{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,9]],"date-time":"2026-06-09T07:13:44Z","timestamp":1780989224124,"version":"3.54.1"},"reference-count":73,"publisher":"MDPI AG","issue":"13","license":[{"start":{"date-parts":[[2022,6,21]],"date-time":"2022-06-21T00:00:00Z","timestamp":1655769600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100014410","name":"Pedagogical University of Krakow, Poland","doi-asserted-by":"publisher","award":["BN.610-147\/PBU\/2020"],"award-info":[{"award-number":["BN.610-147\/PBU\/2020"]}],"id":[{"id":"10.13039\/501100014410","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100014410","name":"Pedagogical University of Krakow, Poland","doi-asserted-by":"publisher","award":["16.16.160.557"],"award-info":[{"award-number":["16.16.160.557"]}],"id":[{"id":"10.13039\/501100014410","id-type":"DOI","asserted-by":"publisher"}]},{"name":"the subsidy of Polish Ministry of Science and Education to Piotr Suder","award":["BN.610-147\/PBU\/2020"],"award-info":[{"award-number":["BN.610-147\/PBU\/2020"]}]},{"name":"the subsidy of Polish Ministry of Science and Education to Piotr Suder","award":["16.16.160.557"],"award-info":[{"award-number":["16.16.160.557"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>The constant increase in the resistance of pathogenic bacteria to the commonly used drugs so far makes it necessary to search for new substances with antibacterial activity. Taking up this challenge, we obtained a series of rhodanine-3-carboxyalkyl acid derivatives containing 2- or 3- or 4-pyridinyl moiety at the C-5 position. These compounds were tested for their antibacterial and antifungal activities. They showed activity against Gram-positive bacteria while they were inactive against Gram-negative bacteria and yeast. In order to explain the relationship between the activity of the compounds and their structure, for selected derivatives crystal structures were determined using the X-ray diffraction method. Modeling of the isosurface of electron density was also performed. For all tested compounds their lipophilicity was determined by the RP-TLC method and by calculation methods. On the basis of the carried-out research, it was found that the derivatives with 1.5 N\u00b7\u00b7\u00b7S electrostatics interactions between the nitrogen atom in the pyridine moiety and the sulfur atom in the rhodanine system showed the highest biological activity.<\/jats:p>","DOI":"10.3390\/molecules27133975","type":"journal-article","created":{"date-parts":[[2022,6,22]],"date-time":"2022-06-22T04:12:01Z","timestamp":1655871121000},"page":"3975","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Synthesis, Crystal Structures, Lipophilic Properties and Antimicrobial Activity of 5-Pyridylmethylidene-3-rhodanine-carboxyalkyl Acids Derivatives"],"prefix":"10.3390","volume":"27","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1946-9370","authenticated-orcid":false,"given":"Ewa","family":"\u017bes\u0142awska","sequence":"first","affiliation":[{"name":"Institute of Biology, Pedagogical University of Krakow, Podchor\u0105\u017cych 2, 30-084 Krak\u00f3w, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert","family":"Zakrzewski","sequence":"additional","affiliation":[{"name":"Faculty of Chemistry, University of Lodz, Tamka 12, 91-403 \u0141\u00f3d\u017a, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arkadiusz","family":"Nowicki","sequence":"additional","affiliation":[{"name":"Faculty of Chemistry, University of Lodz, Tamka 12, 91-403 \u0141\u00f3d\u017a, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1634-0387","authenticated-orcid":false,"given":"Izabela","family":"Korona-G\u0142owniak","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Microbiology, Medical University of Lublin, Chod\u017aki 1, 20-093 Lublin, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anton\u00edn","family":"Ly\u010dka","sequence":"additional","affiliation":[{"name":"Department of Chemistry, University of Hradec Kr\u00e1lov\u00e9, Rokitansk\u00e9ho 62, 500 03 Hradec Kr\u00e1lov\u00e9 III, Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2986-0592","authenticated-orcid":false,"given":"Agnieszka","family":"Kania","sequence":"additional","affiliation":[{"name":"Institute of Biology, Pedagogical University of Krakow, Podchor\u0105\u017cych 2, 30-084 Krak\u00f3w, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6042-2510","authenticated-orcid":false,"given":"Krzysztof Kazimierz","family":"Zborowski","sequence":"additional","affiliation":[{"name":"Faculty of Chemistry, Jagiellonian University in Krak\u00f3w, Gronostajowa 2, 30-387 Krak\u00f3w, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4511-1241","authenticated-orcid":false,"given":"Piotr","family":"Suder","sequence":"additional","affiliation":[{"name":"Department of Analytical Chemistry and Biochemistry, Faculty of Materials Science and Ceramics, AGH University of Science and Technology, Mickiewicza 30, 30-059 Krak\u00f3w, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0911-5344","authenticated-orcid":false,"given":"Agnieszka","family":"Sk\u00f3rska-Stania","sequence":"additional","affiliation":[{"name":"Faculty of Chemistry, Jagiellonian University in Krak\u00f3w, Gronostajowa 2, 30-387 Krak\u00f3w, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8336-4288","authenticated-orcid":false,"given":"Waldemar","family":"Tejchman","sequence":"additional","affiliation":[{"name":"Institute of Biology, Pedagogical University of Krakow, Podchor\u0105\u017cych 2, 30-084 Krak\u00f3w, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,6,21]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1002\/prac.18770160101","article-title":"Ueber die Einwirkung der Monochloressigs\u00e4ure auf Sulfocyans\u00e4ure und ihre Salze","volume":"16","author":"Nencki","year":"1877","journal-title":"J. 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