{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T19:47:59Z","timestamp":1789242479977,"version":"build-2803163510"},"reference-count":49,"publisher":"MDPI AG","issue":"13","license":[{"start":{"date-parts":[[2022,6,21]],"date-time":"2022-06-21T00:00:00Z","timestamp":1655769600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"National Natural Science Foundation of China","award":["81973458"],"award-info":[{"award-number":["81973458"]}]},{"name":"National Natural Science Foundation of China","award":["81903889"],"award-info":[{"award-number":["81903889"]}]},{"name":"National Natural Science Foundation of China","award":["19YF1449100"],"award-info":[{"award-number":["19YF1449100"]}]},{"name":"National Natural Science Foundation of China","award":["E14017"],"award-info":[{"award-number":["E14017"]}]},{"name":"Shanghai Sailing Program","award":["81973458"],"award-info":[{"award-number":["81973458"]}]},{"name":"Shanghai Sailing Program","award":["81903889"],"award-info":[{"award-number":["81903889"]}]},{"name":"Shanghai Sailing Program","award":["19YF1449100"],"award-info":[{"award-number":["19YF1449100"]}]},{"name":"Shanghai Sailing Program","award":["E14017"],"award-info":[{"award-number":["E14017"]}]},{"name":"Shanghai Science and Shanghai E-Research Institute of Bioactive Constituents in Traditional Chinese Medicine","award":["81973458"],"award-info":[{"award-number":["81973458"]}]},{"name":"Shanghai Science and Shanghai E-Research Institute of Bioactive Constituents in Traditional Chinese Medicine","award":["81903889"],"award-info":[{"award-number":["81903889"]}]},{"name":"Shanghai Science and Shanghai E-Research Institute of Bioactive Constituents in Traditional Chinese Medicine","award":["19YF1449100"],"award-info":[{"award-number":["19YF1449100"]}]},{"name":"Shanghai Science and Shanghai E-Research Institute of Bioactive Constituents in Traditional Chinese Medicine","award":["E14017"],"award-info":[{"award-number":["E14017"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>(-)-\u03b1-Bisabolol (BIS) is a sesquiterpene alcohol derived mostly from Matricaria recutita L., which is a traditional herb and exhibits multiple biologic activities. BIS has been reported for treatment of skin disorders, but the effect of BIS on anti-atopic dermatitis (AD) remains unclear. Therefore, we investigated the effects of BIS on 2,4-dinitrochlorobenzene (DNCB)-induced AD in BALB\/c mice and the underlying mechanism in Bone Marrow-Derived Mast Cells (BMMCs). Topical BIS treatment reduced AD-like symptoms and the release of interleukin (IL)-4 without immunoglobulin (Ig)-E production in DNCB-induced BALB\/c mice. Histopathological examination revealed that BIS reduced epidermal thickness and inhibited mast cells in the AD-like lesions skin. Oral administration of BIS effectively and dose-dependently suppressed mast-cell-mediated passive cutaneous anaphylaxis. In IgE-mediated BMMCs, the levels of \u03b2-hexosaminidase (\u03b2-hex), histamine, and tumor necrosis factor (TNF)-\u03b1 were reduced by blocking the activation of nuclear factor-\u049bB (NF-\u049bB) and c-Jun N-terminal kinase (JNK) without P38 mitogen activated protein (P38) and extracellular regulated protein kinases (Erk1\/2). Taken together, our experimental results indicated BIS suppresses AD by inhibiting the activation of JNK and NF-\u03baB in mast cells. BIS may be a promising therapeutic agent for atopic dermatitis and other mast-cell-related diseases.<\/jats:p>","DOI":"10.3390\/molecules27133985","type":"journal-article","created":{"date-parts":[[2022,6,22]],"date-time":"2022-06-22T04:12:01Z","timestamp":1655871121000},"page":"3985","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["(-)-\u03b1-Bisabolol Alleviates Atopic Dermatitis by Inhibiting MAPK and NF-\u03baB Signaling in Mast Cell"],"prefix":"10.3390","volume":"27","author":[{"given":"Guangxia","family":"Li","sequence":"first","affiliation":[{"name":"School of Pharmacy, Shanghai University of Traditional Chinese Medicine, 1200 Cailun Road, Shanghai 201203, China"},{"name":"Institute of Interdisciplinary Integrative Medicine Research, Shanghai University of Traditional Chinese Medicine, 1200 Cailun Road, Shanghai 201203, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huayan","family":"Wu","sequence":"additional","affiliation":[{"name":"School of Pharmacy, Shanghai University of Traditional Chinese Medicine, 1200 Cailun Road, Shanghai 201203, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liqin","family":"Sun","sequence":"additional","affiliation":[{"name":"School of Pharmacy, Shanghai University of Traditional Chinese Medicine, 1200 Cailun Road, Shanghai 201203, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kang","family":"Cheng","sequence":"additional","affiliation":[{"name":"Shanghai Inoherb Cosmetics Co., Ltd., Shanghai 200080, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhi","family":"Lv","sequence":"additional","affiliation":[{"name":"Shanghai Inoherb Cosmetics Co., Ltd., Shanghai 200080, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kaixian","family":"Chen","sequence":"additional","affiliation":[{"name":"School of Pharmacy, Shanghai University of Traditional Chinese Medicine, 1200 Cailun Road, Shanghai 201203, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fei","family":"Qian","sequence":"additional","affiliation":[{"name":"Institute of Interdisciplinary Integrative Medicine Research, Shanghai University of Traditional Chinese Medicine, 1200 Cailun Road, Shanghai 201203, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3416-1331","authenticated-orcid":false,"given":"Yiming","family":"Li","sequence":"additional","affiliation":[{"name":"School of Pharmacy, Shanghai University of Traditional Chinese Medicine, 1200 Cailun Road, Shanghai 201203, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,6,21]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1159\/000479528","article-title":"Sea Buckthorn (Hippophae rhamnoides L.) 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