{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T23:55:12Z","timestamp":1787702112862,"version":"build-2784847793"},"reference-count":98,"publisher":"MDPI AG","issue":"11","license":[{"start":{"date-parts":[[2022,5,31]],"date-time":"2022-05-31T00:00:00Z","timestamp":1653955200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"SIREI project","award":["DGI: 266502021159 to JFR-L"],"award-info":[{"award-number":["DGI: 266502021159 to JFR-L"]}]},{"name":"SIREI project","award":["Exp. 32753 (J.F.R-L.), 84949 (L.J.G.-P.), 153293 (A.P.-O.)"],"award-info":[{"award-number":["Exp. 32753 (J.F.R-L.), 84949 (L.J.G.-P.), 153293 (A.P.-O.)"]}]},{"name":"Sistema Nacional de Investigadores","award":["DGI: 266502021159 to JFR-L"],"award-info":[{"award-number":["DGI: 266502021159 to JFR-L"]}]},{"name":"Sistema Nacional de Investigadores","award":["Exp. 32753 (J.F.R-L.), 84949 (L.J.G.-P.), 153293 (A.P.-O.)"],"award-info":[{"award-number":["Exp. 32753 (J.F.R-L.), 84949 (L.J.G.-P.), 153293 (A.P.-O.)"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>Chrysin (5,7-dihydroxyflavone) is a flavonoid isolated from plants, such as Passiflora coerulea, Passiflora incarnata, and Matricaria chamomilla. This natural molecule exerts diverse pharmacological effects, which includes antioxidant, anti-inflammatory, anti-cancer, neuroprotective, and anti-apoptotic effects. Additionally, in brain structures, such as the hippocampus, prefrontal cortex, raphe nucleus, and striatum, involved in the physiopathology of anxiety and depression disorders, several neuropharmacological activities, including the activation of neurotransmitter systems (GABAergic, serotonergic, dopaminergic, and noradrenergic), neurotrophic factors, such as brain-derived neurotrophic factor and the nerve growth factor, and some signaling pathways are affected. The results showed that the anxiolytic and antidepressant-like effects of chrysin occurs through its interaction with specific neurotransmitter systems, principally the GABAergic and the serotonergic, and activation of other neurotrophic factors. However, it is not possible to discard the antioxidant and anti-inflammatory activities of chrysin while producing its anxiolytic- and antidepressant-like effects. Although these results have been obtained principally from pre-clinical research, they consistently demonstrate the potential therapeutic use of flavonoid chrysin as an anxiolytic and antidepressant agent. Therefore, this flavonoid could be considered as a promising novel therapy for anxiety and depression disorders.<\/jats:p>","DOI":"10.3390\/molecules27113551","type":"journal-article","created":{"date-parts":[[2022,6,1]],"date-time":"2022-06-01T03:33:18Z","timestamp":1654054398000},"page":"3551","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":62,"title":["Pharmacological, Neurochemical, and Behavioral Mechanisms Underlying the Anxiolytic- and Antidepressant-like Effects of Flavonoid Chrysin"],"prefix":"10.3390","volume":"27","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5837-103X","authenticated-orcid":false,"given":"Juan Francisco","family":"Rodr\u00edguez-Landa","sequence":"first","affiliation":[{"name":"Laboratorio de Neurofarmacolog\u00eda, Instituto de Neuroetolog\u00eda, Universidad Veracruzana, Xalapa 91190, Mexico"},{"name":"Facultad de Qu\u00edmica Farmac\u00e9utica Biol\u00f3gica, Universidad Veracruzana, Xalapa 91000, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Le\u00f3n Jes\u00fas","family":"German-Ponciano","sequence":"additional","affiliation":[{"name":"Laboratorio de Neurofarmacolog\u00eda, Instituto de Neuroetolog\u00eda, Universidad Veracruzana, Xalapa 91190, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5968-0210","authenticated-orcid":false,"given":"Abraham","family":"Puga-Olgu\u00edn","sequence":"additional","affiliation":[{"name":"Unidad de Salud Integrativa, Centro de EcoAlfabetizaci\u00f3n y Di\u00e1logo de Saberes, Universidad Veracruzana, Xalapa 91060, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0730-4907","authenticated-orcid":false,"given":"Oscar Jer\u00f3nimo","family":"Olmos-V\u00e1zquez","sequence":"additional","affiliation":[{"name":"Laboratorio de Neurofarmacolog\u00eda, Instituto de Neuroetolog\u00eda, Universidad Veracruzana, Xalapa 91190, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,5,31]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s11101-020-09736-y","article-title":"Natural products in drug discovery and human health","volume":"20","author":"Ferreira","year":"2021","journal-title":"Phytochem. 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