{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T07:25:39Z","timestamp":1792481139013,"version":"4.5.0"},"reference-count":34,"publisher":"MDPI AG","issue":"11","license":[{"start":{"date-parts":[[2022,6,5]],"date-time":"2022-06-05T00:00:00Z","timestamp":1654387200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>2,4-bis (3,5-dimethyl-1H-pyrazol-1-yl)-6-methoxy-1,3,5-triazine (BPMT) pincer ligand was used to synthesize the new [Zn(BPMT)(NCS)2] (1) and [Zn(BPMT)(Br)2] (2) complexes by a reaction with Zn(NO3)2\u00b76H2O in the presence of either KSCN or KBr, respectively. The structure of complex 1 has been exclusively confirmed using single crystal X-ray diffraction. In this neutral heteroleptic complex, the BPMT is a pincer chelate coordinating the Zn(II) ion via three interactions with the two pyrazole moieties and the s-triazine core. Hence, BPMT is a tridentate NNN-chelate. The coordination environment of Zn(II) is completed by two strong interactions with two terminal SCN\u2212 ions via the N-atom. Hence, the Zn(II) is penta-coordinated with a distorted square pyramidal coordination geometry. Hirshfeld analysis indicated the predominance of H\u2026H, H\u2026C and N\u2026H intermolecular interactions. Additionally, the S\u2026H, S\u2026C and S\u2026N contacts are the most significant. The free ligand has no or weak antimicrobial, antioxidant and anticancer activities while the studied Zn(II) complexes showed interesting biological activity. Complex 1 has excellent antibacterial activity against B. subtilis (2.4 \u03bcg\/mL) and P. vulgaris (4.8 \u03bcg\/mL) compared to Gentamycin (4.8 \u03bcg\/mL). Additionally, complex 1 (78.09 \u00b1 4.23 \u00b5g\/mL) has better antioxidant activity than 2 (365.60 \u00b1 20.89 \u00b5g\/mL). In addition, complex 1 (43.86 \u00b1 3.12 \u00b5g\/mL) and 2 (30.23 \u00b1 1.26 \u00b5g\/mL) have 8 and 12 times the anticancer activity of the free BPMT ligand (372.79 \u00b1 13.64 \u00b5g\/mL).<\/jats:p>","DOI":"10.3390\/molecules27113625","type":"journal-article","created":{"date-parts":[[2022,6,5]],"date-time":"2022-06-05T10:47:11Z","timestamp":1654426031000},"page":"3625","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Synthesis, Structure and Biological Evaluations of Zn(II) Pincer Complexes Based on S-Triazine Type Chelator"],"prefix":"10.3390","volume":"27","author":[{"given":"Heba M.","family":"Refaat","sequence":"first","affiliation":[{"name":"Department of Chemistry, Faculty of Science, Alexandria University, P.O. Box 426, Ibrahimia, Alexandria 21321, Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Atallh A. M.","family":"Alotaibi","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Faculty of Science, Alexandria University, P.O. Box 426, Ibrahimia, Alexandria 21321, Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0660-4721","authenticated-orcid":false,"given":"Necmi","family":"Dege","sequence":"additional","affiliation":[{"name":"Department of Physics, Faculty of Arts and Sciences, Ondokuz May\u0131s University, Samsun 55139, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3951-2754","authenticated-orcid":false,"given":"Ayman","family":"El-Faham","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Faculty of Science, Alexandria University, P.O. Box 426, Ibrahimia, Alexandria 21321, Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8405-8370","authenticated-orcid":false,"given":"Saied M.","family":"Soliman","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Faculty of Science, Alexandria University, P.O. Box 426, Ibrahimia, Alexandria 21321, Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,6,5]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"4054","DOI":"10.1021\/jm049892u","article-title":"Discovery of the pyrrolo[2,1-f][1,2,4] triazine nucleus as a new kinase inhibitor template","volume":"47","author":"Hunt","year":"2004","journal-title":"J. Med. 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