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201904047"]}]},{"name":"Construction of High-level Teachers in Beijing Municipal Colleges and Universities (2019)-Youth Talent-Chen Liang","award":["21878014"],"award-info":[{"award-number":["21878014"]}]},{"name":"Construction of High-level Teachers in Beijing Municipal Colleges and Universities (2019)-Youth Talent-Chen Liang","award":["22078014"],"award-info":[{"award-number":["22078014"]}]},{"name":"Construction of High-level Teachers in Beijing Municipal Colleges and Universities (2019)-Youth Talent-Chen Liang","award":["20372508D"],"award-info":[{"award-number":["20372508D"]}]},{"name":"National Natural Science Foundation of China","award":["2021Z009-KXZ"],"award-info":[{"award-number":["2021Z009-KXZ"]}]},{"name":"National Natural Science Foundation of China","award":["SG030801"],"award-info":[{"award-number":["SG030801"]}]},{"name":"National Natural Science Foundation of China","award":["CIT&TCD 201904047"],"award-info":[{"award-number":["CIT&TCD 201904047"]}]},{"name":"National Natural Science Foundation of China","award":["21878014"],"award-info":[{"award-number":["21878014"]}]},{"name":"National Natural Science Foundation of China","award":["22078014"],"award-info":[{"award-number":["22078014"]}]},{"name":"National Natural Science Foundation of China","award":["20372508D"],"award-info":[{"award-number":["20372508D"]}]},{"name":"Hebei Key Research and Development Project","award":["2021Z009-KXZ"],"award-info":[{"award-number":["2021Z009-KXZ"]}]},{"name":"Hebei Key Research and Development Project","award":["SG030801"],"award-info":[{"award-number":["SG030801"]}]},{"name":"Hebei Key Research and Development Project","award":["CIT&TCD 201904047"],"award-info":[{"award-number":["CIT&TCD 201904047"]}]},{"name":"Hebei Key Research and Development Project","award":["21878014"],"award-info":[{"award-number":["21878014"]}]},{"name":"Hebei Key Research and Development Project","award":["22078014"],"award-info":[{"award-number":["22078014"]}]},{"name":"Hebei Key Research and Development Project","award":["20372508D"],"award-info":[{"award-number":["20372508D"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>Metal organic frameworks (MOFs) are formed by self-assembly of metal ions and organic ligands. A special type of MOF called ZIF-8, which is formed by self-assembly of zinc ions and 2-methylimidazole, shows excellent stability in aqueous solutions and disintegrates under acidic conditions. These properties make ZIF-8 a suitable carrier material for pH-stimulated drug delivery systems. Glabridin is an isoflavane compound that is widely present in the roots of licorice. Because of its outstanding skin whitening properties, glabridin is widely used as a whitener in the cosmetics industry. In this study, ZIF-8 was employed to encapsulate glabridin. Glabridin-loaded ZIF-8 was successfully prepared with a drug encapsulation efficiency of 98.67%. The prepared sample showed a fusiform or cruciate flower-like structure, and its size was about 3 \u03bcm. ZIF-8 enabled pH-controlled release of glabridin. Moreover, ZIF-8 encapsulation significantly enhanced the intracellular anti-oxidant activity and melanogenesis inhibitory activity of glabridin. This study provides a new approach that shows great potential to improve the biological application of glabridin.<\/jats:p>","DOI":"10.3390\/molecules27123908","type":"journal-article","created":{"date-parts":[[2022,6,19]],"date-time":"2022-06-19T10:14:52Z","timestamp":1655633692000},"page":"3908","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Self-Assembled pH-Responsive Metal-Organic Frameworks for Enhancing the Encapsulation and Anti-Oxidation and Melanogenesis Inhibition Activities of Glabridin"],"prefix":"10.3390","volume":"27","author":[{"given":"Liang","family":"Chen","sequence":"first","affiliation":[{"name":"College of Bioengineering, Beijing Polytechnic, Beijing 100176, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zexun","family":"Liu","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Chemical Resource Engineering, Beijing University of Chemical Technology, Beijing 100029, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xinying","family":"Zhao","sequence":"additional","affiliation":[{"name":"College of Bioengineering, Beijing Polytechnic, Beijing 100176, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Linying","family":"Liu","sequence":"additional","affiliation":[{"name":"College of Bioengineering, Beijing Polytechnic, Beijing 100176, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiulan","family":"Xin","sequence":"additional","affiliation":[{"name":"College of Bioengineering, Beijing Polytechnic, Beijing 100176, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4799-882X","authenticated-orcid":false,"given":"Hao","family":"Liang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Chemical Resource Engineering, Beijing University of Chemical Technology, Beijing 100029, China"},{"name":"Qinhuangdao Bohai Biological Research Institute, Beijing University of Chemical Technology, Qinhuangdao 066000, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2022,6,18]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1016\/j.fitote.2013.07.003","article-title":"Phytochemistry and biological properties of glabridin","volume":"90","author":"Simmler","year":"2013","journal-title":"Fitoterapia"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1002\/ptr.2362","article-title":"Review of pharmacological effects of Glycyrrhiza sp. 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