{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T20:39:10Z","timestamp":1790368750172,"version":"4.1.0"},"reference-count":50,"publisher":"MDPI AG","issue":"12","license":[{"start":{"date-parts":[[2022,6,11]],"date-time":"2022-06-11T00:00:00Z","timestamp":1654905600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"National Research Foundation of Ukraine","award":["2020.01\/0222"],"award-info":[{"award-number":["2020.01\/0222"]}]},{"name":"National Research Foundation of Ukraine","award":["22\/02-2022 (4)"],"award-info":[{"award-number":["22\/02-2022 (4)"]}]},{"name":"National Academy of Sciences of Ukraine","award":["2020.01\/0222"],"award-info":[{"award-number":["2020.01\/0222"]}]},{"name":"National Academy of Sciences of Ukraine","award":["22\/02-2022 (4)"],"award-info":[{"award-number":["22\/02-2022 (4)"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>Green synthesis of silver-containing nanocomposites based on polylactide (PLA) was carried out in two ways. With the use of green tea extract, Ag+ ions were reduced to silver nanoparticles with their subsequent introduction into the PLA (mechanical method) and Ag+ ions were reduced in the polymer matrix of PLA-AgPalmitate (PLA-AgPalm) (in situ method). Structure, morphology and thermophysical properties of nanocomposites PLA-Ag were studied by FTIR spectroscopy, wide-angle X-ray scattering (WAXS), transmission electron microscopy (TEM), thermogravimetric analysis (TGA), and differential scanning calorimetry (DSC) methods. The antimicrobial, antiviral, and cytotoxic properties were studied as well. It was found that the mechanical method provides the average size of silver nanoparticles in the PLA of about 16 nm, while in the formation of samples by the in situ method their average size was 3.7 nm. The strong influence of smaller silver nanoparticles (3.7 nm) on the properties of nanocomposites was revealed, as with increasing nanosilver concentration the heat resistance and glass transition temperature of the samples decreases, while the influence of larger particles (16 nm) on these parameters was not detected. It was shown that silver-containing nanocomposites formed in situ demonstrate antimicrobial activity against gram-positive bacterium S. aureus, gram-negative bacteria E. coli, P. aeruginosa, and the fungal pathogen of C. albicans, and the activity of the samples increases with increasing nanoparticle concentration. Silver-containing nanocomposites formed by the mechanical method have not shown antimicrobial activity. The relative antiviral activity of nanocomposites obtained by two methods against influenza A virus, and adenovirus serotype 2 was also revealed. The obtained nanocomposites were not-cytotoxic, and they did not inhibit the viability of MDCK or Hep-2 cell cultures.<\/jats:p>","DOI":"10.3390\/molecules27123769","type":"journal-article","created":{"date-parts":[[2022,6,12]],"date-time":"2022-06-12T22:37:20Z","timestamp":1655073440000},"page":"3769","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Structure-Morphology-Antimicrobial and Antiviral Activity Relationship in Silver-Containing Nanocomposites Based on Polylactide"],"prefix":"10.3390","volume":"27","author":[{"given":"Valeriy","family":"Demchenko","sequence":"first","affiliation":[{"name":"Department of Polymer Modification, Institute of Macromolecular Chemistry of the National Academy of Sciences of Ukraine, 48. Kharkivske Shose, 02160 Kyiv, Ukraine"},{"name":"Department of Plastics Welding, Evgeny Oskarovich Paton Electric Welding Institute of the National Academy of Sciences of Ukraine, 11. Kazymyr Malevych Str., 03680 Kyiv, Ukraine"},{"name":"International Polish-Ukrainian Research Laboratory Formation and Characterization of Advanced Polymers and Polymer Composites (ADPOLCOM), Department of Plastics Welding, Evgeny Oskarovich Paton Electric Welding Institute of the National Academy of Sciences of Ukraine, 11. Kazymyr Malevych Str., 03680 Kyiv, Ukraine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yevgen","family":"Mamunya","sequence":"additional","affiliation":[{"name":"Department of Polymer Modification, Institute of Macromolecular Chemistry of the National Academy of Sciences of Ukraine, 48. Kharkivske Shose, 02160 Kyiv, Ukraine"},{"name":"Department of Plastics Welding, Evgeny Oskarovich Paton Electric Welding Institute of the National Academy of Sciences of Ukraine, 11. Kazymyr Malevych Str., 03680 Kyiv, Ukraine"},{"name":"International Polish-Ukrainian Research Laboratory Formation and Characterization of Advanced Polymers and Polymer Composites (ADPOLCOM), Department of Plastics Welding, Evgeny Oskarovich Paton Electric Welding Institute of the National Academy of Sciences of Ukraine, 11. Kazymyr Malevych Str., 03680 Kyiv, Ukraine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4915-2502","authenticated-orcid":false,"given":"Serhii","family":"Kobylinskyi","sequence":"additional","affiliation":[{"name":"Department of Polymer Modification, Institute of Macromolecular Chemistry of the National Academy of Sciences of Ukraine, 48. Kharkivske Shose, 02160 Kyiv, Ukraine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sergii","family":"Riabov","sequence":"additional","affiliation":[{"name":"Department of Polymer Modification, Institute of Macromolecular Chemistry of the National Academy of Sciences of Ukraine, 48. Kharkivske Shose, 02160 Kyiv, Ukraine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Krystyna","family":"Naumenko","sequence":"additional","affiliation":[{"name":"Danylo Kyrylovych Zabolotny Institute of Microbiology and Virology of the National Academy of Sciences of Ukraine, 154. Academic Zabolotny Str., 03680 Kyiv, Ukraine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0892-772X","authenticated-orcid":false,"given":"Svitlana","family":"Zahorodnia","sequence":"additional","affiliation":[{"name":"Danylo Kyrylovych Zabolotny Institute of Microbiology and Virology of the National Academy of Sciences of Ukraine, 154. Academic Zabolotny Str., 03680 Kyiv, Ukraine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olga","family":"Povnitsa","sequence":"additional","affiliation":[{"name":"Danylo Kyrylovych Zabolotny Institute of Microbiology and Virology of the National Academy of Sciences of Ukraine, 154. Academic Zabolotny Str., 03680 Kyiv, Ukraine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nataliya","family":"Rybalchenko","sequence":"additional","affiliation":[{"name":"Danylo Kyrylovych Zabolotny Institute of Microbiology and Virology of the National Academy of Sciences of Ukraine, 154. Academic Zabolotny Str., 03680 Kyiv, Ukraine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maksym","family":"Iurzhenko","sequence":"additional","affiliation":[{"name":"Department of Polymer Modification, Institute of Macromolecular Chemistry of the National Academy of Sciences of Ukraine, 48. Kharkivske Shose, 02160 Kyiv, Ukraine"},{"name":"Department of Plastics Welding, Evgeny Oskarovich Paton Electric Welding Institute of the National Academy of Sciences of Ukraine, 11. Kazymyr Malevych Str., 03680 Kyiv, Ukraine"},{"name":"International Polish-Ukrainian Research Laboratory Formation and Characterization of Advanced Polymers and Polymer Composites (ADPOLCOM), Department of Plastics Welding, Evgeny Oskarovich Paton Electric Welding Institute of the National Academy of Sciences of Ukraine, 11. Kazymyr Malevych Str., 03680 Kyiv, Ukraine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5439-7400","authenticated-orcid":false,"given":"Grazyna","family":"Adamus","sequence":"additional","affiliation":[{"name":"International Polish-Ukrainian Research Laboratory Formation and Characterization of Advanced Polymers and Polymer Composites (ADPOLCOM), Department of Plastics Welding, Evgeny Oskarovich Paton Electric Welding Institute of the National Academy of Sciences of Ukraine, 11. Kazymyr Malevych Str., 03680 Kyiv, Ukraine"},{"name":"Laboratory of Biodegradable Materials, Centre of Polymer and Carbon Materials, Polish Academy of Sciences, 34. M. C. 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