{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,17]],"date-time":"2026-03-17T06:59:06Z","timestamp":1773730746599,"version":"3.50.1"},"reference-count":52,"publisher":"MDPI AG","issue":"13","license":[{"start":{"date-parts":[[2022,6,24]],"date-time":"2022-06-24T00:00:00Z","timestamp":1656028800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Funding of the Key Project at Central Government Level","award":["2060302"],"award-info":[{"award-number":["2060302"]}]},{"name":"Funding of the Key Project at Central Government Level","award":["ZR2019MH037"],"award-info":[{"award-number":["ZR2019MH037"]}]},{"name":"Funding of the Key Project at Central Government Level","award":["2019LJ003"],"award-info":[{"award-number":["2019LJ003"]}]},{"name":"The ability establishment of sustainable use for valuable Chinese medicine resources","award":["2060302"],"award-info":[{"award-number":["2060302"]}]},{"name":"The ability establishment of sustainable use for valuable Chinese medicine resources","award":["ZR2019MH037"],"award-info":[{"award-number":["ZR2019MH037"]}]},{"name":"The ability establishment of sustainable use for valuable Chinese medicine resources","award":["2019LJ003"],"award-info":[{"award-number":["2019LJ003"]}]},{"DOI":"10.13039\/501100007129","name":"Natural Science Foundation of Shandong Province","doi-asserted-by":"publisher","award":["2060302"],"award-info":[{"award-number":["2060302"]}],"id":[{"id":"10.13039\/501100007129","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007129","name":"Natural Science Foundation of Shandong Province","doi-asserted-by":"publisher","award":["ZR2019MH037"],"award-info":[{"award-number":["ZR2019MH037"]}],"id":[{"id":"10.13039\/501100007129","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007129","name":"Natural Science Foundation of Shandong Province","doi-asserted-by":"publisher","award":["2019LJ003"],"award-info":[{"award-number":["2019LJ003"]}],"id":[{"id":"10.13039\/501100007129","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Academic Promotion Programe of Shandong First Medical University","award":["2060302"],"award-info":[{"award-number":["2060302"]}]},{"name":"Academic Promotion Programe of Shandong First Medical University","award":["ZR2019MH037"],"award-info":[{"award-number":["ZR2019MH037"]}]},{"name":"Academic Promotion Programe of Shandong First Medical University","award":["2019LJ003"],"award-info":[{"award-number":["2019LJ003"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>Phytotherapy offers obvious advantages in the intervention of Coronary Artery Disease (CAD), but it is difficult to clarify the working mechanisms of the medicinal materials it uses. DGS is a natural vasoprotective combination that was screened out in our previous research, yet its potential components and mechanisms are unknown. Therefore, in this study, HPLC-MS and network pharmacology were employed to identify the active components and key signaling pathways of DGS. Transgenic zebrafish and HUVECs cell assays were used to evaluate the effectiveness of DGS. A total of 37 potentially active compounds were identified that interacted with 112 potential targets of CAD. Furthermore, PI3K-Akt, MAPK, relaxin, VEGF, and other signal pathways were determined to be the most promising DGS-mediated pathways. NO kit, ELISA, and Western blot results showed that DGS significantly promoted NO and VEGFA secretion via the upregulation of VEGFR2 expression and the phosphorylation of Akt, Erk1\/2, and eNOS to cause angiogenesis and vasodilation. The result of dynamics molecular docking indicated that Salvianolic acid C may be a key active component of DGS in the treatment of CAD. In conclusion, this study has shed light on the network molecular mechanism of DGS for the intervention of CAD using a network pharmacology-driven strategy for the first time to aid in the intervention of CAD.<\/jats:p>","DOI":"10.3390\/molecules27134075","type":"journal-article","created":{"date-parts":[[2022,6,26]],"date-time":"2022-06-26T21:01:41Z","timestamp":1656277301000},"page":"4075","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Investigation Driven by Network Pharmacology on Potential Components and Mechanism of DGS, a Natural Vasoprotective Combination, for the Phytotherapy of Coronary Artery Disease"],"prefix":"10.3390","volume":"27","author":[{"given":"You-Gang","family":"Zhang","sequence":"first","affiliation":[{"name":"School of Pharmacy and Pharmaceutical Science, Shandong First Medical University and Shandong Academy of Medical Sciences, Jinan 250000, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xia-Xia","family":"Liu","sequence":"additional","affiliation":[{"name":"School of Pharmacy and Pharmaceutical Science, Shandong First Medical University and Shandong Academy of Medical Sciences, Jinan 250000, China"},{"name":"School of Pharmaceutical Science, Shanxi Medical University, Taiyuan 030000, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2501-7434","authenticated-orcid":false,"given":"Jian-Cheng","family":"Zong","sequence":"additional","affiliation":[{"name":"Chenland Research Institute, Irvine, CA 92697, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yang-Teng-Jiao","family":"Zhang","sequence":"additional","affiliation":[{"name":"School of Pharmacy and Pharmaceutical Science, Shandong First Medical University and Shandong Academy of Medical Sciences, Jinan 250000, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rong","family":"Dong","sequence":"additional","affiliation":[{"name":"School of Pharmacy and Pharmaceutical Science, Shandong First Medical University and Shandong Academy of Medical Sciences, Jinan 250000, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Na","family":"Wang","sequence":"additional","affiliation":[{"name":"School of Pharmacy and Pharmaceutical Science, Shandong First Medical University and Shandong Academy of Medical Sciences, Jinan 250000, China"},{"name":"School of Pharmaceutical Science, Shanxi Medical University, Taiyuan 030000, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhi-Hui","family":"Ma","sequence":"additional","affiliation":[{"name":"School of Pharmacy and Pharmaceutical Science, Shandong First Medical University and Shandong Academy of Medical Sciences, Jinan 250000, China"},{"name":"School of Pharmacy, Shandong University of Traditional Chinese Medicine, Jinan 250000, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Li","family":"Li","sequence":"additional","affiliation":[{"name":"Chenland Research Institute, Irvine, CA 92697, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shang-Long","family":"Wang","sequence":"additional","affiliation":[{"name":"Chenland Research Institute, Irvine, CA 92697, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yan-Ling","family":"Mu","sequence":"additional","affiliation":[{"name":"School of Pharmacy and Pharmaceutical Science, Shandong First Medical University and Shandong Academy of Medical Sciences, Jinan 250000, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Song-Song","family":"Wang","sequence":"additional","affiliation":[{"name":"School of Pharmacy and Pharmaceutical Science, Shandong First Medical University and Shandong Academy of Medical Sciences, Jinan 250000, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2629-3900","authenticated-orcid":false,"given":"Zi-Min","family":"Liu","sequence":"additional","affiliation":[{"name":"Chenland Nutritionals Inc., Irvine, CA 92697, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Li-Wen","family":"Han","sequence":"additional","affiliation":[{"name":"School of Pharmacy and Pharmaceutical Science, Shandong First Medical University and Shandong Academy of Medical Sciences, Jinan 250000, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2022,6,24]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Juan-Salvadores, P., Jim\u00e9nez D\u00edaz, V.A., Iglesia Carre\u00f1o, C., Guiti\u00e1n Gonz\u00e1lez, A., Veiga, C., Mart\u00ednez Reglero, C., Baz Alonso, J.A., Caama\u00f1o Isorna, F., and I\u00f1iguez Romo, A. 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