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The evolution of the disease can lead to infertility in addition to high treatment costs. Currently, available medications are only effective in treating endometriosis-related pain; however, it is not a targeted treatment. The objective of this work is to review the characteristics of the disease, the diagnostic means and treatments available, as well as to discuss new therapeutic options.<\/jats:p>","DOI":"10.3390\/molecules27134034","type":"journal-article","created":{"date-parts":[[2022,6,23]],"date-time":"2022-06-23T22:43:00Z","timestamp":1656024180000},"page":"4034","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":83,"title":["Endometriosis: A Disease with Few Direct Treatment Options"],"prefix":"10.3390","volume":"27","author":[{"given":"Patricia Ribeiro de Carvalho","family":"Fran\u00e7a","sequence":"first","affiliation":[{"name":"Laborat\u00f3rio de Farmacologia da Dor e da Inflama\u00e7\u00e3o, Instituto de Ci\u00eancias Biom\u00e9dicas, Universidade Federal do Rio de Janeiro, Rio de Janeiro 21941-902, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna Carolina Pereira","family":"Lontra","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio de Farmacologia da Dor e da Inflama\u00e7\u00e3o, Instituto de Ci\u00eancias Biom\u00e9dicas, Universidade Federal do Rio de Janeiro, Rio de Janeiro 21941-902, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6870-6745","authenticated-orcid":false,"given":"Patricia Dias","family":"Fernandes","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio de Farmacologia da Dor e da Inflama\u00e7\u00e3o, Instituto de Ci\u00eancias Biom\u00e9dicas, Universidade Federal do Rio de Janeiro, Rio de Janeiro 21941-902, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,6,23]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1615\/CritRevBiomedEng.2018027414","article-title":"Review of Endometriosis Diagnosis through Advances in Biomedical Engineering","volume":"46","author":"Shah","year":"2018","journal-title":"Crit. 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