolemia in a general Japanese population: NIPPON DATA2010","volume":"25","author":"Fujiyoshi","year":"2018","journal-title":"J. Atheroscler. Thromb."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1016\/j.ihj.2015.06.031","article-title":"Blood glucose and cholesterol levels in adult population of Bangladesh: Results from STEPS 2006 survey","volume":"68","author":"Zaman","year":"2016","journal-title":"Indian Heart J."},{"key":"ref_53","first-page":"1","article-title":"Hypercholesterolemia prevalence, awareness, treatment and control among adults in Malaysia: The 2015 National Health and Morbidity Survey, Malaysia","volume":"10","author":"Rifin","year":"2018","journal-title":"Glob. J. Health Sci."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"108","DOI":"10.5144\/0256-4947.1997.108","article-title":"Prevalence of hypercholesterolemia in a Kuwaiti hospital outpatient population","volume":"17","author":"Olusi","year":"1997","journal-title":"Ann. Saudi. Med."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"1497","DOI":"10.1136\/bmj.321.7275.1497","article-title":"Outcome of case finding among relatives of patients with known heterozygous familial hypercholesterolemia","volume":"321","author":"Bhatnagar","year":"2000","journal-title":"BMJ"},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1016\/j.cca.2015.04.036","article-title":"Clinical correlation between a point-of-care testing system and laboratory automation for lipid profile","volume":"446","author":"Ferreira","year":"2015","journal-title":"Clin. Chim. Acta"},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"911","DOI":"10.1016\/j.clinbiochem.2015.05.012","article-title":"Body fluid matrix evaluation on a Roche cobas 8000 system","volume":"48","author":"Owen","year":"2015","journal-title":"Clin. Biochem."},{"key":"ref_58","first-page":"1","article-title":"Evaluation of various methods of point-of care testing of haemoglobin concentration in blood donors","volume":"29","author":"Singh","year":"2014","journal-title":"Blood Transfus."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"1291","DOI":"10.1515\/cclm-2013-1084","article-title":"Improving CardioCheck PA analytical performance: Three-year study","volume":"52","author":"Matteucci","year":"2014","journal-title":"Clin. Chem. Lab. Med."},{"key":"ref_60","first-page":"81","article-title":"Hyperlipidemia: An Updated Review","volume":"1","author":"Gupta","year":"2011","journal-title":"Int. J. Biopharm. Toxicol. Res."},{"key":"ref_61","doi-asserted-by":"crossref","unstructured":"Soliman, G.A. (2019). Dietary fiber, atherosclerosis, and cardiovascular disease. Nutrients, 11.","DOI":"10.3390\/nu11051155"},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/0002-9149(87)90587-X","article-title":"Dietary fiber, lipids and atherosclerosis","volume":"60","author":"Anderson","year":"1987","journal-title":"Am. J. Cardiol."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1111\/j.1753-4887.2009.00189.x","article-title":"Health benefits of dietary fiber","volume":"67","author":"Anderson","year":"2009","journal-title":"Nutr. Rev."},{"key":"ref_64","unstructured":"Gropper, S.S., and Smith, J. (2013). Advanced Nutrition and Human Metabolism, Wadsworth Publishing. [6th ed.]."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"5542342","DOI":"10.1155\/2021\/5542342","article-title":"Dietary fiber: An opportunity for a global control of hyperlipidemia","volume":"2021","author":"Nie","year":"2021","journal-title":"Oxid. Med. Cell Longev."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"714","DOI":"10.1016\/j.numecd.2015.04.008","article-title":"Quantitative assessment of the effects of beta-glucan consumption on serum lipid profile and glucose level in hypercholesterolemic subjects","volume":"25","author":"Zhu","year":"2015","journal-title":"Nutr. Metab. Cardiovasc. Dis."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"1111","DOI":"10.1093\/ajcn\/76.5.1111","article-title":"Oat bran stimulates bile acid synthesis within 8 h as measured by 7\u03b1-hydroxy-4-cholesten-3-one","volume":"76","author":"Andersson","year":"2002","journal-title":"Am. J. Clin. Nutr."},{"key":"ref_68","first-page":"219","article-title":"A review of hyperlipidemia and medicinal plants","volume":"2","author":"Dhaliya","year":"2013","journal-title":"Int. JA PS BMS"},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1093\/nutrit\/nuv020","article-title":"History of yogurt and current patterns of consumption","volume":"73","author":"Fisberg","year":"2015","journal-title":"Nutr. Rev."},{"key":"ref_70","first-page":"2039","article-title":"Scientific evidence about the role of yogurt and other fermented milks in the healthy diet for the spanish population","volume":"28","author":"Aznar","year":"2013","journal-title":"Nutr. Hosp."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"1569","DOI":"10.1080\/10408398.2014.883356","article-title":"Evidence for the effects of yogurt on gut health and obesity","volume":"57","author":"Pei","year":"2017","journal-title":"Crit. Rev. Food Sci. Nutr."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1093\/nutrit\/nuy060","article-title":"Novel perspectives on fermented milks and cardiometabolic health with a focus on type 2 diabetes","volume":"76","author":"Fernandez","year":"2018","journal-title":"Nutr. Rev."},{"key":"ref_73","first-page":"1","article-title":"The evolution, processing, varieties and health benefits of yogurt","volume":"4","author":"Weerathilake","year":"2014","journal-title":"Int. J. Sci. Res. Publ."},{"key":"ref_74","unstructured":"United States Department of Agriculture (USDA) (2020, December 18). Yogurt, Available online: https:\/\/reedir.arsnet.usda.gov\/codesearchwebapp\/(S(v04bt44vdd5jhdz0lbv5s1he))\/codesearch.aspx."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"1386","DOI":"10.1111\/ijfs.15546","article-title":"Edible mushrooms\u2019 enrichment in food and feed: A mini review","volume":"57","author":"Kumar","year":"2022","journal-title":"Int. J. Food Sci. Tech."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"114","DOI":"10.2174\/138161210789941856","article-title":"The anticancer properties of dietary polyphenols and its relation with apoptosis","volume":"16","author":"Fresco","year":"2010","journal-title":"Curr. Pharm. Des."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"749","DOI":"10.1161\/ATVBAHA.109.199687","article-title":"Specific dietary polyphenols attenuate atherosclerosis in apolipoprotein E\u2013knockout mice by alleviating inflammation and endothelial dysfunction","volume":"30","author":"Loke","year":"2010","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1002\/mnfr.200900172","article-title":"Impact of dietary polyphenols on human platelet function\u2013a critical review of controlled dietary intervention studies","volume":"54","author":"Ostertag","year":"2010","journal-title":"Mol. Nutr. Food Res."},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1079\/BJN2000292","article-title":"Changes in plasma antioxidant status following consumption of diets high or low in fruit and vegetables or following dietary supplementation with an antioxidant mixture","volume":"85","author":"Record","year":"2001","journal-title":"Br. J. Nutr."},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"893","DOI":"10.1016\/j.foodres.2005.03.009","article-title":"Euterpe oleracea juice as a functional pigment for yogurt","volume":"38","author":"Travaglia","year":"2005","journal-title":"Food Res. Int."},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"C241","DOI":"10.1111\/j.1750-3841.2008.00706.x","article-title":"Determination of color, pigment, and phenolic stability in yogurt systems colored with nonacylated anthocyanins from Berberis boliviana L. as compared to other natural\/synthetic colorants","volume":"73","author":"Wallace","year":"2008","journal-title":"J. Food Sci."},{"key":"ref_82","first-page":"253","article-title":"Sour cherry (Prunus cerasus L.) anthocyanins as ingredients for functional foods","volume":"2004","author":"Blando","year":"2004","journal-title":"J. Biomed. Biotechnol."},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"1593","DOI":"10.1016\/0031-9422(92)83113-D","article-title":"Anthocyanins from cell suspension cultures of Daucus carota","volume":"31","author":"Wray","year":"1992","journal-title":"Phytochemistry"},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/S1389-1723(02)80133-5","article-title":"Enhanced anthocyanin production from grape callus in an air-lift type bioreactor using a viscous additive-supplemented medium","volume":"94","author":"Hiroyuki","year":"2002","journal-title":"J. Biosci. Bioeng."},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"1131","DOI":"10.1023\/A:1024556825544","article-title":"Manipulating anthocyanin composition in Vitis vinifera suspension cultures by elicitation with jasmonic acid and light irradiation","volume":"25","author":"Curtin","year":"2003","journal-title":"Biotechnol. Lett."},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1016\/S1369-703X(02)00218-8","article-title":"Effect of methyl jasmonate and p-coumaric acid on anthocyanin composition in a sweet potato cell suspension culture","volume":"14","author":"Plata","year":"2003","journal-title":"Biochem. Eng. J."},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/S0958-6946(01)00033-4","article-title":"Significance and applications of phenolic compounds in the production and quality of milk and dairy products: A review","volume":"11","author":"Fox","year":"2001","journal-title":"Int. Dairy J."},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"1065","DOI":"10.1016\/j.lwt.2010.12.009","article-title":"Phenolic fortification of yogurt using grape and callus extracts","volume":"44","author":"Karaaslan","year":"2011","journal-title":"LWT"},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"1698","DOI":"10.1007\/s13197-015-2100-0","article-title":"Effect of pineapple waste powder on probiotic growth, antioxidant and antimutagenic activities of yogurt","volume":"53","author":"Sah","year":"2016","journal-title":"J. Food Sci. Technol."},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/j.foodres.2017.10.006","article-title":"Enhancement of antioxidant activity and physicochemical properties of yogurt enriched with concentrated strawberry pulp obtained by block freeze concentration","volume":"104","author":"Jaster","year":"2018","journal-title":"Food Res. Int."},{"key":"ref_91","first-page":"2","article-title":"Effect of green tea and Moringa leave extracts fortification on the physicochemical, rheological, sensory and antioxidant properties of set-type yoghurt","volume":"5","author":"Shokery","year":"2017","journal-title":"Adv. Dairy Res."},{"key":"ref_92","doi-asserted-by":"crossref","unstructured":"Dhawi, F., El-Beltagi, H.S., Aly, E., and Hamed, A.M. (2020). Antioxidant, antibacterial activities and mineral content of buffalo yoghurt fortified with fenugreek and Moringa oleifera seed flours. Foods, 9.","DOI":"10.3390\/foods9091157"},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"1145","DOI":"10.1016\/j.lwt.2015.03.113","article-title":"Influence of the addition of different hazelnut skins on the physicochemical, antioxidant, polyphenol and sensory properties of yogurt","volume":"63","author":"Bertolino","year":"2015","journal-title":"LWT"},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1016\/j.lwt.2017.10.047","article-title":"Impact of in-vitro gastro-pancreatic digestion on polyphenols and cinnamaldehyde bioaccessibility and antioxidant activity in stirred cinnamon-fortified yogurt","volume":"89","author":"Helal","year":"2018","journal-title":"LWT"},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1111\/jtxs.12500","article-title":"Physico-Chemical, antioxidant activities, textural, and sensory properties of yoghurt fortified with different states and rates of pomegranate seeds (Punica granatum L.)","volume":"51","author":"Bchir","year":"2020","journal-title":"J.Texture Stud."},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"792","DOI":"10.5851\/kosfa.2019.e69","article-title":"Effects of lotus (Nelumbo nucifera) leaf on quality and antioxidant activity of yogurt during refrigerated storage","volume":"39","author":"Kim","year":"2019","journal-title":"Food Sci. Anim. Resour."},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"110389","DOI":"10.1016\/j.lwt.2020.110389","article-title":"Physicochemical quality attributes and antioxidant properties of set-type yogurt fortified with argel (Solenostemma argel Hayne) leaf extract","volume":"137","author":"Ahmed","year":"2021","journal-title":"LWT"},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1016\/j.powtec.2019.09.082","article-title":"Fortification of yogurt with flaxseed powder and evaluation of its fatty acid profile, physicochemical, antioxidant, and sensory properties","volume":"359","author":"Marand","year":"2020","journal-title":"Powder Technol."},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"330","DOI":"10.3746\/pnf.2016.21.4.330","article-title":"Quality characteristics and antioxidant activity of yogurt supplemented with aronia (Aronia melanocarpa) juice","volume":"21","author":"Nguyen","year":"2016","journal-title":"Prev. Nutr. Food Sci."},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"824","DOI":"10.1080\/19476337.2019.1654548","article-title":"Antioxidant fortification of yogurt with red cactus pear peel and its mucilage","volume":"17","year":"2019","journal-title":"CyTAJ. Food"},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"82","DOI":"10.5398\/medpet.2016.39.2.82","article-title":"Quality and antioxidant activity of yogurt supplemented with roselle during cold storage","volume":"39","author":"Suharto","year":"2016","journal-title":"J. Exot. Pet. Med."},{"key":"ref_102","first-page":"865","article-title":"Antioxidant activity and quality characteristics of yogurt added green olive powder during storage","volume":"37","author":"Cho","year":"2017","journal-title":"Korean J. Food Sci. Anim. Resour."},{"key":"ref_103","doi-asserted-by":"crossref","unstructured":"Georgakouli, K., Mpesios, A., Kouretas, D., Petrotos, K., Mitsagga, C., Giavasis, I., and Jamurtas, A.Z. (2016). The effects of an olive fruit polyphenol-enriched yogurt on body composition, blood redox status, physiological and metabolic parameters and yogurt microflora. Nutrients, 8.","DOI":"10.3390\/nu8060344"},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"1419","DOI":"10.1007\/s10068-018-0370-9","article-title":"Green tea powder supplementation enhances fermentation and antioxidant activity of set-type yogurt","volume":"27","author":"Jeong","year":"2018","journal-title":"Food Sci. Biotechnol."},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1016\/j.jscs.2011.04.006","article-title":"Antioxidant activity and inhibition of key enzymes linked to type-2 diabetes and hypertension by Azadirachta indica-yogurt","volume":"17","author":"Shori","year":"2013","journal-title":"J. Saudi Chem. Soc."},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1111\/jfq.12181","article-title":"Yogurt enrichment with grape pomace: Effect of grape cultivar on physicochemical, microbiological and sensory properties","volume":"39","author":"Marchiani","year":"2016","journal-title":"J. Food Qual."},{"key":"ref_107","doi-asserted-by":"crossref","unstructured":"Jovanovi\u0107, M., Petrovi\u0107, M., Mio\u010dinovi\u0107, J., Zlatanovi\u0107, S., Lali\u010di\u0107Petronijevi\u0107, J., Miti\u0107-\u0106ulafi\u0107, D., and Gorjanovi\u0107, S. (2020). Bioactivity and sensory properties of probiotic yogurt fortified with apple pomace flour. Foods, 9.","DOI":"10.3390\/foods9060763"},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"1045","DOI":"10.1002\/fsn3.645","article-title":"Phytochemicals and syneresis of osmo-dried mulberry incorporated yoghurt","volume":"6","author":"Sigdel","year":"2018","journal-title":"Food Sci. Nutr."},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1016\/j.ejbt.2022.03.003","article-title":"Storage quality and antioxidant properties of yogurt fortified with polyphenol extract from nutmeg, black pepper, and white pepper","volume":"57","author":"Shori","year":"2022","journal-title":"Electron. J. Biotechnol."},{"key":"ref_110","doi-asserted-by":"crossref","unstructured":"Shahein, M.R., Atwaa, E.S.H., El-Zahar, K.M., Elmaadawy, A.A., Hijazy, H.H.A., Sitohy, M.Z., Albrakati, A., and Elmahallawy, E.K. (2022). Remedial action of yoghurt enriched withwatermelon seed milk on renal injured hyperuricemic rats. Fermentation, 8.","DOI":"10.3390\/fermentation8020041"},{"key":"ref_111","doi-asserted-by":"crossref","unstructured":"Atwaa, E.S.H., Shahein, M.R., El-Sattar, E.S.A., Hijazy, H.H.A., Albrakati, A., and Elmahallawy, E.K. (2022). Bioactivity, physciochemcial and sensory properties of probitoic yoghurt made from whole milk powder reconstituted in aqueous fennel extract. Fermentation, 8.","DOI":"10.3390\/fermentation8020052"},{"key":"ref_112","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/1476-511X-12-91","article-title":"The cholesterol lowering efficacy of plant stanol ester yoghurt in a Turkish population: A double-blind, placebo-controlled trial","volume":"12","author":"Buyuktuncer","year":"2013","journal-title":"Lipids Health Dis."},{"key":"ref_113","first-page":"665","article-title":"Long-term effects of plant stanols on the lipid profile of patients with hypercholesterolemia. A randomized clinical trial","volume":"68","year":"2015","journal-title":"Rev. Esp. Cardiol."},{"key":"ref_114","first-page":"1","article-title":"Efficacy of yogurt drink with added plant stanol esters (Benecol\u00ae, Colanta) in reducing total and LDL cholesterol in subjects with moderate hypercholesterolemia: A randomized placebo-controlled crossover trial NCT01461798","volume":"13","year":"2014","journal-title":"Lipids Health Dis."},{"key":"ref_115","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1038\/sj.ejcn.1602318","article-title":"Intake occasion affects the serum cholesterol lowering of a plant sterol-enriched single-dose yoghurt drink in mildly hypercholesterolaemic subjects","volume":"60","author":"Doornbos","year":"2006","journal-title":"Eur. J. Clin. Nutr."},{"key":"ref_116","doi-asserted-by":"crossref","first-page":"298","DOI":"10.3803\/EnM.2020.35.2.298","article-title":"Effects of a Portfolio-Mediterranean Diet and a Mediterranean Diet with or without a Sterol-Enriched Yogurt in Individuals with Hypercholesterolemia","volume":"35","author":"Ferro","year":"2020","journal-title":"Endocrino. Metabol."},{"key":"ref_117","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1079\/BJN2001395","article-title":"Effects of yoghurt enriched with plant sterols on serum lipids in patients with moderate hypercholesterolaemia","volume":"86","author":"Volpe","year":"2001","journal-title":"Br. J. Nutr."},{"key":"ref_118","first-page":"1","article-title":"Cholesterol-lowering efficacy of plant sterol-enriched flavored milk, yogurt, fruit bar, and soya milk in mild hypercholesterolemic Indian subjects","volume":"1","author":"Penchalaraju","year":"2018","journal-title":"Clin. J. Nutr. Diet"},{"key":"ref_119","doi-asserted-by":"crossref","first-page":"743","DOI":"10.1016\/j.nutres.2005.08.004","article-title":"Plant stanol esters in low-fat yogurt reduces total and low-density lipoprotein cholesterol and low-density lipoprotein oxidation in normocholesterolemic and mildly hypercholesterolemic subjects","volume":"25","author":"Hyun","year":"2005","journal-title":"Nutr. Res."},{"key":"ref_120","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1007\/s00394-004-0513-z","article-title":"Plant sterol ester\u2013enriched milk and yoghurt effectively reduce serum cholesterol in modestly hypercholesterolemic subjects","volume":"44","author":"Noakes","year":"2005","journal-title":"Eur. J. Nutr."},{"key":"ref_121","doi-asserted-by":"crossref","first-page":"588","DOI":"10.1080\/07315724.2008.10719742","article-title":"Cholesterol-lowering efficacy of plant sterols in low-fat yogurt consumed as a snack or with a meal","volume":"27","author":"Rudkowska","year":"2008","journal-title":"J. Am. Coll. 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