{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,2]],"date-time":"2026-11-02T12:10:58Z","timestamp":1793621458008,"version":"4.5.0"},"reference-count":81,"publisher":"MDPI AG","issue":"11","license":[{"start":{"date-parts":[[2022,5,30]],"date-time":"2022-05-30T00:00:00Z","timestamp":1653868800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"UNAM-PAPIIT","award":["IN230020"],"award-info":[{"award-number":["IN230020"]}]},{"name":"UNAM-PAPIIT","award":["5000-9047"],"award-info":[{"award-number":["5000-9047"]}]},{"name":"UNAM-PAPIIT","award":["Scholarships 589195"],"award-info":[{"award-number":["Scholarships 589195"]}]},{"name":"Project Grant UNAM-PAIP","award":["IN230020"],"award-info":[{"award-number":["IN230020"]}]},{"name":"Project Grant UNAM-PAIP","award":["5000-9047"],"award-info":[{"award-number":["5000-9047"]}]},{"name":"Project Grant UNAM-PAIP","award":["Scholarships 589195"],"award-info":[{"award-number":["Scholarships 589195"]}]},{"name":"Scholarships from CONACYT awarded to YFP","award":["IN230020"],"award-info":[{"award-number":["IN230020"]}]},{"name":"Scholarships from CONACYT awarded to YFP","award":["5000-9047"],"award-info":[{"award-number":["5000-9047"]}]},{"name":"Scholarships from CONACYT awarded to YFP","award":["Scholarships 589195"],"award-info":[{"award-number":["Scholarships 589195"]}]},{"name":"LANCAD-UNAM-DGTIC-358","award":["IN230020"],"award-info":[{"award-number":["IN230020"]}]},{"name":"LANCAD-UNAM-DGTIC-358","award":["5000-9047"],"award-info":[{"award-number":["5000-9047"]}]},{"name":"LANCAD-UNAM-DGTIC-358","award":["Scholarships 589195"],"award-info":[{"award-number":["Scholarships 589195"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>Casiopeinas are a family of copper(II) coordination compounds that have shown an important antineoplastic effect and low toxicity in normal cells. These compounds induce death cells by apoptosis through a catalytic redox process with endogenous reducing agents. Further studies included a structural variation, improving the activity and selectivity in cancer cells or other targets. In the present work we report the third generation, which contains a bioactive monocharged secondary ligand, as well as the design, synthesis, characterization and antiproliferative activity, of sixteen new copper(II) coordination compounds with curcumin or dimethoxycurcumin as secondary ligands. All compounds were characterized by elemental analysis, FTIR, UV-Vis, magnetic susceptibility, mass spectra with MALDI-flight time, cyclic voltammetry, electron paramagnetic resonance (EPR) spectroscopy and X-ray diffraction. Crystallization of two complexes was achieved in dimethylsulfoxide (DMSO) with polar solvent, and crystal data demonstrated that a square-based or square-base pyramid geometry are possible. A 1:1:1 stoichiometry (diimine: copper: curcuminoid) ratio and the possibility of a nitrate ion as a counterion were supported. 1H, 13C NMR spectra were used for the ligands. A sulforhodamine B assay was used to evaluate the cytotoxicity effect against two human cancer cell lines, SKLU-1 and HeLa. Electronic descriptors and redox potential were obtained by DFT calculations. Structure\u2013activity relationships are strongly determined by the redox potential (E1\/2) of copper(II) and molar volume (V) of the complexes. These compounds can be used as a template to open a wide field of research both experimentally and theoretically.<\/jats:p>","DOI":"10.3390\/molecules27113504","type":"journal-article","created":{"date-parts":[[2022,5,31]],"date-time":"2022-05-31T00:25:12Z","timestamp":1653956712000},"page":"3504","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":34,"title":["Casiopeinas of Third Generations: Synthesis, Characterization, Cytotoxic Activity and Structure\u2013Activity Relationships of Mixed Chelate Compounds with Bioactive Secondary Ligands"],"prefix":"10.3390","volume":"27","author":[{"given":"Yeshenia","family":"Figueroa-DePaz","sequence":"first","affiliation":[{"name":"Departamento de Qu\u00edmica Inorg\u00e1nica y Nuclear, Facultad de Qu\u00edmica, Universidad Nacional Aut\u00f3noma de M\u00e9xico, Avenida Universidad 3000, Mexico City 04510, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5777-2536","authenticated-orcid":false,"given":"Jaime","family":"P\u00e9rez-Villanueva","sequence":"additional","affiliation":[{"name":"Departamento de Sistemas Biol\u00f3gicos, Divisi\u00f3n de Ciencias Biol\u00f3gicas y de la Salud, Universidad Aut\u00f3noma Metropollitana-Xochimilco (UAM-X), Mexico City 04960, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olivia","family":"Soria-Arteche","sequence":"additional","affiliation":[{"name":"Departamento de Sistemas Biol\u00f3gicos, Divisi\u00f3n de Ciencias Biol\u00f3gicas y de la Salud, Universidad Aut\u00f3noma Metropollitana-Xochimilco (UAM-X), Mexico City 04960, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diego","family":"Mart\u00ednez-Otero","sequence":"additional","affiliation":[{"name":"Centro Conjunto de Investigaci\u00f3n en Qu\u00edmica Sustentable UAEM-UNAM, Carretera Toluca-Atlacomulco, Km.14.5, Toluca 50200, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Virginia","family":"G\u00f3mez-Vidales","sequence":"additional","affiliation":[{"name":"Instituto de Qu\u00edmica, Universidad Nacional Aut\u00f3noma de M\u00e9xico, Av. Universidad 3000, C.U., Mexico City 04510, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6523-8018","authenticated-orcid":false,"given":"Luis","family":"Ortiz-Frade","sequence":"additional","affiliation":[{"name":"Centro de Investigaci\u00f3n y Desarrollo Tecnol\u00f3gico en Electroqu\u00edmica S.C. Parque Tecnol\u00f3gico Quer\u00e9taro, Sanfandila, Pedro de Escobedo, Quer\u00e9taro 76703, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3035-4507","authenticated-orcid":false,"given":"Lena","family":"Ruiz-Azuara","sequence":"additional","affiliation":[{"name":"Departamento de Qu\u00edmica Inorg\u00e1nica y Nuclear, Facultad de Qu\u00edmica, Universidad Nacional Aut\u00f3noma de M\u00e9xico, Avenida Universidad 3000, Mexico City 04510, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,5,30]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"908","DOI":"10.1021\/acs.inorgchem.7b02861","article-title":"Coumarin Derivative Directly Coordinated to Lanthanides Acts as an Excellent Antenna for UV\u2013Vis and Near-IR Emission","volume":"57","author":"Guerrero","year":"2018","journal-title":"Inorg. 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