{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T17:37:16Z","timestamp":1787506636677,"version":"build-2736575974"},"reference-count":33,"publisher":"MDPI AG","issue":"12","license":[{"start":{"date-parts":[[2022,6,18]],"date-time":"2022-06-18T00:00:00Z","timestamp":1655510400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"the Government of Russian Federation","award":["# 075-15-2021-637"],"award-info":[{"award-number":["# 075-15-2021-637"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>Screening of a library of novel N-hydroxylactams amenable by the Castagnoli-Cushman reaction identified four lead compounds that facilitated 55Fe transport into P. aeruginosa cells (one of these synthetic siderophores was found to be as efficient at promoting iron uptake as the natural siderophores pyoverdine, pyochelin or enterobactin). Conjugates of the four lead siderophores with ciprofloxacin were tested for antibacterial activity against P. aeruginosa POA1 (wild type) and the \u2206pvdF\u2206pchA mutant strain. The antibacterial activity was found to be pronounced against the \u2206pvdF\u2206pchA mutant strain grown in CAA medium but not for the POA1 strain. This may be indicative of these compounds being \u2018Trojan horse\u2019 antibiotics. Further scrutiny of the mechanism of the antibacterial action of the newly developed conjugates is warranted.<\/jats:p>","DOI":"10.3390\/molecules27123910","type":"journal-article","created":{"date-parts":[[2022,6,19]],"date-time":"2022-06-19T10:14:52Z","timestamp":1655633692000},"page":"3910","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Conjugates of Iron-Transporting N-Hydroxylactams with Ciprofloxacin"],"prefix":"10.3390","volume":"27","author":[{"given":"Olga","family":"Bakulina","sequence":"first","affiliation":[{"name":"Saint Petersburg State University, 26 Universitetskii Prospect, 198504 Peterhof, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1145-0114","authenticated-orcid":false,"given":"Anton","family":"Bannykh","sequence":"additional","affiliation":[{"name":"Saint Petersburg State University, 26 Universitetskii Prospect, 198504 Peterhof, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ekaterina","family":"Levashova","sequence":"additional","affiliation":[{"name":"Saint Petersburg State University, 26 Universitetskii Prospect, 198504 Peterhof, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0200-4772","authenticated-orcid":false,"given":"Mikhail","family":"Krasavin","sequence":"additional","affiliation":[{"name":"Saint Petersburg State University, 26 Universitetskii Prospect, 198504 Peterhof, Russia"},{"name":"Immanuel Kant Baltic Federal University, 236041 Kaliningrad, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,6,18]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"2844","DOI":"10.1111\/j.1462-2920.2011.02556.x","article-title":"New roles for bacterial siderophores in metal transport and tolerance","volume":"13","author":"Schalk","year":"2011","journal-title":"Environ. 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