{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T02:47:02Z","timestamp":1789008422469,"version":"build-2803163510"},"reference-count":41,"publisher":"MDPI AG","issue":"13","license":[{"start":{"date-parts":[[2022,6,29]],"date-time":"2022-06-29T00:00:00Z","timestamp":1656460800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82072297"],"award-info":[{"award-number":["82072297"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["2019-YY-065"],"award-info":[{"award-number":["2019-YY-065"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010014","name":"Six Talent Peaks Project in Jiangsu Province","doi-asserted-by":"publisher","award":["82072297"],"award-info":[{"award-number":["82072297"]}],"id":[{"id":"10.13039\/501100010014","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010014","name":"Six Talent Peaks Project in Jiangsu Province","doi-asserted-by":"publisher","award":["2019-YY-065"],"award-info":[{"award-number":["2019-YY-065"]}],"id":[{"id":"10.13039\/501100010014","id-type":"DOI","asserted-by":"publisher"}]},{"name":"high-level talent support project of Yangzhou University","award":["82072297"],"award-info":[{"award-number":["82072297"]}]},{"name":"high-level talent support project of Yangzhou University","award":["2019-YY-065"],"award-info":[{"award-number":["2019-YY-065"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>To verify the size and emergence time of new permeability pathways (NPPs) in malaria parasites, the permeability of the Plasmodium falciparum-infected erythrocytes was tested with different particle sizes of nanomaterials by flow cytometry assay. The results confirmed the permeability of the host cell membrane increases with parasite maturation for the stage-development evolution of NPPs, and especially found that a particle size of about 50 nm had higher efficiency. As a kind of the novel nanomaterials, nitrogen-doped carbon dots (NCDs) showed no toxicity, specificity binding ability to the malaria parasites, and could label live elder blood-stage P. falciparum through NPPs, indicating the potential application in cell imaging. NPPs and some nanomaterials such as NCDs deserve more attention and exploration for the elimination and prevention of malaria.<\/jats:p>","DOI":"10.3390\/molecules27134163","type":"journal-article","created":{"date-parts":[[2022,6,29]],"date-time":"2022-06-29T22:43:28Z","timestamp":1656542608000},"page":"4163","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Fluorescent Nitrogen-Doped Carbon Dots for Label Live Elder Blood-Stage Plasmodium falciparum through New Permeability Pathways"],"prefix":"10.3390","volume":"27","author":[{"given":"Jiahui","family":"Xu","sequence":"first","affiliation":[{"name":"Jiangsu Key Laboratory of Experimental and Translational Non-Coding RNA Research, School of Medicine, Yangzhou University, Yangzhou 225009, China"},{"name":"Affiliated Hospital of Yangzhou University, Yangzhou 225000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fengyue","family":"Hu","sequence":"additional","affiliation":[{"name":"Jiangsu Key Laboratory of Experimental and Translational Non-Coding RNA Research, School of Medicine, Yangzhou University, Yangzhou 225009, China"},{"name":"The Third People\u2019s Hospital of Yangzhou, Yangzhou 225012, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuang","family":"Li","sequence":"additional","affiliation":[{"name":"Jiangsu Key Laboratory of Experimental and Translational Non-Coding RNA Research, School of Medicine, Yangzhou University, Yangzhou 225009, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiaojiao","family":"Bao","sequence":"additional","affiliation":[{"name":"Affiliated Hospital of Yangzhou University, Yangzhou 225000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Yin","sequence":"additional","affiliation":[{"name":"Jiangsu Key Laboratory of Experimental and Translational Non-Coding RNA Research, School of Medicine, Yangzhou University, Yangzhou 225009, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhenyu","family":"Ren","sequence":"additional","affiliation":[{"name":"Jiangsu Key Laboratory of Experimental and Translational Non-Coding RNA Research, School of Medicine, Yangzhou University, Yangzhou 225009, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Deng","sequence":"additional","affiliation":[{"name":"Jiangsu Key Laboratory of Experimental and Translational Non-Coding RNA Research, School of Medicine, Yangzhou University, Yangzhou 225009, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fang","family":"Tian","sequence":"additional","affiliation":[{"name":"Jiangsu Key Laboratory of Experimental and Translational Non-Coding RNA Research, School of Medicine, Yangzhou University, Yangzhou 225009, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guangyu","family":"Bao","sequence":"additional","affiliation":[{"name":"Affiliated Hospital of Yangzhou University, Yangzhou 225000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian","family":"Liu","sequence":"additional","affiliation":[{"name":"Affiliated Hospital of Yangzhou University, Yangzhou 225000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yinyue","family":"Li","sequence":"additional","affiliation":[{"name":"Jiangsu Key Laboratory of Experimental and Translational Non-Coding RNA Research, School of Medicine, Yangzhou University, Yangzhou 225009, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinlong","family":"He","sequence":"additional","affiliation":[{"name":"Jiangsu Key Laboratory of Experimental and Translational Non-Coding RNA Research, School of Medicine, Yangzhou University, Yangzhou 225009, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juqun","family":"Xi","sequence":"additional","affiliation":[{"name":"Jiangsu Key Laboratory of Experimental and Translational Non-Coding RNA Research, School of Medicine, Yangzhou University, Yangzhou 225009, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Feng","family":"Lu","sequence":"additional","affiliation":[{"name":"Jiangsu Key Laboratory of Experimental and Translational Non-Coding RNA Research, School of Medicine, Yangzhou University, Yangzhou 225009, China"},{"name":"Affiliated Hospital of Yangzhou University, Yangzhou 225000, China"},{"name":"Jiangsu Key Laboratory of Zoonosis, Jiangsu Co-Innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses, Yangzhou 225009, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,6,29]]},"reference":[{"key":"ref_1","unstructured":"WHO (2021, December 06). 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